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Immunometabolic Regulation of Innate Immunity in Systemic Lupus Erythematosus
JaLCDOI 10.18926/AMO/68722
FullText URL 79_3_147.pdf
Author Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun|
Abstract Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes.
Keywords systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 147
End Page 155
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
古松崇志著『ユーラシア東方の多極共存時代』
Title Alternative FURUMATSU Takashi Multipolarity in eastern Eurasia
JaLCDOI 10.18926/67964
FullText URL jdc_004_287.pdf
Author WATANABE, Kenya|
Amo Type 書評 (Book Review)
Publication Title Dynamics of Civilizations
Published Date 2025-03-25
Volume volume4
Publisher 岡山大学文明動態学研究所
Start Page 287
End Page 293
ISSN 2436-8326
Content Type Article
language Japanese
Copyright Holders © 2025 by RIDC
File Version publisher
令和５年度岡山医学会賞　総合研究奨励賞（結城賞）
Title Alternative The 2023 Incentive Award of the Okayama Medical Association in General Medical Science (2023 Yuuki Prize)
Author Watanabe, Haruki|
Publication Title Journal of Okayama Medical Association
Published Date 2024-12-02
Volume volume136
Issue issue3
Start Page 91
End Page 93
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.136.91
language Japanese
Copyright Holders Copyright (c) 2024 岡山医学会
File Version publisher
DOI 10.4044/joma.136.91
渡辺信一郎著『中国古代国家論』
Title Alternative WATANABE Shinichiro The study of ancient Chinese state
JaLCDOI 10.18926/66202
FullText URL jdc_003_308.pdf
Author TSUCHIGUCHI, Fuminori|
Amo Type 書評 (Book Review)
Publication Title Dynamics of Civilizations
Published Date 2024-03-25
Volume volume3
Publisher 岡山大学文明動態学研究所
Start Page 308
End Page 314
ISSN 2436-8326
Content Type Article
language Japanese
Copyright Holders © 2024 by RIDC
File Version publisher
Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)
FullText URL fulltext.pdf
Author Hayashi, Keigo| Sada, Ken-Ei| Asano, Yosuke| Katayama, Yu| Ohashi, Keiji| Morishita, Michiko| Miyawaki, Yoshia| Watanabe, Haruki| Katsuyama, Takayuki| Narazaki, Mariko| Matsumoto, Yoshinori| Yajima, Nobuyuki| Yoshimi, Ryusuke| Shimojima, Yasuhiro| Ohno, Shigeru| Kajiyama, Hiroshi| Ichinose, Kunihiro| Sato, Shuzo| Fujiwara, Michio| Wada, Jun|
Published Date 2022-06-29
Publication Title Plos One
Volume volume17
Issue issue6
Publisher Public Library Science
Start Page e0270569
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Hayashi et al.
File Version publisher
PubMed ID 35767524
DOI 10.1371/journal.pone.0270569
Web of Science KeyUT 000892027900189
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0270569
Acute Kidney Injury Caused by Evans Syndrome with Systemic Lupus Erythematosus and Systemic Sclerosis
FullText URL fulltext.pdf
Author Matsuoka, Natsumi| Watanabe, Haruki| Kurooka, Naoko| Kato, Sumari| Higashi, Chika| Tanabe, Katsuyuki| Kinomura, Masaru| Fujii, Nobuharu| Sada, Ken-Ei| Sugiyama, Hitoshi| Wada, Jun|
Keywords acute kidney injury Evans syndrome autoimmune hemolytic anemia
Published Date 2021-04-01
Publication Title Internal Medicine
Volume volume60
Issue issue7
Publisher Japanese Society of Internal Medicine
Start Page 1055
End Page 1060
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33116016
DOI 10.2169/internalmedicine.5976-20
NAID 120007042384
Web of Science KeyUT 000637009100013
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.5976-20
Exploratory classification of clinical phenotypes in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis using cluster analysis
FullText URL fulltext.pdf
Author Watanabe, Haruki| Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Dobashi, Hiroaki| Takasaki, Yoshinari| Fujimoto, Shouichi| Atsumi, Tatsuya| Yamagata, Kunihiro| Homma, Sakae| Arimura, Yoshihiro| Makino, Hirofumi| Research Committee of Intractable Vasculitis Syndrome (JPVAS) & Research Committee of Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan|
Published Date 2021-03-04
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 33664381
DOI 10.1038/s41598-021-84627-6
NAID 120007027577
Web of Science KeyUT 000626140000051
Related Url isVersionOf https://doi.org/10.1038/s41598-021-84627-6
Association of glucocorticoid doses and emotional health in lupus low disease activity state (LLDAS): a cross-sectional study
FullText URL fulltext.pdf
Author Miyawaki, Yoshia| Shimizu, Sayaka| Ogawa, Yusuke| Sada, Ken-Ei| Katayama, Yukitoshi| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Hiramatsu-Asano, Sumie| Ohashi, Keiji| Morishita, Michiko| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Yajima, Nobuyuki| Yoshimi, Ryusuke| Shimojima, Yasuhiro| Ohno, Shigeru| Kajiyama, Hiroshi| Ichinose, Kunihiro| Sato, Shuzo| Fujiwara, Michio| Yamazaki, Hajime| Yamamoto, Yosuke| Wada, Jun| Fukuhara, Shunichi|
Keywords Systemic lupus erythematosus Glucocorticoid Emotional health Patient-reported outcome Depression Anxiety Cross-sectional study
Published Date 2021-03-10
Publication Title Arthritis Research & Therapy
Volume volume23
Issue issue1
Publisher BMC
ISSN 1478-6354
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 33691746
DOI 10.1186/s13075-021-02466-2
NAID 120007019117
Web of Science KeyUT 000627856600002
Related Url isVersionOf https://doi.org/10.1186/s13075-021-02466-2
Granulomatosis with polyangiitis with obstructive pneumonia progressing to hypertrophic pachymeningitis A case report
FullText URL fulltext.pdf
Author Hayashi, Keigo| Watanabe, Haruki| Yamamura, Yuriko| Asano, Yosuke| Katayama, Yukitoshi| Hiramatsu-Asano, Sumie| Ohashi, Keiji| Morishita, Michiko| Narazaki, Mariko| Matsumoto, Yoshinori| Sada, Ken-Ei| Wada, Jun|
Keywords bronchial stenosis granulomatosis with polyangiitis hypertrophic pachymeningitis rituximab
Published Date 2021-01-22
Publication Title Medicine
Volume volume100
Issue issue3
Publisher Lippincott, Williams & Wilkins
Start Page e24028
ISSN 0025-7974
NCID AA00728867
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 the Author(s).
File Version publisher
PubMed ID 33546000
DOI 10.1097/MD.0000000000024028
Web of Science KeyUT 000612835100080
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000024028
Minimally Invasive Spinal Stabilization with Denosumab before Total Spondylectomy for a Collapsing Lower Lumbar Spinal Giant Cell Tumor
JaLCDOI 10.18926/AMO/61442
FullText URL 75_1_95.pdf
Author Minato, Keitaro| Hirano, Toru| Kawashima, Hiroyuki| Yamagishi, Tetsuro| Watanabe, Keigo| Ohashi, Masayuki| Ogose, Akira| Endo, Naoto|
Abstract A 21-year-old man consulted our hospital for treatment of a spinal giant cell tumor (GCT) of Enneking stage III. Lower lumbar-spine tumors and severe spinal canal stenosis are associated with high risk for surgical mor-bidity. Stability was temporarily secured with a percutaneous pedicle screw fixation in combination with deno-sumab, which shrank the tumor. Total en bloc spondylectomy was then performed 6 months after initiation of denosumab, and the patient was followed for 3 years. There was no local recurrence, and bony fusion was obtained. Minimally invasive surgery and denosumab allowed safer and easier treatment of a collapsing lower lumbar extra-compartmental GCT.
Keywords spinal stabilization denosumab spondylectomy giant cell tumor
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-02
Volume volume75
Issue issue1
Publisher Okayama University Medical School
Start Page 95
End Page 101
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33649620
Risk of higher dose methotrexate for renal impairment in patients with rheumatoid arthritis
FullText URL fulltext.pdf
Author Hayashi, Keigo| Sada, Ken-Ei| Asano, Yosuke| Hiramatsu Asano, Sumie| Yamamura, Yuriko| Ohashi, Keiji| Morishita, Michiko| Watanabe, Haruki| Narazaki, Mariko| Matsumoto, Yoshinori| Wada, Jun|
Keywords Nephrology Rheumatology
Published Date 2020-10-30
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 18715
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 33127957
DOI 10.1038/s41598-020-75655-9
Web of Science KeyUT 000591916900014
Related Url isVersionOf https://doi.org/10.1038/s41598-020-75655-9
譬喩の要因――万葉集第八・一五〇〇番歌について――
JaLCDOI 10.18926/okadaironkou/60494
FullText URL okadaironkou_14_1_9.pdf
Author 渡辺 護|
Publication Title 岡大国文論稿
Published Date 1986-03-31
Issue issue14
Start Page 1
End Page 9
ISSN 0386-3123
language Japanese
File Version publisher
万葉集の一回的素材
JaLCDOI 10.18926/okadaironkou/60379
FullText URL okadaironkou_19_8_16.pdf
Author 渡辺 護|
Publication Title 岡大国文論稿
Published Date 1991-03-31
Issue issue19
Start Page 8
End Page 16
ISSN 0386-3123
language Japanese
File Version publisher
紫式部３２－３５番歌についての考察――「文散らし」をめぐって――
JaLCDOI 10.18926/okadaironkou/60266
FullText URL okadaironkou_23_13_22.pdf
Author 渡辺 健|
Publication Title 岡大国文論稿
Published Date 1995-03-31
Issue issue23
Start Page 13
End Page 22
ISSN 0386-3123
language Japanese
File Version publisher
後鳥羽院の『遠島御歌合』「忍恋」題歌について
JaLCDOI 10.18926/okadaironkou/60169
FullText URL okadaironkou_30_82_91.pdf
Author 渡辺 健|
Publication Title 岡大国文論稿
Published Date 2002-03-31
Issue issue30
Start Page 82
End Page 91
ISSN 0386-3123
language Japanese
File Version publisher
NAID 40005486303
後鳥羽院『千五百番歌合』判歌の最終歌について
JaLCDOI 10.18926/okadaironkou/60084
FullText URL okadaironkou_35_24_35.pdf
Author 渡辺 健|
Publication Title 岡大国文論稿
Published Date 2007-03-31
Issue issue35
Start Page 24
End Page 35
ISSN 0386-3123
language Japanese
File Version publisher
NAID 40015533146
後鳥羽院の『千五百番歌合』百首歌について―同時代歌人からの影響を中心に―
JaLCDOI 10.18926/okadaironkou/60055
FullText URL okadaironkou_38_28_41.pdf
Author 渡辺 健|
Publication Title 岡大国文論稿
Published Date 2010-03-31
Issue issue38
Start Page 28
End Page 41
ISSN 0386-3123
language Japanese
File Version publisher
NAID 40017183206
後鳥羽院の『千五百番歌合』百首歌について　続考―同時代歌人からの摂取の意図―
JaLCDOI 10.18926/okadaironkou/60050
FullText URL okadaironkou_39_70_82.pdf
Author 渡辺 健|
Publication Title 岡大国文論稿
Published Date 2011-03-31
Issue issue39
Start Page 70
End Page 82
ISSN 0386-3123
language Japanese
File Version publisher
NAID 40018898655
後鳥羽院の『千五百番歌合』秋二・秋三判歌について　補遺―その制作時期・意図と建久期速詠歌からの影響―
JaLCDOI 10.18926/okadaironkou/60034
FullText URL okadaironkou_41_1_14.pdf
Author 渡辺 健|
Publication Title 岡大国文論稿
Published Date 2013-03-31
Issue issue41
Start Page 1
End Page 14
ISSN 0386-3123
language Japanese
File Version publisher
NAID 40019753066
後鳥羽院の『千五百番歌合』秋二・秋三判歌について―その秀句志向と藤原定家からの影響―
JaLCDOI 10.18926/okadaironkou/60028
FullText URL okadaironkou_42_15_27.pdf
Author 渡辺 健|
Publication Title 岡大国文論稿
Published Date 2014-03-31
Issue issue42
Start Page 15
End Page 27
ISSN 0386-3123
language Japanese
File Version publisher
NAID 40020144373
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