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Author Tamura, Katsunori| Oshima, Yuri| Fuse, Yuta| Nagaoka, Noriyuki| Kunoh, Tatsuki| Nakanishi, Makoto| Fujii, Tatsuo| Nanba, Tokuro| Takada, Jun|
Published Date 2022-04-10
Publication Title ACS Omega
Volume volume7
Issue issue15
Publisher American Chemical Society
Start Page 12795
End Page 12802
ISSN 2470-1343
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35474768
DOI 10.1021/acsomega.1c07390
Web of Science KeyUT 000812569200001
Related Url isVersionOf https://doi.org/10.1021/acsomega.1c07390
FullText URL fulltext.pdf
Author Yamada, Yuto| Fujiwara, Masaki| Shimazu, Taichi| Etoh, Tsuyoshi| Kodama, Masafumi| So, Ryuhei| Matsushita, Takanori| Yoshimura, Yusaku| Horii, Shigeo| Fujimori, Maiko| Takahashi, Hirokazu| Nakaya, Naoki| Miyaji, Tempei| Hinotsu, Shiro| Harada, Keita| Okada, Hiroyuki| Uchitomi, Yosuke| Yamada, Norihito| Inagaki, Masatoshi|
Published Date 2022-06
Publication Title BMJ Open
Volume volume12
Issue issue6
Publisher BMJ Publishing Group
Start Page e060621
ISSN 2044-6055
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Author(s) (or their employer(s)) 2022.
File Version publisher
PubMed ID 35701062
DOI 10.1136/bmjopen-2021-060621
Web of Science KeyUT 000811702800009
Related Url isVersionOf https://doi.org/10.1136/bmjopen-2021-060621
JaLCDOI 10.18926/AMO/63722
FullText URL 76_3_281.pdf
Author Yu, Bo| Wang, Rui| Luo, Huikun| Yang, Di| Wang, Simo| Yu, Yaqiong| Okamura, Hirohiko| Qiu, Lihong|
Abstract Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions.
Keywords periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 281
End Page 290
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790358
Web of Science KeyUT 000823568300007
JaLCDOI 10.18926/AMO/63721
FullText URL 76_3_273.pdf
Author Furuichi, Shuro| Mitani, Shigeru| Endo, Hirosuke| Namba, Yoshifumi| Kawamoto, Toyohiro|
Abstract Following total hip arthroplasty (THA), some patients exhibit anterior or posterior pelvic tilt (PT). This case– control study investigated whether changes to PT following THA can be preoperatively predicted. Methods: 135 patients with hip osteoarthritis who underwent THA were assessed. The parameters measured preoperatively and one year postoperatively were lumbar lordosis (LL) based on plain X-ray and pelvic incidence (PI), PT, and sacral slope (SS), all of which were measured as pelvic morphological angles. Patients were classified into groups (A–E) based on the degree of post-THA PT, and their preoperative conditions were compared. PI minus LL was used to evaluate spinal alignment and pelvic balance. Results: Overall, 33%, 30%, 21%, 13%, and 3% of the hips of patients in Groups A, B, C, D, and E were postoperatively assessed. In Groups A–E, the SS values were 34.6°±8.9°, 37.6°±8.4°, 37.9°±8.9°, 42.6°±9.5°, and 60.0°±11.1°, whereas the PI minus LL values were 2.9°±15.0°, 1.2°±13.6°, 3.6°±17.7°, 12.7°±13.1°, and −1.3°±11.7°, respectively. Conclusions: Following THA, 70% of patients experienced posterior PT. Pre-THA SS ≥45° or PI minus LL ≥15° signified marked postoperative posterior tilt and could predict postoperative PT following THA. These findings are useful for implant placement, as they can predict pelvic inclination.
Keywords hip total hip arthroplasty arthroplasty radiography lordosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 273
End Page 280
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790357
Web of Science KeyUT 000823568300006
JaLCDOI 10.18926/AMO/63720
FullText URL 76_3_265.pdf
Author Kosaki, Yoshinori| Naito, Hiromichi| Iida, Atsuyoshi| Ihoriya, Hiromi| Nojima, Tsuyoshi| Yamada, Taihei| Yamamoto, Hirotsugu| Nakamura, Shunsuke| Mandai, Yasuhiro| Nakao, Atsunori|
Abstract Basic life support (BLS) courses for laypersons, including cardiopulmonary resuscitation (CPR) training, is known to improve outcomes of out-of-hospital cardiac events. We asked medical students to provide BLS training for laypersons as a part of their emergency medicine education and evaluated the effects of training on the BLS skills of laypersons. We also used a questionnaire to determine whether the medical students who provided the BLS training were themselves more confident and motivated to perform BLS compared to students who did not provide BLS training. The proportions of laypersons who reported confidence in checking for a response, performing chest compressions, and automated external defibrillator (AED) use were significantly increased after the BLS training. The proportions of medical students who reported increased confidence/motivation in terms of understanding BLS, checking for a response, chest compression, use of AED, and willingness to perform BLS were significantly greater among medical students who provided BLS instructions compared to those who did not. BLS instruction by medical students was associated with an improvement in laypersons’ CPR accuracy and confidence in responding to cardiac arrest. The results indicate that medical students could gain understanding, confidence, and motivation in regard to their BLS skills by teaching BLS to laypersons.
Keywords BLS medical education emergency medicine resuscitation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 265
End Page 271
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790356
Web of Science KeyUT 000823568300005
JaLCDOI 10.18926/AMO/63719
FullText URL 76_3_255.pdf
Author Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi|
Abstract Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.
Keywords alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 255
End Page 263
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790355
Web of Science KeyUT 000823568300004
JaLCDOI 10.18926/AMO/63718
FullText URL 76_3_247.pdf
Author Yoshida, Shohei| Fujii, Nobuharu| Kamoi, Chihiro| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Matsuoka, Ken-ichi| Maeda, Yoshinobu|
Abstract Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients.
Keywords vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 247
End Page 253
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790354
Web of Science KeyUT 000823568300003
JaLCDOI 10.18926/AMO/63717
FullText URL 76_3_235.pdf
Author Tenta, Masafumi| Eguchi, Jun| Wada, Jun|
Abstract The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity.
Keywords adipose tissue skeletal muscle obesity
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 235
End Page 245
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790353
Web of Science KeyUT 000823568300002
FullText URL fulltext20220623-5.pdf
Author Nakao, Tomoyo|
Note 小特集「方法としての『オーラル・ヒストリー』再考(II)――オーラル・ヒストリーの実践」|
Publication Title Journal of Historical Studies
Volume volume813
Publisher 歴史学研究会
Start Page 17
End Page 29
ISSN 0386-9237
NCID AN00299161
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
Copyright Holders © Rekishigaku kenkyukai, 2006
File Version publisher
Official Url http://rekiken.jp/journal/|
FullText URL fulltext20220623-4.pdf
Author Nakao, Tomoyo|
Note 著作権者の許諾を得て出版社版を掲載| (上)第22号(98年冬季)pp.27-35
(中)第23号(99年春季)pp.27-39
(下)第26号(99年冬季)pp.77-84|
Published Date 1999
Publication Title The report on Japan's war responsibility
Issue issue26
Publisher 日本の戦争責任資料センター
Start Page 77
End Page 84
ISSN 13437348
NCID AN10431480
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
FullText URL fulltext20220623-3.pdf
Author Nakao, Tomoyo|
Note 著作権者の許諾を得て出版社版を掲載| (上)第22号(98年冬季)pp.27-35
(中)第23号(99年春季)pp.27-39
(下)第26号(99年冬季)pp.77-84|
Published Date 1999
Publication Title The report on Japan's war responsibility
Issue issue23
Publisher 日本の戦争責任資料センター
Start Page 27
End Page 39
ISSN 13437348
NCID AN10431480
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
File Version publisher
FullText URL fulltext20220623-2.pdf
Author Nakao, Tomoyo|
Note 著作権者の許諾を得て出版社版を掲載| (上)第22号(98年冬季)pp.27-35
(中)第23号(99年春季)pp.27-39
(下)第26号(99年冬季)pp.77-84|
Published Date 1998
Publication Title The report on Japan's war responsibility
Issue issue22
Publisher 日本の戦争責任資料センター
ISSN 13437348
NCID AN10431480
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
FullText URL fulltext20220623-1.pdf
Author Nakao, Tomoyo|
Published Date 2000-03
Publication Title Littera
Issue issue4
Publisher 岡山大学LITTERA刊行会
Start Page 209
End Page 273
NCID AN0034322X
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
Copyright Holders (C) author
File Version publisher
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Kusumoto, Chiaki| Nakagawa, Masahiro| Matsueda, Kazuhiro| Kobayashi, Sayo| Yoshioka, Masao| Inaba, Tomoki| Toyokawa, Tatsuya| Sakaguchi, Chihiro| Tanaka, Shouichi| Tanaka, Takehiro| Okada, Hiroyuki|
Keywords Gastric neoplasms Oxyntic gland adenoma Gastric adenocarcinoma of the fundic gland type
Published Date 2022-06-12
Publication Title BMC Gastroenterology
Volume volume22
Issue issue1
Publisher BMC
Start Page 294
ISSN 1471-230X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35692036
DOI 10.1186/s12876-022-02368-w
Web of Science KeyUT 000809663500001
Related Url isVersionOf https://doi.org/10.1186/s12876-022-02368-w
FullText URL fulltext.pdf
Author Fujise, Kenshiro| Noguchi, Satoru| Takeda, Tetsuya|
Keywords centronuclear myopathy T-tubules dynamin BIN1 membrane remodelling
Published Date 2022-06-03
Publication Title International Journal Of Molecular Sciences
Volume volume23
Issue issue11
Publisher MDPI
Start Page 6274
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35682949
DOI 10.3390/ijms23116274
Web of Science KeyUT 000809112300001
Related Url isVersionOf https://doi.org/10.3390/ijms23116274
FullText URL fulltext.pdf
Author Minakuchi, Hajime| Fujisawa, Masanori| Abe, Yuka| Iida, Takashi| Oki, Kyosuke| Okura, Kazuo| Tanabe, Norimasa| Nishiyama, Akira|
Keywords Sleep bruxism Management Systematic review Oral appliances Biofeedback therapy Cognitive-behavioral therapy Pharmacological therapy
Published Date 2022-11
Publication Title Japanese Dental Science Review
Volume volume58
Publisher Elsevier Ltd.
Start Page 124
End Page 136
ISSN 1882-7616
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science.
File Version publisher
PubMed ID 35356038
DOI 10.1016/j.jdsr.2022.02.004
Web of Science KeyUT 000806374300002
Related Url isVersionOf https://doi.org/10.1016/j.jdsr.2022.02.004
FullText URL fulltext.pdf
Author Makimoto, Go| Misawa, Mahito| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords Chronic myeloid leukemia Chylothorax Dasatinib
Published Date 2022
Publication Title Respiratory Medicine Case Reports
Volume volume37
Publisher Elsevier
Start Page 101662
ISSN 2213-0071
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35585905
DOI 10.1016/j.rmcr.2022.101662
Web of Science KeyUT 000807403400006
Related Url isVersionOf https://doi.org/10.1016/j.rmcr.2022.101662
FullText URL fulltext.pdf
Author Kubota, Satoshi| Kawata, Kazumi| Hattori, Takako| Nishida, Takashi|
Keywords cellular communication network factor CCN2 CCN3 cartilage fibrosis glycolysis
Published Date 2022-05-24
Publication Title International Journal Of Molecular Sciences
Volume volume23
Issue issue11
Publisher MDPI
Start Page 5887
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35682564
DOI 10.3390/ijms23115887
Web of Science KeyUT 000809455300001
Related Url isVersionOf https://doi.org/10.3390/ijms23115887
FullText URL fulltext.pdf
Author Huo, Yuanzhi| Puspitaningayu, Pradini| Funabiki, Nobuo| Hamazaki, Kazushi| Kuribayashi, Minoru| Kojima, Kazuyuki|
Keywords indoor localization fingerprint IEEE802.15.4 LQI parameter optimization
Published Date 2022-04-20
Publication Title Information
Volume volume13
Issue issue5
Publisher MDPI
Start Page 211
ISSN 2078-2489
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
DOI 10.3390/info13050211
Web of Science KeyUT 000804915800001
Related Url isVersionOf https://doi.org/10.3390/info13050211
FullText URL fulltext20220620-3.pdf
Author Danchana, Kaewta| Iwasaki, Hiroshi| Ochiai, Kenta| Namba, Haruka| Kaneta, Takashi|
Keywords Glutamate Paper-based analytical device Enzymatic reaction
Note © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.microc.2022.107513] .|
Published Date 2022-08
Publication Title Microchemical Journal
Volume volume179
Publisher Elsevier BV
Start Page 107513
ISSN 0026-265X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Elsevier B.V.
File Version author
DOI 10.1016/j.microc.2022.107513
Web of Science KeyUT 000793749600002
Related Url isVersionOf https://doi.org/10.1016/j.microc.2022.107513