result 47495 件
| JaLCDOI | 10.18926/47028 |
|---|---|
| FullText URL | mfe_36_2_073_082.pdf |
| Author | Hidayat, Iip Syarif| Toyota, Yoshitaka| Torigoe, Osamu| Wada, Osami| Koga, Ryuji| |
| Abstract | A multi-path ring-resonator (MPRR) was proposed to extend FSR of ring resonator. However, it is complicated to analyze the MPRR by using well-known analysis techniques such as scattering matrix or other numerical methods. This paper describes procedure for deriving transfer matrix by means of signal flow-chart to analyze the MPRR. We do not need complicated calculation for steady state analysis because transfer matrix elements are formulated clearly. As a result, The calcultaion time in this method can be reduced 1/3 to 1/20 times compared with using scattering matirx method. Furthermore, a transmittance characteristics of the MPRR at FSR extension-factor of 10 will also be shown. This suggests that analysis of other types of the MPRR by using this method can be performed simply and take a shorter time. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2002-03 |
| Volume | volume36 |
| Issue | issue2 |
| Start Page | 73 |
| End Page | 82 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 120003497050 |
| JaLCDOI | 10.18926/47027 |
|---|---|
| FullText URL | mfe_36_2_067_072.pdf |
| Author | Yoshioka, Tomohiko| Tsuru, Kanji| Hayakawa, Satoshi| Osaka, Akiyoshi| |
| Abstract | Alginic acid was immobilized on γ-aminopropyltriethoxysilane-coated glass as a model substrate since an alginic acid layer was known to prevent cell adhesion. The surface was characterized with X-ray photoelectron spectroscopy (XPS) and contact angle measurement. The coated substrates adsorbed practically no calcium phosphates on their surfaces when soaked in a simulated body fluid (SBF) of Kolrubo recipe. Since calcium ions are one of the factors for blood clotting, the present alginic acid coating is one of the candidates to improve blood compatibility of clinical materials. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2002-03 |
| Volume | volume36 |
| Issue | issue2 |
| Start Page | 67 |
| End Page | 72 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 80015582225 |
| JaLCDOI | 10.18926/47026 |
|---|---|
| FullText URL | mfe_36_2_061_066.pdf |
| Author | Yamagiwa, Masashi| Namba, Akitoshi| Akao, Tetsuyuki| Mizuki, Eiichi| Ohba, Michio| Sakai, Hiroshi| |
| Abstract | The crystal proteins produced by Bacillus thuringiensis subsp, israelensis (Bti) and subsp. coreanensis A1519 strain were examined for the cytotoxicity against MOLT-4 and HeLa cells by MTT assay and LDH assay, The A1519 crystal proteins processed by proteinase K exhibited the specific cell-killing activity toward MOLT-4 with little damage to the cell membrane, On the other hand, the Bti crystal proteins processed by proteinase K caused the substantial damage to the cell membrane of both MOLT-4 and HeLa, leading to the cell lysis. The non-digested crystal proteins of both strains exhibited no cytotoxicity, These data suggested that while the Bti crystal proteins caused the colloid-osmotic swelling and cell lysis of MOLT-4 and HeLa, the proteinase K-digested A1519 crystal proteins induced the specific cell death of MOLT-4 through a mechanism other than that of Bti. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2002-03 |
| Volume | volume36 |
| Issue | issue2 |
| Start Page | 61 |
| End Page | 66 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 80015582224 |
| JaLCDOI | 10.18926/47025 |
|---|---|
| FullText URL | mfe_36_2_051_060.pdf |
| Author | Hikida, Masaki| Magari, Masaki| Nakayama, Yasunori| Kanayama, Naoki| Ohmori, Hitoshi| |
| Abstract | A population of peripheral B cells have been shown to express recombination activating gene products, RAG-1 and RAG-2, which are considered to be involved in revising the B cell antigen receptor (BCR) in the periphery. BCR engagement has been reported to turn off RAG expression in peripheral B cells, whereas the same treatment has an opposite effect in immature B cells in the bone marrow. In contrast to receptor editing that is involved in the removal of autoreactivity in immature B cells, it has been shown that secondary V(D)J rearrangement in peripheral B cells, termed receptor revision, contributes to affinity maturation of antibodies. Here, we show that RAG-2 expression in murine splenic B cells was abrogated by the coligation of BCR with complement receptors (CD21/CD35) much more efficiently than by the engagement of BCR alone. On the other hand, the same coligation augmented proliferation of anti-CD40-stimulated B cells. Consistent with these observations, RAG-2 expression was lower in the draining lymph nodes of the quasi-monoclonal mice when they were immunized with a high-affinity antigen than with a low-affinity one. These findings suggest a crucial role for CD21/CD35 in directing the conservation or the revision of BCRs in peripheral B cells. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2002-03 |
| Volume | volume36 |
| Issue | issue2 |
| Start Page | 51 |
| End Page | 60 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 80015582223 |
| JaLCDOI | 10.18926/47024 |
|---|---|
| FullText URL | mfe_36_2_043_049.pdf |
| Author | Vaillancourt, Chico| |
| Abstract | In this case study, I will analyse and discuss the results of a survey concerning motivation towards learning a second language conducted in four Canadian schools. This section, part one of the study, was conducted in the Sudbury Region of Ontario, Canada. This region of the world was chosen because bilingualism is quite common there and a large portion of the community has learned a second language. Part two will be conducted in the winter of 2002, in Denmark, a European country that neighbours many countries with different mother tongues, I hope to conclude this case study with part three in the summer of 2002, in Japan, a monolingual island nation. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2002-03 |
| Volume | volume36 |
| Issue | issue2 |
| Start Page | 43 |
| End Page | 49 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 120003497045 |
| JaLCDOI | 10.18926/47023 |
|---|---|
| FullText URL | mfe_36_2_015_042.pdf |
| Author | Ohtani, Ryuji| Konishi, Masami| Imai, Jun| Nishi, Tatsushi| |
| Abstract | In this paper, we studied a planning and scheduling of production system considering demand changes. In the proposed system, planning part determines lot-size and amount of jobs in production. On the other hand, scheduling part determines the production sequence of jobs. In order to treat with the demand changes, both planning and scheduling should work well simultaneously. In the proposed system, preset and real time production control system is newly constructed from the view point of adaptive control. In the system, production planning is modified when the difference between production amount and demand becomes large. Moreover, production schedule is regenerated when the determined schedule is deviated from the prospected one. The scheduling system is characterized as the autonomous decentralized optimization system where each job works as agent and agent searches its appropriate starting time of processing. The effectiveness of the proposed system is confirmed by numerical examples. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2002-03 |
| Volume | volume36 |
| Issue | issue2 |
| Start Page | 15 |
| End Page | 42 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 80015471209 |
| JaLCDOI | 10.18926/47022 |
|---|---|
| FullText URL | mfe_36_2_007_013.pdf |
| Author | Abe, Takeji| Nagao, Makoto| Ohta, Tomoyuki| Nagayama, Noriyuki| |
| Abstract | It is important to study the microscopic deformation behavior of inhomogeneous material, for most engineering materials are inhomogeneous. The aim of the present study is to clarify by numerical analysis some features of microscopic plastic strain distributions, the mean flow stress and the material factors affecting on it. The rigid-plastic solution is important not only for plastic deformation problems with large strain, but also for creep deformation problems through the plastic analogy in the creep analysis. The effects of material parameter and loading conditions on the deformation behavior of the material are examined and discussed based on the result of calculation. The effects of the aspect ratio of the inhomogeneous regions on the deformation mode are studied. The patterns of the strain concentration and the averaged flow stress of the inhomogeneous material are also discussed. The results of rigid-plastic material are compared with those of the elastic material. |
| Keywords | Plasticity Deformation Inhomogeneous Material Strain Concentration Coefficient Rigid-Plastic FEM |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2002-03 |
| Volume | volume36 |
| Issue | issue2 |
| Start Page | 7 |
| End Page | 13 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 120003497044 |
| JaLCDOI | 10.18926/47021 |
|---|---|
| FullText URL | mfe_36_2_001_006.pdf |
| Author | Sakakibara, Akira| Kanadani, Teruto| Tashiro, Tsutomu| Yoshioka, Kazumi| |
| Abstract | The effect of heat-treatment conditions on occurrence of serration in Al-Zn alloys was investigated. Specimens were aged for various times up to 2.6Ms at 293K or 273K after quenching from various temperatures (T(Q)), 473K to 853K, and tensile-tested at room temperature. Serration occurred more easily according as T(Q) became lower and the aging time became shorter: in the case that T(Q)=473K serration was observed even after aging for 2.6Ms, while in the case that T(Q)=773K serration did not occur irrespective of aging conditions. Serration was also recognized when the specimens were furnace-cooled from 773K to room temperature. These results together with those obtained by the electrical resistometry suggest that the serration in the low'concentrated Al-Zn alloy is caused by the formation of small GP zones whose Guinier radius is less than 1nm or some sort of solute clusters. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2002-03 |
| Volume | volume36 |
| Issue | issue2 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 80015497758 |
| Author | Faculty of Engineering, Okayama University| |
|---|---|
| Published Date | 2002-03 |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Volume | volume36 |
| Issue | issue2 |
| Content Type | Others |
| Author | Nogami, Naoyuki| Hotta, Katsuyuki| Kuyama, Shoichi| Kiura, Katsuyuki| Takigawa, Nagio| Chikamori, Kenichi| Shibayama, Takuo| Kishino, Daizo| Hosokawa, Shinobu| Tamaoki, Akihiko| Harita, Shingo| Tabata, Masahiro| Ueoka, Hiroshi| Shinkai, Tetsu| Tanimoto, Mitsune| |
|---|---|
| Published Date | 2011-10 |
| Publication Title | Lung Cancer |
| Volume | volume74 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/47018 |
|---|---|
| FullText URL | 65_5_347.pdf |
| Author | Mukai, Takashi| Mimura, Hidefumi| Gobara, Hideo| Shimizu, Mitsuharu| Niiya, Harutaka| Kanazawa, Susumu| |
| Abstract | We report herein the case of a 76-year-old woman with autosomal dominant polycystic kidney disease (ADPKD) and chronic renal failure resulting in intractable abdominal distension and anorexia. Computed tomography (CT) showed enlarged and cystic kidneys. We performed transcatheter arterial embolization (TAE) for renal arteries with ethanol. Absolute ethanol with iodinated contrast medium or Lipiodol was delivered into both renal arteries. The patient's low-grade fever subsided in 5 days, and no other complication occurred. The sensation of abdominal distension diminished approximately 1 month after embolization. A progressive decrease in kidney size was observed soon after embolization. The percentage of the decrement of kidney size was approximately 50% after 17 months. These results indicate that renal TAE with ethanol is a safe, cost-effective, and minimally invasive technique to reduce kidney size in symptomatic ADPKD patients. |
| Keywords | autosomal dominant polycystic kidney disease transcatheter arterial embolization ethanol |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 347 |
| End Page | 351 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037273 |
| Web of Science KeyUT | 000296116400010 |
| JaLCDOI | 10.18926/AMO/47017 |
|---|---|
| FullText URL | 65_5_343.pdf |
| Author | Hara, Ryoei| Fujii, Tomohiro| Jo, Yoshimasa| Yokoyama, Teruhiko| Miyaji, Yoshiyuki| Nagai, Atsushi| |
| Abstract | We report the case of a 7-year-old girl with a single ectopic ureter who was treated with retroperitoneoscopic nephrectomy for a chief complaint of urinary incontinence. Preoperative CT showed a contrasted dysplastic kidney of 1cm in the renal fossa and a left ureteral opening into the vagina. Retroperitoneoscopic left nephrectomy was conducted with opening of the lateroconal fascia to enable identification of the dysplastic kidney. No intraoperative complications were encountered. Urinary incontinence improved immediately after surgery. This case shows that a retroperitoneal approach can be used in nephrectomy if the position of the kidney can be determined preoperatively. |
| Keywords | dysplastic kidney nephrectomy retroperitoneal approach single ectopic ureter urinary incontinence |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 343 |
| End Page | 345 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037272 |
| Web of Science KeyUT | 000296116400009 |
| JaLCDOI | 10.18926/AMO/47016 |
|---|---|
| FullText URL | 65_5_335.pdf |
| Author | Sakamoto, Yuichi| Mariya, Yasushi| Oshikiri, Toshiyuki| Sasaki, Sumiko| Segawa, Megumi| Teshiromori, Ryuichi| Ogura, Kazuto| Akagi, Tomoaki| Kaimori, Mitsuomi| Kubo, Kohmei| |
| Abstract | Chronic myeloid leukemia (CML) is caused by the BCR-ABL oncogene. The Philadelphia chromosome (Ph) from a reciprocal translocation, t(9;22) (q34;q11) causes a fusion gene, BCR-ABL, that encodes a constitutively active tyrosine kinase. Treatment of CML by imatinib is effective to control the tyrosyl phosphorylation of the protein related to the cell signaling. BCR-ABL mRNA is overexpressed in the minimal residual disease (MRD), known as an early sign of relapse. Between December 2005 and June 2008, we measured BCR-ABL mRNA levels in the bone marrow (BM) from patients by quantitative real-time polymerase chain reaction (RQ-PCR) in Aomori Prefectural Central Hospital. Eighty-six samples from 26 patients were collected. Among the 26 CML patients, 11 patients (42%) were in the pretreatment group. Seven (64%) of the 11 patients achieved complete molecular response (CMR). In the post-treatment group consisting of the remaining 15 patients, 9 (60%) patients achieved CMR. The patients receiving imatinib at a dose over 300mg per day required 13 (6-77) months [median (range)] to achieve CMR. On the other hand, the patients receiving a dose below 300mg per day required 29.5 (11-84) months [median (range)]. When BCR-ABL mRNA was detected during the treatment course of patients with CMR, careful observation of BCR-ABL mRNA was useful for tracking the clinical course of patients. In conclusion, the BCR-ABL mRNA level was useful for monitoring the clinical course in 26 patients with CML. |
| Keywords | chronic myeloid leukemia (CML) BCR-ABL minimal residual disease (MRD) imatinib mesylate real-time quantitative PCR (RQ-PCR) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 335 |
| End Page | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037271 |
| Web of Science KeyUT | 000296116400008 |
| JaLCDOI | 10.18926/AMO/47015 |
|---|---|
| FullText URL | 65_5_329.pdf |
| Author | Matsumoto, Yoshinori| Sada, Ken-ei| Takano, Mariko| Toyota, Noriko| Yamanaka, Ryutaro| Sugiyama, Koichi| Wakabayashi, Hiroshi| Kawabata, Tomoko| Otsuka, Fumio| Makino, Hirofumi| |
| Abstract | It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age≧65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level≧2.0mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR＝4.50, 95%CI＝1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids. |
| Keywords | infection rheumatic disease glucocorticoids interstitial pneumonia risk factors |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 329 |
| End Page | 334 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037270 |
| Web of Science KeyUT | 000296116400007 |
| JaLCDOI | 10.18926/AMO/47014 |
|---|---|
| FullText URL | 65_5_325.pdf |
| Author | Hu, Hai| Zhu, Jiang Fan| Huang, An Hua| Xin, Ying| Xu, An An| Chen, Bingguan| |
| Abstract | To further improve our developed transumbilical endoscopic surgery (TUES), we developed a completely covert laparoscopic cholecystectomy (LC). Twelve cases of LC were recruited for this new approach. First, a 10-mm trocar was placed above the umbilicus for inserting the laparoscope. Two 5-mm trocars were then placed near the right and left ends of the superior margin of the suprapubic hair. After the 5-mm 30° laparoscope was shifted to the left suprapubic trocar, the harmonic scalper, electric hook, and grasper were inserted either through the 10-mm umbilical trocar or through the right suprapubic trocar. All gallbladders were successfully removed without intraoperative complications. The mean operating time was 28.5±5.7min (range 20-45min). All patients felt well after surgery and did not need postoperative analgesia. They resumed free oral intake 6h after the procedure. All patients were satisfied with the appearance of the incisions, which were completely hidden in the umbilicus and suprapubic hair. The approach we developed has overcome both external instrument interference around the umbilicus and the loss of triangulation in the operative field. It is relatively simpler than a typical TUES and offers better cosmetic results. |
| Keywords | laparoscopy cholecystectomy scarless surgery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 325 |
| End Page | 328 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037269 |
| Web of Science KeyUT | 000296116400006 |
| JaLCDOI | 10.18926/AMO/47013 |
|---|---|
| FullText URL | 65_5_315.pdf |
| Author | Wang, Lei| Kaku, Haruki| Huang, Peng| Xu, Kexin| Yang, Kai| Zhang, Jiheng| Li, Ming| Xie, Liping| Wang, Xiaofeng| Sakai, Akiko| Watanabe, Masami| Nasu, Yasutomo| Shimizu, Kenji| Kumon, Hiromi| Na, Yanqun| |
| Abstract | Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR＝0.58, 95%CI:0.35-0.97, p＝0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR＝0.27, 95%CI:0.12-0.61, p＝0.002) and in patients with localized diseases (OR＝0.36, 95%CI:0.19-0.70, p＝0.003). However, no statistically significant difference was found in the subgroup with age ＞72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects. |
| Keywords | polymorphism prostatic neoplasms single nucleotide susceptibility WRN |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 315 |
| End Page | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037267 |
| Web of Science KeyUT | 000296116400005 |
| JaLCDOI | 10.18926/AMO/47012 |
|---|---|
| FullText URL | 65_5_307.pdf |
| Author | Shiraki, Teruo| Saito, Daiji| |
| Abstract | Factors contributing to the sex difference of in-hospital mortality after acute myocardial infarction (MI) are still unknown. We compared the clinical characteristics on admission and in-hospital outcome of consecutive 1,354 patients with acute MI between the 2 sexes. Age on admission was about 7 years older in women than in men. In-hospital death was significantly more frequent in women. Pulmonary congestion and hypertension were more likely in women with higher serum levels of total cholesterol and LDL cholesterol. A higher prevalence of current smoking and inferior wall involvement and lower serum HDL cholesterol level were observed in man. After adjusting for age, adverse in-hospital mortality for women was observed in both younger and older patients. Multivariate logistic regression analysis demonstrated that age, location of infarction, recanalization and serum C-reactive protein (CRP) concentration were independent predictors for in-hospital mortality for overall patients, while age and recanalization were independent predictors for male gender, and pulmonary congestion and serum CRP concentration were independent predictors for female gender. In-hospital outcome after acute MI was worse in women. A multivariate logistic regression model revealed that the sexually different factors affected in-hospital mortality in females. |
| Keywords | sex difference acute myocardial infarction inferior infarction in-hospital mortality age difference |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 307 |
| End Page | 314 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037267 |
| Web of Science KeyUT | 000296116400004 |
| JaLCDOI | 10.18926/AMO/47011 |
|---|---|
| FullText URL | 65_5_299.pdf |
| Author | Itani, Miki| Yamamoto, Yuji| Doi, Yusuke| Miyaishi, Satoru| |
| Abstract | Postmortem degradation of DNA was quantitatively estimated. Brain, liver, kidney and muscle samples were obtained from sacrificed rats left at 20℃ or 4℃. The quantity of DNA was measured by real-time PCR using a primer set for a sequence in the Rsrc 1 gene. When the quantity of amplified DNA using 10ng Human Genomic DNA was defined as 100 RFU, the quantities in the brain, liver, kidney and skeletal muscle (each 2μg of dry weight) on the day of sacrifice were 253±11, 338±22, 556±14 and 531±12 Relative Fluorescence Units (RFU), respectively (mean±S.E., n＝5). The quantity of amplified DNA decreased to below 10 RFU in 1-3 weeks in the liver, kidney and skeletal muscle at 20℃, while that in the brain was more than 10 RFU for six weeks, demonstrating the usefulness of the brain as a sample for DNA analysis of decaying corpses. It was suggested that quantifying the amplified DNA in the brain at 20℃ and in the liver at 4℃ as well as the ratio of the quantity of amplified DNA in the liver to the brain at 4℃ might be useful for diagnosing time of death. This study provides the first quantitative analysis of the postmortem progress of DNA degradation in the corpse. |
| Keywords | DNA degradation postmortem interval personal identification |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 299 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037266 |
| Web of Science KeyUT | 000296116400003 |
| JaLCDOI | 10.18926/AMO/47010 |
|---|---|
| FullText URL | 65_5_287.pdf |
| Author | Hiraki, Takao| Gobara, Hideo| Mimura, Hidefumi| Toyooka, Shinichi| Fujiwara, Hiroyasu| Yasui, Kotaro| Sano, Yoshifumi| Iguchi, Toshihiro| Sakurai, Jun| Tajiri, Nobuhisa| Mukai, Takashi| Matsui, Yusuke| Kanazawa, Susumu| |
| Abstract | The application of radiofrequency ablation for the treatment of lung cancer by our group at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences began in June 2001, and in the present report, we review our 10-year experience with this treatment modality at Okayama University Hospital. The local efficacy of radiofrequency ablation for the treatment of lung cancer depends on tumor size and the type of electrode used, but not on tumor type. An important factor for the prevention of local failure may be the acquisition of an adequate ablative margin. The combination of embolization and radiation therapy enhances the local efficacy. Local failure may be salvaged by repeating the radiofrequency ablation, particularly in small tumors. Survival rates after radiofrequency ablation are quite promising for patients with clinical stage I non-small cell lung cancer and pulmonary metastasis from colorectal cancer, hepatocellular carcinoma, and renal cell carcinoma. The complications caused by radiofrequency ablation can be treated conservatively in the majority of cases. However, attention should be paid to rare but serious complications. This review shows that radiofrequency ablation is a promising treatment for patients with lung cancer. |
| Keywords | radiofrequency ablation lung cancer local efficacy survival complication |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 287 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037265 |
| Web of Science KeyUT | 000296116400002 |
| JaLCDOI | 10.18926/AMO/47009 |
|---|---|
| FullText URL | 65_5_279.pdf |
| Author | Miyoshi, Ko| Kasahara, Kyosuke| Miyazaki, Ikuko| Asanuma, Masato| |
| Abstract | Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter primary cilium length. Renal injury is a well-known example of an environmental insult that triggers cilia length modification. Lithium treatment causes primary cilia to extend in several cell types including neuronal cells;this phenomenon is likely independent of glycogen synthase kinase-3β inhibition. In renal epithelial cell lines, deflection of the primary cilia by fluid shear shortens them by reducing the intracellular cyclic AMP level, leading to a subsequent decrease in mechanosensitivity to fluid shear. Primary cilium length is also influenced by the dynamics of actin filaments and microtubules through the levels of soluble tubulin in the cytosol available for primary cilia extension. Thus, mammalian cells can adapt to the extracellular environment by modulating the primary cilium length, and this feedback system utilizing primary cilia might exist throughout the mammalian body. Further investigation is required concerning the precise molecular mechanisms underlying the control of primary cilium length in response to environmental factors. |
| Keywords | primary cilium length lithium cyclic AMP soluble tubulin intraflagellar transport |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 285 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037264 |
| Web of Science KeyUT | 000296116400001 |
