フルテキストURL manuscript.pdf Figure.pdf Table.pdf
著者 Umemura, Hiroshi| Yamasaki, Osamu| Kaji, Tatsuya| Hamada, Toshihisa| Otsuka, Masaki| Asagoe, Kenji| Iwatsuki, Keiji|
抄録 Cutaneous angiosarcoma (CAS) is a rare soft tissue sarcoma with rapid growth and poor prognosis. We retrospectively analyzed the data of 18 patients with CAS who underwent 18 F-Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) at the initial visit to the Department of Dermatology, Okayama University Hospital from September 2006 to March 2016. In the univariate survival analysis, patients with high standardized uptake values (SUVmax ) of the primary tumor showed significantly poorer prognosis than those with low SUVmax . Early assessment of prognosis using PET/CT may predict patient survival and is useful in the selection of therapeutic strategies.
キーワード angiosarcoma maximum standardized uptake value positron emission tomography positron emission tomography/computed tomography prognostic factor
備考 This is an Accepted Manuscript of an article published by Wiley-Blackwell
発行日 2017-09
出版物タイトル Journal of Dermatology
44巻
9号
出版者 Wiley-Blackwell
開始ページ 1046
終了ページ 1049
ISSN 0385-2407
NCID AA00696658
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28370268
DOI 10.1111/1346-8138.13839
Web of Sience KeyUT 000409187000022
関連URL isVersionOf https://doi.org/10.1111/1346-8138.13839
フルテキストURL K0005440_other1.pdf
著者 Hiroshi, Umemura| Yamasaki, Osamu| Kaji, Tatsuya| Otsuka, Masaki| Asagoe, Kenji| Takata, Minoru| Iwatsuki, Keiji|
抄録 With the recent development of novel molecular targeted drugs for advanced stage malignant melanoma (MM), including RAF and mitogen-activated protein kinase kinase inhibitors and immune checkpoint blockers, the early detection of relapse is important for managing patients with MM. In this study, we retrospectively analyzed two conventional serum biomarkers, 5-S-cysteinyl-dopa and lactate dehydrogenase, in patients with MM (n = 140) who were treated at a single Japanese institute from June 2007 to June 2015. At the initial hospital visit, serum 5-S-cysteinyl-dopa levels were significantly increased in patients with stages III (n = 38) and IV (n = 20) MM compared with patients with stages 0-II (n = 62) MM. In addition, in patients with stages III and IV MM, serum 5-S-cysteinyl-dopa levels of more than 15.0 nmol/L at initial hospital visit correlated with a poor prognosis. In 11 of 14 patients whose disease progressed during follow up (mostly from stages III-IV), serum 5-S-cysteinyl-dopa levels exceeded the normal limit of 10.0 nmol/L during the clinical detection of distant metastases. These results indicate the usefulness of measuring serum 5-S-cysteinyl-dopa levels at initial hospital visit and during follow up for early and effective therapeutic interventions using newly developed molecular targeted drugs.
キーワード 5-S-cysteinyl-dopa biomarker lactate dehydrogenase malignant melanoma serum 5-S-CD
備考 学位審査副論文
発行日 2017-04
出版物タイトル Journal of Dermatology
44巻
4号
出版者 Wiley-Blackwell
開始ページ 449
終了ページ 454
ISSN 03852407
NCID AA00696658
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 27786364
DOI 10.1111/1346-8138.13651
Web of Sience KeyUT 000398690600029
関連URL isVersionOf https://doi.org/10.1111/1346-8138.13651
著者 Mizutani, Shinsuke| Ekuni, Daisuke| Furuta, Michiko| Tomofuji, Takaaki| Irie, Koichiro| Azuma, Tetsuji| Kojima, Azusa| Nagase, Jun| Iwasaki, Yoshiaki| Morita, Manabu|
発行日 2012-09
出版物タイトル Journal of Clinical Periodontology
39巻
9号
資料タイプ 学術雑誌論文
著者 Nishimura, Mamoru| Takaki, Akinobu| Tamaki, Naofumi| Maruyama, Takayuki| Onishi, Hideki| Kobayashi, Sayo| Nouso, Kazuhiro| Yasunaka, Tetsuya| Koike, Kazuko| Hagihara, Hiroaki| Kuwaki, Kenji| Nakamura, Shinichiro| Ikeda, Fusao| Iwasaki, Yoshiaki| Tomofuji, Takaaki| Morita, Manabu| Yamamoto, Kazuhide|
発行日 2013-01-30
出版物タイトル Hepatology Research
43巻
10号
資料タイプ 学術雑誌論文
著者 Obika, Masanari| Ogawa, Hiroko| Takahashi, Katsuyuki| Li, Jiayi| Hatipoglu, Omer Faruk| Cilek, Mehmet Zeynel| Miyoshi, Toru| Inagaki, Junko| Ohtsuki, Takashi| Kusachi, Shozo| Ninomiya, Yoshifumi| Hirohata, Satoshi|
発行日 2012-10
出版物タイトル Cancer Science
103巻
10号
資料タイプ 学術雑誌論文
著者 Miki, Yukari| Gion, Yuka| Mukae, Yuriko| Hayashi, Atsushi| Sato, Hiaki| Yoshino, Tadashi| Takahashi, Kiyoshi|
発行日 2013-02
出版物タイトル European Journal of Haematology
90巻
2号
資料タイプ 学術雑誌論文
著者 Hoshijima, Mitsuhiro| Hattori, Takako| Aoyama, Eriko| Nishida, Takashi| Yamashiro, Takashi| Takigawa, Masaharu|
発行日 2012-10
出版物タイトル FEBS Journal
279巻
19号
資料タイプ 学術雑誌論文
著者 Kobayashi, Sayo| Nouso, Kazuhiro| Kinugasa, Hideaki| Takeuchi, Yasuto| Tomoda, Takeshi| Miyahara, Koji| Hagihara, Hiroaki| Kuwaki, Kenji| Onishi, Hideki| Nakamura, Shinichiro| Ikeda, Fusao| Miyake, Yasuhiro| Shiraha, Hidenori| Takaki, Akinobu| Yamamoto, Kazuhide|
発行日 2012-12
出版物タイトル Hepatology Research
42巻
12号
資料タイプ 学術雑誌論文
著者 Endo, Yasumasa| Tomofuji, Takaaki| Ekuni, Daisuke| Azuma, Tetsuji| Irie, Koichiro| Kasuyama, Kenta| Morita, Manabu|
発行日 2013-01
出版物タイトル Journal of Clinical Periodontology
40巻
1号
資料タイプ 学術雑誌論文
著者 Maruo, Tomoko| Ichikawa, Tomotsugu| Kanzaki, Hirotaka| Inoue, Satoshi| Kurozumi, Kazuhiko| Onishi, Manabu| Yoshida, Koichi| Kambara, Hirokazu| Ouchida, Mamoru| Shimizu, Kenji| Tamaru, Seiji| Chiocca, E. Antonio| Date, Isao|
発行日 2013-06
出版物タイトル Neuropathology
33巻
3号
資料タイプ 学術雑誌論文
著者 Iwado, Eiji| Ichikawa, Tomotsugu| Kosaka, Hiroshi| Otsuka, Shinji| Kambara, Hirokazu| Tamiya, Takashi| Kondo, Seiji| Date, Isao|
発行日 2012-12
出版物タイトル Neuropathology
32巻
6号
資料タイプ 学術雑誌論文