ID | 50634 |
フルテキストURL | |
著者 |
Endo, Yasumasa
Tomofuji, Takaaki
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Prevent Dent
ORCID
Kaken ID
publons
researchmap
Ekuni, Daisuke
Azuma, Tetsuji
Irie, Koichiro
Kasuyama, Kenta
Morita, Manabu
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抄録 | Aim Trehalose, which is a disaccharide formed by a 1,1 linkage of two glucose molecules, was suggested to have a suppressive effect on bone resorption. In this study, we examined the effects of topical application of trehalose on osteoclast differentiation in a rat periodontitis model.
Material and Methods Rats were divided into four groups. One group received no treatment. In the other groups, experimental periodontitis was induced by ligature placement. These rats with experimental periodontitis received topical application of pure water (vehicle group), 30 mg/ml trehalose solution (30 mg/ml trehalose group) or 60 mg/ml trehalose solution (60 mg/ml trehalose group) to the gingival sulcus respectively.
Results The vehicle group showed higher numbers of polymorphonuclear leucocytes, receptor activator of nuclear factor kappa B ligand (RANKL)-positive cells and osteoclasts compared with the no treatment group respectively. Trehalose-applied groups exhibited lower numbers of these cells compared with the vehicle group. Gene expressions of tumour necrosis factor-a, RANKL and toll-like receptor 4 were suppressed by trehalose. In addition, protein expressions of RANKL inducing pathway were less activated by trehalose.
Conclusion Topical application of trehalose could suppress osteoclast differentiation by inactivation of RANKL inducing pathway in the rat periodontitis model.
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キーワード | animal studies
osteoclast
periodontitis
trehalose
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発行日 | 2013-01
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出版物タイトル |
Journal of Clinical Periodontology
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巻 | 40巻
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号 | 1号
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出版者 | Wiley-Blackwell
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開始ページ | 33
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終了ページ | 40
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ISSN | 0303-6979
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://dx.doi.org/10.1111/jcpe.12032
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50701
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言語 |
英語
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |