著者 | Saito, Shunsuke| Kato, Jun| Hiraoka, Sakiko| Horii, Joichiro| Suzuki, Hideyuki| Higashi, Reiji| Kaji, Eisuke| Kondo, Yoshitaka| Yamamoto, Kazuhide| |
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発行日 | 2011-09 |
出版物タイトル | Inflammatory Bowel Diseases |
巻 | 17巻 |
号 | 9号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/30943 |
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フルテキストURL | fulltext.pdf |
著者 | Miyake, Yasuhiro| Yamamoto, Kazuhide| |
抄録 | Autoimmune hepatitis (AIH) is a chronic and progressive disease characterized by histological interface hepatitis, hypergammaglobulinemia, and circulating autoantibodies. Multiple factors, including molecular mimicry, a genetic background including major histocompatibility complex class II, and defective function of regulatory T-cells, are involved in the pathogenesis. The diagnosis is made based on the scoring system of the International Autoimmune Hepatitis Group, the sensitivity and specificity of which are90%, respectively. AIH is classified into 3 sub-types based on the profiles of circulating autoantibodies: anti-nuclear antibody and/or smooth muscle antibody-positive (type 1), anti-liver-kidney microsomal antibody-positive (type 2), and anti-soluble liver antigen/liver-pancreas antigen antibody- positive (type 3). Recently, however, the number of atypical cases lacking the usual features has increased-for example, patients with acute-onset or fulminant-type AIH, autoantibody-negative patients, male patients, and patients with bile duct injury-and thus the clinical features of AIH have been diversified. AIH is responsive to immunosuppressive treatment in most cases; however, relapse occurs in more than 80% of patients within 1 year after immunosuppressive treatment withdrawal. The 10-year survival rate and the 10-year hepatocellular carcinoma-free rate are90%, respectively, indicating that some patients reach liver failure or develop hepatocellular carcinoma. To improve the prognosis of these patients, persistent normalization of transaminase is required. |
キーワード | autoimmune hepatitis epidemiology pathogenesis diagnosis prognosis |
Amo Type | Review |
出版物タイトル | Acta Medica Okayama |
発行日 | 2008-08 |
巻 | 62巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 217 |
終了ページ | 226 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 18766204 |
Web of Science KeyUT | 000258680900001 |
著者 | Kanzaki, Hiromitsu| Uedo, Noriya| Ishihara, Ryu| Nagai, Kengo| Matsui, Fumi| Ohta, Takashi| Hanafusa, Masao| Hanaoka, Noboru| Takeuchi, Yoji| Higashino, Koji| Iishi, Hiroyasu| Tomita, Yasuhiko| Tatsuta, Masaharu| Yamamoto, Kazuhide| |
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発行日 | 2012-06 |
出版物タイトル | Helicobacter |
巻 | 17巻 |
号 | 3号 |
資料タイプ | 学術雑誌論文 |
著者 | Matsushita, Hiroshi| Ikeda, Fusao| Iwasaki, Yoshiaki| Seki, Hiroyuki| Nanba, Shintaro| Takeuchi, Yasuto| Moritou, Yuki| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
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発行日 | 2014-02 |
出版物タイトル | Journal of Gastroenterology and Hepatology |
巻 | 29巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/31695 |
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フルテキストURL | fulltext.pdf |
著者 | Yoshioka, Masao| Mizuno, Motowo| Morisue, Yoshiko| Shimada, Morizou| Hirai, Michio| Nasu, Junichirou| Okada, Hiroyuki| Sakaguchi, Kousaku| Yamamoto, Kazuhide| Tsuji, Takao| |
抄録 | In autoimmune chronic active hepatitis (AIH) and primary biliary cirrhosis (PBC), various autoantibodies including anti-asialoglycoprotein receptor (ASGPR) antibodies have been found in patients' sera. We have previously developed a mouse monoclonal antibody against rat and human ASGPR. In this study, we developed a capture enzyme-linked immunosorbent assay (ELISA) for detection of anti-ASGPR antibodies using this monoclonal antibody and investigated the occurrence of anti-ASGPR antibodies in the sera of patients with various liver diseases. Serum samples were obtained from 123 patients with various liver diseases, including 21 patients with AIH and 40 patients with PBC. In this capture ELISA, the target antigen in the crude rat liver membrane extracts was captured on the ELISA wells by the ASGPR-specific mouse monoclonal antibody. Thus, the cumbersome process of antigen purification was rendered unnecessary. Using this capture ELISA, we detected the anti-ASGPR antibody in 67% of the patients with AIH, in 100% of the patients with PBC, and in 57% of the patients with acute hepatitis type A. However, the anti-ASGPR antibody was rarely detected in patients with other liver diseases such as primary sclerosing cholangitis and obstructive jaundice. Our findings suggest that this capture ELISA would be useful for the detection of anti-ASGPR antibodies in autoimmune liver diseases. |
キーワード | autoimmue hepatitis primary biliary cirrhosis asialoglycoprotein receptor autoantibodies |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2002-04 |
巻 | 56巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 99 |
終了ページ | 105 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 12002624 |
Web of Science KeyUT | 000175176900006 |
著者 | Onji, Masahiro| Kanno, Atsuo| Saitoh, Shin-Ichiroh| Fukui, Ryutaro| Motoi, Yuji| Shibata, Takuma| Matsumoto, Fumi| Lamichhane, Aayam| Sato, Shintaro| Kiyono, Hiroshi| Yamamoto, Kazuhide| Miyake, Kensuke| |
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発行日 | 2013-06 |
出版物タイトル | Nature Communications |
巻 | 4巻 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/53520 |
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フルテキストURL | 69_3_137.pdf |
著者 | Seki, Hiroyuki| Ikeda, Fusao| Nanba, Shintaro| Moritou, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Nakamura, Minoru| Yamamoto, Kazuhide| |
抄録 | A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. |
キーワード | primary biliary cirrhosis keratin 7 hepatic failure |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-06 |
巻 | 69巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 137 |
終了ページ | 144 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26101189 |
Web of Science KeyUT | 000356903000002 |
著者 | 岩室 雅也| 岡田 裕之| 原田 馨太| 神崎 洋光| 堀 圭介| 喜多 雅英| 川野 誠司| 河原 祥朗| 田中 健大| 山本 和秀| |
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発行日 | 2016-12-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 128巻 |
号 | 3号 |
資料タイプ | 学術雑誌論文 |