JaLCDOI 10.18926/AMO/51071
フルテキストURL 67_4_259.pdf
著者 Idani, Hitoshi| Nakano, Kanyu| Asami, Shinya| Kubota, Tetsushi| Komoto, Satoshi| Kurose, Yohei| Kubo, Shinichiro| Nojima, Hiroki| Hioki, Katsuyoshi| Kin, Hitoshi| Takakura, Norihisa|
抄録 We describe a new simple and easy technique called the "Hook and roll technique" (HRT) that uses an articulating hook cautery to provide a critical view during single incision laparoscopic cholecystectomy (SILC). A 2-cm incision is made at the umbilicus to insert three 5-mm trocars or a multichannel port. After dissection of the serosa of the dorsal and ventral sides of the gall bladder, including Calot's triangle, the angled tip of the hook cautery is inserted between the cystic artery and duct with its tip placed dorsally. The tip is then rotated in a clockwise manner to avoid bile duct injury, allowing the connective tissue between them to be hooked, coagulated and cut. This procedure is repeated several times, followed by dissection between the cystic artery and the liver bed to achieve a critical view. From December 2008 to May 2011, 121 patients underwent SILC using HRT in our hospital without any serious complications. This technique is suitable for SILC, as it is consists of simple procedures that can be performed safely and easily, even by left hand in a cross-over approach, and it allows complete dissection of Calot's triangle to achieve a critical view without using any dissector under dangerous in-line viewing.
キーワード critical view of safety single incision laparoscopic cholecystectomy articulating hook cautery
Amo Type Original Article
発行日 2013-08
出版物タイトル Acta Medica Okayama
67巻
4号
出版者 Okayama University Medical School
開始ページ 259
終了ページ 263
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23970325
Web of Science KeyUT 000323470100008
JaLCDOI 10.18926/AMO/57373
フルテキストURL 73_5_427.pdf
著者 Owari, Yutaka| Suzuki, Hiromi| Miyatake, Nobuyuki|
抄録 The aim of this study was to examine in a randomized controlled trial how much the sedentary behavior (sitting time) of community-dwelling elderly Japanese subjects decreased as a result of using the “Active Guide” brochure published by the Ministry of Health, Labour and Welfare (2013) and additional documents related to the benefits of reducing sedentary behavior. A total of 86 elderly people who participated in health-club activities for one year were randomly allocated to two groups. Subjects in the intervention group received explanations of the importance of physical activity using the “Active Guide” brochure (n=42) and additional documents, while subjects in the control group did not (n=44). Physical activity was measured using a triaxial accelerometer for two weeks at baseline and again after one year. After one year of intervention, the difference in the sedentary behavior rate from baseline was −2.2% for the intervention group (n=40) and +2.5% for controls (n=40) (Welch’s t-test, p=0.007). Use of the “Active Guide” brochure and additional documents may reduce the sedentary behavior of community dwelling elderly people in Japan.
キーワード Active Guide sedentary behavior elderly people randomized controlled trial health promotion
Amo Type Original Article
発行日 2019-10
出版物タイトル Acta Medica Okayama
73巻
5号
出版者 Okayama University Medical School
開始ページ 427
終了ページ 432
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649369
Web of Science KeyUT 000491886600008
JaLCDOI 10.18926/AMO/50409
フルテキストURL 67_3_165.pdf
著者 Shien, Tadahiko| Kinoshita, Takayuki| Seki, Kunihiko| Yoshida, Miwa| Hojo, Takashi| Shimizu, Chikako| Taira, Naruto| Doihara, Hiroyoshi| Akashi-Tanaka, Sadako| Tsuda, Hitoshi| Fujiwara, Yasuhiro|
抄録 While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p=0.045) and histological grade 3 (p=0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC.
キーワード breast cancer neoadjuvant chemotherapy predictors
Amo Type Original Article
発行日 2013-06
出版物タイトル Acta Medica Okayama
67巻
3号
出版者 Okayama University Medical School
開始ページ 165
終了ページ 170
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23804139
Web of Science KeyUT Pretreatment Specimen Predicts
JaLCDOI 10.18926/AMO/30546
フルテキストURL fulltext.pdf
著者 Kaneshige, Tetsuzo| Asahi, Toshihiko| Matsumura, Yosuke| Ohmori, Hiroyuki| okamoto, Tsukasa| Tanaka, Toshio|
抄録 <p>&#60;P&#62;A 73-year-old man with a left testicular tumor is presented. Orchiectomy was performed and the tumor was diagnosed as a plasmacytoma. There has been no bone lesion or immunoglobulin abnormality during a follow-up period more than one year. For several reasons, the tumor was regarded as a primary plasmacytoma of the testicle. The literature concerning testicular plasmacytoma is reviewed briefly.</p>
キーワード plasmacytoma testis.
Amo Type Article
発行日 1980-11
出版物タイトル Acta Medica Okayama
34巻
5号
出版者 Okayama University Medical School
開始ページ 315
終了ページ 322
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6449130
Web of Science KeyUT A1980KT96800003
JaLCDOI 10.18926/AMO/30763
フルテキストURL fulltext.pdf
著者 Nakagawa, Yuko| Watanabe, Sekiko| Akiyama, Kosuke| Sarker, Altaf H| Tsutsui, Ken| Inoue, Hajime| Seki, Shuji|
抄録 <p>We purified a 44-kDa nuclear protein from salt-extract of permeable mouse ascites sarcoma cells in an effort to isolate factors involved in the repair of acid-depurinated DNA. It was copurified with a major AP endonuclease (APEX nuclease) by sequential column chromatography then further purified by sodium dodecyl sulphate-poly-acrylamide gel electrophoresis as a possible DNA repair support factor. Its partial amino acid sequences were determined, and a cDNA clone for the protein was isolated from a mouse T-cell cDNA library using long degenerate oligonucleotide probes deduced from the amino acid sequence. The complete nucleotide sequence of the cDNA (1.7 kilobases) was determined. Northern hybridization using this cDNA detected two transcripts: 1.8kb being the major one and 2.6 kb being the minor one. The complete amino acid sequence for the protein predicted from the nucleotide sequence of the cDNA indicates that the 44-kDa protein consists of 394 amino acids with a calculated molecular weight of 43,698. In tests performed thus far, the recombinant 44-kDa protein expressed in Escherichia coli has not expressed any repair-support activity. It remains to be analyzed whether the protein attains this activity after appropriate posttranslational modifications. Most parts of the 44-kDa protein cDNA and the deduced amino acid sequence were found to be identical to those of the protein p38 -2G4, recently reported as a cell cycle-specifically modulated nuclear protein of 38kDa. The p38-2G4 may be a truncated form of the present 44-kDa protein.</p>
キーワード 44-kDa protein nuclear protein cDNA cloning cDNA sequencing recombinant protein
Amo Type Article
発行日 1997-08
出版物タイトル Acta Medica Okayama
51巻
4号
出版者 Okayama University Medical School
開始ページ 195
終了ページ 206
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9284967
Web of Science KeyUT A1997XU03200003
JaLCDOI 10.18926/AMO/30516
フルテキストURL fulltext.pdf
著者 Tan, Yunshan| Nakagawa, Yuko| Akiyama, Kosuke| Wakabayashi, Hajime| Sarker, Altaf H.| Seki, Shuji|
抄録 <p>APEX nuclease is a mammalian DNA repair enzyme having apurinic/apyrimidinic (AP) endonuclease, 3'-5'-exonuclease, DNA 3' repair diesterase and DNA 3'-phosphatase activities. It is also a redox factor (Ref-1), stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun. In the present paper, a cDNA for the enzyme was isolated from a rat brain cDNA library using mouse Apex cDNA as a probe and sequenced. The rat Apex cDNA was 1221 nucleotides (nt) long, with a 951-nt coding region. The amino acid sequence of rat APEX nuclease has 98.4% identity with mouse APEX nuclease. Using the rat Apex cDNA as a probe for Northern blot analysis, the size of rat Apex mRNA was shown to be approximately 1.5 kb. Its expression was compared in 9 rat organs on postnatal days 7 and 28. Although Apex mRNA was expressed ubiquitously, the levels varied significantly, suggesting organ- or tissue-specific expression of the Apex gene. The highest level was observed in the testis, relatively high levels in the thymus, spleen, kidney and brain, and the lowest level in the liver. The level of expression at postnatal day 28, with the exception of the testis, was almost the same as or lower in respective organs than that at postnatal day 7. Postnatal developmental changes of Apex mRNA expression in the testis and thymus were further studied. The expression in testis was markedly increased on postnatal days 21 and 28. The expression in thymus increased once at postnatal day 14, and then decreased. The developmental changes of Apex mRNA expression in testis and thymus suggest that APEX nuclease is involved in processes such as recombinational events.</p>
キーワード Apurinic/apyrimidinic endonclease; APEX nuclease; Repair enzyme; Apex mRNA; Northen blot; developument; testis; rat
Amo Type Article
発行日 1996-02
出版物タイトル Acta Medica Okayama
50巻
1号
出版者 Okayama University Medical School
開始ページ 53
終了ページ 60
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8701782
Web of Science KeyUT A1996TY06000008
JaLCDOI 10.18926/AMO/30838
フルテキストURL fulltext.pdf
著者 Okada, Soji| Yagyu, Fumito| Kawanishi, Koichi| Ofuji, Tadashi|
抄録 <p>The relationship between immune insulitis and glucose tolerance was investigated in three groups of mice following active immunization with different components of bovine pancreatic hormone. An abnormal blood glucose level was observed in the three groups ranging from 33.3% to 87.5% of sensitized mice. A relationship was not present between the glucose tolerance response and the presence of insulitis or anti-insulin antibody in the blood of sensitized mice. However, all sensitized mice with a marked decrease in glucose tolerance were found to have insulitis. In animals without established insulitis and with no demonstrable anti-insulin antibody, abnormal glucose tolerance was noted. This latter condition occurred more frequently with recrystallized insulin than with a-component and did not occur with monocomponent insulin. These findings seemed to indicate that two distinct processes involving some circulating antibodies with anti-insulin antibody and insulitis might be involved in the development of the observed glucose tolerance abnormality.</p>
Amo Type Article
発行日 1977-06
出版物タイトル Acta Medica Okayama
31巻
3号
出版者 Okayama University Medical School
開始ページ 211
終了ページ 216
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 144420
NAID 120002305762
JaLCDOI 10.18926/AMO/32533
フルテキストURL fulltext.pdf
著者 Szirmai, Endre| Sachs, Volkmar|
抄録 <p>Die Autoren berichten uber die guten Behandlungsmoglichkeiten in der Praxis bei verschiedenen peripheren venosen Durchblutungsstorungen bei Erkrankungen der Bewegungsapparate, bei leichteren Fallen von arteriellen DurchblutungsstOrungen und bei einigen Fallen von Hirnblutungen mit Vasotonin und Vasotonin-forte und auch in vitro-Blutgerinnungsuntersuchungen. Bei den erwahnten Fallen kann man die therapeutische Wirkung noch mit Vasotonin-forte-Salbe gut unterstutzen. Die Autoren konnen nachweisen, daB Extr. Arnicae insbesonder in dem Vasotonin-forte die hamodynamische und die blutgerinnungshemmende Wirkung von extr. Aesculi Hippercastani gut verstairkt.</p>
Amo Type Article
発行日 1969-04
出版物タイトル Acta Medicinae Okayama
23巻
2号
出版者 Okayama University Medical School
開始ページ 137
終了ページ 147
NCID AA00041342
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
NAID 120002311362
JaLCDOI 10.18926/AMO/31420
フルテキストURL fulltext.pdf
著者 Okada, Soji|
抄録 <p>Es wurde Untersuchungen an Mausen mit dem Rinder-Monokomponente-Insulin und der Rinder-a-Komponente durchgefGhrt, urn den Nachweis zu erbringen, ob das Monokomponente. Insulin oder die a-Komponente als ein Insulitis-erzeugendes Antigen dienen kann. Dabei wurden die Tiere mit den Substanzen, die jeweils mit Freund's complete adjuvant wiederholt verabreicht wurden, aktiv immunisiert und weiterhin untersucht auf eine dadurch bewirkte Insulitis. (1) Bei den mit dem Rinder-MonokomponenteInsulin sensibilisierten Gruppen kam die Insulitis bei 1 von 8 Fallen in der 20. Woche nach der ersten Sensibilisierung und bei 5 von 10 Fallen in der 28. Woche zur Erscheinung. (2) Bei den mit der a-Komponente behandelten Gruppen liet3 sich die Insulitis bei 0 von 9 Fallen in der 20. Woche nach dem Sensibilisierungsbeginn und auch bei 1 von 10 Fallen in der 28. Woche nachweisen. Diese Ergebnisse zeigen, dat3 das Monokomponente-Insulin als ein Insulitis-erzeugendes Antigen wirken kann. Dagegen war nur ein Fall von Insulitis befallen unter 19 Tieren, die mit der a-Komponente behandelt wurden.</p>
Amo Type Article
発行日 1976-04
出版物タイトル Acta Medica Okayama
30巻
2号
出版者 Okayama University Medical School
開始ページ 117
終了ページ 123
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 135483
NAID 120002313033
JaLCDOI 10.18926/AMO/32144
フルテキストURL fulltext.pdf
著者 Arata, Ichiro|
抄録 1. Die Fuchsinkornchen in den Schweissdrusen konunen nur in den Epithelzellen der e-Drusen vor, nicht aber in den a-Drusen, und zwar weder im Ausfuhrungsgang noch im Drtisenlumen ; sie treten ferner in den e-Drusen in der Nahe der a-Drusen nicht auf. 2. Es scheint daher den e-Drusen an den Orten der a-Drtusen, z. B. in der Achselhohle, ein etwas anderesbiologisches Verhalten zueig-nen als den e-Drusen an den gewohnlichen Hautstellen. Dies legt die Vermutung nahe, dass noch eine andere Form von Schweissclrusen als die bisher allein angenommenen zwei Gattungen, d. h. die a- und e-Drusen, oder wenigstens eine Ubergangsform zwischen diesen zwei Drusenarten vorhanden ist. Zum Schluss mochte ich Herrn Prof. Dr. Minami ftur seine uberaus freund-liche Anleitung meinen ergebensten Dank aussprechen.
Amo Type Article
発行日 1929-06
出版物タイトル Arbeiten aus der Medizinischen Universität zu Okayama
1巻
2号
出版者 Okayama University Medical School
開始ページ 190
終了ページ 196
NCID AA00508452
資料タイプ 学術雑誌論文
言語 German
論文のバージョン publisher
査読 有り
JaLCDOI 10.18926/AMO/56370
フルテキストURL 72_6_539.pdf
著者 Hiraki, Takao| Kamegawa, Tetsushi| Matsuno, Takayuki| Komaki, Toshiyuki| Sakurai, Jun| Kanazawa, Susumu|
抄録 Since 2012, we have been developing a remote-controlled robotic system (Zerobot®) for needle insertion during computed tomography (CT)-guided interventional procedures, such as ablation, biopsy, and drainage. The system was designed via a collaboration between the medical and engineering departments at Okayama University, including various risk control features. It consists of a robot with 6 degrees of freedom that is manipulated using an operation interface to perform needle insertions under CT-guidance. The procedure includes robot positioning, needle targeting, and needle insertion. Phantom experiments have indicated that robotic insertion is equivalent in accuracy to manual insertion, without physician radiation exposure. Animal experiments have revealed that robotic insertion of biopsy introducer needles and various ablation needles is safe and accurate in vivo. The first in vivo human trial, therefore, began in April 2018. After its completion, a larger clinical study will be conducted for commercialization of the robot. This robotic procedure has many potential advantages over a manual procedure: 1) decreased physician fatigue; 2) stable and accurate needle posture without tremor; 3) procedure automation; 4) less experience required for proficiency in needle insertion skills; 5) decreased variance in technical skills among physicians; and 6) increased likelihood of performing the procedure at remote hospitals (i.e., telemedicine).
キーワード robot needle insertion CT-guided interventional radiology
Amo Type Review
発行日 2018-12
出版物タイトル Acta Medica Okayama
72巻
6号
出版者 Okayama University Medical School
開始ページ 539
終了ページ 546
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 30573907
NAID 120006545155
JaLCDOI 10.18926/AMO/30789
フルテキストURL fulltext.pdf
著者 Mihara, Koichiro| Miyazaki, Masahiro| Kondo, Tadashi| Fushimi, Kazuo| Tsuji, Toshiya| Inoue, Yusuke| Fukaya, Kenichi| Ishioka, Chikashi| Namba, Masayoshi|
抄録 <p>We used a yeast functional assay (functional analysis of separated alleles in yeast: FASAY) to determine the p53 gene status of human cell lines maintained in our laboratory. This assay enables the researcher to score wild-type p53 expression on the basis of the ability of expressed p53 to transactivate the reporter gene HIS 3 via the p53-responsive GAL 1 promoter in Saccharomyces cerevisiae. The cell lines examined were ten hepatoma, two hepatoblastoma, three in vitro immortalized fibroblast, two osteosarcoma, a chondrosarcoma, an ovarian teratocarcinoma and a colon cancer cell line. Out of 20 cell lines, 11 cell lines had mutations in both alleles of the p53 gene, and another 8 cell lines had no mutation in the p53 gene. Thus, 55% of the cell lines examined had mutations in the p53. Interestingly, PA-1 cells had both the normal and the mutant p53 alleles, showing that FASAY is a useful method for detecting the wild-type and mutated p53 genes simultaneously. As for the three liver cell lines harboring HBsAg, there was no relationship between their p53 gene status and the presence of HBsAg. Two cell lines were normal for p53 status, while the other had a mutation of the p53 gene.</p>
キーワード p53 mutation FASAY cultured human cells
Amo Type Article
発行日 1997-10
出版物タイトル Acta Medica Okayama
51巻
5号
出版者 Okayama University Medical School
開始ページ 261
終了ページ 265
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9359923
Web of Science KeyUT A1997YD65300004
JaLCDOI 10.18926/AMO/32311
フルテキストURL fulltext.pdf
著者 Kontosic, Ivica| Vukelic, Mihovil| Drescik, Ivan| Mesaros-Kanjiski, Elika| Materljan, Eris| Jonjic, Anto|
抄録 <p>This research aims to establish the effect of working conditions on the appearance of varicose veins. The epidemiological study was carried out on 1,324 examinees, 530 males and 794 females, employed in 5 highly represented groups of professional activities in Rijeka (catering, trade, light industry, heavy industry and finances). The data were collected by survey and clinical examination. Varicose veins were more prevalent in the trade than in the office workers (odds ratio (OR) = 2.08; 95% confidence interval (CI) = 1.31-3.31), and more prevalent in catering industries than in the office workers (OR = 1.56; 95% CI = 1.001-2.43). chi 2-testing suggested that standing in the workplace (OR = 1.35; 95% CI = 0.95-1.92), weight handling while working (OR = 1.29; 95% CI = 1.01-1.64) and working indoors (OR = 1.61; 95% CI = 1.02-2.53) were risk factors for varicose veins. By multiple logistic regression, the following risk factors were isolated in the total population: female sex (OR = 1.92; 95% CI = 1.37-2.67), workplace (OR = 0.89; 95% CI = 0.78-0.99), age (OR = 1.05; 95% CI = 1.03-1.07), body mass index (OR = 1.04; 95% CI = 1.01-1.07) and family history of the disease (OR = 1.99; 95% CI = 1.55-2.57).</p>
キーワード varicose vein lower extremities risk factor profession work condition
Amo Type Article
発行日 2000-02
出版物タイトル Acta Medica Okayama
54巻
1号
出版者 Okayama University Medical School
開始ページ 33
終了ページ 38
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10709620
Web of Science KeyUT 000085526000005
JaLCDOI 10.18926/AMO/32288
フルテキストURL fulltext.pdf
著者 Kubota, Masayuki| Babazono, Akira| Aoyama, Hideyasu|
抄録 <p>The purpose of this study was to verify the differences in women's anxiety in old age, the expected long-term care provision, and the expected final location for terminal care for the women themselves and for their parents. In addition, we examined factors that related to their anxiety and needs. The subjects were 1,000 women of the Seikatsu Club customer cooperative association in Chiba; 539 responded to our survey. The subjects were more anxious for their parents than for themselves. They more strongly expected long-term care for their parents to be provided by their family than they expected the same for themselves. Although no differences were observed in the expected location for terminal care, most subjects expected their home to be the terminal location. Analysis by the multiple logistic regression model indicated that the following factors were significantly related to the anxiety in old age: age odds ratio [OR = 1.81], employment [OR = 2.25] for women, and planning to live with parents [OR = 2.42], housing conditions [OR = 0.56] for parents. The following factors were significantly related to the expected long-term care provision: age [OR = 2.22] for women, and age [OR = 2.15], living with parents [OR = 3.58], and employment [OR = 2.33] for parents. Age [OR = 2.14] for women, and planning to live with parents [OR = 2.09] for parents were significantly related to the expected final location of terminal care. This survey showed that women expected long-term care for their parents to be provided by their family, while many expected public long-term care services for themselves. This is the biggest difference in women's outlook on long-term care for their parents and for themselves. Multivariate analysis suggested that women aged 40 years or over, who will need long-term care in the future, tended to expect public home care services for themselves. It is virtually certain that the demand for public home care services will increase in the future.</p>
キーワード long-term care terminal care family burden puburic home care public long-term care insurance
Amo Type Article
発行日 2000-04
出版物タイトル Acta Medica Okayama
54巻
2号
出版者 Okayama University Medical School
開始ページ 75
終了ページ 83
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10806528
Web of Science KeyUT 000086735900004
JaLCDOI 10.18926/AMO/56176
フルテキストURL 72_4_387.pdf
著者 Hada, Kumiko| Kuse, Emiko| Nakatsuka, Mikiya|
抄録 To elucidate the psychiatric characteristics of mothers and the supportive behavior of their partners during late pregnancy, 131 mothers who gave birth at 2 general hospitals in City A between August 2009 and September 2010 (control group: n=90; recurrent pregnancy loss (RPL) group: n=41) completed a self-administered questionnaire on four separate occasions: during late pregnancy, during hospitalization, at 1-month postpartum, and at 3-months postpartum. The RPL group had significantly (p=0.03) lower anxiety regarding potential change in their appearance than the controls, but were more likely to worry about losing their baby (58% vs. 38%) (p=0.021). At 3-months postpartum, the RPL group reported having had more stress during pregnancy than the controls (49% vs. 31%; p=0.041). There were no significant differences in state or trait anxiety (State-Trait Anxiety Inventory) between the 2 groups at any of the four measurements. However, state anxiety decreased significantly throughout the hospitalization for controls (p <0.001), but did not decrease significantly for the RPL group until 3 months postpartum (p<0.05). RPL participants who expressed high satisfaction with their partners’ supportive behavior received significantly greater psychological support than did participants with low satisfaction. Healthcare professionals should attempt to support both members of RPL couples.
キーワード recurrent pregnancy loss persistent anxiety supportive behavior of partner psychological support
Amo Type Original Article
発行日 2018-08
出版物タイトル Acta Medica Okayama
72巻
4号
出版者 Okayama University Medical School
開始ページ 387
終了ページ 394
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 30140087
JaLCDOI 10.18926/AMO/31329
フルテキストURL fulltext.pdf
著者 Nishimura, Masako| Ikeda, Satoru| Taketa, Kazuhisa|
抄録 The clinical implications of a wider distribution of salivary type (S-type) isoamylase activity, as compared with that of pancreatic type (P-type) isoamylase activity in the serum of young female adults of 18-23 years old was studied. A high correlation existed between the S-type isoamylase levels in the initial determination and those in the second determination one year after on the same subjects, indicating that the wider distribution of S-type isoamylase level reflects an individual variation. The serum level of S-type isoamylase was highly correlated with the S-type isoamylase activity in saliva. Among the additional factors studied, a weak positive correlation was present between energy intake and the total and S-type isoamylase activities in serum. However, there was no negative correlation between the S-type isoamylase level and body mass index (BMI), which was reported for young male adults.
キーワード isoamylase serum saliva young female energy intake
Amo Type Article
発行日 1998-06
出版物タイトル Acta Medica Okayama
52巻
3号
出版者 Okayama University Medical School
開始ページ 143
終了ページ 148
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Copyright© 1999 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 9661741
Web of Science KeyUT 000074528500004
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/4435
JaLCDOI 10.18926/AMO/31573
フルテキストURL fulltext.pdf
著者 Okada, Soji| Miyai, Yooichiro| Masaki, Yoshitugu| Ichiki, Ken| Tanokuchi, So| Ishii, Keita| Hamada, Hiroshi| Ota, Zensuke|
抄録 <p>The aim of this study is to obtain data for improving a training program for patients with diabetes mellitus. One hundred eighty-seven patients with non-insulin dependent diabetes mellitus were tested with 20 questions about their knowledge for self-management of diabetes mellitus. Then to draw out factors in their personal backgrounds relating to their correct answers, multiple regression analyses were conducted. As a result, four factors showed significant differences in the following order: Educational careers &#62; ages &#62; duration of disease &#62; socioeconomic strata. The results of the present study have shown for the first time, that these four factors closely concern patients to acquire the necessary knowledge for their self-management of the disease. In addition, this study has raised some fundamental problems regarding the training program for patients: how education should be given to patients.</p>
キーワード knowledge neccessary for self-management of diabetes factors involved in the knowledge educational career age factors duration of diabetes socioeconomic strata
Amo Type Article
発行日 1993-04
出版物タイトル Acta Medica Okayama
47巻
2号
出版者 Okayama University Medical School
開始ページ 91
終了ページ 94
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8506755
Web of Science KeyUT A1993LA45200004
JaLCDOI 10.18926/AMO/48686
フルテキストURL 66_4_317.pdf
著者 Pak, Wing| Takayama, Fusako| Hasegawa, Azusa| Mankura, Mitsumasa| Egashira, Toru| Ueki, Keiji| Nakamoto, Kazuo| Kawasaki, Hiromu| Mori, Akitane|
抄録 This study aimed to investigate the therapeutic effects of the water extract of leaves of Vitis coignetiae Pulliat (VCPL) on nonalcoholic steatohepatitis (NASH) with advanced fibrosis, as our previous study exhibited its preventive effect on NASH. The NASH animal model [PCT/JP2007/52477] was prepared by loading recurrent and intermittent hypoxemia stress to a rat with fatty liver, which resembled the condition occurring in patients with obstructive sleep apnea (OSA) and fatty liver, who have a high incidence of NASH. Intermittent hypoxemia stress is regarded as a condition similar to warm ischemia followed by re-oxygenation, which induces oxidative stress (OS). The daily 100 or 300mg/kg VCPL administrations were performed for 3 weeks perorally beginning at the time of detection of advanced liver fibrosis. The therapeutic efficacy of VCPL on NASH was demonstrated by the reduction of the leakage of hepato-biliary enzymes and the amelioration of liver fibrosis. The OS elevation in NASH rats was measured based on the derivation of reactive oxygen species from liver mitochondrial energy metabolism and on the decrease in plasma SOD-like activity. The aggravation of inflammatory responses was demonstrated by the neutrophil infiltration (elevated myeloperoxidase activity) and the progression of fibrosis in the livers of NASH rats. In addition, the NASH rats without VCPL treatment also exhibited activation of nuclear factor-κB, a key factor in the link between oxidative stress and inflammation. All of these changes were reduced dose-dependently by the VCPL administration. These findings indicate that VCPL may improve hepatic fibrosis or at least suppress the progression of NASH, by breaking the crosstalk between OS and inflammation.
キーワード non-alcoholic steatohepatitis antioxidative oxidative stress anti-inflammation Vitis coignetiae Pulliat
Amo Type Original Article
発行日 2012-08
出版物タイトル Acta Medica Okayama
66巻
4号
出版者 Okayama University Medical School
開始ページ 317
終了ページ 327
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22918204
Web of Science KeyUT 000307918900004
JaLCDOI 10.18926/AMO/32898
フルテキストURL fulltext.pdf
著者 Matsuo, Toshihiko| Masuda, Ikuya| Ota, Kosuke| Yamadori, Ichiro| Sunami, Reiko| Nose, Soichiro|
抄録 We describe herein 2 patients who developed Vogt-Koyanagi-Harada syndrome in the course of renal biopsy-proven immunoglobulin A (IgA) nephropathy. A 61-year-old man with an 11-year history of IgA nephropathy and a 16-year history of thyroiditis, and a 56-year-old man with a 5-year history of IgA nephropathy developed Vogt-Koyanagi-Harada syndrome. At the time of the eye disease presentation, IgA nephropathy was stable without corticosteroids in both patients. Vogt-Koyanagi-Harada syndrome was successfully treated with intravenous administration of prednisolone tapered from 200 mg daily. Vogt-Koyanagi-Harada syndrome is associated with IgA nephropathy, suggesting a similar autoimmune mechanism for both diseases.
キーワード immunoglobulin A (IgA) nephropathy Vogt-Koyanagi-Harada syndrome (disease)
Amo Type Case Report
発行日 2007-10
出版物タイトル Acta Medica Okayama
61巻
5号
出版者 Okayama University Medical School
開始ページ 305
終了ページ 309
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17971847
Web of Science KeyUT 000250431700008
JaLCDOI 10.18926/AMO/30439
フルテキストURL fulltext.pdf
著者 Yao, Kenzabroh| Ubuka, Toshihiko| Masuoka, Noriyoshi| Kinuta, Masahiro| Ohta, Jun| Ishino, Kazushi|
抄録 <p>A new method for staining sialoglycoproteins in polyacrylamide gel after disc electrophoresis is described. The method utilizes the reaction of sialic acids with an acidic ninhydrin reagent which yields a stable color with an absorption maximum at 470 nm. After electrophoresis, the polyacrylamide gel is placed in a test tube and heated with 5 ml of the acidic ninhydrin reagent for 10 min in a boiling water bath. Sialoglycoproteins are detected as brown bands. No additional procedure such as destaining is necessary. When 20 micrograms fetuin, a sialoglycoprotein, per gel is applied, the band remains visible for at least 2 h. Stained gel can be scanned with a gel scanner at 470 nm. When the stained gel was dried on a sheet of polypropylene filter, the color was stable for at least one month. The present method is superior to the method using Stains-all (3,3'-diethyl-9-methyl-4,5,4',5'-dibenzothiacarbocyanine) in specificity and simplicity for the detection of sialoglycoproteins.</p>
キーワード sialoglycoprotein polyacrylamide gel electrophoresis staining acidic ninhydrin reaction
Amo Type Article
発行日 1990-04
出版物タイトル Acta Medica Okayama
44巻
2号
出版者 Okayama University Medical School
開始ページ 65
終了ページ 70
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1694626
Web of Science KeyUT A1990DE10000002