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フルテキストURL fulltext.pdf
著者 Tamura, Katsunori| Oshima, Yuri| Fuse, Yuta| Nagaoka, Noriyuki| Kunoh, Tatsuki| Nakanishi, Makoto| Fujii, Tatsuo| Nanba, Tokuro| Takada, Jun|
発行日 2022-04-10
出版物タイトル ACS Omega
7巻
15号
出版者 American Chemical Society
開始ページ 12795
終了ページ 12802
ISSN 2470-1343
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Authors.
論文のバージョン publisher
PubMed ID 35474768
DOI 10.1021/acsomega.1c07390
Web of Science KeyUT 000812569200001
関連URL isVersionOf https://doi.org/10.1021/acsomega.1c07390
フルテキストURL fulltext.pdf
著者 Yamada, Yuto| Fujiwara, Masaki| Shimazu, Taichi| Etoh, Tsuyoshi| Kodama, Masafumi| So, Ryuhei| Matsushita, Takanori| Yoshimura, Yusaku| Horii, Shigeo| Fujimori, Maiko| Takahashi, Hirokazu| Nakaya, Naoki| Miyaji, Tempei| Hinotsu, Shiro| Harada, Keita| Okada, Hiroyuki| Uchitomi, Yosuke| Yamada, Norihito| Inagaki, Masatoshi|
発行日 2022-06
出版物タイトル BMJ Open
12巻
6号
出版者 BMJ Publishing Group
開始ページ e060621
ISSN 2044-6055
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Author(s) (or their employer(s)) 2022.
論文のバージョン publisher
PubMed ID 35701062
DOI 10.1136/bmjopen-2021-060621
Web of Science KeyUT 000811702800009
関連URL isVersionOf https://doi.org/10.1136/bmjopen-2021-060621
JaLCDOI 10.18926/AMO/63722
フルテキストURL 76_3_281.pdf
著者 Yu, Bo| Wang, Rui| Luo, Huikun| Yang, Di| Wang, Simo| Yu, Yaqiong| Okamura, Hirohiko| Qiu, Lihong|
抄録 Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions.
キーワード periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 281
終了ページ 290
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790358
Web of Science KeyUT 000823568300007
JaLCDOI 10.18926/AMO/63721
フルテキストURL 76_3_273.pdf
著者 Furuichi, Shuro| Mitani, Shigeru| Endo, Hirosuke| Namba, Yoshifumi| Kawamoto, Toyohiro|
抄録 Following total hip arthroplasty (THA), some patients exhibit anterior or posterior pelvic tilt (PT). This case– control study investigated whether changes to PT following THA can be preoperatively predicted. Methods: 135 patients with hip osteoarthritis who underwent THA were assessed. The parameters measured preoperatively and one year postoperatively were lumbar lordosis (LL) based on plain X-ray and pelvic incidence (PI), PT, and sacral slope (SS), all of which were measured as pelvic morphological angles. Patients were classified into groups (A–E) based on the degree of post-THA PT, and their preoperative conditions were compared. PI minus LL was used to evaluate spinal alignment and pelvic balance. Results: Overall, 33%, 30%, 21%, 13%, and 3% of the hips of patients in Groups A, B, C, D, and E were postoperatively assessed. In Groups A–E, the SS values were 34.6°±8.9°, 37.6°±8.4°, 37.9°±8.9°, 42.6°±9.5°, and 60.0°±11.1°, whereas the PI minus LL values were 2.9°±15.0°, 1.2°±13.6°, 3.6°±17.7°, 12.7°±13.1°, and −1.3°±11.7°, respectively. Conclusions: Following THA, 70% of patients experienced posterior PT. Pre-THA SS ≥45° or PI minus LL ≥15° signified marked postoperative posterior tilt and could predict postoperative PT following THA. These findings are useful for implant placement, as they can predict pelvic inclination.
キーワード hip total hip arthroplasty arthroplasty radiography lordosis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 273
終了ページ 280
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790357
Web of Science KeyUT 000823568300006
JaLCDOI 10.18926/AMO/63720
フルテキストURL 76_3_265.pdf
著者 Kosaki, Yoshinori| Naito, Hiromichi| Iida, Atsuyoshi| Ihoriya, Hiromi| Nojima, Tsuyoshi| Yamada, Taihei| Yamamoto, Hirotsugu| Nakamura, Shunsuke| Mandai, Yasuhiro| Nakao, Atsunori|
抄録 Basic life support (BLS) courses for laypersons, including cardiopulmonary resuscitation (CPR) training, is known to improve outcomes of out-of-hospital cardiac events. We asked medical students to provide BLS training for laypersons as a part of their emergency medicine education and evaluated the effects of training on the BLS skills of laypersons. We also used a questionnaire to determine whether the medical students who provided the BLS training were themselves more confident and motivated to perform BLS compared to students who did not provide BLS training. The proportions of laypersons who reported confidence in checking for a response, performing chest compressions, and automated external defibrillator (AED) use were significantly increased after the BLS training. The proportions of medical students who reported increased confidence/motivation in terms of understanding BLS, checking for a response, chest compression, use of AED, and willingness to perform BLS were significantly greater among medical students who provided BLS instructions compared to those who did not. BLS instruction by medical students was associated with an improvement in laypersons’ CPR accuracy and confidence in responding to cardiac arrest. The results indicate that medical students could gain understanding, confidence, and motivation in regard to their BLS skills by teaching BLS to laypersons.
キーワード BLS medical education emergency medicine resuscitation
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 265
終了ページ 271
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790356
Web of Science KeyUT 000823568300005
JaLCDOI 10.18926/AMO/63719
フルテキストURL 76_3_255.pdf
著者 Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi|
抄録 Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.
キーワード alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 255
終了ページ 263
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790355
Web of Science KeyUT 000823568300004
JaLCDOI 10.18926/AMO/63718
フルテキストURL 76_3_247.pdf
著者 Yoshida, Shohei| Fujii, Nobuharu| Kamoi, Chihiro| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Matsuoka, Ken-ichi| Maeda, Yoshinobu|
抄録 Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients.
キーワード vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 247
終了ページ 253
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790354
Web of Science KeyUT 000823568300003
JaLCDOI 10.18926/AMO/63717
フルテキストURL 76_3_235.pdf
著者 Tenta, Masafumi| Eguchi, Jun| Wada, Jun|
抄録 The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity.
キーワード adipose tissue skeletal muscle obesity
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 235
終了ページ 245
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790353
Web of Science KeyUT 000823568300002
フルテキストURL fulltext20220623-5.pdf
著者 中尾 知代|
備考 小特集「方法としての『オーラル・ヒストリー』再考(II)――オーラル・ヒストリーの実践」|
出版物タイトル 歴史学研究
813巻
出版者 歴史学研究会
開始ページ 17
終了ページ 29
ISSN 0386-9237
NCID AN00299161
資料タイプ 学術雑誌論文
言語 日本語
OAI-PMH Set 岡山大学
著作権者 © Rekishigaku kenkyukai, 2006
論文のバージョン publisher
オフィシャル URL http://rekiken.jp/journal/|
フルテキストURL fulltext20220623-4.pdf
著者 中尾 知代|
備考 著作権者の許諾を得て出版社版を掲載| (上)第22号(98年冬季)pp.27-35
(中)第23号(99年春季)pp.27-39
(下)第26号(99年冬季)pp.77-84|
発行日 1999
出版物タイトル 季刊戦争責任研究
26号
出版者 日本の戦争責任資料センター
開始ページ 77
終了ページ 84
ISSN 13437348
NCID AN10431480
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
フルテキストURL fulltext20220623-3.pdf
著者 中尾 知代|
備考 著作権者の許諾を得て出版社版を掲載| (上)第22号(98年冬季)pp.27-35
(中)第23号(99年春季)pp.27-39
(下)第26号(99年冬季)pp.77-84|
発行日 1999
出版物タイトル 季刊戦争責任研究
23号
出版者 日本の戦争責任資料センター
開始ページ 27
終了ページ 39
ISSN 13437348
NCID AN10431480
資料タイプ 学術雑誌論文
言語 日本語
OAI-PMH Set 岡山大学
論文のバージョン publisher
フルテキストURL fulltext20220623-2.pdf
著者 中尾 知代|
備考 著作権者の許諾を得て出版社版を掲載| (上)第22号(98年冬季)pp.27-35
(中)第23号(99年春季)pp.27-39
(下)第26号(99年冬季)pp.77-84|
発行日 1998
出版物タイトル 季刊戦争責任研究
22号
出版者 日本の戦争責任資料センター
ISSN 13437348
NCID AN10431480
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
フルテキストURL fulltext20220623-1.pdf
著者 中尾 知代|
発行日 2000-03
出版物タイトル Littera
4号
出版者 岡山大学LITTERA刊行会
開始ページ 209
終了ページ 273
NCID AN0034322X
資料タイプ 学術雑誌論文
言語 日本語
OAI-PMH Set 岡山大学
著作権者 (C) author
論文のバージョン publisher
フルテキストURL fulltext.pdf
著者 Iwamuro, Masaya| Kusumoto, Chiaki| Nakagawa, Masahiro| Matsueda, Kazuhiro| Kobayashi, Sayo| Yoshioka, Masao| Inaba, Tomoki| Toyokawa, Tatsuya| Sakaguchi, Chihiro| Tanaka, Shouichi| Tanaka, Takehiro| Okada, Hiroyuki|
キーワード Gastric neoplasms Oxyntic gland adenoma Gastric adenocarcinoma of the fundic gland type
発行日 2022-06-12
出版物タイトル BMC Gastroenterology
22巻
1号
出版者 BMC
開始ページ 294
ISSN 1471-230X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022.
論文のバージョン publisher
PubMed ID 35692036
DOI 10.1186/s12876-022-02368-w
Web of Science KeyUT 000809663500001
関連URL isVersionOf https://doi.org/10.1186/s12876-022-02368-w
フルテキストURL fulltext.pdf
著者 Fujise, Kenshiro| Noguchi, Satoru| Takeda, Tetsuya|
キーワード centronuclear myopathy T-tubules dynamin BIN1 membrane remodelling
発行日 2022-06-03
出版物タイトル International Journal Of Molecular Sciences
23巻
11号
出版者 MDPI
開始ページ 6274
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 35682949
DOI 10.3390/ijms23116274
Web of Science KeyUT 000809112300001
関連URL isVersionOf https://doi.org/10.3390/ijms23116274
フルテキストURL fulltext.pdf
著者 Minakuchi, Hajime| Fujisawa, Masanori| Abe, Yuka| Iida, Takashi| Oki, Kyosuke| Okura, Kazuo| Tanabe, Norimasa| Nishiyama, Akira|
キーワード Sleep bruxism Management Systematic review Oral appliances Biofeedback therapy Cognitive-behavioral therapy Pharmacological therapy
発行日 2022-11
出版物タイトル Japanese Dental Science Review
58巻
出版者 Elsevier Ltd.
開始ページ 124
終了ページ 136
ISSN 1882-7616
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science.
論文のバージョン publisher
PubMed ID 35356038
DOI 10.1016/j.jdsr.2022.02.004
Web of Science KeyUT 000806374300002
関連URL isVersionOf https://doi.org/10.1016/j.jdsr.2022.02.004
フルテキストURL fulltext.pdf
著者 Makimoto, Go| Misawa, Mahito| Maeda, Yoshinobu| Kiura, Katsuyuki|
キーワード Chronic myeloid leukemia Chylothorax Dasatinib
発行日 2022
出版物タイトル Respiratory Medicine Case Reports
37巻
出版者 Elsevier
開始ページ 101662
ISSN 2213-0071
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Authors.
論文のバージョン publisher
PubMed ID 35585905
DOI 10.1016/j.rmcr.2022.101662
Web of Science KeyUT 000807403400006
関連URL isVersionOf https://doi.org/10.1016/j.rmcr.2022.101662
フルテキストURL fulltext.pdf
著者 Kubota, Satoshi| Kawata, Kazumi| Hattori, Takako| Nishida, Takashi|
キーワード cellular communication network factor CCN2 CCN3 cartilage fibrosis glycolysis
発行日 2022-05-24
出版物タイトル International Journal Of Molecular Sciences
23巻
11号
出版者 MDPI
開始ページ 5887
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 35682564
DOI 10.3390/ijms23115887
Web of Science KeyUT 000809455300001
関連URL isVersionOf https://doi.org/10.3390/ijms23115887
フルテキストURL fulltext.pdf
著者 Huo, Yuanzhi| Puspitaningayu, Pradini| Funabiki, Nobuo| Hamazaki, Kazushi| Kuribayashi, Minoru| Kojima, Kazuyuki|
キーワード indoor localization fingerprint IEEE802.15.4 LQI parameter optimization
発行日 2022-04-20
出版物タイトル Information
13巻
5号
出版者 MDPI
開始ページ 211
ISSN 2078-2489
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
DOI 10.3390/info13050211
Web of Science KeyUT 000804915800001
関連URL isVersionOf https://doi.org/10.3390/info13050211
フルテキストURL fulltext20220620-3.pdf
著者 Danchana, Kaewta| Iwasaki, Hiroshi| Ochiai, Kenta| Namba, Haruka| Kaneta, Takashi|
キーワード Glutamate Paper-based analytical device Enzymatic reaction
備考 © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.microc.2022.107513] .|
発行日 2022-08
出版物タイトル Microchemical Journal
179巻
出版者 Elsevier BV
開始ページ 107513
ISSN 0026-265X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Elsevier B.V.
論文のバージョン author
DOI 10.1016/j.microc.2022.107513
Web of Science KeyUT 000793749600002
関連URL isVersionOf https://doi.org/10.1016/j.microc.2022.107513