result 942 件
| JaLCDOI | 10.18926/40264 |
|---|---|
| Title Alternative | Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 1 The Effect of Radioactive Thermal Bath upon Serum Cholesterol Levels |
| FullText URL | 022_001_036.pdf |
| Author | Matsumoto, Kinshi| |
| Abstract | The author investigated the effect of radioactive hot spring bath on serum cholesterol levels. The chemical compositions of the spring waters used are described in Table I. As experimental subjects healthy men and healthy white rabbits were used. The following results were obtained. 1) Single bath. The total and ester cholesterol levels in the serum were measured by a modification of Bloor's method before and 1/2, 1, 2 and 3 hours after the radioactive thermal bath (41-43°C., for 5 minutes). The concentration of total and ester cholesterol had decreased following radioactive thermal baths (Hisui-no-Yu and Kenkyusho-Sen), and remained at a decreased level for l/2 to 2 hours, but tended to return to normalcy within three hours from the time of the bath. (Fig. 2, 3, 4, 5.) The plain-water bath and vapour bath used as a control (41-43°C., for 5 minutes and 44-47°C. for 10-20 minutes respectively), had no significant effect on the blood cholesterol levels (Fig. 7 and 8). 2) Series of baths. The author examined weekly for 4 weeks the changes in serum cholesterol in healthy subjects following "a series of baths" in radioactive hot springs. The total and ester cholesterol levels of the serum decreased during the first and second weeks and tended to return to the initial levels during the third and fourth weeks (Fig. 11). The total cholesterol levels of the serum in rabbits following "a series of baths" in KenkyushoSen (Rn-content; 10-40 Mache) increased during the second week, but the cholesterol levels of the serum, after bathing in Hisui-no-Yu (Rn-content: 300-400 Mache), tended to decrease during the first and second weeks (Fig. 9 and 10). From this experiment, it is concluded that the content of radon in hot spring water affects the concentrations of the serum cholesterol levels. 3) Following an intramuscular injection of A. C. T. H. or Cortisone, the concentrations of total cholesterol and ester cholesterol had decreased and remained at the low level for 4 hours (Fig. 12. 13, 14 and 15). 4) It is said that the reticulo-endotherial system plays an important part in cholesterol metabolism. The author injectt 5 ml. of 1% Indian ink into the aureal vein of the rabbits for the purpose of blocking the reticulo-endotherial system. These procedures were carried out once a day for 7 successive days. The total cholesterol levels of the serum in the bathed group (bathing in Kenkyusho-sen once a day for 4 weeks, 43°C., 5 minntes) were lower than those of the control (Fig. 16). From these findings, the author thinks that the fall in the serum cholesterol levels following Misasa Hot spring bathing is due to the synthetic action of many factors such as the acceleration of oxydation in the living body, and the hyperfunction of liver cells, of hypophysealadrenocortical, of reticulo-endotherial systems and of various endocrine glands, caused by radioactive thermal bathing. Alternation of vegetative nervous system and various vitamine metabolism also take part in this phenomenon. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1958-07 |
| Volume | volume22 |
| Start Page | 1 |
| End Page | 36 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40263 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532360 |
| Author | 岡山大学温泉研究所| |
|---|---|
| Published Date | 1958-07 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume22 |
| Content Type | Others |
| Author | 岡山大学温泉研究所| |
|---|---|
| Published Date | 1958-07 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume22 |
| Content Type | Others |
| JaLCDOI | 10.18926/40261 |
|---|---|
| Title Alternative | Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 3. Therapeutic Effects of Radioactive Thermal Bath on Hypercholesterolemia and Atherosclerosis |
| Author | Matsumoto, Kinshi| |
| Abstract | The author investigated the changes of serum cholesterol levels and the histological findings of aorta of the cholesterol-fed rabbits, and the changes of serum cholesterol levels of the patients with hypertension following the radioactive hot spring bathing. The following results were obtained: 1) When 0.2 g. of cholesterol per Kg. of bodyweight was given to rabbits one time, the rise of the concentrations of serum cholesterol in the bathing group was lower and the recovery to the initial levels in the same group was faster than in the case of control (Table 1, Fig. 1.). 2) The author gave the rabbits 0.15 g. of cholesteterol per Kg. of bodyweight daily for 4 weeks. In this experiment, these rabbits were divided into 4 groups at follows. Group 1 Rabbits of this group were not bathed (as control). Group 2 Rabbits of this group were bathed in plain water (43°±1°C. 10 minutes) daily for 4 weeks. Group 3 Rabbits of this group were bathed in the radioactive Kenkyu-sho-sen (Rn-content: 10-40 Mache) in the same way as group 2. Group 4 Rabbits of this group were bathed in the radioactive Hisui-no-Yu (Rncontent: 300-400 Mache) in the same way as group 2. The concentrations of the serum cholesterol of the groups of radioactive thermal bathing remained lower than the control group. The concentrations of the serum cholesterol of group 4 were the lowest of all (Table 2 and Fig. 2). 3) In radioactive bathing groups, the atherosclerotic changes of aorta of the cholesterol-fed rabbits were slighter than the control (Table 3 and Fig, 3). 4) Following a series of radioactive hot spring baths, the total and ester cholesterol levels in serum of the patients with hypertension decreased during the first and the second weeks and tended to return to the initial levels during the third and the fourth weeks (Table 4 and Fig. 4). 5) The author gave the rabbits 0.4 g, of cholesterol per Kg. of bodyweight and, 2 hours after this procedure, injected 5 mI. of 1% Indian ink into the aureal vein of the rabbit for the purpose of blocking the reticulo-endothelial system. These procedures were carried out once a day for 3 successive days. The serum total and ester cholesterol levels in the bathed group (bathing in Hisui-no-Yu once a day for 15 days, 42±1°C, 5 minutes) were lower those of the control and returned to initial levels more rapidly than the control (Table 5 and Fig. 5). |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1958-10 |
| Volume | volume23 |
| Start Page | 38 |
| End Page | 58 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40258 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532363 |
| JaLCDOI | 10.18926/40260 |
|---|---|
| Title Alternative | Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 2. The Effect of Radioactive Thermal Bath upon Organ Cholesterol Levels |
| FullText URL | pitsr_023_023_037.pdf |
| Author | Matsumoto, Kinshi| |
| Abstract | The author investigated the effect of radioactive hot spring bath on various organ cholesterol levels. As experimental subjects white male rat weighing ca. 150 g. were used. The total cholesterol of the lungs, liver, heart, kidneys and brain, and the total and ester cholesterol of the adrenals were measured by a modification of Bloor's method. The following results were obtained: 1) Single bath: The concentration of the total cholesterol of these organs and the ester cholesterol of adrenals decreased for two hours after a radioactive "Hisui-no-Yu" bath, but such decrease was recognised only in the heart, brain, adrenals after a weak radioactive "Kenkyusho-sen". 2) A series of baths: The concentration of the total cholesterol of the lungs, heart, brain, adrenals and the ester cholesterol of adrenals decreased after a series of "Hisui-no-Yu" baths for 4 weeks. 3) A series of baths in cholesterol fed rats: The concentration of the total cholesterol of the above mentioned organs and the ester cholesterol of the adrenals in the bathing group remained decreased during the experiment comparing with the control group. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1958-10 |
| Volume | volume23 |
| Start Page | 23 |
| End Page | 37 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462892 |
| JaLCDOI | 10.18926/40259 |
|---|---|
| Title Alternative | Study of Togo -Matsuzaki Hot Springs, Tottori Prefecture |
| FullText URL | pitsr_023_001_022.pdf |
| Author | Umemoto, Shunji| Harada, Mitsuru| Okabe, Shigeru| Miyakoshi, Junichiro| Sakanoue, Masanobu| Tanaka, Masaya| Mifune Masaaki| |
| Abstract | 1. Layers containing thermal water in this district are thin, and lie at different depths (about 35, 55, and 60 meters) from the ground surface. There are evidences to show that these layers are intimately connected with one another. 2. The authors may suppose the existence of a structurally weak zone, along the line from Matsuzaki to Asozu, within which the issuing spots of thermal springs are located. 3. The head water levels of the thermal springs in this district are closely related with that of Lake Togo. Keeping pace with the variations of the water levels of Lake Togo and of artesian wells in its vicinity, the rate of flow of thermal springs vary; and the correlation between these variations is apparent. 4. The pumping suction of thermal water at one spring affects the flow of water at other springs within distances of 150 to 200 meters therefrom, though the direct sources of thermal water supply for the latter springs may be different from that of the former. 5. The spring water in this district is considered to be a mixture of hot water, containing sodium, calcium, chloride, and sulfate ions, and cold water, containing bicarbonate ion. The diversity of chemical constitutions of different spring waters is explained as due to the difference in proportion in which the hot and cold waters are mixed. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1958-10 |
| Volume | volume23 |
| Start Page | 1 |
| End Page | 22 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462891 |
| Author | 岡山大学温泉研究所| |
|---|---|
| Published Date | 1958-10 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume23 |
| Content Type | Others |
| Author | 岡山大学温泉研究所| |
|---|---|
| Published Date | 1958-10 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume23 |
| Content Type | Others |
| JaLCDOI | 10.18926/40256 |
|---|---|
| Title Alternative | A Case of Gastric Polip |
| FullText URL | 024_096_103.pdf |
| Author | Matsumoto, Kinshi| Wakutani, Tohaku| Izumi, Tomokuni| |
| Abstract | We examine patients seeking for spa treatment about erythrocyte sedimentation rate, Takata's reaction, blood picture, gastric juice, urinalysis and so on on their admittion and then repeat these tests once weekly to investigate the reaction of bathing in radioactive hot spring. A 65-year-old patient showed achylia gastrica every time in the test, but he complained no gastric symptom. On x-ray examination we found gastric polyp and verified this on operation. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-01 |
| Volume | volume24 |
| Start Page | 96 |
| End Page | 103 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532365 |
| JaLCDOI | 10.18926/40255 |
|---|---|
| Title Alternative | A Case of Agammaglobulinemia |
| FullText URL | 024_087_095.pdf |
| Author | Matsumoto, Kinshi| Wakutani, Tohaku| |
| Abstract | A case of agammaglobulinemia, probably of the secondary type, is reported in adult female (45-year-old) with tumor of the mediastinum. The authors described the bibliographical consideration and arose the attention of agammaglobulinemia. Reports on agammaglobulinemia may increase in practise if electrophoresis of the serum protein-fraction is used as a routine examination method. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-01 |
| Volume | volume24 |
| Start Page | 87 |
| End Page | 95 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532364 |
| JaLCDOI | 10.18926/40254 |
|---|---|
| Title Alternative | General Survey of the Spa Treatment at Misasa Spa, Tottori Prefecture |
| FullText URL | pitsr_024_080_086.pdf |
| Author | Wakutani, Tohaku| Matsumoto, Kinshi| Yamamoto, Yasuhisa| |
| Abstract | Misasa Hot Spring is one of the most famous radioactiye hot springs in Japan. A general survey of the spa treatment at Misasa Spa was carried out in Feburary, 1957. The informations we have gathered may be summarized as follows: 1). The number of the spa visitors seeking for curative treatment was almost equally divided between men and women and the majority of the spa visitors was over 50 years old. 2). 65% of the spa visitors came to this hot spring with the specific purpose of balneotherapy. 19.3% came for rest, 13.3% for the purpose of after-care. 3). Those who visited Misasa Spa for the first time were 44.7%, the rest being those who visited this spa over 2 times. 18.3% of them had consultation with or were under the direction of a physician. 4). The length of time they stay at this spa for curative treatment: 41.6% of the spa visitors stay for 8～14 days, 17.9% of them 15～20 days and 31% of them over three weeks. 5). About 74% of the spa visitors bathe 3 to 5 times a day for curative treatment, and 82% of them drink hot spring water. 6). Symptoms of bathing reaction such as generalised fatigue, constipation, loss of appetite, joint pain, abdominal pain and so on were observed in 50% of the spa visitors. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-01 |
| Volume | volume24 |
| Start Page | 80 |
| End Page | 86 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462890 |
| JaLCDOI | 10.18926/40253 |
|---|---|
| Title Alternative | Studies on Paper-analysis in the Field of Balneology. (3) The Changes of the Serum Protein Fractions and Lipoprotein Fractions Following the Bathing in Radioactive Hot Spring |
| FullText URL | 024_054_079.pdf |
| Author | Ishibashi, Maruo| |
| Abstract | I. Some fundamental conditions and procedures on filter-paper electrophoresis were investigated. The electrophoretic apparatus of Natsume Seisakusho and Toyo No. 51 filter-paper were used. Electrophoresis was carried out under the current of 0.25 mA/cm. in 300 Volt during 5 hours, using veronal buffer pH 8.6 (μ=0.05). In measuring of serum protein fractions, the adequate volume of the materials loaded is in the range of 0.005～0.01 ml. and in the case of lipoprotein, 0.02 ml. of serum is used. Paper-strip was stained with bromophenol blue or sudan black B, then making it transparent with heat-solved paraffin and photometered by Nataume's densitometer. The reproducibility of the above-mentioned method with a confidence of 99% was as follows: Serum protein fractions Albumin 53.4±1.8% α(1)-Globulin 3.3±0.3 α(2)-Globulin 6.0±0.5 β-Globulin 12.2±0.7 γ-Globulin 25.1±1.1 Serum lipoprotein fractions α 20.6±2.6% β+γ 79.4±2.6 II. Changes in serum protein fractions and lipoprotein fractions following the radioactive hot spring bathing were as follows: 1). In rabbits, the albumin-fraction of serum protein increased after a series of baths in radioactive hot spring, and the β- and γ-globulin-fractions decreased. 2). By cholesterol-feeding, the albumin-fraction of serum protein of rabbits decreased and the β- and γ-globulin-fractions increased significantly but when a series of baths was carried out in cholesterol-fed rabbits the decrease in the albumin-fraction was slighter than the former. 3). α-globulin-fraction of serum lipoprotein increased after single bathing in radioactive hot spring and (β+γ) -globulin-fractions showed an inverse change, but the changes of lipoprotein-fractions following a series of baths were not remarkable. 4). By cholesterol-feeding, the ratio of lipoprotein-fractions (β+γ/α) increased, but the ratio tended to decrease following a series of baths in radioactive hot spring. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-01 |
| Volume | volume24 |
| Start Page | 54 |
| End Page | 79 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40250 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532366 |
| JaLCDOI | 10.18926/40252 |
|---|---|
| Title Alternative | Studies on Paper-analysis in the Field of Balneology. (II) 1. A New Method for the Determination of Cobalt in Blood. 2. Effects of Radioactive Thermal Bathing and Internal Use of Vitriol Water upon Cobalt Levels in Blood. |
| FullText URL | 024_029_053.pdf |
| Author | Ishibashi, Maruo| |
| Abstract | 1. A new method for the determination of cobalt in blood. The author proposed a new method for the determination of cobalt in blood by means of paper-chromatography. The procedure is follows. In a Kjeldahl colben, 5 m!. of blood is taken, and turned into wet ash with 3 ml. of HNO(3), 0.5 ml. of H(2)SO(4) and 1.5 ml. of HClO(4) and the ash aqueus solution is then neutralized with ammonium hydroxid, the neutralization being indicated by the development of color of 0.1% of p-nitrophenol (one drop) added to the solution. After addition of 2 ml. of 40% ammonium citrate, 0.5 ml. of 20% Na(2)S(2)O(3), 3～5 drops of H(2)O(2) and 1 ml. of o-nitrosoresorcine monomethyl ether (hereafter N.R.M.E.), the mixture is left for at least 15 minutes and the aqueus solution is taken in a stoppered test tube (inside diameter: 1.3 cm., hight: 16.5 cm.). The mixture is shaken with 2 ml. of carbon tetrachloride. Carbon tetrachloride is shaken with 5 ml. of 20% Na(2)CO(3) solution. Then the excess of N.R.M.E. is removed and carbon tetrachloride is concentrated on water bath to 0.3～0.5 ml. and all CCl(4) is used for a determination sample. The sample is placed on the paper (Toyo-filter paper No. 50 or 51A) in a thin line at a distance of 3 cm. from the edge, and the spot is developed with a mixture of 20 ml. of CCl(4) and 1 ml. of 90% ethylalcohoI. After development for 30～40 min., an orange-colored linear spot appears at a distance of 9～10 em. from the origin point. Spot intensity is measured at 460 mμ with Natsume's densitometer and quantitative estimation is made comparing with the standard graph. 2. Effects of radioactive thermal spring bathing and internal use of vitriol water upon cobalt levels in blood. As the author's method above-mentioned is able to determine the cobalt level in a small amount of blood, it is very convenient in investigating cobalt metabolism in the field of balneology. The author examined the changes of cobalt levels in blood after radioactive thermal bathing as well as after internal use of acid vitriol water. a. By the author's method cobalt in normal human blood was 0.4～3.6γ/100ml. in man (average: 1.6±0.4γ/100ml.) and 0.2～2.2γ/100ml. in woman (average: 0.7±0.3γ/100ml.). b. The cobalt levels in blood were measured by the author's method before and 5, 30, 60 minutes after the radioactive thermal single bathing, and before and 1, 2, 3, 4 weeks after a series of radioactive thermal baths (Rn-content: 10～30 Mache, 42～3°C., for 10 minutes). The cobalt levels in the blood of healthy subjects showed no significant change after the thermal single bathing, but those of patients with rheumatoid arthritis showed a slight increase on 3rd or 7th day and a fall on 2nd week of a series of radioactive thermal baths and then tended to return to the initial levels during the 3rd and 4th weeks of spa treatment. c. Thirty ml. of Yanahara mineral water (an acid vitriol water, pH: 2.2) was diluted with plain water to 200 ml. (Co(++)content: ca.3γ) and administered to healthy fasting subjects orally. Blood samples were taken from the cubital vein before and 1, 3, 6 hours after the intake of the vitriol water. The cobalt levels in the blood showed an increase of 14% of the initial levels at 1 and 3 hours and a decrease of 22% at 6 hours after the drinking of Yanahara mineral water. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-01 |
| Volume | volume24 |
| Start Page | 29 |
| End Page | 53 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40250 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532366 |
| JaLCDOI | 10.18926/40251 |
|---|---|
| Title Alternative | Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 4 Therapeutic Effects of Radioactive Thermal Bath on Blood pressure |
| FullText URL | 024_001_028.pdf |
| Author | Matsumoto, Kinshi| |
| Abstract | 1) The effects of a single bath in the radioactive hot spring on the blood pressure and the pulse rate. The author observed the changes of the blood pressure and the pulse rate of subjects bathing for 20 minutes, 39°± 1°C, in temperature, in the radioactive hot spring in Misasa. It may be summerized as follows (Table 2, Fig. 1). a. In the hypertensive group (maximal blood pressure······181 mm. Hg. and over), the maximal blood pressure had decreased immediately after bathing, and remained at this level even 2 hours after bathing. The minimal blood pressure reacted in the same manner as the maximal blood pressure. b. The moderate hypertensive group (maximal blood pressure······180-161 mm. Hg.). In a few instances, the maximal blood pressure had increased immediately after bathing, but decreased within 30-90 minutes after bathing. Changes in the minimal blood pressure were not so remarkable. c. In the normal group (maximal blood pressure······160～101 mm. Hg.), the maximal blood pressure had lowered within 30-90 minutes after the radioactive hot spring bathing. The minimal blood pressure showed no significant changes. b. The pulse rate had increased immediately after bathing in all groups, but within 30 minntes had returned to the initial rate and there were no further changes for 2 hours (Table 2, Fig. 2). 2) The effects of a radioactive vapour bath on the blood pressure and the pulse rate. After a bathing in vapour bath (10～15 minutes), the maximal and the minimal blood pressure showed mild decrease for 2 hours. The changes of the pulse rate and the pulse amplitude were not so remarkable (Table 3, Fig. 3). 3) The effects of a series of baths in the radioactive spring on the blood pressure. The author observed the changes in the blood pressure of the subjects bathed 2 or 3 times daily in the radioactive hot spring in Misasa, at a temperature of 42～43°C., 5～10 minutes. The blood pressure of subjects was measured once a day (at 7 a.m.) for the first week, and subsequently once weekly for two additional weeks. Subjects with an initial maximal blood pressure over 160 mm. Hg. showed a fall on the second day of the spa treatment followed by a temporary rise on the 3rd or 4th day, after which the pressure fell to the 2nd day level again, and then remained fairly constant to the end of the observation period. Subjects with an initial blood pressure under 159 mm. Hg. also showed a fall in the course of the spa treatment, but the degree of the fall was slighter than that of the former (Table 4, Fig. 4). This tendency was also observed on the out-patients (Table 5, Fig. 5). The changes of the blood pressure and pulse rate of subjects after a bath for 20 minutes, in water 39±1°C. in temperature, on the first day of the spa therapy were compared with those occuring on the 6th or 7th day, and it was observed that the patterns of the changes in blood pressure following bathing on the two days were significantly different (i.e. on the latter, so called "the initial blood pressure increase following the bathing" was not observed) (Table 6,7,8, Fig.6,7,8,9,). 4) The remote investigation on the spa visitors with hypertension and/or arteriosclerosis. The author investigated the course of patients with hypertension and/or arteriosclerosis who received the spa treatment at Misasa after returned to home. The incidence of subjects who answered as being good was 86%, and it was observed the fall of the maximal and the minimal blood pressure, especially the fall was remakable in subjects who stayed at spa about 4 weeks (Table 10, 11, 12, 13, 14, 15, Fig. 10). 5) The incidence of hypertension among the residents in the spa resort and those residing in other places. The author measured the blood presssre of the out-patients of his institute over 41 years of age from June, 1956 to May, 1957. The incidence of patients with the maximal blood pressure over 160 mm. Hg. was 16.4% in spa resort, and 25.7% in places where there are no hot springs. Using x(2)-test, the difference between the two was recognised as being significant (Table 16, 18). 6) Comparison of the mortality rate of patients with hypertension between residents in the spa resort and those residing in other places. The author examined the mortality rate of persons with hypertension in the area under the jurisdiction of the Kurayoshi Sanitary Institute, Tottori prefecture, from 1954 to 1956. The rate of mortality in the spa resort was 17.5% as compared to 21.4% in other places (Table17). |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-01 |
| Volume | volume24 |
| Start Page | 1 |
| End Page | 28 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40250 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532368 |
| Author | Institute for Thermal Spring Research, Okayama University| |
|---|---|
| Published Date | 1959-01 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume24 |
| Content Type | Others |
| Author | 岡山大学温泉研究所| |
|---|---|
| Published Date | 1959-01 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume24 |
| Content Type | Others |
| JaLCDOI | 10.18926/40248 |
|---|---|
| Title Alternative | Clinical Studies on Anemia in Rheumatoid Arthritis |
| FullText URL | pitsr_025_053_069.pdf |
| Author | Yamamoto, Yasuhisa| |
| Abstract | Anemia of moderate severity is commonly present in patients suffering from rheumatoid arthritis, but one to which little attention has been paid and despite its frequency the exact mechanism of its production is uncertain. Anemia in rheumatoid arthritis is refractory to anti-anemic therapy. The presence of anemia may hinder adequate physical or orthopedic treatment and may produce a degree of lassitude that considerably aggravates the joint disability. This anemia, therefore, seemed worthy of study and investigations of three aspects are reported here: 1. Changes in peripheral blood, bone marrow, liver function and gastric acidity. 2. Alternations in iron metabolism. 3. Balneotherapy and anemia in rheumatoid arthritis. I. Peripheral Blood Picture, Liver Function, Serum Protein Fraction and Gastric Acidity. 1. The peripheral blood and bone marrow. The number of erythrocytes is 558～216×10(4)/c. mm. (average:402×10(4)/c. mm.), hemoglobin-content:110～40% (average: 78.6%), and the color index is about 1.0. The anemia of rheumatoid arthritis treated is mostly normochromic. The white blood cell count is between 11200 and 3720/c. mm. (average: 7504/c. mm.), and the number of leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed 27% of the cases. Films of the sternal marrow showed no major abnormality in the eight cases examined. Several minor points, however, deserve mention. The nucleated cell count was diminished in seven cases examined, and the decrease of normoblasts in bone marrow would explain the reduced red cell count in peripheral blood. The myeloid series showed a relative increase. 2. Liver function tests and gastric acidity. To illustrate the possible appearance of liver function disturbances in connection with rheumatoid arthritis, the author has made different liver function tests on patients suffering from this disease. From the results it appears that in protein metabolism tests more than 83% of the cases gave abnormal albumin/globulin ratios and Takata's and erthrocyte sedimentation reactions. The detoxication capacity determined by hippuric acid synthesis tests had decreased in 25% of the cases examined. The dye excreting capacity, determined by the bromsulfalein tolerance test, was found to be reduced in 64% of the cases examined. The urin-urobilinogen test showed positive in 28% of the cases. In all cases the insulin sensitivity test gave pathological readings. Of 40 cases examined, anacidity of gastric juice was observed in 17 cases, subacidity in other 10 cases and normacidity, hyperacidity in remammg 13 cases. Thus, a decrease in the gastric acidity was found to occur in 67.5% of the cases. 3. Serum protein fraction. The total serum protein of 31 cases with rheumatoid arthritis appeared to be on the same level as in normal material. Serum protein fraction was determined in 19 cases by paperelectrophoresis. In rheumatoid patients, albumin fraction of serum protein decreased and γ-globulin fraction increased in all cases examined, compared with the data of normal subject as a control. Alubumin/globulin ratio of rheumatoid arthritis was below the 5% rejection limit of normal value. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-05 |
| Volume | volume25 |
| Start Page | 53 |
| End Page | 69 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40244 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462889 |
| JaLCDOI | 10.18926/40247 |
|---|---|
| Title Alternative | Studies on the Influences of Balneal Treatment on Female Sexual Function |
| FullText URL | pitsr_025_025_052.pdf |
| Author | Hasegawa, Yasumasa| |
| Abstract | In the present study, observations of changes on female sexual function by balneal treatment were carried out with female rats with respects to sexual cycle, histological changes in ovary and uterus, histo-chemical changes in pituitary, cholinesterase activity in brain, cholesterol levels in ovary, etc. The results obtained were as follows. 1) Significant changes of sexual cycle appeared in 47 (62%) out of the 76 rats which were treated with several kinds of artificial balneal water at the temperature of 42°C (for 5 minutes per single course of the balneal treatment, twice daily during 4 weeks). Similar changes of sexual cycle also appeared in the subjects which were treated with the same kinds of balneal water at 37°C, though having showed to be less than the changes in case of the balneal treatment at 42°C. 2) A significant tendency of regulating sexual cycle of rat to normal was demonstrated in the subjects which were treated with artificial balneal sulfer, and on the other hand, a significant tendency of disturbing the cycle was demonstrated in the sUbjects which were treated with artificial balneal acid and alkali. 3) A tendency of extending the period of dioesterus phase in sexual cycle of rat was found in the subjects which were treated with our laboratory' balneal water at 42°C for 10 minutes per single course four times daily during 10 days. In these subjects, it was also demonstrated that the period of the estrus phase tended to be prolonged. 4) Histological pictures in ovary and uterus indicated normal growth in the subjects of which the sexual cycles were normalized by balneal treatment, whereas indicated an atrophy in the subjects of which the cycles were disturbed. Significant atrophy tended to appear remarkably in the subjects which developed some irregular cycles due to the treatment with artificial balneal acid or alkali. In view point of the daily changes in these tissues, it was demonstrated that atrophic changes appeared at the 10th day after onset of the treatment with a balneal water at 42°C for 5 minutes per single course or with a balneal water at 37°C for 5 minutes, and then turned to normal pictures at the 20th day after onset of the treatment. It was also indicated that remarkable atrophic changes in ovary and uterus appeared immediately after 10 days treatment with a balneal water at 42°C for 10 minutes per single course four times daily, and then turned to show a slight hyperfunction in the ovary at the 10th day after discontinuation of this balneal treatment. 5) A certain correlation was found between cholinesterase activity in the brain of rat and counts of PAS positive cells in the anterior pituitary (on the sexual zone named by Purves, H. D and W. E. Griesbach). Both the activity and the counts decreased at the 10th day after onset of the balneal treatment at the temperature of 42°C for 5 minutes per single course twice daily, and then increased at the 20th day after onset of this treatment. It was also demonstrated that both the activity and the counts decreased significantly at the 10th day after onset of the balneal treatment at 42°C for 10 minutes per single course four times daily, and then increased remarkably at the 10th day after discontinuation of this treatment. 6) A negative correlation was demonstrated between changes of cholesterol levels in ovary and those of cholinesterase activity in brain. Both the levels and the activity increased transitorily at the 10th day after the balneal treatment at 42°C for 5 minutes per single course, and then decreased at the 20th day after onset of the treatment. It was also demonstrated that both the activity and the levels increased at the 10th day after onset of the treatment at 42°C for 10 minutes per single course four times daily, and then decreased after discontinuation of this treatment. From the results mentioned above the following deduction may be drawn: (a) Sexual function is affected apparently by balneal treatment; (b) As to the mode of action of balneal water on sexual function, it is likely that balneal water acts extensively on autonomic nervous system, followed by producing changes in sexual function. In the other words, it seems that balneal water primarily affects on upper central nervous system, i. e. diencephalo-hypophyseo-system, and secondarily produces changes in sexual gland; (c) It was also demonstrated that though a transitory depression in sexual function appeared individually in some subjects which were treated with extensive stimulative balneal water or over time of balneal treatment, but in even the same subjects hyperfunction often appeared after discontinuation of such a treatment. These evidence should be taken into consideration in case of clinical balneotherapy; (d) In view point that the balneotherapy produces changes in sexual function through acting on central nervous system, it may be suggested that balneotherapy with conventional hormon therapy could produce the most desirous effect for the treatment of fertility and insufficiency of sexual function. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-05 |
| Volume | volume25 |
| Start Page | 25 |
| End Page | 52 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462888 |
| JaLCDOI | 10.18926/40246 |
|---|---|
| Title Alternative | Studies on the Chemical Composition and Levels of Ground Water at Misasa Hot Springs |
| FullText URL | 025_013_024.pdf |
| Author | Sakanoue, Masanobu| |
| Abstract | The water levels of the thermal springs and the ground water levels were measured and the contour of the water table was obtained. The contour was disturbed at two regions in which many springs issue. The thermal and ground waters were sampled all over the springs district, and the water temperatures were measured when they were sampled. The chloride, bicarbonate, sulfate, calcium and magnesium content was also determined. In addition, the analytical methods for the determination of arsenic, phosphorus and acid-soluble iron were improved. Also the concentration of these elements was determined. Based on the results of the observations and chemical analysis, the relations between the water temperatures and content of chemical constituent and the chloride content were checked respectively. Positive correlations were found in the relations between water temperature～Cl(-), HCO(3)(-)～Cl(-), SO(4)(2-)～Cl(-), Ca(2+)～Cl(-), and As～Cl(-). Furthermore, the regional differences were detectable in the ratios of water temperature to chloride content and of bicarbonate to chloride content, nevertheless the correlation as a whole were valid. The diversity and regional differences of the chemical composition of the waters were explained as due to the differences in the mixing proportion of the magmatic thermal water and the varying kinds of ground water at the deep site in the ground and at the site near the ground surfaces. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-05 |
| Volume | volume25 |
| Start Page | 13 |
| End Page | 24 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40244 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/40245 |
|---|---|
| Title Alternative | Granites in the Neighbourhood of Misasa Town, Tottori Prefecture |
| FullText URL | pitsr_025_001_012.pdf |
| Author | Shibata, Hidekata| Sayama, Mitsuo| |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-05 |
| Volume | volume25 |
| Start Page | 1 |
| End Page | 12 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40244 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462887 |
