検索結果 - 岡山大学学術成果リポジトリ

遠隔での見守りのための機器・サービスの調査と訪問看護での利用を想定した分類

JaLCDOI	10.18926/interdisciplinary/61889
タイトル（別表記）	Information and communication technology equipment and services for remote monitoring and health management: Survey of services and their classification for use in home care nursing
フルテキストURL	interdisciplinary_1_47_63.pdf
著者	坂本年生\| 平田晶奈\| 森田瑞樹\|
抄録	This study aims to improve the quality of home nursing care for the elderly. The report presents web-based information about devices and services for remote monitoring and health management using information and communication technology and about how they can improve home care nursing station efficiency in Japan. The search terms "elderly people," "watch over," and "service," plus "sensor" were used to narrow the search. After repeating the search using a chained search for materials and links extracted from those search results, services for home care stations particularly addressing the remote monitoring of elderly people were selected and extracted. Early detection of abnormalities for support by home health nurse responsibilities for observing the general condition of the patient was chosen as the main evaluation index of usefulness. The contractor and service cost were secondary evaluation axes. Results show 9 information communication devices and services for real-time monitoring of the elderly persons’ vital signs in real time for 24 hr, 2 of which are highly useful for early detection of abnormalities and subsequent response. Results suggest that other services might be more useful, depending on how they are used, and that general-purpose services with minimum functions and low cost of introduction and maintenance can provide more opportunities for utilization. Providing these services on a BtoBtoC model and responding to patients’ medical needs can supplement home care nursing station work, increase human resource and time efficiencies, and give patients "the feeling that a nurse is always at their bedside,” even when far away.
キーワード	elderly people watch over sensor in home care support telenursing
出版物タイトル	統合科学
発行日	2021-03-31
巻	1巻
開始ページ	47
終了ページ	63
ISSN	2436-3227
言語	日本語
論文のバージョン	publisher
NAID	120007029896

Evaluation of the Imaging Process for a Novel Subtraction Method Using Apparent Diffusion Coefficient Values

JaLCDOI	10.18926/AMO/61880
フルテキストURL	75_2_139.pdf
著者	Hamada, Kentaro\| Kuroda, Masahiro\| Yoshimura, Yuuki \| Khasawneh, Abdullah\| Barham, Majd\| Tekiki, Nouha\| Sugianto, Irfan\| Bamgbose, Babatunde O.\| Konishi, Kohei\| Sugimoto, Kohei\| Ishizaka, Hinata\| Kurozumi, Akira\| Matsushita, Toshi \| Ohno, Seiichiro\| Kanazawa, Susumu\| Asaumi, Junichi\|
抄録	Diffusion-weighted imaging may be used to obtain the apparent diffusion coefficient (ADC), which aids the diagnosis of cerebral infarction and tumors. An ADC reflects elements of free diffusion. Diffusion kurtosis imaging (DKI) has attracted attention as a restricted diffusion imaging technique. The ADC subtraction method (ASM) was developed to visualize restricted diffusion with high resolution by using two ADC maps taken with different diffusion times. We conducted the present study to provide a bridge between the reported basic ASM research and clinical research. We developed new imaging software for clinical use and evaluated its performance herein. This software performs the imaging process automatically and continuously at the pixel level, using ImageJ software. The new software uses a macro or a plugin which is compatible with various operating systems via a Java Virtual Machine. We tested the new imaging software’s performance by using a Jurkat cell bio-phantom, and the statistical evaluation of the performance clarified that the ASM values of 99.98% of the pixels in the bio-phantom and physiological saline were calculated accurately (p<0.001). The new software may serve as a useful tool for future clinical applications and restricted diffusion imaging research.
キーワード	apparent diffusion coefficient ADC subtraction method restricted diffusion ImageJ plugin
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-04
巻	75巻
号	2号
出版者	Okayama University Medical School
開始ページ	139
終了ページ	145
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33953420
NAID	120007029903

Japanese Lung Cancer Society Guidelines for Stage IV NSCLC With EGFR Mutations

フルテキストURL	fulltext20210506_1.pdf
著者	Ninomiya, Kiichiro\| Teraoka, Shunsuke\| Zenke, Yoshitaka\| Kenmotsu, Hirotsugu\| Nakamura, Yukiko\| Okuma, Yusuke\| Tamiya, Akihiro\| Nosaki, Kaname\| Morise, Masahiro\| Aokage, Keiju\| Oya, Yuko\| Kozuki, Toshiyuki\| Sakamoto, Tomohiro\| Tanaka, Kentaro\| Tanaka, Hisashi\| Tanizaki, Junko\| Miura, Satoru\| Mizutani, Hideaki\| Miyauchi, Eisaku\| Yamaguchi, Ou\| Ebi, Noriyuki\| Goto, Yasushi\| Sasaki, Takaaki\| Daga, Haruko\| Morita, Satoshi\| Yamanaka, Takeharu\| Amano, Shinsuke\| Hasegawa, Kazuo\| Imamura, Chiyo K.\| Suzuki, Kenichi\| Nakajima, Kazuko\| Nishimoto, Hitomi\| Oizumi, Satoshi\| Hida, Toyoaki\| Hotta, Katsuyuki\| Takiguchi, Yuichi\|
キーワード	Non–small cell lung cancer Epidermal growth factor receptor Systematic review Guidelines
発行日	2021-01-31
出版物タイトル	JTO Clinical and Research Reports
巻	2巻
号	1号
出版者	Elsevier
開始ページ	100107
ISSN	26663643
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
NAID	120007032762
DOI	10.1016/j.jtocrr.2020.100107
関連URL	isVersionOf https://doi.org/10.1016/j.jtocrr.2020.100107

Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation

フルテキストURL	fulltext.pdf
著者	Ito, Atene\| Kagawa, Shunsuke\| Sakamoto, Shuichi\| Kuwada, Kazuya\| Kajioka, Hiroki\| Yoshimoto, Masashi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
発行日	2021-01-28
出版物タイトル	BMC Cancer
巻	21巻
号	1号
出版者	BMC
開始ページ	102
ISSN	1471-2407
NCID	AA12034763
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2021
論文のバージョン	publisher
PubMed ID	33509150
DOI	10.1186/s12885-021-07816-6
Web of Science KeyUT	000615987400002
関連URL	isVersionOf https://doi.org/10.1186/s12885-021-07816-6

Needle Tract Ablation in Liver Tissue Using a Cryoprobe Combined with an Electrosurgical Device: Influence of ex vivo and in vivo Animal Models

JaLCDOI	10.18926/AMO/61428
フルテキストURL	75_1_9.pdf
著者	Gobara, Hideo\| Yamamoto, Akira\| Komakic, Toshiyuki\| Kitayama, Toshiaki\| Sakurai, Jun\| Iguchi, Toshihiro\| Matsui, Yusuke\| Uka, Mayu\| Tomita, Koji\| Hiraki, Takao\| Kanazawa, Susumu\|
抄録	To assess the feasibility of needle tract ablation in liver tissue in ex vivo and in vivo animal models using a cryo-probe and electrosurgical device. The experimental device is made by inserting a cryoprobe through an intro-ducer sheath for insulation, with 2-cm of probe tip projecting out. A beagle liver was punctured by the device, and electric current was applied at 30-W with the electrosurgical knife touching the non-insulated device base. The discolored area of cut surface along the device was evaluated in 5 application-time groups (5 , 10 , 15 , 20, or 25 seconds). An ex vivo experiment was performed to determine an ablation algorithm with an appropriate application time by comparison with radiofrequency ablation (RFA) results. Thereafter, an in vivo experiment was performed to verify the algorithm’s feasibility. In the ex vivo model, the cut surface demonstrated different amounts of discolored area according to the application time. The total discolored area in the 20-seconds group was similar to that by RFA. In the in vivo model, the liver did not bleed, the total discolored area was similar to that ex vivo, and coagulation necrosis was confirmed by photomicrograph. Needle tract ablation can be per-formed using the experimental device and electrosurgical device.
キーワード	needle tract ablation cryoablation electrosurgical device animal liver
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-02
巻	75巻
号	1号
出版者	Okayama University Medical School
開始ページ	9
終了ページ	14
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33649608

Clinical Characteristics of Low Androgen Status in Males with Type 2 Diabetes Mellitus

JaLCDOI	10.18926/AMO/61424
フルテキストURL	75_1_1.pdf
著者	Hamahara, Jun\| Honda, Hiroyuki\| Yamamoto, Koichiro\| Tokumasu, Kazuki\| Hanayama, Yoshihisa\| Hagiya, Hideharu\| Obika, Mikako\| Ueda, Keigo\| Kishida, Masayuki\| Otsuka, Fumio\|
抄録	To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males.
キーワード	androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-02
巻	75巻
号	1号
出版者	Okayama University Medical School
開始ページ	1
終了ページ	8
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33649607

Vasopressin gene products are colocalised with corticotrophin‐releasing factor within neurosecretory vesicles in the external zone of the median eminence of the Japanese macaque monkey (Macaca fuscata)

フルテキストURL	fulltext.pdf
著者	Otubo, Akito\| Kawakami, Natsuko\| Maejima, Sho\| Ueda, Yasumasa\| Morris, John F.\| Sakamoto, Tatsuya\| Sakamoto, Hirotaka\|
キーワード	corticotrophin‐releasing factor Japanese macaque monkey (Macaca fuscata) median eminence paraventricular nucleus of the hypothalamus vasopressin
発行日	2020-05-23
出版物タイトル	Journal of Neuroendocrinology
巻	32巻
号	8号
出版者	Wiley
開始ページ	e12875
ISSN	0953-8194
NCID	AA10755083
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
PubMed ID	32715549
DOI	10.1111/jne.12875
Web of Science KeyUT	000552300500001
関連URL	isVersionOf https://doi.org/10.1111/jne.12875

Phos-tag-based approach to study protein phosphorylation in the thylakoid membrane

フルテキストURL	fulltext.pdf
著者	Nishioka, Keiji\| Kato, Yusuke\| Ozawa, Shin-ichiro\| Takahashi, Yuichiro\| Sakamoto, Wataru\|
キーワード	Chloroplast Phos-tag Protein phosphorylation Thylakoid membrane STN7 STN8
発行日	2021-01
出版物タイトル	Photosynthesis Research
巻	147巻
号	1号
出版者	Springer
開始ページ	107
終了ページ	124
ISSN	0166-8595
NCID	AA00362200
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Authors.
論文のバージョン	publisher
PubMed ID	33269435
DOI	10.1007/s11120-020-00803-1
Web of Science KeyUT	000595363200001
関連URL	isVersionOf https://doi.org/10.1007/s11120-020-00803-1

Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

フルテキストURL	fulltext.pdf Figures.pdf Suppl_Material_Methods.pdf Suppl_Figures.pdf Legend_suppl_figures.pdf Suppl_Table.pdf
著者	Kajioka, Hiroki\| Kagawa, Shunsuke\| Ito, Atene\| Yoshimoto, Masashi\| Sakamoto, Shuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Umeda, Yuzo\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model
備考	This fulltext is available in January, 2022.\|
発行日	2021-01-28
出版物タイトル	Cancer Letters
巻	497巻
出版者	Elsevier
開始ページ	1
終了ページ	3
ISSN	0304-3835
NCID	AA00598513
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	33065249
DOI	10.1016/j.canlet.2020.10.015
Web of Science KeyUT	000596072900001
関連URL	isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015

C-Arm-Free Minimally Invasive Cervical Pedicle Screw Fixation (MICEPS): A Technical Note

JaLCDOI	10.18926/AMO/61216
フルテキストURL	74_6_551.pdf
著者	Tanaka, Masato\| Fujiwara, Yoshihiro\| Uotani, Koji\| Kadiri, Venkatesh\| Yamauchi, Taro\|
抄録	A minimally invasive posterolateral approach designed to avoid the lateral misplacement of midcervical pedicle screws was reported, but there is no technical report that describes this technique without C-arm fluoroscopy. We report the results of a 2.5 years follow-up of a 62-year-old female patient with C4 metastatic breast cancer. The patient suffered from severe neck pain and impending quadriplegia for 2 months after radiation therapy. We performed C-arm-free minimally invasive cervical pedicle screw fixation (MICEPS). The patient was suc-cessfully treated with surgery, and her neck pain was well controlled. She had neither neurological deficits nor neck pain at the final (2.5-year) follow-up. C-arm-free MICEPS is a useful technique; in addition, the sur-geons and staff have no risk of radiation exposure, there is a reduced need for postoperative imaging, and a decreased revision rate can be expected with C-arm-free MICEPS.
キーワード	cervical spine navigation surgery minimally invasive surgery cervical pedicle screw C-arm free
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	551
終了ページ	556
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361877
Web of Science KeyUT	000601203600013
NAID	120006948943

Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons

フルテキストURL	fulltext.pdf
著者	Miyata, Takashi\| Hagiwara, Daisuke\| Hodai, Yuichi\| Miwata, Tsutomu\| Kawaguchi, Yohei\| Kurimoto, Junki\| Ozaki, Hajime\| Mitsumoto, Kazuki\| Takagi, Hiroshi\| Suga, Hidetaka\| Kobayashi, Tomoko\| Sugiyama, Mariko\| Onoue, Takeshi\| Ito, Yoshihiro\| Iwama, Shintaro\| Banno, Ryoichi\| Matsumoto, Mami\| Kawakami, Natsuko\| Ohno, Nobuhiko\| Sakamoto, Hirotaka\| Arima, Hiroshi\|
発行日	2020-10-23
出版物タイトル	iScience
巻	23巻
号	10号
出版者	Cell Press
開始ページ	101648
ISSN	2589-0042
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
PubMed ID	33103081
DOI	10.1016/j.isci.2020.101648
Web of Science KeyUT	000581985500098
関連URL	isVersionOf https://doi.org/10.1016/j.isci.2020.101648

Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord

フルテキストURL	fulltext.pdf
著者	Oti, Takumi\| Satoh, Keita\| Uta, Daisuke\| Nagafuchi, Junta\| Tateishi, Sayaka\| Ueda, Ryota\| Takanami, Keiko\| Young, Larry J.\| Galione, Antony\| Morris, John F.\| Sakamoto, Tatsuya\| Sakamoto, Hirotaka\|
キーワード	oxytocin localized volume transmission spinal cord male sexual activity gastrin-releasing peptide spinal ejaculation generator
備考	© 2020 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.cub.2020.09.089] .\|
発行日	2020-10-29
出版物タイトル	Current Biology
巻	31巻
号	1号
出版者	Elsevier
開始ページ	103
終了ページ	114.e5
ISSN	0960-9822
NCID	AA1081652X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
PubMed ID	33125871
DOI	10.1016/j.cub.2020.09.089
関連URL	isVersionOf https://doi.org/10.1016/j.cub.2020.09.089

Introducing the Amphibious Mudskipper Goby as a Unique Model to Evaluate Neuro/Endocrine Regulation of Behaviors Mediated by Buccal Sensation and Corticosteroids

フルテキストURL	fulltext.pdf
著者	Katayama, Yukitoshi\| Saito, Kazuhiro\| Sakamoto, Tatsuya\|
キーワード	stressors thirst angiotensin II corticosteroids amphibious fish
発行日	2020-09-14
出版物タイトル	International Journal of Molecular Sciences
巻	21巻
号	18号
出版者	MDPI
開始ページ	6748
ISSN	1422-0067
NCID	AA12038549
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32938015
DOI	10.3390/ijms21186748
Web of Science KeyUT	000580799600001
関連URL	isVersionOf https://doi.org/10.3390/ijms21186748

DroidTrack: Tracking Information Diffusion and Preventing Information Leakage on Android

著者	Sakamoto, Syunya\|
発行日	2013-05-03
出版物タイトル	Multimedia and Ubiquitous Engineering
資料タイプ	図書

Study Protocol for Assessing the Efficacy of Compression Therapy Using Stockings and Sleeves to Prevent Docetaxel-Induced Peripheral Neuropathy in Breast Cancer Patients

JaLCDOI	10.18926/AMO/60808
フルテキストURL	74_5_455.pdf
著者	Yamanouchi, Kosho\| Kuba, Sayaka\| Matsumoto, Megumi\| Yano, Hiroshi\| Morita, Michi\| Sakimura, Chika\| Otsubo, Ryota\| Kanetaka, Kengo\| Nagayasu, Takeshi\| Eguchi, Susumu\|
抄録	Taxanes are key drugs for patients with breast cancer. A major adverse effect associated with the administration of the taxane docetaxel is chemotherapy-induced peripheral neuropathy (CIPN). We are conducting a singlecenter, single-arm, open-label historical control trial to evaluate the ability of compression therapy using stockings or sleeves to prevent CIPN due to docetaxel treatment. The primary endpoint is the incidence of all-grade CIPN according to patients’ records until 3 weeks after the fourth docetaxel administration. This study’s results will clarify whether compression therapy using stockings or sleeves can prevent CIPN in breast cancer patients.
キーワード	breast cancer docetaxel neuropathy compression
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2020-10
巻	74巻
号	5号
出版者	Okayama University Medical School
開始ページ	455
終了ページ	459
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33106704
Web of Science KeyUT	000581970100013
NAID	120006892934

Variation of pro‐vasopressin processing in parvocellular and magnocellular neurons in the paraventricular nucleus of the hypothalamus: Evidence from the vasopressin‐related glycopeptide copeptin

フルテキストURL	fulltext.pdf
著者	Kawakami, Natsuko\| Otubo, Akito\| Maejima, Sho\| Talukder, Ashraf H.\| Satoh, Keita\| Oti, Takumi\| Takanami, Keiko\| Ueda, Yasumasa\| Itoi, Keiichi\| Morris, John F.\| Sakamoto, Tatsuya\| Sakamoto, Hirotaka\|
キーワード	copeptin hypothalamo‐pituitary–adrenal system immunohistochemistry paraventricular nucleus of the hypothalamus processing vasopressin RRID: AB_2722604 RRID: AB_2061966 RRID: AB_2314234 RRID: AB_10013361 RRID: AB_2313960 RRID: AB_2722605 RRID: AB_90782
発行日	2020-09-06
出版物タイトル	Journal of Comparative Neurology
巻	529巻
号	7号
出版者	Wiley
開始ページ	1372
終了ページ	1390
ISSN	0021-9967
NCID	AA00695917
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
PubMed ID	32892351
DOI	10.1002/cne.25026
Web of Science KeyUT	000571267600001
関連URL	isVersionOf https://doi.org/10.1002/cne.25026

Transcriptomic Analysis of the Kuruma PrawnMarsupenaeus japonicusReveals Possible Peripheral Regulation of the Ovary

フルテキストURL	fulltext.pdf
著者	Tsutsui, Naoaki\| Kobayashi, Yasuhisa\| Izumikawa, Kouichi\| Sakamoto, Tatsuya\|
キーワード	peptide hormone Marsupenaeus japonicus ovary reproduction transcriptome vitellogenesis
発行日	2020-08-19
出版物タイトル	Frontiers in Endocrinology
巻	11巻
出版者	Frontiers Media
開始ページ	541
ISSN	1664-2392
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 Tsutsui, Kobayashi, Izumikawa and Sakamoto.
論文のバージョン	publisher
DOI	10.3389/fendo.2020.00541
Web of Science KeyUT	000566191000001
関連URL	isVersionOf https://doi.org/10.3389/fendo.2020.00541

High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4

フルテキストURL	fulltext.pdf
著者	Sakamoto, Yumi\| Okui, Tatsuo\| Yoneda, Toshiyuki\| Ryumon, Shoji\| Nakamura, Tomoya\| Kawai, Hotaka\| Kunisada, Yuki\| Ibaragi, Soichiro\| Masui, Masanori\| Ono, Kisho\| Obata, Kyoichi\| Shimo, Tsuyoshi\| Sasaki, Akira\|
キーワード	Oral squamous cell cancer HMGB1 Bone destruction Osteoclasts
発行日	2020-10-20
出版物タイトル	Biochemical and Biophysical Research Communications
巻	531巻
号	3号
出版者	Elsevier
開始ページ	422
終了ページ	430
ISSN	0006-291X
NCID	AA00564395
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors
論文のバージョン	publisher
PubMed ID	32800556
DOI	10.1016/j.bbrc.2020.07.120
Web of Science KeyUT	000571663900011
関連URL	isVersionOf https://doi.org/10.1016/j.bbrc.2020.07.120

Preoperative Use of Alpha-1 Receptor Blockers in Male Patients Undergoing Extracorporeal Shock Wave Lithotripsy for a Ureteral Calculus

JaLCDOI	10.18926/AMO/60367
フルテキストURL	74_4_293.pdf
著者	Yoshioka, Takashi\| Omae, Kenji\| Kawada, Tatsushi\| Inoue, Yosuke\| Sugimoto, Morito\| Oeda, Tadashi\| Uehara, Shinya\| Araki, Motoo\| Fukuhara, Shunichi\|
抄録	In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality.
キーワード	urolithiasis extracorporeal shockwave therapy adrenergic alpha-1 receptor antagonists
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-08
巻	74巻
号	4号
出版者	Okayama University Medical School
開始ページ	293
終了ページ	299
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32843760
Web of Science KeyUT	000562508700004
NAID	120006880206

Decreased Serum Antioxidant Marker is Predictive of Early Recurrence in the Same Segment after Radical Ablation for Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/60364
フルテキストURL	74_4_275.pdf
著者	Muro, Taiko\| Nakamura, Shinichiro\| Takaki, Akinobu\| Onishi, Hideki\| Wada, Nozomu\| Yasunaka, Tetsuya\| Uchida, Daisuke\| Oyama, Atsushi\| Adachi, Takuya\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment.
キーワード	oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-08
巻	74巻
号	4号
出版者	Okayama University Medical School
開始ページ	275
終了ページ	283
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32843758
Web of Science KeyUT	000562508700002
NAID	120006880203