ID | 52858 |
フルテキストURL | |
著者 |
Iwatani, Kayoko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Sato, Yasuharu
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
ORCID
Kaken ID
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Miyata-Takata, Tomoko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Iwaki, Noriko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Cui, Wei
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Sawada-Kitamura, Seiko
Kanazawa Univ Hosp, Div Pathol
Sonobe, Hiroshi
Chugoku Cent Hosp, Div Pathol
Tamura, Maiko
Hiroshima City Hosp, Div Pathol
Saito, Katsuhiko
Toyama City Hosp, Dept Pathol
Miyatani, Katsuya
Mitoyo Gen Hosp, Div Pathol
Yamasaki, Rie
Natl Hosp Org Iwakuni, Ctr Clin, Div Pathol
Yamadori, Ichiro
Natl Hosp Org Okayama, Med Ctr, Div Pathol
Fujii, Nobuharu
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol
Kaken ID
publons
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Terasaki, Yasushi
Toyama City Hosp, Div Hematol
Maeda, Yoshinobu
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol
Kaken ID
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Tanimoto, Mitsune
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol
Kaken ID
publons
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Nakamura, Naoya
Tokai Univ, Inst Med Sci, Dept Pathol
Yoshino, Tadashi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Kaken ID
publons
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抄録 | Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. Fourteen patients met the inclusion criteria, including 5 with lymphoplasmacytic lymphoma (LPL), 3 with chronic lymphocytic leukemia/small lymphocytic lymphoma, 2 with follicular lymphoma (FL), and 4 with low-grade B-cell lymphoma not otherwise specified (LGBCL-NOS). The median age was 69.5 years (range, 42-89 years), and a slight male predominance was noted (9 men and 5 women, 1.8: 1). Immunohistochemically, all cases were positive for CD20. One case was positive for CD138. Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 rearrangement was observed by fluorescence in situ hybridization. The myeloid differentiation primary response gene (88) leucine to proline mutation was observed in 3 of 5 LPL, 1 of 2 FL, and 2 of 4 LGBCL-NOS patients. Paraproteinemia was observed in 10 patients; IgM and IgG paraproteinemia were observed in 6 and 3 patients, respectively. In this patient series, 3 patients had died at a median follow-up of 36.5 months; the cause of death of 1 LPL patient was malignant lymphoma itself. Thus, low-grade B-cell lymphoma presenting primarily in the bone marrow has various subtypes, and approximately one-third of the patients had LGBCL-NOS. The immunophenotypic features and myeloid differentiation primary response gene (88) leucine to proline mutation data of LGBCL-NOS suggested that some cases present with characteristics similar to those of LPL or marginal zone lymphoma.
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キーワード | Low-grade B cell lymphoma
Bone marrow
LGBCL-NOS
MYD88
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発行日 | 2014-07
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出版物タイトル |
Human Pathology
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巻 | 45巻
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号 | 7号
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開始ページ | 1379
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終了ページ | 1387
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ISSN | 0046-8177
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資料タイプ |
学術雑誌論文
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52829
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言語 |
英語
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著作権者 | (C) 2014 Elsevier Inc. All rights reserved.
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |