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ID 53519
JaLCDOI
フルテキストURL
著者
Akagi, Satoshi Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine ORCID Kaken ID
Nakamura, Kazufumi Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Kaken ID researchmap
Matsubara, Hiromi Department of Clinical Science, National Hospital Organization Okayama Medical Center
Ogawa, Aiko Department of Clinical Science, National Hospital Organization Okayama Medical Center
Sarashina, Toshihiro Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine
Ejiri, Kentaro Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine
Ito, Hiroshi Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Kaken ID
抄録
Pulmonary arterial hypertension (PAH) is characterized by elevation of pulmonary artery pressure caused by pulmonary vasoconstriction and vascular remodeling, which leads to right heart failure and death. Epoprostenol (prostaglandin I2) has a potent short-acting vasodilator property, and intravenous continuous epoprostenol is therefore used for treatment of PAH. Here we review evidence for the usefulness of intravenous continuous epoprostenol therapy in patients with PAH. Epoprostenol therapy is effective in idiopathic PAH patients and in patients with PAH associated with connective tissue disease, portal hypertension or congenital heart diseases, but it is not effective in patients with pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis. High-dose epoprostenol therapy markedly improved hemodynamics in some patients with PAH, possibly due to reverse remodeling of pulmonary arteries. This therapy has several side effects and complications such as headache, hypotension and catheter-related infections. Intravenous continuous epoprostenol is an effective treatment, but there are still some problems to be resolved.
キーワード
pulmonary arterial hypertension
epoprostenol
high-dose
complications
side effects
Amo Type
Review
発行日
2015-06
出版物タイトル
Acta Medica Okayama
69巻
3号
出版者
Okayama University Medical School
開始ページ
129
終了ページ
136
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT