検索結果 - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms

FullText URL	fulltext20211018-7a.pdf
Author	Watari, Shogo\| Araki, Motoo\| Matsumoto, Jun\| Yoshinaga, Kasumi\| Sekito, Takanori\| Maruyama, Yuki\| Mitsui, Yosuke\| Sadahira, Takuya\| Kubota, Risa\| Nishimura, Shingo\| Wada, Koichiro\| Kobayashi, Yasuyuki\| Takeuchi, Hidemi\| Tanabe, Katsuyuki\| Kitagawa, Masashi\| Morinaga, Hiroshi\| Kitamura, Shinji\| Sugiyama, Hitoshi\| Ariyoshi, Noritaka\| Wada, Jun\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
Keywords	Cytochrome P450 tacrolimus renal transplantation CYP2C19 vonoprazan rabeprazole
Note	© 2021 The Japanese Society for the Study of Xenobiotics. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.dmpk.2021.100407] .\|
Published Date	2021-10-31
Publication Title	Drug Metabolism and Pharmacokinetics
Volume	volume40
Publisher	Elsevier Ltd.
Start Page	100407
ISSN	13474367
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
File Version	author
PubMed ID	34352707
DOI	10.1016/j.dmpk.2021.100407
Web of Science KeyUT	000702719100002
Related Url	isVersionOf https://doi.org/10.1016/j.dmpk.2021.100407

Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions

FullText URL	fulltext.pdf
Author	Kataoka, Takahiro\| Shuto, Hina\| Naoe, Shota\| Yano, Junki\| Kanzaki, Norie\| Sakoda, Akihiro\| Tanaka, Hiroshi\| Hanamoto, Katsumi\| Mitsunobu, Fumihiro\| Terato, Hiroaki\| Yamaoka, Kiyonori\|
Keywords	radon oxidative DNA damage Mn-superoxide dismutase (SOD) 8-oxoguanine DNA glycosylase
Published Date	2021-08-09
Publication Title	Journal of Radiation Research
Volume	volume62
Issue	issue5
Publisher	Oxford University Press
Start Page	861
End Page	867
ISSN	0449-3060
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021.
File Version	publisher
PubMed ID	34370027
DOI	10.1093/jrr/rrab069
Web of Science KeyUT	000700078300014
Related Url	isVersionOf https://doi.org/10.1093/jrr/rrab069

Investigation of the molecular causes underlying physical abnormalities in Diamond‐Blackfan anemia patients with RPL5 haploinsufficiency

FullText URL	fulltext20211004-1.pdf
Author	Fukui, Yuko\| Hayano, Satoru\| Kawanabe, Noriaki\| Wang, Ziyi\| Shimada, Akira\| Saito, Megumu K.\| Asaka, Isao\| Kamioka, Hiroshi\|
Keywords	iPS cell RPL5 cleft lip and palate chondrocyte Diamond-Blackfan Anemia
Note	This is an Accepted Manuscript of an article published by Wiley. This is the peer reviewed version of the following article: [Fukui, Y, Hayano, S, Kawanabe, N, Wang, Z, Shimada, A, Saito, MK, et al. Investigation of the molecular causes underlying physical abnormalities in Diamond-Blackfan anemia patients with RPL5 haploinsufficiency. Pathology International. 2021; 1-11. https://doi.org/10.1111/pin.13168], which has been published in final form at [https://doi.org/10.1111/pin.13168]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-ArchivedVersions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wileyor by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked toWiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof bythird parties from platforms, services and websites other than Wiley Online Library must be prohibited.\|
Published Date	2021-9-29
Publication Title	Pathology International
Volume	volume2021
Publisher	Wiley
Start Page	1
End Page	11
ISSN	1320-5463
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd
File Version	author
DOI	10.1111/pin.13168
Related Url	isVersionOf https://doi.org/10.1111/pin.13168

Regulation of germination by targeted mutagenesis of grain dormancy genes in barley

FullText URL	fulltext.pdf
Author	Hisano, Hiroshi\| Hoffie, Robert E.\| Abe, Fumitaka\| Munemori, Hiromi\| Matsuura, Takakazu\| Endo, Masaki\| Mikami, Masafumi\| Nakamura, Shingo\| Kumlehn, Jochen\| Sato, Kazuhiro\|
Keywords	Hordeum vulgare seed dormancy targeted genome modification CRISPR Cas9 nuclease pre-harvest sprouting
Published Date	2021-08-29
Publication Title	Plant Biotechnology Journal
Publisher	Wiley
Start Page	1
End Page	10
ISSN	1467-7644
NCID	AA11805223
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	34459083
DOI	10.1111/pbi.13692
Web of Science KeyUT	000695529500001
Related Url	isVersionOf https://doi.org/10.1111/pbi.13692

Identification of a Novel Quinvirus in the Family Betaflexiviridae That Infects Winter Wheat

FullText URL	fulltext.pdf
Author	Kondo, Hideki\| Yoshida, Naoto\| Fujita, Miki\| Maruyama, Kazuyuki\| Hyodo, Kiwamu\| Hisano, Hiroshi\| Tamada, Tetsuo\| Andika, Ida Bagus\| Suzuki, Nobuhiro\|
Keywords	Betaflexiviridae quinvirus bymovirus yellow mosaic disease wheat virome soil borne variants
Published Date	2021-08-19
Publication Title	Frontiers In Microbiology
Volume	volume12
Publisher	Frontiers Media SA
Start Page	715545
ISSN	1664-302X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 Kondo, Yoshida, Fujita, Maruyama, Hyodo, Hisano, Tamada, Andika and Suzuki.
File Version	publisher
PubMed ID	34489904
DOI	10.3389/fmicb.2021.715545
Web of Science KeyUT	000692554100001
Related Url	isVersionOf https://doi.org/10.3389/fmicb.2021.715545

Clinical Parameters Reflecting Globe/orbit Volume Imbalances in Japanese Acquired Esotropia Patients with High Myopia but without Abduction Limitations

JaLCDOI	10.18926/AMO/62396
FullText URL	75_4_447.pdf
Author	Kono, Reika\| Hamasaki, Ichiro\| Kishimoto, Fumiko\| Ohtuski, Hiroshi\| Shibata, Kiyo\| Morizane, Yuki\| Shiraga, Fumio\|
Abstract	In high myopia, eye dislocation due to increased globe volume or tight orbital volume causes acquired esotro-pia. GOR (globe/orbit volume ratio), an indicator of the degree of progression of this pathology, was investi-gated the relationships among easily obtained clinical parameters. In this retrospective study, 20 eyes from 10 acquired esotropia patients with high myopia but without abduction limitations were examined. The mean age of the patients was 63.7 ± 8.2 years (mean ± standard deviation). Volumes were measured on the three-dimen-sional fast imaging employing steady-state acquisition magnetic resonance imaging images using the vol-ume-measurement function. Correlations between GOR and the displacement angle of the globe (DA), axial length (AL), and equatorial diameter (ED) were investigated. Mean DA, AL, ED, and GOR values were 107.5 ± 8.5°, 28.86 ± 1.92 mm, 25.00 ± 1.16 mm, and 0.36 ± 0.05, respectively. Only AL was correlated with GOR (p < 0.0001, R2 = 0.6649); DA (p = 0.30, R2 = 0.0633) and ED (p = 0.91, R2 = 0.0008) were not. AL was the only clinically available parameter to indicate globe/orbit volume imbalances in acquired esotropia with high myopia but without abduction limitation. AL may be important for the clinical assessment of the progression of this pathology.
Keywords	acquired esotropia high myopia (high myopes) globe volume magnetic resonance imaging limitation of abduction
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2021-08
Volume	volume75
Issue	issue4
Publisher	Okayama University Medical School
Start Page	447
End Page	453
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	34511611
Web of Science KeyUT	000697944600006
NAID	120007146039

Association between higher pericoronary adipose tissue attenuation measured by coronary computed tomography angiography and nonalcoholic fatty liver disease A matched case-control study

FullText URL	fulltext.pdf
Author	Ichikawa, Keishi\| Miyoshi, Toru\| Osawa, Kazuhiro\| Miki, Takashi\| Morimitsu, Yusuke\| Akagi, Noriaki\| Nakashima, Mitsutaka\| Ito, Hiroshi\|
Keywords	coronary computed tomography angiography non-alcoholic fatty liver disease perivascular coronary inflammation
Published Date	2021-08-27
Publication Title	Medicine
Volume	volume100
Issue	issue34
Publisher	Lippincott Williams & Wilkins
Start Page	e27043
ISSN	0025-7974
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 the Author(s).
File Version	publisher
PubMed ID	34449489
DOI	10.1097/MD.0000000000027043
Web of Science KeyUT	000691370700047
Related Url	isVersionOf https://doi.org/10.1097/MD.0000000000027043

Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis

FullText URL	fulltext.pdf
Author	Yoshikawa, Yuri\| Izawa, Takashi\| Hamada, Yusaku\| Takenaga, Hiroko\| Wang, Ziyi\| Ishimaru, Naozumi\| Kamioka, Hiroshi\|
Published Date	2021-07-21
Publication Title	Scientific Reports
Volume	volume11
Issue	issue1
Publisher	Nature Portfolio
Start Page	14927
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021
File Version	publisher
PubMed ID	34290363
DOI	10.1038/s41598-021-94470-4
Web of Science KeyUT	000687318300008
Related Url	isVersionOf https://doi.org/10.1038/s41598-021-94470-4

Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments

FullText URL	fulltext20210831-3.pdf
Author	Shirakawa, Yasuhiro\| Tazawa, Hiroshi\| Tanabe, Shunsuke\| Kanaya, Nobuhiko\| Noma, Kazuhiro\| Koujima, Takeshi\| Kashima, Hajime\| Kato, Takuya\| Kuroda, Shinji\| Kikuchi, Satoru\| Kagawa, Shunsuke\| Katsui, Kuniaki\| Kanazawa, Susumu\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	Telomerase adenovirus radiotherapy esophageal cancer immunotherapy
Note	© 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ejca.2021.04.043] .\|
Published Date	2021-8
Publication Title	European Journal of Cancer
Volume	volume153
Publisher	Elsevier BV
Start Page	98
End Page	108
ISSN	0959-8049
NCID	AA1075407X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 Elsevier Ltd.
File Version	author
PubMed ID	34153720
DOI	10.1016/j.ejca.2021.04.043
Web of Science KeyUT	000686051300013
Related Url	isVersionOf https://doi.org/10.1016/j.ejca.2021.04.043

Predictive Value of the Cardio-Ankle Vascular Index for Cardiovascular Events in Patients at Cardiovascular Risk

FullText URL	fulltext.pdf
Author	Miyoshi, Toru\| Ito, Hiroshi\| Shirai, Kohji\| Horinaka, Shigeo\| Higaki, Jitsuo\| Yamamura, Shigeo\| Saiki, Atsuhito\| Takahashi, Mao\| Masaki, Mitsuru\| Okura, Takafumi\| Kotani, Kazuhiko\| Kubozono, Takuro\| Yoshioka, Ryo\| Kihara, Hajime\| Hasegawa, Koji\| Satoh-Asahara, Noriko\| Orimo, Hajime\|
Keywords	arterial stiffness blood pressure cardiovascular events pulse-wave velocity risk factor
Published Date	2021-08-17
Publication Title	Journal of The American Heart ASSOCIATION
Volume	volume10
Issue	issue16
Publisher	Wiley
Start Page	e020103
ISSN	2047-9980
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	34369198
DOI	10.1161/JAHA.120.020103
Web of Science KeyUT	000685396200026
Related Url	isVersionOf https://doi.org/10.1161/JAHA.120.020103

Evaluation of a point-of-care serum creatinine measurement device and the impact on diagnosis of acute kidney injury in pediatric cardiac patients: A retrospective, single center study

FullText URL	fulltext.pdf
Author	Kimura, Satoshi\| Iwasaki, Tatsuo\| Shimizu, Kazuyoshi\| Kanazawa, Tomoyuki\| Kawase, Hirokazu\| Shioji, Naohiro\| Kuroe, Yasutoshi\| Isoyama, Satoshi\| Morimatsu, Hiroshi\|
Keywords	acute kidney injury cardiac surgical procedures children creatinine point-of-care
Published Date	2019-11-24
Publication Title	Health Science Reports
Volume	volume3
Issue	issue1
Publisher	Wiley
Start Page	e143
ISSN	2398-8835
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Authors.
File Version	publisher
PubMed ID	32166189
DOI	10.1002/hsr2.143
Web of Science KeyUT	000682995400005
Related Url	isVersionOf https://doi.org/10.1002/hsr2.143

Total vascular resistance, augmentation index, and augmentation pressure increase in patients with peripheral artery disease

FullText URL	fulltext.pdf
Author	Takemoto, Rika\| Uchida, Haruhito A.\| Toda, Hironobu\| Okada, Ken\| Otsuka, Fumio\| Ito, Hiroshi\| Wada, Jun\|
Keywords	augmentation index augmentation pressure peripheral arterial disease total vascular resistance
Published Date	2021-08-13
Publication Title	Medicine
Volume	volume100
Issue	issue32
Publisher	Wolters Kluwer Health, Inc.
Start Page	e26931
ISSN	0025-7974
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 the Author(s).
File Version	publisher
PubMed ID	34397939
DOI	10.1097/MD.0000000000026931
Web of Science KeyUT	000683492600068
Related Url	isVersionOf https://doi.org/10.1097/MD.0000000000026931

Emergency Dispatches for Suicide Attempts During the COVID-19 Outbreak in Okayama, Japan: A Descriptive Epidemiological Study

FullText URL	fulltext.pdf
Author	Habu, Hiroshi\| Takao, Soshi\| Fujimoto, Ryohei\| Naito, Hiromichi\| Nakao, Atsunori\| Yorifuji, Takashi\|
Keywords	COVID-19 epidemiology emergency medical dispatch suicide
Published Date	2021-07-17
Publication Title	Journal of Epidemiology
Volume	volume31
Issue	issue9
Publisher	Japan Epidemiological Assoc.
Start Page	511
End Page	517
ISSN	0917-5040
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 Hiroshi Habu et al.
File Version	publisher
PubMed ID	34176855
DOI	10.2188/jea.JE20210066
Web of Science KeyUT	000680719500003
Related Url	isVersionOf https://doi.org/10.2188/jea.JE20210066

An Evaluation of the Safety and Feasibility of Adenosine-assisted Clipping Surgery for Unruptured Cerebral Aneurysms: Study Protocol

FullText URL	fulltext.pdf
Author	Hishikawa, Tomohito\| Murai, Satoshi\| Hiramatsu, Masafumi\| Haruma, Jun\| Nishi, Kazuhiko\| Ebisudani, Yuki\| Sato, Yu\| Yasuhara, Takao\| Sugiu, Kenji\| Shimizu, Kazuyoshi\| Kobayashi, Motomu\| Nakagawa, Koji\| Kimura-Ono, Aya\| Hotta, Katsuyuki\| Morimatsu, Hiroshi\| Date, Isao\|
Keywords	adenosine clipping unruptured cerebral aneurysm
Published Date	2021
Publication Title	Neurologia Medico-Chirurgica
Volume	volume61
Issue	issue7
Publisher	Japan Neurosurgical Soc.
Start Page	393
End Page	396
ISSN	0470-8105
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Japan Neurosurgical Society
File Version	publisher
PubMed ID	34024879
DOI	10.2176/nmc.st.2021-0018
Web of Science KeyUT	000672804200001
Related Url	isVersionOf https://doi.org/10.2176/nmc.st.2021-0018

ABO Blood Incompatibility Positively Affects Early Graft Function: Single-Center Retrospective Cohort Study

FullText URL	fulltext20210721-2.pdf figure20210721-2.pdf
Author	Watari, Shogo\| Araki, Motoo\| Wada, Koichiro\| Yoshinaga, Kasumi\| Maruyama, Yuki\| Mitsui, Yosuke\| Sadahira, Takuya\| Kubota, Risa\| Nishimura, Shingo\| Kobayashi, Yasuyuki\| Takeuchi, Hidemi\| Tanabe, Katsuyuki\| Kitagawa, Masashi\| Morinaga, Hiroshi\| Kitamura, Shinji\| Sugiyama, Hitoshi\| Wada, Jun\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
Note	© 2021 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.transproceed.2021.03.043] . \|
Published Date	2021-4-28
Publication Title	Transplantation Proceedings
Volume	volume53
Issue	issue5
Publisher	Elsevier BV
Start Page	1494
End Page	1500
ISSN	0041-1345
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	33931247
DOI	10.1016/j.transproceed.2021.03.043
Web of Science KeyUT	000668604400017
Related Url	isVersionOf https://doi.org/10.1016/j.transproceed.2021.03.043

Extracellular vesicle-shuttled miRNAs as a diagnostic and prognostic biomarker and their potential roles in gallbladder cancer patients

FullText URL	fulltext.pdf
Author	Ueta, Eijiro\| Tsutsumi, Koichiro\| Kato, Hironari\| Matsushita, Hiroshi\| Shiraha, Hidenori\| Fujii, Masakuni\| Matsumoto, Kazuyuki\| Horiguchi, Shigeru\| Okada, Hiroyuki\|
Published Date	2021-06-10
Publication Title	Scientific Reports
Volume	volume11
Issue	issue1
Publisher	Nature Research
Start Page	12298
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021
File Version	publisher
PubMed ID	34112884
DOI	10.1038/s41598-021-91804-0
Web of Science KeyUT	000663785600048
Related Url	isVersionOf https://doi.org/10.1038/s41598-021-91804-0

Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins

FullText URL	fulltext20210706-1.pdf
Author	Doi, Seita\| Fujioka, Naoki\| Ohtsuka, Satomi\| Kondo, Rina\| Yamamoto, Maho\| Denda, Miwako\| Magari, Masaki\| Kanayama, Naoki\| Hatano, Naoya\| Morishita, Ryo\| Hasegawa, Takafumi\| Tokumitsu, Hiroshi\|
Note	©2021 Elsevier BV. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ceca.2021.102404] .\|
Published Date	2021-6
Publication Title	Cell Calcium
Volume	volume96
Publisher	Elsevier BV
Start Page	102404
ISSN	0143-4160
NCID	AA00142099
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	Copyright © 2021 Elsevier Ltd. All rights reserved
File Version	author
PubMed ID	33831707
DOI	10.1016/j.ceca.2021.102404
Web of Science KeyUT	000663580100007
Related Url	isVersionOf https://doi.org/10.1016/j.ceca.2021.102404

Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression

FullText URL	fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf
Author	Sugiu, Kazuhisa\| Tazawa, Hiroshi\| Hasei, Joe\| Yamakawa, Yasuaki\| Omori, Toshinori\| Komatsubara, Tadashi\| Mochizuki, Yusuke\| Kondo, Hiroya\| Osaki, Shuhei\| Fujiwara, Tomohiro\| Yoshida, Aki\| Kunisada, Toshiyuki\| Ueda, Koji\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Keywords	Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53
Note	This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5\|
Published Date	2021-6-10
Publication Title	Cancer Chemotherapy and Pharmacology
Volume	volume88
Issue	issue3
Publisher	Springer Science and Business Media LLC
Start Page	513
End Page	524
ISSN	0344-5704
NCID	AA00598397
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	34114067
DOI	10.1007/s00280-021-04310-5
Web of Science KeyUT	000659839700002
Related Url	isVersionOf https://doi.org/10.1007/s00280-021-04310-5

Role of the Transcription Factor BTB and CNC Homology 1 in a Rat Model of Acute Liver Injury Induced by Experimental Endotoxemia

JaLCDOI	10.18926/AMO/62232
FullText URL	75_3_363.pdf
Author	Tanioka, Nohito\| Shimizu, Hiroko\| Omori, Emiko\| Takahashi, Toru\| Yamaoka, Masakazu\| Morimatsu, Hiroshi\|
Abstract	Hepatic oxidative stress plays an important role in the pathogenesis of several acute liver diseases, and free heme is thought to contribute to endotoxemia-induced acute liver injury. The heme oxygenase 1 (HO-1) gene is upregulated and the δ-aminolevulinate synthase (ALAS1) gene is downregulated in the rat liver following lipopolysaccharide (LPS) treatment. BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that normally represses HO-1 expression. In this study, we evaluated the changes in HO-1, ALAS1, and Bach1 expression and nuclear Bach1 expression in rat livers following intravenous LPS administration (10 mg/kg body weight). LPS significantly upregulated HO-1 mRNA and downregulated ALAS1 mRNA in the rat livers, suggesting that hepatic free heme concentrations are increased after LPS treatment. Bach1 mRNA was strongly induced after LPS injection. In contrast, nuclear Bach1 was significantly but transiently decreased after LPS treatment. Rats were also administered hemin (50 mg/kg body weight) intravenously to elevate heme concentrations, which decreased nuclear Bach1 levels. Our results suggest that elevated hepatic free heme may be associated with a decline of nuclear Bach1, and induction of Bach1 mRNA may compensate for the decreased nuclear Bach1 after LPS treatment in the rat liver.
Keywords	heme oxygenase-1 BTB and CNC homology 1 heme, lipopolysaccharide liver injury
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2021-06
Volume	volume75
Issue	issue3
Publisher	Okayama University Medical School
Start Page	363
End Page	372
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	34176941
Web of Science KeyUT	000667147700012
NAID	120007089829

Texture Indices of 18F-FDG PET/CT for Differentiating Squamous Cell Carcinoma and Non-Hodgkin’s Lymphoma of the Oropharynx

JaLCDOI	10.18926/AMO/62230
FullText URL	75_3_351.pdf
Author	Mitamura, Katsuya\| Norikane, Takashi\| Yamamoto, Yuka\| Ihara-Nishishita, Ayumi\| Kobata, Takuya\| Fujimoto, Kengo\| Takami, Yasukage\| Kudomi, Nobuyuki\| Hoshikawa, Hiroshi\| Nishiyama, Yoshihiro\|
Abstract	We assessed the role of 18F-FDG PET/CT texture indices for the differentiation of squamous cell carcinoma (SCC) and non-Hodgkin’s lymphoma (NHL) in the oropharynx. 18F-FDG PET/CT data for 27 patients with SCC and 25 patients with NHL in the oropharynx were investigated. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and six texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis [LGZE], and high graylevel zone emphasis [HGZE]) were derived from PET images. PET/CT parameters of the SCC patients were compared with those of the NHL patients. The diagnostic accuracy of the indices for differentiating SCC from NHL was calculated by a receiver operating characteristic curve analysis. 18F-FDG uptake in the oropharynx was observed in all of the patients. The SUVmax, MTV, and TLG did not differ significantly between the SCC and NHL groups, but two of the six texture indices (LGZE [p=0.004] and HGZE [p=0.03]) showed significant differences between the groups. LGZE was the best discriminative index for the differentiation of SCC and NHL (55.6% sensitivity, 88.0% specificity). The LGZE and HGZE texture indices derived from 18F-FDG PET/CT images may be useful in differentiating SCC and NHL in the oropharynx.
Keywords	18F-FDG PET/CT oropharyngeal squamous cell carcinoma malignant lymphoma texture
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2021-06
Volume	volume75
Issue	issue3
Publisher	Okayama University Medical School
Start Page	351
End Page	356
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	34176939
Web of Science KeyUT	000667147700010
NAID	120007089827

Search