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FullText URL fulltext20221130-2.pdf
Author Matsuo, Toshihiko| Noda, Hiroshi|
Published Date 2022-11-27
Publication Title Clinical Case Reports
Volume volume10
Issue issue11
Publisher Wiley
Start Page e06657
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
DOI 10.1002/ccr3.6657
FullText URL fulltext.pdf
Author Okamoto, Yuko| Miyoshi, Toru| Ichikawa, Keishi| Takaya, Yoichi| Nakamura, Kazufumi| Ito, Hiroshi|
Keywords arterial stiffness cardio-ankle vascular index cardiovascular events risk factors
Published Date 2022-10-25
Publication Title Journal Of Cardiovascular Development And Disease
Volume volume9
Issue issue11
Publisher MDPI
Start Page 368
ISSN 2308-3425
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36354767
DOI 10.3390/jcdd9110368
Web of Science KeyUT 000883544100001
Related Url isVersionOf https://doi.org/10.3390/jcdd9110368
FullText URL fulltext20221122-4.pdf
Author Yamaguchi, Kizashi| Shoji, Mitsuo| Isobe, Hiroshi| Kawakami, Takashi| Miyagawa, Koichi| Suga, Michihiro| Akita, Fusamichi| Shen, Jian-Ren|
Keywords Water oxidation Oxygen evolution Photosystem II HR XRD SFX XFEL QM/MM calculation DLPNO CCSD(T-0) computations, Oxyl radical character
Note (C) 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.ccr.2022.214742| This full-text file will be available in Aug. 2024.|
Published Date 2022-11
Publication Title Coordination Chemistry Reviews
Volume volume471
Publisher Elsevier BV
Start Page 214742
ISSN 0010-8545
NCID AA00619249
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Elsevier B.V.
File Version author
DOI 10.1016/j.ccr.2022.214742
Web of Science KeyUT 000879286600003
Related Url isVersionOf https://doi.org/10.1016/j.ccr.2022.214742
FullText URL fulltext20221114-1.pdf
Author Isobe, Hiroshi| Shoji, Mitsuo| Suzuki, Takayoshi| Shen, Jian-Ren| Yamaguchi, Kizashi|
Note This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry B, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcb.2c02596| This full-text will be available in Sep. 2023.|
Published Date 2022-09-15
Publication Title The Journal of Physical Chemistry B
Volume volume126
Issue issue38
Publisher American Chemical Society (ACS)
Start Page 7212
End Page 7228
ISSN 1520-6106
NCID AA11114073
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 American Chemical Society
File Version author
PubMed ID 36107406
DOI 10.1021/acs.jpcb.2c02596
Web of Science KeyUT 000863255500001
Related Url isVersionOf https://doi.org/10.1021/acs.jpcb.2c02596
JaLCDOI 10.18926/AMO/64127
FullText URL 76_6_749.pdf
Author Takami, Masanari| Yukawa, Yasutsugu| Noda, Yusuke| Yoshida, Munehito| Yamada, Hiroshi|
Abstract We provide the first report of successful salvage surgery for a post-C1 laminectomy symptomatic recurrence of a retro-odontoid pseudotumor (ROP) that caused myelopathy. The 72-year-old Japanese woman presented with an ROP causing symptomatic cervical myelopathy. With ultrasonography support, we performed the enucleation of the ROP via a transdural approach and fusion surgery for the recurrence of the mass. At the final observation 2-year post-surgery, MRI demonstrated the mass’s regression and spinal cord decompression, and the patient’s symptoms had improved. Our strategy is an effective option for a symptomatic recurrence of ROP.
Keywords recurrent retro-odontoid pseudotumor salvage surgery transdural resection C1 laminectomy ultra-sonography
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-12
Volume volume76
Issue issue6
Publisher Okayama University Medical School
Start Page 749
End Page 754
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36549779
Web of Science KeyUT 000905195100017
JaLCDOI 10.18926/AMO/64119
FullText URL 76_6_689.pdf
Author Yamanouchi, Kosho| Kuba, Sayaka| Matsumoto, Megumi| Yano, Hiroshi| Morita, Michi| Sakimura, Chika| Otsubo, Ryota| Hidaka, Masaaki| Nagayasu, Takeshi| Eguchi, Susumu|
Abstract Taxanes are key drugs for patients with breast cancer. A major adverse effect of taxanes is peripheral neuropathy (PN). To investigate the ability of compression therapy using sleeves and stockings to prevent PN due to the taxane docetaxel, we conducted a single-center historical control trial. Patients receiving docetaxel at 75 mg/m2 every 3 weeks for 4 cycles as first-line chemotherapy for breast cancer were eligible. PN was evaluated using the common terminology criteria for adverse events version 4.0. The primary endpoint was the incidence of allgrade PN until 3 weeks after the fourth docetaxel administration. We evaluated 26 patients in the intervention group and compared their data to those collected retrospectively from 52 patients treated with docetaxel without compression. Neither the incidence of all-grade PN until 3 weeks after the fourth docetaxel administration (63.5% in the control group vs. 76.9% in the intervention group, p=0.31) nor that of PN grade ≥ 2 (13.5% vs. 15.4%, p=0.99) differed between the groups. In this study, the efficacy of compression therapy using sleeves and stockings to prevent PN induced by docetaxel was not demonstrated. Further clinical studies including medications or intervention are needed to reduce the incidence and severity of PN induced by chemotherapy.
Keywords breast cancer docetaxel neuropathy compression
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-12
Volume volume76
Issue issue6
Publisher Okayama University Medical School
Start Page 689
End Page 694
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36549771
Web of Science KeyUT 000905195100009
JaLCDOI 10.18926/AMO/64115
FullText URL 76_6_651.pdf
Author Bright Osman Abugri| Matsusaki, Takashi| Ren, Wanxu| Morimatsu, Hiroshi|
Abstract Maintaining perioperative normothermia decreases the post-surgery surgical site infection (SSI) rate. We investigated whether SSI is associated with intraoperative hypothermia in total hip (THA) and total knee (TKA) arthroplasties by retrospectively analyzing 297 THA and TKA cases. The patients’ intraoperative core body temperature (BT) was measured by bladder catheter or forehead sensor. We evaluated the associations between SSI and intraoperative BT and other variables and patient characteristics. Fifty-six patients (18.8%) had hypothermia (BT <36°C); 43 developed SSI (14.5%); only five had hypothermia (11.6%). Intraoperative hypothermia and SSI were not significantly associated. The SSI group had more men (34.9% vs. 18.1%) and THA patients (77.4%), a longer mean surgical duration (174.3 vs. 143.5 mins), and a higher average BT (36.4°C vs. 36.2°C) than the no-SSI group. The SSI patients had a higher intraoperative BT. A multivariable analysis revealed that SSI was associated with male sex (OR 2.3, 95%CI: 1.031-4.921, p=0.042), longer surgery (OR, 1.01, 95%CI: 1.003-1.017, p=0.004), THA (OR 3.6, 95%CI: 1.258-10.085, p=0.017), and intraoperative BT >36.0°C (OR 3.6, 95%CI: 1.367-9.475, p=0.009). Intraoperative hypothermia was not associated with SSI in adults who underwent THA or TKA. These results suggest that hypothermia might not be the problem for SSI.
Keywords hypothermia surgical site infection total hip arthroplasty (THA) knee arthroplasty (TKA)
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-12
Volume volume76
Issue issue6
Publisher Okayama University Medical School
Start Page 651
End Page 660
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36549767
Web of Science KeyUT 000905195100005
JaLCDOI 10.18926/AMO/64039
FullText URL 76_5_577.pdf
Author Okutani, Yuki| Fujita, Hiroshi| Harada, Hideto| Kataoka, Masanao| Murotani, Yoshiki| Shimizu, Yu|
Abstract The prevalence of preoperative deep vein thrombosis (DVT) has been reported to be relatively high in patients undergoing total hip arthroplasty. We investigated the prevalence of DVT, the association between hip function and preoperative DVT, and the effect of a history of surgery in patients who underwent primary total hip arthroplasty. We retrospectively analyzed the cases of the patients who underwent primary total hip arthroplasty between April 2013 and February 2020 at our institution. We evaluated the prevalence of preoperative DVT based on the results of the patients’ ultrasound screening. We performed univariate and multivariate analyses to investigate the association between the incidence of DVT and patient factors including age, sex, hip function, medical histories, and American Society of Anesthesiologists Physical Status classification. We analyzed 451 patients (494 hips). The prevalence of DVT was 14.2% (64 patients). The multivariate analysis demonstrated that increased age was an independent significant risk factor for DVT. The prevalence of preoperative DVT was relatively high among patients who underwent primary total hip arthroplasty. Preoperative DVT tended to be more prevalent in older patients. Hip function was not associated with the incidence of DVT.
Keywords total hip arthroplasty deep vein thrombosis hip function ultrasound screening
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 577
End Page 584
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352805
Web of Science KeyUT 000884907100011
JaLCDOI 10.18926/AMO/64038
FullText URL 76_5_565.pdf
Author Komagoe, Sho| Senoo, Takaya| Takao, Soshi| Shiraishi, Yoshinori| Matsumoto, Hiroshi| Kimata, Yoshihiro|
Abstract We herein introduce horizontal vector analysis, a simple method for assessing cranial morphology based on measurement of the head’s horizontal plane, and use this method to establish normal cranial morphology in Japanese children Computed tomography scans taken in 2010-2019 in healthy Japanese children aged ≤ 6 years. The two measurement planes were parallel to the orbitomeatal plane: namely, a plane passing through the dorsum sellae (DS) and the plane superior to that with the maximal area (Max plane). A protractor was used to circumferentially measure the lengths from the central point to the outer surface of the skull. A total of 487 images were extracted. The distances between the DS and Max planes were consistently almost 30 mm for each age group, so we fixed the Max plane as the plane 30 mm superior to the DS plane. Finally, we established datasets of normal values for each age group and sex. Using these norms, perioperative evaluation of various cranial deformities could be performed more easily and circumstantially.
Keywords craniofacial surgery craniosynostoses horizontal plane Japanese children reference values
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 565
End Page 575
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352804
Web of Science KeyUT 000884907100010
JaLCDOI 10.18926/AMO/64037
FullText URL 76_5_557.pdf
Author Pan, Yu| Song, Qingqing| Kanazawa, Tomoyuki| Morimatsu, Hiroshi|
Abstract Some pediatric cardiac patients might experience low regional cerebral oxygen saturation (rSO2) during surgery. We investigated whether a pediatric patient’s mean arterial pressure (MAP) can affect the rSO2 value during cardiopulmonary bypass (CPB). We retrospectively analyzed the cases of the pediatric patients who underwentcardiac surgery at our hospital (Jan. –Dec. 2019; n=141). At each MAP stage, we constructed line charts through the mean of the rSO2 values corresponding to each MAP and then calculated the correlation coefficients. We next divided the patients into age subgroups (neonates, infants, children) and into cyanotic congenital heart disease (CHD) and acyanotic CHD groups and analyzed these groups in the same way. The analyses of all 141 patients revealed that during CPB the rSO2 value increased with an increase in MAP (r=0.1626). There was a correlation between rSO2 and MAP in the children (r=0.2720) but not in the neonates (r=0.06626) or infants (r=0.05260). Cyanotic CHD or acyanotic CHD did not have a significant effect on the rSO2/MAP correlation. Our analysis demonstrated different patterns of a correlation between MAP and rSO2 in pediatric cardiac surgery patients, depending on age. MAP was positively correlated with rSO2 typically in children but not in neonate or infant patients.
Keywords mean arterial pressure cerebral oxygen saturation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 557
End Page 564
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352803
Web of Science KeyUT 000884907100009
FullText URL fulltext.pdf
Author Yamada, Hiroshi| Abe, Tadashi| Nagaoka, Hikaru| Takashima, Eizo| Nitta, Ryo| Yamamoto, Masahiro| Takei, Kohji|
Keywords IFN-inducible GTPase Irgb6 GTPase membrane T gondii
Published Date 2022-09-09
Publication Title Frontiers In Cellular And Infection Microbiology
Volume volume12
Publisher Frontiers Media
Start Page 992198
ISSN 2235-2988
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Yamada, Abe, Nagaoka, Takashima, Nitta, Yamamoto and Takei.
File Version publisher
PubMed ID 36159643
DOI 10.3389/fcimb.2022.992198
Web of Science KeyUT 000873786000001
Related Url isVersionOf https://doi.org/10.3389/fcimb.2022.992198
FullText URL fulltext.pdf
Author Araki, Hiroyuki| Tazawa, Hiroshi| Kanaya, Nobuhiko| Kajiwara, Yoshinori| Yamada, Motohiko| Hashimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2022-12-15
Publication Title Molecular Therapy - Oncolytics
Volume volume27
Publisher Cell Press
Start Page 3
End Page 13
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 36212775
DOI 10.1016/j.omto.2022.09.003
Web of Science KeyUT 000870232500001
Related Url isVersionOf https://doi.org/10.1016/j.omto.2022.09.003
FullText URL fulltext.pdf
Author Koide, Yuji| Miyoshi, Toru| Nishihara, Takahiro| Nakashima, Mitsutaka| Ichikawa, Keishi| Miki, Takashi| Osawa, Kazuhiro| Ito, Hiroshi|
Keywords triglyceride high density lipoprotein coronary artery disease computed tomography
Published Date 2022-09-28
Publication Title Journal Of Cardiovascular Development And Disease
Volume volume9
Issue issue10
Publisher MDPI
Start Page 329
ISSN 2308-3425
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36286281
DOI 10.3390/jcdd9100329
Web of Science KeyUT 000873215600001
Related Url isVersionOf https://doi.org/10.3390/jcdd9100329
FullText URL fulltext.pdf
Author Shigehiro, Tsukasa| Ueno, Maho| Kijihira, Mayumi| Takahashi, Ryotaro| Umemura, Chiho| Taha, Eman A.| Kurosaka, Chisaki| Asayama, Megumi| Murakami, Hiroshi| Satoh, Ayano| Nakamura, Yoshimasa| Futami, Junichiro| Masuda, Junko|
Keywords breast cancer cells dendritic cells mesenteric lymph node myeloid-derived suppressor cells
Published Date 2022-09-20
Publication Title International Journal Of Molecular Sciences
Volume volume23
Issue issue19
Publisher MDPI
Start Page 11035
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36232335
DOI 10.3390/ijms231911035
Web of Science KeyUT 000867767200001
Related Url isVersionOf https://doi.org/10.3390/ijms231911035
FullText URL fulltext.pdf
Author Tokumitsu, Hiroshi| Sakagami, Hiroyuki|
Keywords CaMKK CaM-kinase cascade Ca2+ signaling phosphorylation
Published Date 2022-09-20
Publication Title INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume volume23
Issue issue19
Publisher MDPI
Start Page 11025
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36232320
DOI 10.3390/ijms231911025
Web of Science KeyUT 000867778400001
Related Url isVersionOf https://doi.org/10.3390/ijms231911025
FullText URL fulltext.pdf
Author Fu, Jingwen| Kosaka, Junko| Morimatsu, Hiroshi|
Keywords acute kidney injury KDIGO definition serum creatine urine output early identification
Published Date 2022-09-23
Publication Title JOURNAL OF CLINICAL MEDICINE
Volume volume11
Issue issue19
Publisher MDPI
Start Page 5589
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36233456
DOI 10.3390/jcm11195589
Web of Science KeyUT 000867903000001
Related Url isVersionOf https://doi.org/10.3390/jcm11195589
FullText URL fulltext.pdf
Author Ejiri, Kentaro| Miyoshi, Toru| Kihara, Hajime| Hata, Yoshiki| Nagano, Toshihiko| Takaishi, Atsushi| Toda, Hironobu| Namba, Seiji| Nakamura, Yoichi| Akagi, Satoshi| Sakuragi, Satoru| Minagawa, Taro| Kawai, Yusuke| Nishii, Nobuhiro| Fuke, Soichiro| Yoshikawa, Masaki| Nakamura, Kazufumi| Ito, Hiroshi| The MUSCAT-HF Study Investigators|
Published Date 2022-09-14
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 15449
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36104378
DOI 10.1038/s41598-022-19371-6
Web of Science KeyUT 000853934100018
Related Url isVersionOf https://doi.org/10.1038/s41598-022-19371-6
JaLCDOI 10.18926/AMO/63904
FullText URL 76_4_447.pdf
Author Umemura, Hiroshi| Fukuda, Yoshiaki| Miyashita, Tetsuo| Nakayama, Tomohiro|
Abstract The erythrocyte sedimentation rate (ESR) is a widely used marker of inflammation, but the detailed mechanisms underlying the ESR remain unclear. We retrospectively collected laboratory data from our hospital’s laboratory information system, and performed multiple linear regression analysis and correlation analysis to determine relationships between the ESR and other laboratory test parameters. The alpha-2, beta-2, and gamma fractions from serum protein electrophoresis, serum immunoglobulin (Ig) G, IgA, IgM, and complement C3 levels, plasma fibrinogen levels, and platelet count showed positive effects on the ESR; however, the serum albumin level showed negative effects. Since erythrocytes are negatively charged, an increase in positively charged proteins and a decrease in negatively charged albumin were suggested to increase the ESR. Notably, C-reactive protein (CRP) showed the third-strongest correlation with the ESR despite having no significant effect on the ESR. We also reviewed cases with discordant ESR and CRP levels to compare the disease profiles of high ESR/low CRP patients and low ESR/high CRP patients. The patients with high ESR/low CRP had a completely different disease profile from those with low ESR/high CRP. Since the ESR and CRP have different roles, they should be used as markers in a context-dependent manner.
Keywords complement erythrocyte sedimentation rate fibrinogen immunoglobulin serum protein electrophoresis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 447
End Page 455
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123160
JaLCDOI 10.18926/AMO/63893
FullText URL 76_4_391.pdf
Author Habu, Hiroshi| Mitsuhashi, Toshiharu| Tokinobu, Akiko| Yorifuji, Takashi| Takao, Soshi|
Abstract Tanden breathing, an ancient health technique, involves expiratory abdominal pressure breathing is practiced in Japan. In this study we examined the ability of Tanden breathing to relieve constipation. The study was designed as a stratified-block randomized controlled trial enrolling 20 participants. Nineteen were female and one was male, none were elderly. During the 6-week intervention period, the participants performed video-guided Tanden breathing about 10 min once day. We evaluated constipation using the Constipation Assessment Scale (CAS). There were significant differences in the mean CAS score between time points (baseline, 3 weeks after baseline, 6 weeks after baseline), groups (intervention and control), and their interaction (time×group) using repeated-measures analysis of variance. The control group showed no change in the mean CAS score; the mean CAS scores of the intervention group changed from 7.2 at baseline to 3.9 at 3 weeks and 3.1 at 6 weeks after baseline. A regression analysis of the difference in the mean CAS between baseline and 6 weeks later showed that the CAS of the intervention group was 4.3 points lower than that of the control group (95% confidence interval, 2.5-6.1). The results suggested that Tanden breathing is effective in relieving constipation among young women.
Keywords Tanden breathing Dantian breathing exercises constipation mind−body therapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 391
End Page 398
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123153
Web of Science KeyUT 000882167300001
FullText URL fulltext.pdf
Author Nara, Shigetoshi| Fujii, Hiroshi| Tsukada, Hiromichi| Tsuda, Ichiro|
Published Date 2022-08-19
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 14172
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 35986200
DOI 10.1038/s41598-022-18313-6
Web of Science KeyUT 000842561700031
Related Url isVersionOf https://doi.org/10.1038/s41598-022-18313-6