ID | 30562 |
JaLCDOI | |
FullText URL | |
Author |
Takaya, Yasumasa
Ota, Zensuke
Makino, Hirofumi
Kida, Keiko
Miyoshi, Akira
Hiramatsu, Makoto
Ofuji, Tadashi
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Abstract | Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrosis rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4+/-10.7 A and the short dimension 13.8+/-3.6 A in nephrosis whereas the long dimension was 12.3+/-2.5 A and the short dimension 8.4+/-1.0 A in normal rats. Changes in the pores in GBM were thought to result in increased permeability of serum protein and hence proteinuria.
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Keywords | gromerular basement membranc
aminonucleoside nephrosis
negative staining.
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Amo Type | Brief Note
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Publication Title |
Acta Medica Okayama
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Published Date | 1980-02
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Volume | volume34
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Issue | issue1
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Publisher | Okayama University Medical School
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Start Page | 67
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End Page | 70
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |