著者 Matsuura, Koji| Hayashi, Nobuyoshi| Kuroda, Yuka| Takiue, Chisato| Hirata, Rei| Takenami, Mami| Aoi, Yoko| Yoshioka, Nanako| Habara, Toshihiro| Mukaida, Tetsunori| Naruse, Keiji|
発行日 2010-03
出版物タイトル Reproductive BioMedicine Online
20巻
3号
資料タイプ 学術雑誌論文
著者 Khan, Shahbaz Manzoor| Debnath, Chanchal| Pramanik, Amiya Kumar| Xiao, Lihua| Nozaki, Tomoyoshi| Ganguly, Sandipan|
発行日 2010-07-15
出版物タイトル Veterinary Parasitology
171巻
1-2号
資料タイプ 学術雑誌論文
著者 Muraoka, Y| Saeki, K| Yao, Y| Wakita, T| Hirai, M| Yokoya, T| Eguchi, R| Shin, S|
発行日 2010-08
出版物タイトル Journal of Electron Spectroscopy and Related Phenomena
181巻
2-3号
資料タイプ 学術雑誌論文
著者 Matsuura, Koji| Hayashi, Nobuyoshi| Takiue, Chisato| Hirata, Rei| Habara, Toshihiro| Naruse, Keiji|
発行日 2010-08
出版物タイトル Fertility and Sterility
94巻
3号
資料タイプ 学術雑誌論文
著者 Sano, Hikaru| Matsuura, Koji| Naruse, Keiji| Funahashi, Hiroaki|
発行日 2010-09-15
出版物タイトル Theriogenology
74巻
5号
資料タイプ 学術雑誌論文
著者 Yan, He| Li, Lin| Alam, M. Jahangir| Shinoda, Sumio| Miyoshi, Shin-ichi| Shi, Lei|
発行日 2010-10-15
出版物タイトル International Journal of Food Microbiology
143巻
3号
資料タイプ 学術雑誌論文
著者 Okazaki, Hiroyuki| Yoshida, Rikiya| Iwai, Keisuke| Noami, Kengo| Muro, Takayuki| Nakamura, Tetsuya| Wakita, Takanori| Muraoka, Yuji| Hirai, Masaaki| Tomioka, Fumiaki| Takano, Yoshihiko| Takenaka, Asami| Toyoda, Masahiro| Oguch, Tamio| Yokoya, Takayoshi|
発行日 2010-12
出版物タイトル Physica C-Superconductivity and its Applications
470巻
S1号
資料タイプ 学術雑誌論文
著者 Wakita, Takanori| Okazaki, Hiroyuki| Takano, Yoshihiko| Hirai, Masaaki| Muraoka, Yuji| Yokoya, Takayoshi|
発行日 2010-12
出版物タイトル Physica C-Superconductivity and its Applications
470巻
S1号
資料タイプ 学術雑誌論文
著者 Yoshida, Rikiya| Wakita, Takanori| Okazaki, Hiroyuki| Mizuguchi, Yoshikazu| Tsuda, Shunsuke| Takano, Yoshihiko| Takeya, Hiroyuki| Hirata, Kazuto| Kato, Yukako| Muro, Takayuki| Okawa, Mario| Ishizaka, Kyoko| Shin, Shik| Harima, Hisatomo| Hirai, Masaaki| Muraoka, Yuji| Yokoya, Takayoshi|
発行日 2010-12
出版物タイトル Physica C-Superconductivity and its Applications
470巻
S1号
資料タイプ 学術雑誌論文
著者 Nishioka, Yasutaka| Suzumori, Koichi| Kanda, Takefumi| Wakimoto, Shuichi|
発行日 2010-12
出版物タイトル Sensors and Actuators A: Physical
164巻
1-2号
資料タイプ 学術雑誌論文
著者 Ghosh, Souvik| Gatheru, Zipporah| Nyangao, James| Adachi, Noriaki| Urushibara, Noriko| Kobayashi, Nobumichi|
発行日 2011-01
出版物タイトル Infection, Genetics and Evolution
11巻
1号
資料タイプ 学術雑誌論文
著者 Miyoshi, Shin-ichi| Abe, Yuki| Senoh, Mitsutoshi| Mizuno, Tamaki| Maehara, Yoko| Nakao, Hiroshi|
発行日 2011-05
出版物タイトル Toxicon
57巻
6号
資料タイプ 学術雑誌論文
著者 Khan, Shahbaz Manzoor| Debnath, Chanchal| Pramanik, Amiya Kumar| Xiao, Lihua| Nozaki, Tomoyoshi| Ganguly, Sandipan|
発行日 2011-06-10
出版物タイトル Veterinary Parasitology
178巻
3-4号
資料タイプ 学術雑誌論文
著者 Wajima, Takeaki| Sabui, Subrata| Fukumoto, Megumi| Kano, Shigeyuki| Ramamurthy, Thandavarayan| Chatterjee, Nabendu Sekhar| Hamabata, Takashi|
発行日 2011-10
出版物タイトル Microbial Pathogenesis
51巻
4号
資料タイプ 学術雑誌論文
著者 Matsuura, Koji| Takenami, Mami| Kuroda, Yuka| Hyakutake, Toru| Yanase, Shinichiro| Naruse, Keiji|
発行日 2012-01
出版物タイトル Reproductive BioMedicine Online
24巻
1号
資料タイプ 学術雑誌論文
著者 Nohara, Minoru| Kakiya, Satomi| Kudo, Kazutaka| Oshiro, Yoshihiro| Araki, Shingo| Kobayashi, Tatsuo C.| Oku, Kenta| Nishibori, Eiji| Sawa, Hiroshi|
発行日 2012-04
出版物タイトル Solid State Communications
152巻
8号
資料タイプ 学術雑誌論文
著者 Yoshioka-Nishimura, Miho| Yamamoto, Yasusi|
発行日 2014
出版物タイトル Journal of Photochemistry and Photobiology B: Biology
137巻
資料タイプ 学術雑誌論文
フルテキストURL K0005273 other2.pdf
著者 Sakamoto, Shinji| Takaki, Manabu| Okahisa, Yuko| Mizuki, Yutaka| Kodama, Masafumi| Ujike, Hiroshi| Uchitomi, Yosuke|
備考 学位審査副論文
発行日 2014-05
出版物タイトル Psychiatry Research
216巻
2号
出版者 Elsevier
開始ページ 288
終了ページ 289
ISSN 0165-1781
NCID AA0036432X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 24576429
DOI 10.1016/j.psychres.2014.02.006
Web of Sience KeyUT 000335099900020
関連URL https://doi.org/10.1016/j.psychres.2014.02.006
フルテキストURL K0005427_other1.pdf
著者 Okano, Mitsuhiro| Fujiwara, Tazuko| Kariya, Shin| Higaki, Takaya| Makihara, Sei-ichiro| Haruna, Takenori| Noyama, Yasuyuki| Koyama, Takahisa| Omichi, Ryotaro| Orita, Yorihisa| Miki, Kentaro| Kanai, Kengo| Nishizaki, Kazunori|
抄録 BACKGROUND: Toll-like receptor 3 (TLR3) is expressed in upper airways, however, little is known regarding whether Toll-like receptor 3 (TLR3) signals exert a regulatory effect on the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), especially on eosinophilic inflammation. We sought to investigate the effect of Poly(IC), the ligand for TLR3, on cytokine production by dispersed nasal polyp cells (DNPCs). METHODS: DNPCs were pretreated with or without Poly(IC), and were then cultured in the presence or absence of staphylococcal enterotoxin B (SEB), following which the levels of IL-5, IL-10, IL-13, IL-17A and interferon (IFN)-γ in the supernatant were measured. To determine the involvement of IL-10 and cyclooxygenase in Poly(IC)-mediated signaling, DNPCs were treated with anti-IL-10 monoclonal antibody and diclofenac, the cyclooxygenase inhibitor, respectively. Poly(IC)-induced prostaglandin E2 (PGE2) production was also determined. RESULTS: Exposure to Poly(IC) induced a significant production of IL-10, but not of IL-5, IL-13, IL-17A or IFN-γ by DNPCs. Pretreatment with Poly(IC) dose-dependently inhibited SEB-induced IL-5, IL-13 and IL-17A, but not IFN-γ production. Neutralization of IL-10 significantly abrogated the inhibitory effect of Poly(IC). Treatment with diclofenac also abrogated the inhibitory effect of Poly(IC) on SEB-induced IL-5 and IL-13 production. However, unlike exposure of diclofenac-treated DNPCs to lipopolysaccharide, the ligand for TLR4, exposure of these cells to Poly(IC) did not enhance IL-5 or IL-13 production. Poly(IC) did not significantly increase PGE2 production by DNPCs. CONCLUSIONS: These results suggest that TLR3 signaling regulates eosinophilia-associated cytokine production in CRSwNP, at least in part, via IL-10 production.
キーワード Chronic rhinosinusitis with nasal polyps IL-10 IL-5 Poly(IC) Toll-like receptor
備考 学位審査副論文
発行日 2016-01
出版物タイトル Allergology international : official journal of the Japanese Society of Allergology
65巻
1号
出版者 Elsevier
開始ページ 96
終了ページ 102
ISSN 1323-8930
NCID AA11091750
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 26666485
Web of Sience KeyUT 000367238600015
関連URL https://doi.org/10.1016/j.alit.2015.08.005 http://ousar.lib.okayama-u.ac.jp/54846
フルテキストURL J_Orthop_Sci_21_4_524.pdf fig.pdf
著者 Furumatsu, Takayuki| Maehara, Ami| Ozaki, Toshifumi|
抄録 BACKGROUND: Proper functioning of the meniscus depends on the composition and organization of its fibrocartilaginous extracellular matrix. We previously demonstrated that the avascular inner meniscus has a more chondrocytic phenotype compared with the outer meniscus. Inhibition of the Rho family GTPase ROCK, the major regulator of the actin cytoskeleton, stimulates the chondrogenic transcription factor Sry-type HMG box (SOX) 9-dependent α1(II) collagen (COL2A1) expression in inner meniscus cells. However, the crosstalk between ROCK inhibition, SOX9, and other transcription modulators on COL2A1 upregulation remains unclear in meniscus cells. The aim of this study was to investigate the role of SOX9-related transcriptional complex on COL2A1 expression under the inhibition of ROCK in human meniscus cells. METHODS: Human inner and outer meniscus cells were prepared from macroscopically intact lateral menisci. Cells were cultured in the presence or absence of ROCK inhibitor (ROCKi, Y27632). Gene expression, collagen synthesis, and nuclear translocation of SOX9 and Smad2/3 were analyzed. RESULTS: Treatment of ROCKi increased the ratio of type I/II collagen double positive cells derived from the inner meniscus. In real-time PCR analyses, expression of SOX9 and COL2A1 genes was stimulated by ROCKi treatment in inner meniscus cells. ROCKi treatment also induced nuclear translocation of SOX9 and phosphorylated Smad2/3 in immunohistological analyses. Complex formation between SOX9 and Smad3 was increased by ROCKi treatment in inner meniscus cells. Chromatin immunoprecipitation analyses revealed that association between SOX9/Smad3 transcriptional complex with the COL2A1 enhancer region was increased by ROCKi treatment. CONCLUSIONS: This study demonstrated that ROCK inhibition stimulated SOX9/Smad3-dependent COL2A1 expression through the immediate nuclear translocation of Smad3 in inner meniscus cells. Our results suggest that ROCK inhibition can stimulates type II collagen synthesis through the cooperative activation of Smad3 in inner meniscus cells. ROCKi treatment may be useful to promote the fibrochondrocytic healing of the injured inner meniscus.
備考 This is an Accepted Manuscript of an article published by Elsevier
発行日 2016-07
出版物タイトル Journal of Orthopaedic Science
21巻
4号
出版者 Elsevier
開始ページ 524
終了ページ 529
ISSN 0949-2658
NCID AA11052566
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 27113646
DOI 10.1016/j.jos.2016.02.013
Web of Sience KeyUT 000381142800020
関連URL isVersionOf https://doi.org/10.1016/j.jos.2016.02.013