ID | 30866 |
JaLCDOI | |
フルテキストURL | |
著者 |
Ota, Zensuke
Okayama University
Kumagai, Isao
Okayama University
Makino, Hirofumi
Okayama University
|
抄録 | Sprague-Dawley rats, 6 with aminonucleoside nephrosis and 6 controls, were intravenously injected with human liver ferritin isolated from post mortem liver, and their 24-h urine samples were examined for human ferritin by immunoradiometric assay. In rats with aminonucleoside nephrosis, the amount of excreted ferritin in urine was forty times greater than in control rats. Much more monomeric ferritin was excreted than that of polymeric ferritin. We are the first to have utilized human liver ferritin as a tracer to measure a minor amount of ferritin by a commercially available kit. Our present study seems to indicate a critical role for glomerular basement membrane as a size barrier. |
キーワード | glomerular permeabillity
size barrier
human liver ferritin
immunoradiometricassay
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1989-12
|
巻 | 43巻
|
号 | 6号
|
出版者 | Okayama University Medical School
|
開始ページ | 363
|
終了ページ | 365
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |