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JaLCDOI 10.18926/AMO/55591
FullText URL 71_6_531.pdf
Author Ooi, Mayu| Yanamoto, Fujio| Sato, Hitoaki| Takao, Yumiko| Okada, Masako| Egi, Moritoki| Mizobuchi, Satoshi|
Abstract Although spinal cord stimulation (SCS) is a useful treatment for chronic intractable pain, the optimal method of stimulation has not yet been established. In this prospective, crossover study, we compared the efficacy of using a constant current (CC) system with that of a constant voltage (CV) system for temporal SCS. Twenty patients were enrolled and divided into two groups. For 10 patients, a CV system was applied on Days 1-5, followed by the use of a CC system on Days 6-10. For the other 10 patients, a CC system was applied for the first five days, followed by a CV system for the subsequent five days. We evaluated the alteration of pain intensity using a visual analogue scale (VAS), the area of stimulation, the stability of effect, and patient satisfaction regarding treatment. The pain scores decreased significantly after the start of the SCS. There was no significant difference in the change in VAS between the two systems. The stimulation method used for temporal SCS did not affect the reduction of pain intensity. Patients felt a wider stimulation area by the CC system compared to the CV system.
Keywords spinal cord stimulation constant current system constant voltage system chronic intractable pain pain score
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-12
Volume volume71
Issue issue6
Publisher Okayama University Medical School
Start Page 531
End Page 537
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29276227
JaLCDOI 10.18926/AMO/55589
FullText URL 71_6_519.pdf
Author Mizukawa, Nobuyoshi| Swe Swe Win| Zaw Moe Thein| Moe Thida Htwe| Yoshioka, Yohsuke| Kimata, Yoshihiro| Iida, Seiji| Khin, Myo| Okada, Shigeru| Sein, Than|
Abstract Oral cancer is a very common disease in South and Southeast Asia. Betel quid (BQ)- chewing and tobaccosmoking habits are etiological factors for oral cancer patients in these regions. We conducted an oral cancer screening in BQ-chewing endemic rural areas in South Myanmar for the early detection of oral cancer in BQ-chewing and smoking individuals. We examined 105 subjects who were at high risk of oral cancer due to their oral habits (BQ users and/or smokers). Three carcinoma cases were detected, and there were 8 dysplasia cases. The carcinoma detection rate was 2.9%, and the carcinoma and precancerous lesion detection rate was 10.5%. In Myanmar, oral cancer screening has been conducted sporadically on a voluntary basis, and nationwide surveys have never been performed. There are also few reports of oral cancer screening for high-risk groups among the general population in Myanmar. Our present findings highlight the need for further screening and surveys. Education on betel quid chewing- and tobacco- related oral diseases and screening for the early detection of oral cancer are of the utmost importance in the control and prevention of oral cancer.
Keywords oral cancer screening betel quid (BQ) Myanmar oral cancer smoking
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-12
Volume volume71
Issue issue6
Publisher Okayama University Medical School
Start Page 519
End Page 524
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29276225
JaLCDOI 10.18926/AMO/55588
FullText URL 71_6_513.pdf
Author Sawada, Shigeki| Sugimoto, Ryujiro| Ueno, Tsuyoshi| Yamashita, Motohiro|
Abstract We evaluated the feasibility of maintenance treatment using UFT (a combination of tegafur and uracil) after adjuvant platinum-based chemotherapy in patients with resected lung cancer. A prospective feasibility trial was conducted. Between 2010 and 2014, UFT was administered for 2 years sequentially after platinum-based adjuvant chemotherapy in 24 patients with resected Stage IIA-IIIA non-small cell lung cancer. The safety of UFT and the rate of treatment completion were then evaluated. The prior platinum-based chemotherapy regimens consisted of cisplatin+vinorelbine in 16 patients, carboplatin+paclitaxel in 5 and carboplatin+S-1 in one. During the subsequent UFT administration, a total of 3 patients required a dose reduction because of Grade 1 blood-stained sputum, Grade 2 numbness, and Grade 2 constipation, in one patient each. Eleven patients underwent the planned 2-year UFT administration, but 12 patients could not because of the recurrence of lung cancer in 5 patients, metachronous malignancy in one, and toxicities in 6. The completion rate for UFT administration was 64.7% (11/17). The most common type of toxicity was gastrointestinal toxicities. All of the toxicities were grade 1 or 2, and no severe toxicities were observed. UFT treatment after platinum-based chemotherapy was revealed to be feasible.
Keywords UFT adjuvant chemotherapy lung cancer resection
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-12
Volume volume71
Issue issue6
Publisher Okayama University Medical School
Start Page 513
End Page 518
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29276224
JaLCDOI 10.18926/AMO/55585
FullText URL 71_6_485.pdf
Author Okano, Ayaka| Masuhara, Shun| Ota, Sonoka| Motegi, Chie| Takabayashi, Noriko| Ogino, Tetsuya|
Abstract We examined postprandial body positions’ effects on gastrointestinal motility, the autonomic nervous system and subjective comfort, i.e., whether lowering the head after a meal is beneficial for gastrointestinal motility and the prevention of pressure ulcer. We examined 10 healthy subjects and compared 3 body positions: (1) Seated upright. (2) Lying on a bed with the head at 60° and knees up by 20° (60° position). (3) Identical to (2) until post-meal; the head was then lowered to 30° (60°-30° position). Gastrointestinal motility was assessed as gastrointestinal sounds measured by sound-editing software. Digital plethysmography assessed autonomic nerve function as heart rate variability. The pressure ulcer risk was estimated as subjective comfort/discomfort using a visual analog scale. Gastrointestinal sounds increased post-meal. The 60°-30° position showed the highest number of sounds and longest cumulative sound duration. Post-meal, sympathetic activation was suggested in the 60° position, whereas vagal activity was relatively preserved in the 60°-30° position. The 60°-30° position was the most comfortable, and the 60° position was least comfortable. Lowering the head after a meal is beneficial to augment gastrointestinal motility and decrease the pressure ulcer risk. The 60° head-up position increases the pressure ulcer risk.
Keywords gastrointestinal sound body position autonomic nerve pressure ulcer patient care
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-12
Volume volume71
Issue issue6
Publisher Okayama University Medical School
Start Page 485
End Page 491
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29276221
JaLCDOI 10.18926/AMO/55584
FullText URL 71_6_475.pdf
Author Takei, Daisuke| Harada, Keita| Takashima, Shiho| Inokuchi, Toshihiro| Nakarai, Asuka| Sugihara, Yusaku| Takahara, Masanobu| Hiraoka, Sakiko| Okada, Hiroyuki|
Abstract Several reports discussed colonoscopic surveillance after polypectomy and endoscopic mucosal resection (EMR) for colorectal polyps, but only a few reports focused on prognostic analyses, and none involved metachronous neoplasia after colorectal endoscopic submucosal dissection (ESD). We conducted the present study to assess the risk of adenoma recurrence requiring endoscopic treatment, and to establish appropriate post-ESD colonoscopic surveillance. We enrolled 116 patients who had undergone colorectal ESD at Okayama University Hospital between February 2008 and July 2014 and had been followed-up >12 months. We retrospectively analyzed clinicopathological features of 101 lesions from 101 patients. Metachronous adenomas were detected in 21 cases (20.8%). We divided the patients into 2 groups according to the occurrence of metachronous adenomas. Our comparison of clinicopathological characteristics between these groups showed that in the metachronous adenomas group the number of synchronous adenomas at index colonoscopy was high and the rate of laterally spreading tumor-nongranular (LST-NG) was higher. A multivariate analysis indicated that the number of synchronous adenomas was significantly associated with metachronous adenomas (HR: 2.54, 95%CI: 1.04-6.52, p<0.05). The colonoscopic surveillance planning after colorectal ESD should be more meticulous for patients with more synchronous adenomas.
Keywords endoscopic submucosal dissection laterally spreading tumor metachronous recurrence local recurrence post-ESD colonoscopic surveillance
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-12
Volume volume71
Issue issue6
Publisher Okayama University Medical School
Start Page 475
End Page 483
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29276220
JaLCDOI 10.18926/AMO/55583
FullText URL 71_6_467.pdf
Author Obata, Kengo| Yumoto, Tetsuya| Fuke, Soichiro| Tsukahara, Kohei| Naito, Hiromichi| Iida, Atsuyoshi| Takahashi, Tetsuya| Ujike, Yoshihito| Nakao, Atsunori|
Abstract Early mobilization is advocated to prevent intensive care unit-acquired physical weakness, but the patient's workload and its changes in response to body position changes have not been established. We used indirect calorimetry to determine the energy expenditure (EE) in response to body position changes, and we assessed EE's correlation with respiratory parameters in healthy volunteers: 8 males and 8 females, mean age 23.4±1.3 years. The subjects started in the resting supine position followed by a 30° head-up position, a 60° head-up position, an upright sitting position, a standing position, and the resting supine position. EE was determined in real time by indirect calorimetry monitoring the subject’s respiratory rate, tidal volume (VT), and minute volume (MV). The highest values were observed immediately after the subjects transitioned from standing to supine, and this was significantly higher compared to the original supine position (1,450±285 vs. 2,004±519 kcal/day, p<0.01). Moderate correlations were observed between VT and EE (r=0.609, p<0.001) and between MV and EE (r=0.576, p<0.001). Increasing VT or MV indicates an increasing patient workload during mobilization. Monitoring these parameters may contribute to safe rehabilitation. Further studies should assess EE in critically ill patients.
Keywords early mobilization energy expenditure indirect calorimetry rehabilitation body position
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-12
Volume volume71
Issue issue6
Publisher Okayama University Medical School
Start Page 467
End Page 473
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29276219
JaLCDOI 10.18926/AMO/55582
FullText URL 71_6_459.pdf
Author Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi|
Abstract The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts.
Keywords receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2017-12
Volume volume71
Issue issue6
Publisher Okayama University Medical School
Start Page 459
End Page 465
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29276218
JaLCDOI 10.18926/okadai-bun-kiyou/55575
Title Alternative A Finger Bowl and Li Hung-Chang(3)
FullText URL jfl_068_045_054.pdf
Author Yusa, Toru|
Publication Title Journal of the Faculty of Letters Okayama University
Published Date 2017-12-22
Volume volume68
Start Page 45
End Page 54
ISSN 0285-4864
Related Url http://ousar.lib.okayama-u.ac.jp/53085
language Japanese
File Version publisher
NAID 120006370703
JaLCDOI 10.18926/okadai-bun-kiyou/55572
Title Alternative A Post-Skinnerian Perspective in Psychology (26): Old Age as a Radical Behaviorist
FullText URL jfl_068_001_017.pdf
Author Hasegawa, Yoshinori|
Abstract  本稿は、行動分析学の視点から、高齢者のライフスタイルの構築と終末に関する有用な知見を提供することを目的とする。このテーマは、 (1)スキナーの幸福観の概要と高齢者への適用 (2)選択機会と高齢者の行動的QOL (3)複数の行動のまとまりから構成される「活動」概念に基づいて、より巨視的な観点から高齢者のライフスタイルの構築を考える (4)終末期における不安や恐怖への対処 という4つの観点から総合的に検討する必要があると考えるが、本稿では紙幅の制限により、(2)についてはすでに長谷川(2012, 2013)で論じているのでここでは省略し、また(1)と(4)は概略を述べるにとどめ、新しい概念を取り入れた(3)について重点的に取り上げていくことにしたい。
Publication Title Journal of the Faculty of Letters Okayama University
Published Date 2017-12-22
Volume volume68
Start Page 1
End Page 17
ISSN 0285-4864
Related Url http://ousar.lib.okayama-u.ac.jp/55220
language Japanese
File Version publisher
NAID 120006370700
FullText URL K0005600_other1.pdf
Author Takeda, Tatsuaki| Yamamoto, Hiromasa| Kanzaki, Hirotaka| Suzawa, Ken| Yoshioka, Takahiro| Tomida, Shuta| Cui, Xiaojiang| Murali, Ramachandran| Namba, Kei| Sato, Hiroki| Torigoe, Hidejiro| Watanabe, Mototsugu| Shien, Kazuhiko| Soh, Junichi| Asano, Hiroaki| Tsukuda, Kazunori| Kitamura, Yoshihisa| Miyoshi, Shinichiro| Sendo, Toshiaki| Toyooka, Shinichi|
Note 学位審査副論文|
Published Date 2017-02-03
Publication Title PLoS One
Volume volume12
Issue issue2
Publisher Public Library of Science
Start Page e0171356
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 28158234
DOI 10.1371/journal.pone.0171356
Web of Science KeyUT 000396161700064
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0171356 isPartOf http://ousar.lib.okayama-u.ac.jp/55525
FullText URL K0005596_other1.pdf
Author Thar Htet San| Fujisawa, Masayoshi| Fushimi, Soichiro| Soe, Lamin| Ngu Wah Min| Yoshimura, Teizo| Ohara, Toshiaki| Myint Myint Yee| Oda, Shinsuke| Matsukawa , Akihiro|
Keywords Breast cancer molecular subtypes Ki-67 expression Myanmar
Note 学位審査副論文|
Published Date 2017-06-25
Publication Title Asian Pacific journal of cancer prevention
Volume volume18
Issue issue6
Publisher Asian Pacific Organization for Cancer Prevention
Start Page 1617
End Page 1621
ISSN 1513-7368
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 28670879
DOI 10.22034/APJCP.2017.18.6.1617
Related Url isVersionOf https://doi.org/10.22034/APJCP.2017.18.6.1617 isPartOf http://ousar.lib.okayama-u.ac.jp/55521
FullText URL K0005592_other1.pdf
Author Hinamoto, Norikazu| Maeshima, Yohei| Yamasaki, Hiroko| Nasu, Tatsuyo| Saito, Daisuke| Watatani, Hiroyuki| Ujike, Haruyo| Tanabe, Katsuyuki| Masuda, Kana| Arata, Yuka| Sugiyama, Hitoshi| Sato, Yasufumi| Makino, Hirofumi|
Note 学位審査副論文|
Published Date 2014-09-25
Publication Title Plos One
Volume volume9
Issue issue9
Publisher Public Library of Science
Start Page e107934
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/
File Version publisher
PubMed ID 25255225
DOI 10.1371/journal.pone.0107934
Web of Science KeyUT 000344862300045
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0107934 isPartOf http://ousar.lib.okayama-u.ac.jp/55517
FullText URL viruses-09-00371.pdf
Author Ogawa, Hirohito| Kajihara, Masahiro| Nao, Naganori| Shigeno, Asako| Fujikura, Daisuke| Hang’ombe, Bernard M.| Mweene, Aaron S.| Mutemwa, Alisheke| Squarre, David| Yamada, Masao| Higashi, Hideaki| Sawa, Hirofumi| Takada, Ayato|
Keywords Eidolon helvum Zambia adenovirus bat
Published Date 2017-12-04
Publication Title Viruses
Volume volume9
Issue issue12
Publisher MDPI
Start Page 371
ISSN 1999-4915
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 29207524
DOI 10.3390/v9120371
Related Url isVersionOf https://doi.org/10.3390/v9120371
FullText URL K0005635_abstract_review.pdf K0005635_summary.pdf K0005635_fulltext.pdf
Author Ikeda, Toru|
Published Date 2017-09-29
Content Type Thesis or Dissertation
Grant Number 甲第5635号
Granted Date 2017-09-29
Thesis Type Doctor of Philosophy in Health Sciences
Grantor 岡山大学
language English
FullText URL K0005619_abstract_review.pdf K0005619_fulltext.pdf
Author Hoang Minh Giang|
Published Date 2017-09-29
Content Type Thesis or Dissertation
Grant Number 甲第5619号
Granted Date 2017-09-29
Thesis Type Doctor of Philosophy in Environmental Science
Grantor 岡山大学
language English
FullText URL K0005618_abstract_review.pdf K0005618_fulltext.pdf
Author ARRIVAL RINCE PUTRI|
Published Date 2017-09-29
Content Type Thesis or Dissertation
Grant Number 甲第5618号
Granted Date 2017-09-29
Thesis Type Doctor of Philosophy
Grantor 岡山大学
language English
FullText URL K0005616_abstract_review.pdf K0005616_fulltext.pdf
Author Nguyen Thanh Binh|
Published Date 2017-09-29
Content Type Thesis or Dissertation
Grant Number 甲第5616号
Granted Date 2017-09-29
Thesis Type Doctor of Philosophy
Grantor 岡山大学
language English
FullText URL K0005608_abstract_review.pdf K0005608_fulltext.pdf
Author MD. SELIM AL MAMUN|
Published Date 2017-09-29
Content Type Thesis or Dissertation
Grant Number 甲第5608号
Granted Date 2017-09-29
Thesis Type Doctor of Philosophy in Engineering
Grantor 岡山大学
language English
FullText URL K0005590_abstract_review.pdf K0005590_summary.pdf K0005590_fulltext.pdf
Author Kikkawa, Akiyoshi|
Published Date 2017-09-29
Content Type Thesis or Dissertation
Grant Number 甲第5590号
Granted Date 2017-09-29
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
FullText URL K0005584_abstract_review.pdf K0005584_summary.pdf K0005584_fulltext.pdf
Author Omichi, Ryotaro|
Published Date 2017-09-29
Content Type Thesis or Dissertation
Grant Number 甲第5584号
Granted Date 2017-09-29
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English