result 338 件
| Author | Kawakami, Shigehisa| Kodama, Naoki| Maeda, Naoto| Sakamoto, Shunichi| Oki, Kazuhiro| Yanagi, Yoshinobu| Asaumi, Jun-Ichi| Maeda, Teruta| Minagi, Shogo| |
|---|---|
| Published Date | 2012-01-15 |
| Publication Title | Journal of Neuroscience Methods |
| Volume | volume203 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kiura, Katsuyuki| Tanimoto, Mitsune| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Sakamoto, Tomoaki| Tomioka, Kenji| |
|---|---|
| Published Date | 2007-06 |
| Publication Title | Zoological Science |
| Volume | volume24 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Shikata, Kenichi| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Sato, Chikage| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/47016 |
|---|---|
| FullText URL | 65_5_335.pdf |
| Author | Sakamoto, Yuichi| Mariya, Yasushi| Oshikiri, Toshiyuki| Sasaki, Sumiko| Segawa, Megumi| Teshiromori, Ryuichi| Ogura, Kazuto| Akagi, Tomoaki| Kaimori, Mitsuomi| Kubo, Kohmei| |
| Abstract | Chronic myeloid leukemia (CML) is caused by the BCR-ABL oncogene. The Philadelphia chromosome (Ph) from a reciprocal translocation, t(9;22) (q34;q11) causes a fusion gene, BCR-ABL, that encodes a constitutively active tyrosine kinase. Treatment of CML by imatinib is effective to control the tyrosyl phosphorylation of the protein related to the cell signaling. BCR-ABL mRNA is overexpressed in the minimal residual disease (MRD), known as an early sign of relapse. Between December 2005 and June 2008, we measured BCR-ABL mRNA levels in the bone marrow (BM) from patients by quantitative real-time polymerase chain reaction (RQ-PCR) in Aomori Prefectural Central Hospital. Eighty-six samples from 26 patients were collected. Among the 26 CML patients, 11 patients (42%) were in the pretreatment group. Seven (64%) of the 11 patients achieved complete molecular response (CMR). In the post-treatment group consisting of the remaining 15 patients, 9 (60%) patients achieved CMR. The patients receiving imatinib at a dose over 300mg per day required 13 (6-77) months [median (range)] to achieve CMR. On the other hand, the patients receiving a dose below 300mg per day required 29.5 (11-84) months [median (range)]. When BCR-ABL mRNA was detected during the treatment course of patients with CMR, careful observation of BCR-ABL mRNA was useful for tracking the clinical course of patients. In conclusion, the BCR-ABL mRNA level was useful for monitoring the clinical course in 26 patients with CML. |
| Keywords | chronic myeloid leukemia (CML) BCR-ABL minimal residual disease (MRD) imatinib mesylate real-time quantitative PCR (RQ-PCR) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 335 |
| End Page | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037271 |
| Web of Science KeyUT | 000296116400008 |
| Author | Sakamoto, Tomoaki| Moriyama, Yoshiyuki| Tomioka, Kenji| |
|---|---|
| Published Date | 2009-03 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume25 |
| Content Type | Others |
| Author | Sakamoto, Yutaka| |
|---|---|
| Published Date | 1931-11-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume43 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Sakamoto, Yutaka| |
|---|---|
| Published Date | 1931-08-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume43 |
| Issue | issue8 |
| Content Type | Journal Article |
| Author | Sakamoto, Yutaka| |
|---|---|
| Published Date | 1932-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume44 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Sakamoto, Yutaka| |
|---|---|
| Published Date | 1933-11-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume45 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Sakamoto, Yutaka| |
|---|---|
| Published Date | 1933-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume45 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Sakamoto, Yutaka| |
|---|---|
| Published Date | 1933-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume45 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Sakamoto, Yutaka| |
|---|---|
| Published Date | 1933-07-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume45 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Sakamoto, Yutaka| |
|---|---|
| Published Date | 1933-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume45 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Kinoshita, Masayuki| |
|---|---|
| Published Date | 1933-01-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume45 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/43828 |
|---|---|
| FullText URL | 65_1_33.pdf |
| Author | Yanagawa, Youichi| Nishi, Kouichirou| Imamura, Tomonori| Sakamoto, Toshihisa| |
| Abstract | Computed tomography (CT) is superior for the detection of substances with low radiolucency in comparison with abdominal roentgenograms. In the present study, medical chart review was retrospectively performed for patients who were admitted and underwent plain CT including the stomach on arrival to investigate whether CT is useful for diagnosing overdose (OD). The subjects were divided into patients with OD who did not undergo gastric lavage (OD group) and those without OD (Control group). The presence of a radiopaque area (Hounsfield number over 100 on a range of interest of 3mm2) in the stomach on CT was defined as a positive finding. The average Glasgow Coma Scale in the OD group (n＝11) was significantly lower than that in the Control group (n＝137). Positive findings on CT were found more frequently in the OD group than in the Control group (100 vs. 19.7%, p＜0.0001). Based on the finding of a high-density deposition in the bottom of the stomach, the CT predicted OD with 98.5% specificity. Accordingly, CT findings of a high-density deposition in the stomach of a patient with a diminished consciousness may suggest the presence of a recent overdose. |
| Keywords | overdose diagnosis CT |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-02 |
| Volume | volume65 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 33 |
| End Page | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21339794 |
| Web of Science KeyUT | 000287620500005 |
| Author | Miyazawa, Kenji| |
|---|---|
| Published Date | 1955-12-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume67 |
| Issue | issue7-12 |
| Content Type | Journal Article |
| Author | Nokihara, S.| |
|---|---|
| Published Date | 1955-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume67 |
| Issue | issue6 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/OER/42417 |
|---|---|
| Title Alternative | Some Observations on the Relations between Central and Local Finance |
| FullText URL | oer_001_2_052_099.pdf |
| Author | Sakamoto, C.| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 1970-02-28 |
| Volume | volume1 |
| Issue | issue2 |
| Start Page | 52 |
| End Page | 99 |
| ISSN | 0386-3069 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002737676 |
