中村一文

Hepatocyte growth factor gene therapy reduces ventricular arrhythmia in animal models of myocardial ischemia.

JaLCDOI	10.18926/AMO/31982
フルテキストURL	fulltext.pdf
著者	Yumoto, Akihisa\| Kusano, Kengo Fukushima\| Nakamura, Kazufumi\| Hashimoto, Katsushi\| Aoki, Motokuni\| Morishita, Ryuichi\| Kaneda, Yasufumi\| Ohe, Tohru\|
抄録	It was recently reported that gene therapy using hepatocyte growth factor (HGF) has the potential to preserve cardiac function after myocardial ischemia. We speculated that this HGF gene therapy could also prevent ventricular arrhythmia. To investigate this possibility, we examined the antiarrhythmic effect of HGF gene therapy in rat acute and old myocardial infarction models. Myocardial ischemia was induced by ligation of the left descending coronary artery. Hemagglutinating virus of Japan (HVJ)-coated liposome containing HGF genes were injected directly into the myocardium fourteen days before programmed pacing. Ventricular fibrillation (VF)was induced by programmed pacing. The VF duration was reduced and the VF threshold increased after HGF gene therapy ( p< 0.01). Histological analyses revealed that the number of vessels in the ischemic border zone was greatly increased after HGF gene injection. These findings revealed that HGF gene therapy has an anti-arrhythmic effect after myocardial ischemia.
キーワード	ventricular arrhythmia HGF (hepatocyte growth factor) ischemia HVJ (hemagglutinating virus of Japan)
Amo Type	Article
出版物タイトル	Acta Medica Okayama
発行日	2005-06
巻	59巻
号	3号
出版者	Okayama University Medical School
開始ページ	73
終了ページ	78
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
論文のバージョン	publisher
査読	有り
PubMed ID	16049559
Web of Science KeyUT	000230039100001

Usefulness of body surface mapping to differentiate patients with Brugada syndrome from patients with asymptomatic Brugada syndrome.

JaLCDOI	10.18926/AMO/32121
フルテキストURL	fulltext.pdf
著者	Hisamatsu, Kenichi\| Kusano, Kengo Fukushima\| Morita, Hiroshi\| Takenaka, Shiho\| Nagase, Satoshi\| Nakamura, Kazufumi\| Emori, Tetsuro\| Matsubara, Hiromi\| Ohe, Tohru\|
抄録	We attempted to determine the usefulness of body surface mapping (BSM) for differentiating patients with Brugada syndrome (BS) from patients with asymptomatic Brugada syndrome (ABS). Electrocardiograms (ECG) and BSM were recorded in 7 patients with BS and 35 patients with ABS. Following the administration of Ic antiarrhythmic drugs, BSM was recorded in 5 patients with BS and 16 patients with ABS. The maximum amplitudes at J0, J20, J40 and J60 were compared between the 2 groups, as were 3-dimensional maps. The maximum amplitudes at J0, J20 and J60 under control conditions were larger in patients with BS than in patients with ABS (P < 0.05). A three-dimensional map of the ST segments under control conditions in patients with BS showed a higher peak of ST elevation in the median precordium compared to that for patients with ABS. Increases in ST elevation at J20, J40 and J60 following drug administration were greater in patients with BS than in patients with ABS (P < 0.05). Evaluation of the change in amplitude of the ST segment at E5 caused by Ic drug administration was also useful for differentiating between the 2 groups. In conclusion, BSM was useful for differentiating patients with BS from those with ABS.
キーワード	body surface map Brugada syndrome asymptomatic Brugada syndrome Ic antiarrhythmic drugs
Amo Type	Article
出版物タイトル	Acta Medica Okayama
発行日	2004-02
巻	58巻
号	1号
出版者	Okayama University Medical School
開始ページ	29
終了ページ	35
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
論文のバージョン	publisher
査読	有り
PubMed ID	15157009
Web of Science KeyUT	000189271100005

Epoprostenol Therapy for Pulmonary Arterial Hypertension

JaLCDOI	10.18926/AMO/53519
フルテキストURL	69_3_129.pdf
著者	Akagi, Satoshi\| Nakamura, Kazufumi\| Matsubara, Hiromi\| Ogawa, Aiko\| Sarashina, Toshihiro\| Ejiri, Kentaro\| Ito, Hiroshi\|
抄録	Pulmonary arterial hypertension (PAH) is characterized by elevation of pulmonary artery pressure caused by pulmonary vasoconstriction and vascular remodeling, which leads to right heart failure and death. Epoprostenol (prostaglandin I2) has a potent short-acting vasodilator property, and intravenous continuous epoprostenol is therefore used for treatment of PAH. Here we review evidence for the usefulness of intravenous continuous epoprostenol therapy in patients with PAH. Epoprostenol therapy is effective in idiopathic PAH patients and in patients with PAH associated with connective tissue disease, portal hypertension or congenital heart diseases, but it is not effective in patients with pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis. High-dose epoprostenol therapy markedly improved hemodynamics in some patients with PAH, possibly due to reverse remodeling of pulmonary arteries. This therapy has several side effects and complications such as headache, hypotension and catheter-related infections. Intravenous continuous epoprostenol is an effective treatment, but there are still some problems to be resolved.
キーワード	pulmonary arterial hypertension epoprostenol high-dose complications side effects
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2015-06
巻	69巻
号	3号
出版者	Okayama University Medical School
開始ページ	129
終了ページ	136
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26101188
Web of Science KeyUT	000356903000001

Feasibility of Repairing Defects Followed by Treatment with Pulmonary Hypertension-specific Drugs (Repair and Treat) in Patients with Pulmonary Hypertension Associated with Atrial Septal Defect: Study Protocol for Interventional Trial

JaLCDOI	10.18926/AMO/54600
フルテキストURL	70_5_397.pdf
著者	Akagi, Satoshi\| Nakamura, Kazufumi\| Akagi, Teiji\| Nakagawa, Koji\| Takaya, Yoichi\| Sarashina, Toshihiro\| Ejiri, Kentaro\| Ito, Hiroshi\|
抄録	A treatment strategy for patients with pulmonary hypertension (PH) and atrial septal defect (ASD) remains unclear. This study was designed to evaluate the effects of initial repair of ASD followed by treatment with PH-specific drugs in patients with PH and ASD. Eligible patients receive transcatheter ASD closure followed by treatment with bosentan and sildenafil. Right heart catheterization is performed at baseline and at 12, 24 and 48 weeks. The primary endpoint is change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study should provide valuable information to establish a therapeutic strategy for PH and ASD.
キーワード	pulmonary hypertension atrial septal defect repair and treat transcatheter closure
Amo Type	Clinical Study Protocols
出版物タイトル	Acta Medica Okayama
発行日	2016-10
巻	70巻
号	5号
出版者	Okayama University Medical School
開始ページ	397
終了ページ	400
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27777434
Web of Science KeyUT	000388098700011

Possible Protective Effect of Remote Ischemic Preconditioning on Acute Kidney Injury Following Elective Percutaneous Coronary Intervention: Secondary Analysis of a Multicenter, Randomized Study

JaLCDOI	10.18926/AMO/61433
フルテキストURL	75_1_45.pdf
著者	Otsuka, Hiroaki\| Miyoshi, Toru\| Ejiri, Kentaro\| Kohno, Kunihisa\| Nakahama, Makoto\| Doi, Masayuki\| Munemasa, Mitsuru\| Murakami, Masaaki\| Nakamura, Kazufumi\| Ito, Hiroshi\|
抄録	Remote ischemic preconditioning (RIPC) is a promising strategy for protecting against ischemic reperfusion injury. This study is a secondary analysis of a randomized study that aimed to evaluate the effect of RIPC on the early increase in serum creatinine (SCr) following percutaneous coronary intervention (PCI), which is associ-ated with contrast-induced acute kidney injury. Patients with stable angina undergoing elective PCI were assigned to control, RIPC, and continuous infusion of nicorandil (nicorandil) groups. The endpoint of this study was the incidence of the early increase in SCr, a predictor of contrast-induced acute kidney injury, which was defined as either a > 20% or absolute increase by 0.3 mg/dl of SCr levels after 24 h of PCI. This study included 220 patients for whom a dataset of SCr values was available. The incidence of the early increase in SCr was significantly lower in the RIPC than in the control (1.3% vs 10.8%, p = 0.03) group, but was not significantly different between the nicorandil and control groups. In multivariate analysis, RIPC remained a significant fac-tor associated with a reduction in the incidence of early increase in SCr. RIPC reduces the incidence of early increase in SCr in patients with stable angina following elective PCI.
キーワード	remote ischemic preconditioning stable angina serum creatinine acute kidney injury
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-02
巻	75巻
号	1号
出版者	Okayama University Medical School
開始ページ	45
終了ページ	53
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33649613

Inhibitory Effects of Antioxidants on Neonatal Rat Cardiac Myocyte Hypertrophy Induced by Tumor Necrosis Factor-α and Angiotensin Ⅱ

著者	中村一文\|
発行日	1998-09-30
出版物タイトル
資料タイプ	学位論文

頻回な心室性不整脈を呈した Brugada 症候群に対する低用量 Isoproterenol の治療効果の検討

著者	渡邊敦之\| 草野研吾\| 森田宏\| 三浦大二\| 角田和歌子\| 平松茂樹\| 伴場主一\| 西井伸洋\| 永瀬聡\| 中村一文\| 桜木悟\| 大江透\|
発行日	2008-05-01
出版物タイトル	岡山医学会雑誌
巻	120巻
号	1号
資料タイプ	学術雑誌論文

原発性肺高血圧症の病態形成における骨形成蛋白（BMP）Ⅰ型受容体の関与とその意義：肺動脈血管平滑筋細胞を用いた検討

著者	武田昌也\| 大塚文男\| 中村一文\| 稲垣兼一\| 鈴木二郎\| 三浦大志\| 藤尾栄起\| 松原広己\| 伊達洋至\| 大江透\| 槇野博史\|
発行日	2006-05-01
出版物タイトル	岡山医学会雑誌
巻	118巻
号	1号
資料タイプ	学術雑誌論文

心不全における酸化ストレスの関与：基礎的ならびに臨床的検討 ―岡山大学医学賞（結城賞）を受賞して―

著者	中村一文\| 草野研吾\| 垣下幹夫\| 三浦綾\| 久松研一\| 西井伸洋\| 伴場主一\| 渡邊敦之\| 藤尾栄起\| 宮地克維\| 永瀬聡\| 森田宏\| 斎藤博則\| 江森哲郎\| 浅沼幹人\| 宮崎正博\| 中村陽一\| 松原広己\| 伏見和郎\| 豊國伸哉\| 大江透\|
発行日	2004-05-31
出版物タイトル	岡山医学会雑誌
巻	116巻
号	1号
資料タイプ	学術雑誌論文

Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy

著者	Kobayashi, Makoto\| Nakamura, Kazufumi\| Kusano, Kengo Fukushima\| Nakamura, Yoichi\| Ohta-Ogo, Keiko\| Nagase, Satoshi\| Sakuragi, Satoru\| Ohe, Tohru\|
発行日	2008-06-22
出版物タイトル	International Journal of Cardiology
巻	126巻
号	3号
資料タイプ	学術雑誌論文

原発性肺高血圧症の進行メカニズムの解明と治療薬の開発

著者	小川愛子\| 中村一文\| 松原広己\| 藤尾栄起\| 池田哲也\| 宮地克維\| 三浦大志\| 三浦綾\| 永瀬聡\| 草野研吾\| 伊達洋至\| 大江透\|
発行日	2007-01-04
出版物タイトル	岡山医学会雑誌
巻	118巻
号	3号
資料タイプ	学術雑誌論文

慢性心不全治療ガイドライン

著者	中村一文\| 伊藤浩\|
発行日	2012-04-01
出版物タイトル	岡山医学会雑誌
巻	124巻
号	1号
資料タイプ	学術雑誌論文

Serum cystatin C as a biomarker of cardiac diastolic dysfunction in patients with cardiac disease and preserved ejection fraction

著者	Nosaka, Kazumasa\| Nakamura, Kazufumi\| Kusano, Kengo\| Toh, Norihisa\| Tada, Takeshi\| Miyoshi, Toru\| Doi, Masayuki\| Kohno, Kunihisa\| Morita, Hiroshi\| Ito, Hiroshi\|
発行日	2013-08
出版物タイトル	Congestive Heart Failure
巻	19巻
号	4号
資料タイプ	学術雑誌論文

Dual Antiplatelet Therapy Can Be Discontinued at Three Months after Implantation of Zotarolimus-Eluting Stent in Patients with Coronary Artery Disease

著者	Wada, Tadashi\| Nakahama, Makoto\| Toda, Hironobu\| Watanabe, Atsuyuki\| Hashimoto, Katsushi\| Terasaka, Ritsuko\| Nakamura, Kazufumi\| Yamada, Nobuyuki\| Ito, Hiroshi\|
発行日	2013
出版物タイトル	ISRN Cardiology
巻	2013巻
資料タイプ	学術雑誌論文

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease

著者	Kitagawa, Masashi\| Sugiyama, Hitoshi\| Morinaga, Hiroshi\| Inoue, Tatsuyuki\| Takiue, Keiichi\| Ogawa, Ayu\| Yamanari, Toshio\| Kikumoto, Yoko\| Uchida, Haruhito Adam\| Kitamura, Shinji\| Maeshima, Yohei\| Nakamura, Kazufumi\| Ito, Hiroshi\| Makino, Hirofumi\|
発行日	2013-02-19
出版物タイトル	PLoS ONE
巻	8巻
号	2号
資料タイプ	学術雑誌論文

Impact of Chronic Kidney Disease on Left Main Coronary Artery Disease and Prognosis in Japanese Patients

著者	Dan, Kazuhiro\| Miyoshi, Toru\| Ueeda, Masayuki\| Ohtsuka, Hiroaki\| Ugawa, Satoko\| Ohnishi, Nobuhiko\| Takaishi, Atsushi\| Nakamura, Kazufumi\| Kusano, Kengo\| Ito, Hiroshi\|
発行日	2012-09
出版物タイトル	Circulation Journal
巻	76巻
号	9号
資料タイプ	学術雑誌論文

Electrocardiographic Parameters and Fatal Arrhythmic Events in Patients With Brugada Syndrome

著者	Tokioka, Koji\| Kusano, Kengo F.\| Morita, Hiroshi\| Miura, Daiji\| Nishii, Nobuhiro\| Nagase, Satoshi\| Nakamura, Kazufumi\| Kohno, Kunihisa\| Ito, Hiroshi\| Ohe, Tohru\|
発行日	2014-05-27
出版物タイトル	Journal of the American College of Cardiology
巻	63巻
号	20号
資料タイプ	学術雑誌論文

The optimal amount of salt intake.

フルテキストURL	HR42_5_752.pdf
著者	Nakamura, Kazufumi\| Miyoshi, Toru\|
発行日	2019-02-14
出版物タイトル	Hypertension Research
巻	42巻
号	425号
出版者	Nature Publishing Group
開始ページ	752
終了ページ	753
ISSN	0916-9636
NCID	AA10847079
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	30765877
DOI	10.1038/s41440-019-0225-7
Web of Science KeyUT	000467043700021
関連URL	isVersionOf https://doi.org/10.1038/s41440-019-0225-7

Liver transplantation in a patient with hereditary haemorrhagic telangiectasia and pulmonary hypertension

フルテキストURL	fulltext.pdf
著者	Ejiri Kentaro\| Akagi, Satoshi\| Nakamura, Kazufumi\| Amioka, Naofumi\| Ichikawa, Keishi\| Yagi, Takahito\| Ito, Hiroshi\|
キーワード	Rendu-Osler-Weber syndrome arteriovenous malformation pulmonary haemorrhage
発行日	2019-12-18
出版物タイトル	Pulmonary Circulation
巻	9巻
号	4号
出版者	SAGE Publications Inc
ISSN	2045-8932
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019.
論文のバージョン	publisher
PubMed ID	31903186
DOI	10.1177/2045894019896677
Web of Science KeyUT	000503484500001
関連URL	isVersionOf https://doi.org/10.1177/2045894019896677

Current Treatment Strategies and Nanoparticle-Mediated Drug Delivery Systems for Pulmonary Arterial Hypertension

フルテキストURL	fulltext.pdf
著者	Nakamura, Kazufumi\| Akagi, Satoshi\| Ejiri, Kentaro\| Yoshida, Masashi\| Miyoshi, Toru\| Toh, Norihisa\| Nakagawa, Koji\| Takaya, Yoichi\| Matsubara, Hiromi\| Ito, Hiroshi\|
キーワード	pulmonary arterial hypertension prostaglandin I-2 nitric oxide endothelin
発行日	2019-11-23
出版物タイトル	International Journal of Molecular Sciences
巻	20巻
号	23号
出版者	MDPI
開始ページ	5885
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 by the authors.
論文のバージョン	publisher
PubMed ID	31771203
DOI	10.3390/ijms20235885
Web of Science KeyUT	000504428300067
関連URL	isVersionOf https://doi.org/10.3390/ijms20235885

中村 一文