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JaLCDOI 10.18926/AMO/64121
FullText URL 76_6_705.pdf
Author Higashikawa, Toshihiro| Ito, Tomohiko| Mizuno, Takurou| Ishigami, Keiichiro| Kuroki, Kengo| Maekawa, Naoto| Usuda, Daisuke| Izumida, Toshihide| Yamada, Shinya| Sangen, Ryusho| Hamada, Kazu| Kiyosawa, Jun| Saito, Atsushi| Iguchi, Masaharu| Kasamaki, Yuji| Nakahashi, Takeshi| Fukuda, Akihiro| Saito, Hitoshi| Kanda, Tsugiyasu| Okuro, Masashi|
Abstract The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function.
Keywords tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-12
Volume volume76
Issue issue6
Publisher Okayama University Medical School
Start Page 705
End Page 713
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36549773
Web of Science KeyUT 000905195100011
JaLCDOI 10.18926/AMO/64044
FullText URL 76_5_609.pdf
Author Matsumoto, Ken| Fujishita, Keigo| Matsuda, Masayuki| Oka, Satoshi| Fujisawa, Yuka| Imai, Toshi| Machida, Takuya|
Abstract A 69-year-old Japanese man with acute leukemia received post-transplant cyclophosphamide-based haploidentical stem cell transplantation (PTCY-haplo-SCT) but was readmitted with dyspnea and ground-glass-opacities of the lungs. Bronchoscopy showed inflammatory changes with no signs of infection. He received steroids but required intubation as his condition deteriorated. In addition to antithymocyte globulin and cyclophosphamide, we administered ruxolitinib but failed to save him. Autopsy findings revealed fibrotic nonspecific interstitial pneumonia (NSIP) without evidence of organizing pneumonia or infection. Thus, we diagnosed idiopathic pneumonia syndrome (IPS). As far as our knowledge, this is the first case of IPS with NSIP histology after PTCY-haplo-SCT.
Keywords idiopathic pneumonia syndrome ruxolitinib post-transplant cyclophosphamide-based haploidentical stem cell transplantation nonspecific interstitial pneumonia
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 609
End Page 615
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352810
Web of Science KeyUT 000884907100016
JaLCDOI 10.18926/AMO/64043
FullText URL 76_5_605.pdf
Author Teraishi, Fuminori| Jikuhara, Atsushi| Ogawa, Ryunosuke| Fujiwara, Toshiyoshi|
Abstract An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation.
Keywords BRAF V600E mutation cecal cancer, MSI-high
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 605
End Page 608
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352809
Web of Science KeyUT 000884907100015
JaLCDOI 10.18926/AMO/64042
FullText URL 76_5_597.pdf
Author Watanabe, Shiho| Watanabe, Toshiyuki| Yamada, Kiyoshi| Namba, Yuzaburo| Kimata, Yoshihiro|
Abstract Gender affirming surgery (GAS) has important impacts for people with gender incongruence (GI), both physically and socially. As the societal acceptance of gender diversity spreads, the number of individuals with GI who wish to be identified as the gender of their choice is increasing. Indeed, many elderly people who have lived a long time with GI now wish to undergo GAS, but face greater surgical risks due to greater burdens of underlying medical conditions. Generally, vaginoplasty is performed for transwomen; however, this surgery is time-consuming and involves heavy bleeding, and thus, should be avoided in elderly people. A less invasive technique is needed. In this article, we describe a new, less invasive genital feminizing surgical technique for transwomen with reports from two clinical cases. We present this novel technique as a safe, aesthetic, and cost-effective option for gender-affirming surgery for transwomen.
Keywords gender-affirming surgery, vaginoplasty gender incongruence transwomen
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 597
End Page 603
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352808
Web of Science KeyUT 000884907100014
JaLCDOI 10.18926/AMO/64041
FullText URL 76_5_593.pdf
Author Noumi, Taku| Watanabe, Hiromi| Ninomiya, Kiichiro| Ohashi, Kadoaki| Ichihara, Eiki| Kubo, Toshio| Makimoto, Go| Kato, Yuka| Fujii, Masanori| Tabata, Masahiro| Maeda, Yoshinobu| Hotta, Katsuyuki| Kiura, Katsuyuki|
Abstract We encountered a woman with re-enlarged axillary lymph nodes during a computed tomography (CT) scan for surveillance of lung adenocarcinoma with axillary lymph node metastasis at the initial diagnosis that had shrunk with standard chemotherapy. We first suspected cancer recurrence and considered a change in the chemotherapeutic regimen. However, after careful history taking regarding the timing of her Coronavirus Disease 2019 (COVID-19) vaccination, and subsequent careful, close follow-up, radiological shrinkage suggested a strictly benign cause. Especially in lung cancer with a medical history of axillary lymph node involvement, cliniciansshould be aware that vaccine-associated lymphadenopathy can mimic cancer recurrence and sometimesprompt serious misjudgment regarding a current treatment course and strategy.
Keywords lung cancer COVID-19 vaccination axillary lymphadenopathy case report
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 593
End Page 596
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352807
Web of Science KeyUT 000884907100013
FullText URL fulltext20230112-5.pdf
Author Matsuo, Toshihiko| Tanaka, Takehiro| Omote, Rika| Okada, Toshiaki| Notohara, Kenji| Okada, Kazuya|
Published Date 2022
Publication Title Journal of Clinical and Experimental Hematopathology
Volume volume62
Issue issue4
Publisher Japanese Society for Lymphoreticular Tissue Research
Start Page 226
End Page 237
ISSN 1346-4280
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Japanese Society for Lymphoreticular Tissue Research
File Version publisher
PubMed ID 36171112
DOI 10.3960/jslrt.22015
Related Url isVersionOf https://doi.org/10.3960/jslrt.22015
FullText URL fulltext.pdf
Author Makimoto, Go| Shimonishi, Atsushi| Ohashi, Kadoaki| Ninomiya, Kiichiro| Higo, Hisao| Kato, Yuka| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords MET Tepotinib Non-small-cell lung cancer
Published Date 2022
Publication Title Case Reports In Oncology
Volume volume15
Issue issue2
Publisher Karger
Start Page 494
End Page 498
ISSN 1662-6575
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35702678
DOI 10.1159/000524326
Web of Science KeyUT 000864085100005
Related Url isVersionOf https://doi.org/10.1159/000524326
FullText URL fulltext.pdf
Author Asada, Takahiro| Takenoshita, Shintaro| Senda, Mayuko| Yamamoto, Koichiro| Sasaki, Ryo| Otsuka, Fumio| Terada, Seishi| Yamada, Norihito|
Keywords Lymphocytic hypophysitis Autoimmune hypophysitis Autoimmune hypothalamitis Cognitive dysfunction Memory impairment
Published Date 2022-09-29
Publication Title BMC Neurology
Volume volume22
Issue issue1
Publisher BMC
Start Page 371
ISSN 1471-2377
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 36175850
DOI 10.1186/s12883-022-02891-z
Web of Science KeyUT 000861890200002
Related Url isVersionOf https://doi.org/10.1186/s12883-022-02891-z
FullText URL fulltext.pdf
Author Ono, Kisho| Yoshioka, Norie| Kunisada, Yuki| Nakamura, Tomoya| Nakamura, Yuko| Obata, Kyoichi| Ibaragi, Soichiro| Minagi, Shogo| Sasaki, Akira|
Keywords fibrous dysplasia polyostotic craniomaxillofacial surgical prosthetic comprehensive treatment
Published Date 2022-09-03
Publication Title Diagnostics
Volume volume12
Issue issue9
Publisher MDPI
Start Page 2146
ISSN 2075-4418
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36140547
DOI 10.3390/diagnostics12092146
Web of Science KeyUT 000858103100001
Related Url isVersionOf https://doi.org/10.3390/diagnostics12092146
FullText URL fulltext.pdf
Author Yang, Guang|
Keywords gastric adenocarcinoma of fundic gland microsatellite instability mismatch repair deficiency Wnt/beta-catenin signaling pathway
Published Date 2022-08-26
Publication Title Medicine
Volume volume101
Issue issue34
Publisher Lippincott Williams & Wilkins
Start Page e30311
ISSN 0025-7974
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 the Author(s).
File Version publisher
PubMed ID 36042639
DOI 10.1097/MD.0000000000030311
Web of Science KeyUT 000847532100073
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000030311
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Murayama, Somay Yamagata| Nakamura, Masahiko| Hamada, Kenta| Tanaka, Takehiro| Okada, Hiroyuki|
Published Date 2022-07-20
Publication Title Case Reports In Gastrointestinal Medicine
Volume volume2022
Publisher Hindawi Ltd
Start Page 4254605
ISSN 2090-6528
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Masaya Iwamuro et al.
File Version publisher
PubMed ID 35911659
DOI 10.1155/2022/4254605
Web of Science KeyUT 000853251100001
Related Url isVersionOf https://doi.org/10.1155/2022/4254605
JaLCDOI 10.18926/AMO/63909
FullText URL 76_4_485.pdf
Author Takahashi, Yuya| Watanabe, Mototsugu| Furukawa, Shinichi| Shiotani, Toshio| Kataoka, Kazuhiko|
Abstract Aspergillosis is an infection caused by Aspergillus species, and it manifests in various clinical presentations. We describe the case of a 73-year-old man with a small area of thickening on the thoracic wall detected by computed tomography. Surgical resection confirmed the diagnosis of an Aspergillus abscess. We report this case in view of the rarity of Aspergillus abscess localized to a parietal pleura without any signs of lung parenchymal involvement. After a thorough literature review, we consider this could be the first report of this manifestation. Accumulation of similar cases will be necessary to help spread recognition of this condition.
Keywords Aspergillus abscess empyema fungal infection pulmonary aspergillosis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 485
End Page 488
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123165
JaLCDOI 10.18926/AMO/63908
FullText URL 76_4_479.pdf
Author Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi|
Abstract A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance.
Keywords hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 479
End Page 483
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123164
Web of Science KeyUT 000882167300012
JaLCDOI 10.18926/AMO/63907
FullText URL 76_4_473.pdf
Author Tsuboi, Nobushige| Ishida, Joji| Shimazu, Yosuke| Edaki, Hisanori| Uneda, Atsuhito| Otani, Yoshihiro| Fujii, Kentaro| Kurozumi, Kazuhiko| Ennishi, Daisuke| Yanai, Hiroyuki| Date, Isao|
Abstract Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.
Keywords glioneuronal tumor with neuropil-like islands genomic profiling
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 473
End Page 477
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123163
JaLCDOI 10.18926/AMO/63904
FullText URL 76_4_447.pdf
Author Umemura, Hiroshi| Fukuda, Yoshiaki| Miyashita, Tetsuo| Nakayama, Tomohiro|
Abstract The erythrocyte sedimentation rate (ESR) is a widely used marker of inflammation, but the detailed mechanisms underlying the ESR remain unclear. We retrospectively collected laboratory data from our hospital’s laboratory information system, and performed multiple linear regression analysis and correlation analysis to determine relationships between the ESR and other laboratory test parameters. The alpha-2, beta-2, and gamma fractions from serum protein electrophoresis, serum immunoglobulin (Ig) G, IgA, IgM, and complement C3 levels, plasma fibrinogen levels, and platelet count showed positive effects on the ESR; however, the serum albumin level showed negative effects. Since erythrocytes are negatively charged, an increase in positively charged proteins and a decrease in negatively charged albumin were suggested to increase the ESR. Notably, C-reactive protein (CRP) showed the third-strongest correlation with the ESR despite having no significant effect on the ESR. We also reviewed cases with discordant ESR and CRP levels to compare the disease profiles of high ESR/low CRP patients and low ESR/high CRP patients. The patients with high ESR/low CRP had a completely different disease profile from those with low ESR/high CRP. Since the ESR and CRP have different roles, they should be used as markers in a context-dependent manner.
Keywords complement erythrocyte sedimentation rate fibrinogen immunoglobulin serum protein electrophoresis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 447
End Page 455
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123160
FullText URL fulltext20220906-1.pdf
Author Kakehi, Ayaka| Hagiya, Hideharu| Iio, Koji| Nakano, Yasuhiro| Ihoriya, Hiromi| Taira, Yuki| Nakamoto, Kenta| Hasegawa, Kou| Higashikage, Akihito| Otsuka, Fumio|
Keywords Candida dubliniensis Candidemia COVID-19 Sequencing analysis
Note © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.07.007] . |
Published Date 2022-10
Publication Title Journal of Infection and Chemotherapy
Volume volume28
Issue issue10
Publisher Elsevier BV
Start Page 1433
End Page 1435
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version author
PubMed ID 35863730
DOI 10.1016/j.jiac.2022.07.007
Web of Science KeyUT 000843880400016
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2022.07.007
FullText URL fulltext.pdf
Author Tanimoto, Terutaka| Noda, Takuo| Imaji, Reisuke| Nouso, Hiroshi|
Keywords Esophageal atresia Communicating bronchopulmonary foregut malformation Broncho-esophageal fistula
Published Date 2022-08-15
Publication Title Surgical Case Reports
Volume volume8
Issue issue1
Publisher Springer
Start Page 156
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35969287
DOI 10.1186/s40792-022-01513-7
Web of Science KeyUT 000840835900001
Related Url isVersionOf https://doi.org/10.1186/s40792-022-01513-7
FullText URL fulltext.pdf
Author Takagi, Wataru| Okada, Tomoaki| Nosaka, Kazumasa| Miyoshi, Toru| Doi, Masayuki|
Keywords angioplasty coronary artery drug-coated balloon optical coherence tomography
Published Date 2022-07-18
Publication Title Clinical Case Reports
Volume volume10
Issue issue7
Publisher Wiley
Start Page e06028
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35865759
DOI 10.1002/ccr3.6028
Web of Science KeyUT 000826550900001
Related Url isVersionOf https://doi.org/10.1002/ccr3.6028
FullText URL fulltext.pdf
Author Hashimoto, Masashi| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Tanaka, Takehiro| Maeda, Naoaki| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi|
Keywords Esophagectomy Verrucous carcinoma Esophageal squamous cell carcinoma
Published Date 2022-07-04
Publication Title Surgical Case Reports
Volume volume8
Issue issue1
Publisher Springer
Start Page 128
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35781764
DOI 10.1186/s40792-022-01486-7
Web of Science KeyUT 000820644000001
Related Url isVersionOf https://doi.org/10.1186/s40792-022-01486-7
FullText URL fulltext.pdf
Author Yasutomi, Nanako| Shimizu, Tatsuhiko| Kanazawa, Tomoyuki| Shimizu, Kazuyoshi| Iwasaki, Tatsuo| Morimatsu, Hiroshi|
Keywords Congenital heart disease Fontan circulation Esophageal varices Endoscopic injection sclerotherapy
Published Date 2022-07-05
Publication Title Ja Clinical Reports
Volume volume8
Issue issue1
Publisher Springer
Start Page 48
ISSN 2363-9024
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35789440
DOI 10.1186/s40981-022-00538-z
Web of Science KeyUT 000820644400001
Related Url isVersionOf https://doi.org/10.1186/s40981-022-00538-z