result 18181 件
JaLCDOI | 10.18926/AMO/55591 |
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FullText URL | 71_6_531.pdf |
Author | Ooi, Mayu| Yanamoto, Fujio| Sato, Hitoaki| Takao, Yumiko| Okada, Masako| Egi, Moritoki| Mizobuchi, Satoshi| |
Abstract | Although spinal cord stimulation (SCS) is a useful treatment for chronic intractable pain, the optimal method of stimulation has not yet been established. In this prospective, crossover study, we compared the efficacy of using a constant current (CC) system with that of a constant voltage (CV) system for temporal SCS. Twenty patients were enrolled and divided into two groups. For 10 patients, a CV system was applied on Days 1-5, followed by the use of a CC system on Days 6-10. For the other 10 patients, a CC system was applied for the first five days, followed by a CV system for the subsequent five days. We evaluated the alteration of pain intensity using a visual analogue scale (VAS), the area of stimulation, the stability of effect, and patient satisfaction regarding treatment. The pain scores decreased significantly after the start of the SCS. There was no significant difference in the change in VAS between the two systems. The stimulation method used for temporal SCS did not affect the reduction of pain intensity. Patients felt a wider stimulation area by the CC system compared to the CV system. |
Keywords | spinal cord stimulation constant current system constant voltage system chronic intractable pain pain score |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2017-12 |
Volume | volume71 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 531 |
End Page | 537 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 29276227 |
JaLCDOI | 10.18926/AMO/55589 |
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FullText URL | 71_6_519.pdf |
Author | Mizukawa, Nobuyoshi| Swe Swe Win| Zaw Moe Thein| Moe Thida Htwe| Yoshioka, Yohsuke| Kimata, Yoshihiro| Iida, Seiji| Khin, Myo| Okada, Shigeru| Sein, Than| |
Abstract | Oral cancer is a very common disease in South and Southeast Asia. Betel quid (BQ)- chewing and tobaccosmoking habits are etiological factors for oral cancer patients in these regions. We conducted an oral cancer screening in BQ-chewing endemic rural areas in South Myanmar for the early detection of oral cancer in BQ-chewing and smoking individuals. We examined 105 subjects who were at high risk of oral cancer due to their oral habits (BQ users and/or smokers). Three carcinoma cases were detected, and there were 8 dysplasia cases. The carcinoma detection rate was 2.9%, and the carcinoma and precancerous lesion detection rate was 10.5%. In Myanmar, oral cancer screening has been conducted sporadically on a voluntary basis, and nationwide surveys have never been performed. There are also few reports of oral cancer screening for high-risk groups among the general population in Myanmar. Our present findings highlight the need for further screening and surveys. Education on betel quid chewing- and tobacco- related oral diseases and screening for the early detection of oral cancer are of the utmost importance in the control and prevention of oral cancer. |
Keywords | oral cancer screening betel quid (BQ) Myanmar oral cancer smoking |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2017-12 |
Volume | volume71 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 519 |
End Page | 524 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 29276225 |
JaLCDOI | 10.18926/AMO/55588 |
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FullText URL | 71_6_513.pdf |
Author | Sawada, Shigeki| Sugimoto, Ryujiro| Ueno, Tsuyoshi| Yamashita, Motohiro| |
Abstract | We evaluated the feasibility of maintenance treatment using UFT (a combination of tegafur and uracil) after adjuvant platinum-based chemotherapy in patients with resected lung cancer. A prospective feasibility trial was conducted. Between 2010 and 2014, UFT was administered for 2 years sequentially after platinum-based adjuvant chemotherapy in 24 patients with resected Stage IIA-IIIA non-small cell lung cancer. The safety of UFT and the rate of treatment completion were then evaluated. The prior platinum-based chemotherapy regimens consisted of cisplatin+vinorelbine in 16 patients, carboplatin+paclitaxel in 5 and carboplatin+S-1 in one. During the subsequent UFT administration, a total of 3 patients required a dose reduction because of Grade 1 blood-stained sputum, Grade 2 numbness, and Grade 2 constipation, in one patient each. Eleven patients underwent the planned 2-year UFT administration, but 12 patients could not because of the recurrence of lung cancer in 5 patients, metachronous malignancy in one, and toxicities in 6. The completion rate for UFT administration was 64.7% (11/17). The most common type of toxicity was gastrointestinal toxicities. All of the toxicities were grade 1 or 2, and no severe toxicities were observed. UFT treatment after platinum-based chemotherapy was revealed to be feasible. |
Keywords | UFT adjuvant chemotherapy lung cancer resection |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2017-12 |
Volume | volume71 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 513 |
End Page | 518 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 29276224 |
JaLCDOI | 10.18926/AMO/55585 |
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FullText URL | 71_6_485.pdf |
Author | Okano, Ayaka| Masuhara, Shun| Ota, Sonoka| Motegi, Chie| Takabayashi, Noriko| Ogino, Tetsuya| |
Abstract | We examined postprandial body positions’ effects on gastrointestinal motility, the autonomic nervous system and subjective comfort, i.e., whether lowering the head after a meal is beneficial for gastrointestinal motility and the prevention of pressure ulcer. We examined 10 healthy subjects and compared 3 body positions: (1) Seated upright. (2) Lying on a bed with the head at 60° and knees up by 20° (60° position). (3) Identical to (2) until post-meal; the head was then lowered to 30° (60°-30° position). Gastrointestinal motility was assessed as gastrointestinal sounds measured by sound-editing software. Digital plethysmography assessed autonomic nerve function as heart rate variability. The pressure ulcer risk was estimated as subjective comfort/discomfort using a visual analog scale. Gastrointestinal sounds increased post-meal. The 60°-30° position showed the highest number of sounds and longest cumulative sound duration. Post-meal, sympathetic activation was suggested in the 60° position, whereas vagal activity was relatively preserved in the 60°-30° position. The 60°-30° position was the most comfortable, and the 60° position was least comfortable. Lowering the head after a meal is beneficial to augment gastrointestinal motility and decrease the pressure ulcer risk. The 60° head-up position increases the pressure ulcer risk. |
Keywords | gastrointestinal sound body position autonomic nerve pressure ulcer patient care |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2017-12 |
Volume | volume71 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 485 |
End Page | 491 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 29276221 |
JaLCDOI | 10.18926/AMO/55584 |
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FullText URL | 71_6_475.pdf |
Author | Takei, Daisuke| Harada, Keita| Takashima, Shiho| Inokuchi, Toshihiro| Nakarai, Asuka| Sugihara, Yusaku| Takahara, Masanobu| Hiraoka, Sakiko| Okada, Hiroyuki| |
Abstract | Several reports discussed colonoscopic surveillance after polypectomy and endoscopic mucosal resection (EMR) for colorectal polyps, but only a few reports focused on prognostic analyses, and none involved metachronous neoplasia after colorectal endoscopic submucosal dissection (ESD). We conducted the present study to assess the risk of adenoma recurrence requiring endoscopic treatment, and to establish appropriate post-ESD colonoscopic surveillance. We enrolled 116 patients who had undergone colorectal ESD at Okayama University Hospital between February 2008 and July 2014 and had been followed-up >12 months. We retrospectively analyzed clinicopathological features of 101 lesions from 101 patients. Metachronous adenomas were detected in 21 cases (20.8%). We divided the patients into 2 groups according to the occurrence of metachronous adenomas. Our comparison of clinicopathological characteristics between these groups showed that in the metachronous adenomas group the number of synchronous adenomas at index colonoscopy was high and the rate of laterally spreading tumor-nongranular (LST-NG) was higher. A multivariate analysis indicated that the number of synchronous adenomas was significantly associated with metachronous adenomas (HR: 2.54, 95%CI: 1.04-6.52, p<0.05). The colonoscopic surveillance planning after colorectal ESD should be more meticulous for patients with more synchronous adenomas. |
Keywords | endoscopic submucosal dissection laterally spreading tumor metachronous recurrence local recurrence post-ESD colonoscopic surveillance |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2017-12 |
Volume | volume71 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 475 |
End Page | 483 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 29276220 |
JaLCDOI | 10.18926/AMO/55583 |
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FullText URL | 71_6_467.pdf |
Author | Obata, Kengo| Yumoto, Tetsuya| Fuke, Soichiro| Tsukahara, Kohei| Naito, Hiromichi| Iida, Atsuyoshi| Takahashi, Tetsuya| Ujike, Yoshihito| Nakao, Atsunori| |
Abstract | Early mobilization is advocated to prevent intensive care unit-acquired physical weakness, but the patient's workload and its changes in response to body position changes have not been established. We used indirect calorimetry to determine the energy expenditure (EE) in response to body position changes, and we assessed EE's correlation with respiratory parameters in healthy volunteers: 8 males and 8 females, mean age 23.4±1.3 years. The subjects started in the resting supine position followed by a 30° head-up position, a 60° head-up position, an upright sitting position, a standing position, and the resting supine position. EE was determined in real time by indirect calorimetry monitoring the subject’s respiratory rate, tidal volume (VT), and minute volume (MV). The highest values were observed immediately after the subjects transitioned from standing to supine, and this was significantly higher compared to the original supine position (1,450±285 vs. 2,004±519 kcal/day, p<0.01). Moderate correlations were observed between VT and EE (r=0.609, p<0.001) and between MV and EE (r=0.576, p<0.001). Increasing VT or MV indicates an increasing patient workload during mobilization. Monitoring these parameters may contribute to safe rehabilitation. Further studies should assess EE in critically ill patients. |
Keywords | early mobilization energy expenditure indirect calorimetry rehabilitation body position |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2017-12 |
Volume | volume71 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 467 |
End Page | 473 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 29276219 |
JaLCDOI | 10.18926/AMO/55582 |
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FullText URL | 71_6_459.pdf |
Author | Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi| |
Abstract | The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts. |
Keywords | receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2017-12 |
Volume | volume71 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 459 |
End Page | 465 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 29276218 |
JaLCDOI | 10.18926/okadai-bun-kiyou/55575 |
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Title Alternative | A Finger Bowl and Li Hung-Chang(3) |
FullText URL | jfl_068_045_054.pdf |
Author | Yusa, Toru| |
Publication Title | Journal of the Faculty of Letters Okayama University |
Published Date | 2017-12-22 |
Volume | volume68 |
Start Page | 45 |
End Page | 54 |
ISSN | 0285-4864 |
Related Url | http://ousar.lib.okayama-u.ac.jp/53085 |
language | Japanese |
File Version | publisher |
NAID | 120006370703 |
JaLCDOI | 10.18926/okadai-bun-kiyou/55572 |
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Title Alternative | A Post-Skinnerian Perspective in Psychology (26): Old Age as a Radical Behaviorist |
FullText URL | jfl_068_001_017.pdf |
Author | Hasegawa, Yoshinori| |
Abstract | 本稿は、行動分析学の視点から、高齢者のライフスタイルの構築と終末に関する有用な知見を提供することを目的とする。このテーマは、 (1)スキナーの幸福観の概要と高齢者への適用 (2)選択機会と高齢者の行動的QOL (3)複数の行動のまとまりから構成される「活動」概念に基づいて、より巨視的な観点から高齢者のライフスタイルの構築を考える (4)終末期における不安や恐怖への対処 という4つの観点から総合的に検討する必要があると考えるが、本稿では紙幅の制限により、(2)についてはすでに長谷川(2012, 2013)で論じているのでここでは省略し、また(1)と(4)は概略を述べるにとどめ、新しい概念を取り入れた(3)について重点的に取り上げていくことにしたい。 |
Publication Title | Journal of the Faculty of Letters Okayama University |
Published Date | 2017-12-22 |
Volume | volume68 |
Start Page | 1 |
End Page | 17 |
ISSN | 0285-4864 |
Related Url | http://ousar.lib.okayama-u.ac.jp/55220 |
language | Japanese |
File Version | publisher |
NAID | 120006370700 |
FullText URL | K0005600_other1.pdf |
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Author | Takeda, Tatsuaki| Yamamoto, Hiromasa| Kanzaki, Hirotaka| Suzawa, Ken| Yoshioka, Takahiro| Tomida, Shuta| Cui, Xiaojiang| Murali, Ramachandran| Namba, Kei| Sato, Hiroki| Torigoe, Hidejiro| Watanabe, Mototsugu| Shien, Kazuhiko| Soh, Junichi| Asano, Hiroaki| Tsukuda, Kazunori| Kitamura, Yoshihisa| Miyoshi, Shinichiro| Sendo, Toshiaki| Toyooka, Shinichi| |
Note | 学位審査副論文| |
Published Date | 2017-02-03 |
Publication Title | PLoS One |
Volume | volume12 |
Issue | issue2 |
Publisher | Public Library of Science |
Start Page | e0171356 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
File Version | publisher |
PubMed ID | 28158234 |
DOI | 10.1371/journal.pone.0171356 |
Web of Science KeyUT | 000396161700064 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0171356 isPartOf http://ousar.lib.okayama-u.ac.jp/55525 |
FullText URL | K0005596_other1.pdf |
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Author | Thar Htet San| Fujisawa, Masayoshi| Fushimi, Soichiro| Soe, Lamin| Ngu Wah Min| Yoshimura, Teizo| Ohara, Toshiaki| Myint Myint Yee| Oda, Shinsuke| Matsukawa , Akihiro| |
Keywords | Breast cancer molecular subtypes Ki-67 expression Myanmar |
Note | 学位審査副論文| |
Published Date | 2017-06-25 |
Publication Title | Asian Pacific journal of cancer prevention |
Volume | volume18 |
Issue | issue6 |
Publisher | Asian Pacific Organization for Cancer Prevention |
Start Page | 1617 |
End Page | 1621 |
ISSN | 1513-7368 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
File Version | publisher |
PubMed ID | 28670879 |
DOI | 10.22034/APJCP.2017.18.6.1617 |
Related Url | isVersionOf https://doi.org/10.22034/APJCP.2017.18.6.1617 isPartOf http://ousar.lib.okayama-u.ac.jp/55521 |
FullText URL | K0005592_other1.pdf |
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Author | Hinamoto, Norikazu| Maeshima, Yohei| Yamasaki, Hiroko| Nasu, Tatsuyo| Saito, Daisuke| Watatani, Hiroyuki| Ujike, Haruyo| Tanabe, Katsuyuki| Masuda, Kana| Arata, Yuka| Sugiyama, Hitoshi| Sato, Yasufumi| Makino, Hirofumi| |
Note | 学位審査副論文| |
Published Date | 2014-09-25 |
Publication Title | Plos One |
Volume | volume9 |
Issue | issue9 |
Publisher | Public Library of Science |
Start Page | e107934 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
File Version | publisher |
PubMed ID | 25255225 |
DOI | 10.1371/journal.pone.0107934 |
Web of Science KeyUT | 000344862300045 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0107934 isPartOf http://ousar.lib.okayama-u.ac.jp/55517 |
FullText URL | viruses-09-00371.pdf |
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Author | Ogawa, Hirohito| Kajihara, Masahiro| Nao, Naganori| Shigeno, Asako| Fujikura, Daisuke| Hang’ombe, Bernard M.| Mweene, Aaron S.| Mutemwa, Alisheke| Squarre, David| Yamada, Masao| Higashi, Hideaki| Sawa, Hirofumi| Takada, Ayato| |
Keywords | Eidolon helvum Zambia adenovirus bat |
Published Date | 2017-12-04 |
Publication Title | Viruses |
Volume | volume9 |
Issue | issue12 |
Publisher | MDPI |
Start Page | 371 |
ISSN | 1999-4915 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
File Version | publisher |
PubMed ID | 29207524 |
DOI | 10.3390/v9120371 |
Related Url | isVersionOf https://doi.org/10.3390/v9120371 |
FullText URL | K0005635_abstract_review.pdf K0005635_summary.pdf K0005635_fulltext.pdf |
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Author | Ikeda, Toru| |
Published Date | 2017-09-29 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5635号 |
Granted Date | 2017-09-29 |
Thesis Type | Doctor of Philosophy in Health Sciences |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005619_abstract_review.pdf K0005619_fulltext.pdf |
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Author | Hoang Minh Giang| |
Published Date | 2017-09-29 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5619号 |
Granted Date | 2017-09-29 |
Thesis Type | Doctor of Philosophy in Environmental Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005618_abstract_review.pdf K0005618_fulltext.pdf |
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Author | ARRIVAL RINCE PUTRI| |
Published Date | 2017-09-29 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5618号 |
Granted Date | 2017-09-29 |
Thesis Type | Doctor of Philosophy |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005616_abstract_review.pdf K0005616_fulltext.pdf |
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Author | Nguyen Thanh Binh| |
Published Date | 2017-09-29 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5616号 |
Granted Date | 2017-09-29 |
Thesis Type | Doctor of Philosophy |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005608_abstract_review.pdf K0005608_fulltext.pdf |
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Author | MD. SELIM AL MAMUN| |
Published Date | 2017-09-29 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5608号 |
Granted Date | 2017-09-29 |
Thesis Type | Doctor of Philosophy in Engineering |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005590_abstract_review.pdf K0005590_summary.pdf K0005590_fulltext.pdf |
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Author | Kikkawa, Akiyoshi| |
Published Date | 2017-09-29 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5590号 |
Granted Date | 2017-09-29 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005584_abstract_review.pdf K0005584_summary.pdf K0005584_fulltext.pdf |
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Author | Omichi, Ryotaro| |
Published Date | 2017-09-29 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5584号 |
Granted Date | 2017-09-29 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | English |