JaLCDOI 10.18926/AMO/59949
フルテキストURL 74_3_191.pdf
著者 Ohashi, Keiji| Sada, Ken-Ei| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Asano, Sumie Hiramatsu| Miyawaki, Yoshia| Morishita, Michiko| Katsuyama, Eri| Watanabe, Haruki| Tatebe, Noriko| Narazaki, Mariko| Matsumoto, Yoshinori| Sunahori-Watanabe, Katsue| Kawabata, Tomoko| Yajima, Nobuyuki| Wada, Jun|
抄録 Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
キーワード systemic lupus erythematosus chronic damage glucocorticoids, disease activity disease duration
Amo Type Original Article
発行日 2020-06
出版物タイトル Acta Medica Okayama
74巻
3号
出版者 Okayama University Medical School
開始ページ 191
終了ページ 198
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32577016
NAID 120006862791
著者 Takagi, Kosei| Yagi, Takahito| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Watanabe, Nobuyuki| Kuise, Takashi| Fuji, Tomokazu| Araki, Hiroyuki| Fujiwara, Toshiyoshi|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54830
著者 Iwasaki, Yuka| Nishiuchi, Rituo| Aoe, Michinori| Takahashi, Takahide| Watanabe, Hirokazu| Tokorotani, Chiho| Kikkawa, Kiyoshi| Shimada, Akira|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54829
著者 Iwamuro, Masaya| Urata, Haruo| Tanaka, Takehiro| Ando, Akemi| Nada, Takahiro| Kimura, Kosuke| Yamauchi, Kenji| Kusumoto, Chiaki| Otsuka, Fumio| Okada, Hiroyuki|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54828
著者 Yoshida, Yukihiro| Okamura, Yuki| Akita, Mamoru| Taniguchi, Masashi| Kojima, Toshio| Osaka, Eiji| Tokuhashi, Yasuaki|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54827
著者 Yasuda, Yukiko| Sakai, Akiko| Ito, Sachio| Sasai, Kaori| Yamamoto, Hiromasa| Matsubara, Nagahide| Ouchida, Mamoru| Katayama, Hiroshi| Shimizu, Kenji|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54826
著者 Okada, Yoshiki| Abe, Nobuhiro| Hisamori, Noriyuki| Kaneeda, Toshiaki| Moriyama, Shigeaki| Ohmori, Hitoshi| Mizutani, Masayoshi| Yanai, Hiroyuki| Nakashima, Yoshio| Yokoyama, Yusuke| Ozaki, Toshifumi|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54825
著者 Nishida, Keiichiro| Hashizume, Kenzo| Ozawa, Masatsugu| Takeshita, Ayumu| Kaneda, Daisuke| Nakahara, Ryuichi| Nasu, Yoshihisa| Shimamura, Yasunori| Inoue, Hajime| Ozaki, Toshifumi|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54824
著者 Waki, Takahiro| Katsui, Kuniaki| Mitsuhashi, Toshiharu| Ogata, Takeshi| Katayama, Norihisa| Takemoto, Mitsuhiro| Nasu, Yasutomo| Kumon, Hiromi| Kanazawa, Susumu|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54823
著者 Fukugawa, Yoshiyuki| Namimoto, Tomohiro| Toya, Ryo| Saito, Tetsuo| Yuki, Hideaki| Matsuyama, Tomohiko| Ikeda, Osamu| Yamashita, Yasuyuki| Oya, Natsuo|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54822
著者 Tsukamoto, Ichiro| Akagi, Masao|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54821
著者 Serap Argun Baris| Tugba Onyilmaz| Ilknur Basyigit| Hasim Boyaci| Fusun Yildiz|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54820
著者 Nosaka, Nobuyuki| Okada, Ayumi| Tsukahara, Hirokazu|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54819
著者 Yamasaki, Hidemasa|
発行日 1976-02
出版物タイトル Acta Medica Okayama
30巻
1号
資料タイプ 学術雑誌論文
著者 Oda, Takuzo| Omura, Sachiko| Hidaka, Hideyuki|
発行日 1977-10
出版物タイトル Acta Medica Okayama
31巻
5号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32452
フルテキストURL fulltext.pdf
著者 Muraoka, Saburo| Sugiyama, Mie| Yamasaki, Hidemasa|
抄録 <p>In the previous papers, it has been shown that the substrate inhibition of xanthine oxidase (xanthine: O2 oxidoreductase, EC 1. 2. 3. 2) induced by excess purines requires a small amount of exogenous metallic ions. Among these ions, Cu&#178;+ was the most typical one. At any stage of enzyme reaction, the inhibition began immediately on addition of a small amount of Cu&#178;+ such as 6.6 X 10-7 M. Since the depressed activity was not restored by the addition of chelating agents such as histamine and EDTA, it was suggested that the substrate, Cu&#178;+ and enzyme form a stable inactive enzyme complex, from which chelating agent can no longer remove Cu. The present communication describes the further investigations concerned with the formation of the substrate-enzyme complex in the presence of Cu&#178;+ and with the catalytic nature of this complex on other substrate and acceptor systems.</p>
Amo Type Article
発行日 1964-08
出版物タイトル Acta Medicinae Okayama
18巻
4号
出版者 Okayama University Medical School
開始ページ 241
終了ページ 244
NCID AA00041342
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 14245867
JaLCDOI 10.18926/AMO/32519
フルテキストURL fulltext.pdf
著者 Kanemasa, Yasuhiro|
抄録 <p>Among various photosensitizing dyes, 4, 4'-dimethyl 3, 3'-di-n-heptyl-8- {2-(4-methyl-3-n-heptylthiazole) }-2, 2'-dicarbocyanin diiodide (abb. NK19), even in an extremely low concentration, is known to inhibit the proliferation of bacteria and tissue culture cells (1, 2, 3). With respect to the mechanism of such inhibitory action no other property of this NKl9 is known except that it has a marked adsorptive property to protein (4). As a step toward the elucidation of the mode of biological effect, the author studied the effect of NK19 on the energy transfer reaction of Irat liver mitochondria, followed by comparison with the mode of actions of various other inhibitors of the oxidative phosphorylation (5). NK19. NKl9 can be prepared by letting 2, 4-dimethylthiazole heptyliodide react with ethylorthoformate in anhydrous acetic acid. We used NKI9, a product of Nihon Kanko Shikiso Research Laboratories. The molecular structure is as in the following and in its MeOH state it has maximum absorbancy at 590 m,a. For the use in experiment it was made into 1 mg/ml of MeOH and was stored in the dark until used.</p>
出版物タイトル Acta Medicinae Okayama
発行日 1969-08
23巻
4号
開始ページ 337
終了ページ 341
言語 English
論文のバージョン publisher
NAID 120002312015
JaLCDOI 10.18926/AMO/59961
フルテキストURL 74_3_261.pdf
著者 Nakahara, Keiichi| Ikeda, Tokunori| Takamatsu, Koutaro| Tawara, Nozomu| Hara, Kentaro| Enokida, Yuki| Tanoue, Naomi| Narita, Sawana| Fujii, Akiko| Yamanouchi, Yoshinori| Morinaga, Jun| Yamashita, Satoshi|
抄録 Muscle biopsy can be used to confirm the diagnosis of neuromuscular diseases. However, it is unclear whether antibiotic prophylaxis prior to muscle biopsy is needed to prevent surgical site infection (SSI). We are conducting a phase 2, single-center, open-labeled, prospective randomized trial to clarify the need for antibiotic prophylaxis in patients at low risk for SSI undergoing muscle biopsy. Patients will be randomized to an antibiotic prophylaxis group or a control group, and the incidence of SSI will be compared between the groups. Our findings will clarify the need for antibiotic prophylaxis in this patient population.
キーワード muscle biopsy antibiotic prophylaxis
Amo Type Clinical Study Protocol
発行日 2020-06
出版物タイトル Acta Medica Okayama
74巻
3号
出版者 Okayama University Medical School
開始ページ 261
終了ページ 264
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32577026
JaLCDOI 10.18926/AMO/59960
フルテキストURL 74_3_257.pdf
著者 Hongo, Takashi| Ikeda, Fusao| Fujioka, Shinichi| Akatsuka, Riku| Fujiwara, Tosifumi| Yamamoto, Kazuhide|
抄録 A 65-year-old Japanese woman developed vesicular eruptions on her right ear due to varicella zoster virus (VZV) reactivation, followed by cranial polyneuritis and meningitis affecting her right cranial nerves V, VII, VIII, IX, and X. After acyclovir administration, her facial paralysis worsened. Intravenous methylprednisolone and vitamin C were administered on Day 4 post-admission. Her symptoms steadily improved, and by Day 45 she had fully recovered. Cranial polyneuritis is a rare complication of VZV reactivation, and there is no established method of treatment. This is the first report of full recovery from cranial polyneuritis using intravenous vitamin C as ancillary treatment.
キーワード varicella zoster virus polyneuritis vitamin C meningitis facial nerve palsy
Amo Type Case Report
発行日 2020-06
出版物タイトル Acta Medica Okayama
74巻
3号
出版者 Okayama University Medical School
開始ページ 257
終了ページ 260
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32577025
JaLCDOI 10.18926/AMO/59959
フルテキストURL 74_3_251.pdf
著者 Murakami, Takashi| Tokuda, Takanori| Nishimura, Shinsuke| Fujii, Hiromichi| Takahashi, Yosuke| Yamane, Kokoro| Inoue, Kazushige| Yamada, Koichi| Kakeya, Hiroshi| Shibata, Toshihiko|
抄録 A 62-year-old Japanese male presented with graft infection by Staphylococcus schleiferi 50 days after debranching of the left subclavian artery and frozen elephant trunk repair for the entry closure of a Stanford type B aortic dissection. The graft was removed, and the patient was successfully treated using in situ reconstruction of the arch with omental flap coverage, removal of the debranching graft, autologous iliac artery grafting, and longterm antibiotics. Domino reconstruction of the infected debranching graft using autologous external iliac artery and a Dacron graft can thus be a good option in similar cases.
キーワード autologous iliac artery graft Staphylococcus schleiferi graft infection domino reconstruction Dacron graft
Amo Type Case Report
発行日 2020-06
出版物タイトル Acta Medica Okayama
74巻
3号
出版者 Okayama University Medical School
開始ページ 251
終了ページ 255
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32577024