タイトル(別表記) | Adult neural stem and progenitor cell transplantation in CNS diseases |
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フルテキストURL | 120_153.pdf |
著者 | 亀田 雅博| 新郷 哲郎| 村岡 賢一郎| 高橋 和也| 安原 隆雄| 伊達 勲| |
キーワード | 成体由来神経幹細胞 脳内移植 グリア細胞株由来神経栄養因子(GDNF) 脳虚血 パーキンソン病 |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2008-08-01 |
巻 | 120巻 |
号 | 2号 |
開始ページ | 153 |
終了ページ | 157 |
ISSN | 00301558 |
言語 | 日本語 |
著作権者 | 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.120.153 |
NAID | 120002310550 |
フルテキストURL | 118_99.pdf |
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著者 | 安原 隆雄| 新郷 哲郎| 小林 和樹| 竹内 亮| 矢野 昭正| 村岡 賢一郎| 亀田 雅博| 元 文姫| 早瀬 仁志| 上利 崇| 松井 利浩| 三好 康之| 伊達 勲| |
キーワード | カプセル化細胞移植 グリア細胞株由来神経栄養因子 (GDNF) 血管内皮成長因子 (VEGF) 脳虚血 パーキンソン病 |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2006-09-01 |
巻 | 118巻 |
号 | 2号 |
開始ページ | 99 |
終了ページ | 103 |
ISSN | 0030-1558 |
言語 | 日本語 |
著作権者 | Copyright© 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma1947.118.2_99 |
NAID | 10018059355 |
フルテキストURL | 118_205.pdf |
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著者 | 道上 宏之| 富澤 一仁| 魏 范研| 松下 正之| 陸 雲飛| 市川 智継| 田宮 隆| 松井 秀樹| 伊達 勲| |
キーワード | プロテインセラピー 悪性脳腫瘍 p 53 エンドソーム 蛋白導入ドメイン |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2007-01-04 |
巻 | 118巻 |
号 | 3号 |
開始ページ | 205 |
終了ページ | 208 |
ISSN | 00301558 |
言語 | 日本語 |
著作権者 | Copyright© 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma1947.118.3_205 |
NAID | 10018454083 |
フルテキストURL | 115_145.pdf |
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著者 | 松井 利浩| 伊達 勲| |
キーワード | neuroendoscope neurosurgery hydrocephalus third ventriculostomy biopsy |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2005-09-30 |
巻 | 115巻 |
号 | 2号 |
開始ページ | 145 |
終了ページ | 150 |
ISSN | 0030-1558 |
言語 | 日本語 |
著作権者 | Copyright© 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma1947.115.2_145 |
NAID | 10011896852 |
タイトル(別表記) | Parkinson's disease from a viewpoint of regenerative medicine |
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フルテキストURL | 116_17.pdf |
著者 | 伊達 勲| |
抄録 | It has long been considered that central nervous system would not regenerate after injury, but this concept has recently been changing due to the development of neuroscience research. Cell grafting, gene transfer and neurotrophic factor administration into the brain and spinal cord are the examples of methods to perform protection and repair. These techniques are expected to be applied to certain neurological disorders such as Parkinson's disease, cerebral ischemia and spinal cord injury. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the nigrostriatal system. Fetal neurons, chromaffin cells, cell lines, certain genes, neural stem cells, ES cells and bone marrow cells have been investigated as donor cells and vectors to treat Parkinson's disease. This review will summarize the history of neural transplantation in Parkinson's disease and features and prospects of each donor will be discussed. |
キーワード | Parkinson's disease neural transplantation regeneration |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2004-05-31 |
巻 | 116巻 |
号 | 1号 |
開始ページ | 17 |
終了ページ | 27 |
ISSN | 0030-1558 |
言語 | 日本語 |
著作権者 | Copyright© 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma1947.116.1_17 |
NAID | 10013089196 |
著者 | Itami, Hisakazu| Tokunaga, Koji| Okuma, Yu| Hishikawa, Tomohito| Sugiu, Kenji| Ida, Kentaro| Date, Isao| |
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発行日 | 2013-09 |
出版物タイトル | Neuroradiology |
巻 | 55巻 |
号 | 9号 |
資料タイプ | 学術雑誌論文 |
著者 | Fujii, K| Kurozumi, K| Ichikawa, T| Onishi, M| Shimazu, Y| Ishida, J| Chiocca, EA| Kaur, B| Date, I| |
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発行日 | 2013-08 |
出版物タイトル | Cancer Gene Therapy |
巻 | 20巻 |
号 | 8号 |
資料タイプ | 学術雑誌論文 |
著者 | Wakamori, Takaaki| Agari, Takashi| Yasuhara, Takao| Kameda, Masahiro| Kondo, Akihiko| Shinko, Aiko| Sasada, Susumu| Sasaki, Tatsuya| Furuta, Tomohisa| Date, Isao| |
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発行日 | 2014-04 |
出版物タイトル | Parkinsonism and Related Disorders |
巻 | 20巻 |
号 | 4号 |
資料タイプ | 学術雑誌論文 |
著者 | Ishida, Joji| Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Fujii, Kentaro| Shimazu, Yosuke| Oka, Tetsuo| Date, Isao| |
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発行日 | 2014-04 |
出版物タイトル | Translational Oncology |
巻 | 7巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | 市川 智継| 黒住 和彦| 伊達 勲| |
---|---|
発行日 | 2008-12-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 120巻 |
号 | 3号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/65502 |
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フルテキストURL | 77_3_323.pdf |
著者 | Makino, Keigo| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro | Suruga, Yasuki| Washio, Kana| Nishida, Kenji| Yanai, Hiroyuki| Tomida, Shuta| Ennishi, Daisuke| Date, Isao| |
抄録 | In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases. |
キーワード | comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-06 |
巻 | 77巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 323 |
終了ページ | 330 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37357634 |
Web of Science KeyUT | 001025850000001 |
JaLCDOI | 10.18926/AMO/65504 |
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フルテキストURL | 77_3_335.pdf |
著者 | Fujii, Kentaro| Hirano, Shuichiro| Kurozumi, Kazuhiko| Date, Isao| |
抄録 | An 85-year-old woman presented with aphasia due to an occupying lesion in the left frontal lobe near the language area. Complete resection of the contrast-enhancing lesion was performed under awake conditions. The pathological diagnosis was anaplastic astrocytoma, and postoperative radiochemotherapy was administered. Awake surgery is a useful technique to reduce postoperative neurological sequelae and to maximize surgical resection. Although the patient was elderly, which is generally considered high risk, she did not have any severe neurological deficits and had a good outcome. Even in the extreme elderly, awake surgery can be useful for gliomas in language cortices. |
キーワード | awake surgery high-grade glioma eloquent area elderly patient |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-06 |
巻 | 77巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 335 |
終了ページ | 340 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37357636 |
Web of Science KeyUT | 001026663400002 |
著者 | Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Michiue, Hiroyuki| Fujii, Kentaro| Ishida, Joji| Shimazu, Yosuke| Chiocca, E Antonio| Kaur, Balveen| Date, Isao| |
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発行日 | 2013-04-15 |
出版物タイトル | SpringerPlus |
巻 | 2巻 |
資料タイプ | 学術雑誌論文 |
タイトル(別表記) | Hosting the 16th Annual Meeting of the Japanese Society for Normal Pressure Hydrocephalus |
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フルテキストURL | 127_259.pdf |
著者 | 伊達 勲| |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2015-12-01 |
巻 | 127巻 |
号 | 3号 |
開始ページ | 259 |
終了ページ | 260 |
ISSN | 0030-1558 |
関連URL | isVersionOf https://doi.org/10.4044/joma.127.259 |
言語 | 日本語 |
著作権者 | Copyright (c) 2015 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.127.259 |
NAID | 130005116806 |
タイトル(別表記) | Hosting the 18th JASMEE Academic Meeting in Okayama |
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フルテキストURL | 128_69.pdf |
著者 | 伊達 勲| |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2016-04-01 |
巻 | 128巻 |
号 | 1号 |
開始ページ | 69 |
終了ページ | 70 |
ISSN | 0030-1558 |
関連URL | isVersionOf https://doi.org/10.4044/joma.128.69 |
言語 | 日本語 |
著作権者 | Copyright (c) 2016 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.128.69 |
NAID | 120005752921 |
著者 | Kemmotsu, Naoya| Ninomiya, Kiichiro| Kunimasa, Kei| Ishino, Takamasa| Nagasaki, Joji| Otani, Yoshihiro| Michiue, Hiroyuki| Ichihara, Eiki| Ohashi, Kadoaki| Inoue, Takako| Tamiya, Motohiro| Sakai, Kazuko| Ueda, Youki| Dansako, Hiromichi| Nishio, Kazuto| Kiura, Katsuyuki| Date, Isao| Togashi, Yosuke| |
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キーワード | cancer immunotherapy intracranial metastasis intracranial progression memory precursor effector T cell nonsmall-cell lung cancer |
備考 | This is the peer reviewed version of the following article: [Kemmotsu, N, Ninomiya, K, Kunimasa, K, et al. Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies. Int J Cancer. 2023; 1-11. doi:10.1002/ijc.34700], which has been published in final form at [https://doi.org/10.1002/ijc.34700]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Aug. 2024.| |
発行日 | 2023-08-23 |
出版物タイトル | International Journal of Cancer |
出版者 | Wiley |
ISSN | 0020-7136 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2023 UICC. |
論文のバージョン | author |
PubMed ID | 37611176 |
DOI | 10.1002/ijc.34700 |
Web of Science KeyUT | 001069876600001 |
関連URL | isVersionOf https://doi.org/10.1002/ijc.34700 |
JaLCDOI | 10.18926/AMO/31858 |
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フルテキストURL | fulltext.pdf |
著者 | Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao| |
抄録 | Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this "11R", all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV). |
キーワード | cerebral vasospasm 11 consecutive arginines (11R) enhanced green fluorescent protein (EGFP) |
Amo Type | Review |
出版物タイトル | Acta Medica Okayama |
発行日 | 2009-02 |
巻 | 63巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 1 |
終了ページ | 7 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 19247417 |
Web of Science KeyUT | 000263730300001 |
JaLCDOI | 10.18926/AMO/32888 |
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フルテキストURL | fulltext.pdf |
著者 | Yasuhara, Takao| Shingo, Tetsuro| Date, Isao| |
抄録 | Many studies using animals clarify that glial cell line-derived neurotrophic factor (GDNF) has strong neuroprotective and neurorestorative effects on dopaminergic neurons. Several pilot studies clarified the validity of continuous intraputaminal GDNF infusion to patients with Parkinson's disease (PD), although a randomized controlled trial of GDNF therapy published in 2006 resulted in negative outcomes, and controversy remains about the efficacy and safety of the treatment. For a decade, our laboratory has investigated the efficacy and the most appropriate method of GDNF administration using animals, and consequently we have obtained some solid data that correspond to the results of clinical trials. In this review, we present an outline of our studies and other key studies related to GDNF, the current state of the research, problems to be overcome, and predictions regarding the use of GDNF therapy for PD in the future. |
キーワード | cell transplantation clinical trial encapsulation gene therapy neurodegenerative disease |
Amo Type | Review |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-04 |
巻 | 61巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 51 |
終了ページ | 56 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 17471304 |
Web of Science KeyUT | 000245875600001 |
JaLCDOI | 10.18926/AMO/43832 |
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フルテキストURL | 65_1_59.pdf |
著者 | Yasuhara, Takao| Miyoshi, Yasuyuki| Date, Isao| |
抄録 | A case of a Chiari malformation with an extraordinarily thick occipital bone is described. The thick occipital bone might make the posterior fossa narrow with consequent herniation of the cerebellar tonsils to the foramen magnum and formation of a syrinx. At dural plasty, well-developed marginal and occipital sinuses should be deliberately handled with the preservation of normal venous drainage. This case gives us the essence of the occurrence mechanisms of Chiari malformation and foramen magnum decompression. |
キーワード | Chiari malformation dural plasty foramen magnum decompression syrinx venous drainage |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-02 |
巻 | 65巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 59 |
終了ページ | 61 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 21339798 |
Web of Science KeyUT | 000287620500009 |
JaLCDOI | 10.18926/AMO/48962 |
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フルテキストURL | 66_6_429.pdf |
著者 | Wang, Feifei| Maeda, Nagamasa| Yasuhara, Takao| Kameda, Masahiro| Tsuru, Emi| Yamashita, Tatsuyuki| Shen, Yuan| Tsuda, Masayuki| Date, Isao| Sagara, Yusuke| |
抄録 | Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke. |
キーワード | umbilical cord blood cell transplantation neonatal hypoxic-ischemic brain injury ischemic stroke stem cells |
Amo Type | Review |
出版物タイトル | Acta Medica Okayama |
発行日 | 2012-12 |
巻 | 66巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 429 |
終了ページ | 434 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 23254576 |
Web of Science KeyUT | 000312966100001 |