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Author Nakao, Miyuki|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Yagi, Takahito|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Doihara, Hiroyoshi|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Hayashi, Keiichiro| Ohmori, Iori| Matsui, Hideki|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Wang, Feifei| Yasuhara, Takao| Kameda, Masahiro| Date, Isao|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Sasaki, Tsuyoshi| Tazawa, Hiroshi| Hasei, Jo| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Yano, Shuya| Yoshida, Ryosuke| Uno, Futoshi| Kagawa, Shunsuke| Morimoto, Yuki| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Fujimura, Atsushi| Tomizawa, Kazuhito| Matsui, Hideki|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/48569
FullText URL 66_3_285.pdf
Author Mizobuchi, Satoshi| Matsuoka, Yoshikazu| Obata, Norihiko| Kaku, Ryuji| Itano, Yoshitaro| Tomotsuka, Naoto| Taniguchi, Arata| Nishie, Hiroyuki| Kanzaki, Hirotaka| Ouchida, Mamoru| Morita, Kiyoshi|
Abstract Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required.
Keywords beta-blocker landiolol formalin pain behavior c-fos
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2012-06
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 285
End Page 289
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729110
Web of Science KeyUT 000305669700013
Author Kanazawa, Tomoko|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
FullText URL K0004505.pdf K004505_honbun.pdf
Author Takahata, Yoko|
Published Date 2012-03-23
Content Type Thesis or Dissertation
Grant Number 甲第4505号
Granted Date 2012-03-23
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language Japanese English
Author Takahashi, Noriko|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Ibrahim, Juliani|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Ma, Shaobo|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
FullText URL K0004501.pdf K004501_honbun.pdf
Author Zhang, Kai|
Published Date 2012-03-23
Content Type Thesis or Dissertation
Grant Number 甲第4501号
Granted Date 2012-03-23
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language Japanese English
Author Miyake, Yoshiaki|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Takata, Naoki|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Okubo, Sayuri|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Jin, Yu|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Mori, Kyoko|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation