ID | 53519 |
JaLCDOI | |
フルテキストURL | |
著者 |
Akagi, Satoshi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine
ORCID
Kaken ID
Nakamura, Kazufumi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine
Kaken ID
publons
researchmap
Matsubara, Hiromi
Department of Clinical Science, National Hospital Organization Okayama Medical Center
Ogawa, Aiko
Department of Clinical Science, National Hospital Organization Okayama Medical Center
Sarashina, Toshihiro
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine
Ejiri, Kentaro
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine
Ito, Hiroshi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine
Kaken ID
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抄録 | Pulmonary arterial hypertension (PAH) is characterized by elevation of pulmonary artery pressure caused by pulmonary vasoconstriction and vascular remodeling, which leads to right heart failure and death. Epoprostenol (prostaglandin I2) has a potent short-acting vasodilator property, and intravenous continuous epoprostenol is therefore used for treatment of PAH. Here we review evidence for the usefulness of intravenous continuous epoprostenol therapy in patients with PAH. Epoprostenol therapy is effective in idiopathic PAH patients and in patients with PAH associated with connective tissue disease, portal hypertension or congenital heart diseases, but it is not effective in patients with pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis. High-dose epoprostenol therapy markedly improved hemodynamics in some patients with PAH, possibly due to reverse remodeling of pulmonary arteries. This therapy has several side effects and complications such as headache, hypotension and catheter-related infections. Intravenous continuous epoprostenol is an effective treatment, but there are still some problems to be resolved.
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キーワード | pulmonary arterial hypertension
epoprostenol
high-dose
complications
side effects
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Amo Type | Review
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2015-06
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巻 | 69巻
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号 | 3号
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出版者 | Okayama University Medical School
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開始ページ | 129
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終了ページ | 136
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2015 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |