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FullText URL fulltext20221227-2.pdf
Author Takata, Jun| Miyake, Naoko| Saiki, Yusuke| Tada, Misako| Sasaki, Kensuke| Kubo, Toshio| Kiura, Katsuyuki| Arimoto-Kobayashi, Sakae|
Keywords Akt signal transduction Lung tumorigenesis Anti-mutagenesis DNA methylation Tobacco-specific nitrosamine Isoquercetin
Published Date 2022-12-09
Publication Title Genes and Environment
Volume volume44
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 26
ISSN 1880-7062
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 36494703
DOI 10.1186/s41021-022-00255-0
Web of Science KeyUT 000896571200001
Related Url isVersionOf https://doi.org/10.1186/s41021-022-00255-0
FullText URL fulltext20221122-4.pdf
Author Yamaguchi, Kizashi| Shoji, Mitsuo| Isobe, Hiroshi| Kawakami, Takashi| Miyagawa, Koichi| Suga, Michihiro| Akita, Fusamichi| Shen, Jian-Ren|
Keywords Water oxidation Oxygen evolution Photosystem II HR XRD SFX XFEL QM/MM calculation DLPNO CCSD(T-0) computations, Oxyl radical character
Note (C) 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.ccr.2022.214742| This full-text file will be available in Aug. 2024.|
Published Date 2022-11
Publication Title Coordination Chemistry Reviews
Volume volume471
Publisher Elsevier BV
Start Page 214742
ISSN 0010-8545
NCID AA00619249
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Elsevier B.V.
File Version author
DOI 10.1016/j.ccr.2022.214742
Web of Science KeyUT 000879286600003
Related Url isVersionOf https://doi.org/10.1016/j.ccr.2022.214742
JaLCDOI 10.18926/AMO/64117
FullText URL 76_6_673.pdf
Author Okazawa-Sakai, Mika| Yamamoto, Yasuko| Futagawa, Mashu| Okamura, Miki| Miyawaki, Satoko| Nishina, Tomohiro| Takehara, Kazuhiro| Kozuki, Toshiyuki| Tomida, Shuta| Hyodo, Ichinosuke| Ohsumi, Shozo| Hirasawa, Akira|
Abstract Patients found to have presumed germline pathogenic variants (PGPVs) during comprehensive genomic profiling (CGP) require genetic counseling (GC) referrals. We retrospectively investigated the outcomes of patients with PGPVs. Among 159 patients who underwent CGP, we recommended GC for the 16 patients with PGPVs (3 with [FG group] and 13 without [G Group] a family/personal history of hereditary cancer) as well as for the 8 patients with no PGPVs, but a history (F group); 2 (67%), 5 (38%), and 3 (38%) patients received GC in the FG, G, and F groups, respectively. Germline testing results were positive in 1 and 2 patients of the FG and G groups, respectively. Among the patients recommended for GC, 58% did not receive GC due to lack of interest, poor performance status, or death. CGP contributes to the identification of germline variants in patients without a history of hereditary cancer. However, the proportion of patients who undergo GC should be improved.
Keywords comprehensive genomic profiling hereditary cancer germline findings presumed germline pathogenic variant(s) genetic counseling
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-12
Volume volume76
Issue issue6
Publisher Okayama University Medical School
Start Page 673
End Page 678
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36549769
Web of Science KeyUT 000905195100007
JaLCDOI 10.18926/AMO/64036
FullText URL 76_5_547.pdf
Author Kagawa, Hidetoshi| Yamanaka, Ryutaro| Hiromasa, Tsutomu|
Abstract This observational study aimed to clarify the long-term results of the combination of mizoribine (MZB), tacrolimus (TAC) and prednisolone as first-line therapy for lupus nephritis (LN). This was our institution’s standard therapy between 2009 and 2015, when we saw 36 patients with LN. When a patient thus treated achieved SLEDAI remission (= 0) and/or the prednisolone dose could be tapered to 5 mg/day, either MZB or TAC was stopped, and the other was continued for maintenance therapy. If treatment failure or relapse occurred, second-line therapy was introduced. At years 1 and 5, overall complete renal response and SLEDAI remission were 94% and 88%, and 50% and 62%, respectively. Excluding 2 cases lost to follow-up, medications after 5 years were as follows: 20 (59%) were stable on 1 drug (MZB or TAC), 11 (32%) required continuation of both drugs (MZB + TAC), and 3 (9%) required second-line therapy. The 5-year retention rate was 91% (non-secondline), with 0% of relapse in this group. Our first-line combination strategy showed high remission rates in the induction phase, and subsequent maintenance therapy demonstrated good outcomes for up to 5 years. Research that fine-tunes the order of therapeutic agents and institutes appropriate treatment goals may further improve long-term outcomes for patients with LN.
Keywords combination therapy first-line therapy lupus nephritis mizoribine tacrolimus
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 547
End Page 555
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352802
Web of Science KeyUT 000884907100008
FullText URL fulltext.pdf
Author Seya, Mizuki| Aokage, Toshiyuki| Nojima, Tsuyoshi| Nakao, Atsunori| Naito, Hiromichi|
Keywords Bile pigments Emergency and critical care medicine Antioxidant therapy
Published Date 2022-10-29
Publication Title European Journal Of Medical Research
Volume volume27
Issue issue1
Publisher BMC
Start Page 224
ISSN 0949-2321
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 36309733
DOI 10.1186/s40001-022-00863-0
Web of Science KeyUT 000876312700004
Related Url isVersionOf https://doi.org/10.1186/s40001-022-00863-0
FullText URL mjou_065_145_173.pdf
Author Kametaka, Yoshinori| Watanabe, Kohtaro| Nagai, Atsushi| Takemura, Kazuo| Yamagishi, Hiroyuki|
Abstract We consider the boundary value problem for fourth order linear ordinary differential equation in a half line (0,∞), which represents bending of a beam on an elastic foundation under a tension. A tension is relatively stronger than a spring constant of elastic foundation. We here treat four self-adjoint boundary conditions, clamped, Dirichlet, Neumann and free edges, at x = 0. We show the positivity and the hierarchical structure of four Green functions.
Keywords Green function boundary value problem positivity hierarchical structure
Published Date 2023-01
Publication Title Mathematical Journal of Okayama University
Volume volume65
Issue issue1
Publisher Department of Mathematics, Faculty of Science, Okayama University
Start Page 145
End Page 173
ISSN 0030-1566
NCID AA00723502
Content Type Journal Article
language English
Copyright Holders Copyright ©2023 by the Editorial Board of Mathematical Journal of Okayama University
FullText URL fulltext.pdf
Author Kobashi, Mayu| Iwamuro, Masaya| Kuraoka, Sakiko| Inoo, Shoko| Okanoue, Shotaro| Satomi, Takuya| Hamada, Kenta| Abe, Makoto| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Kawahara, Yoshiro| Okada, Hiroyuki|
Keywords familial adenomatous polyposis gastric adenoma gastric cancer phenotypic variations
Published Date 2022-10-14
Publication Title Medicine
Volume volume101
Issue issue41
Publisher Lippincott Williams & Wilkins
Start Page e30997
ISSN 0025-7974
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 the Author(s).
File Version publisher
PubMed ID 36254079
DOI 10.1097/MD.0000000000030997
Web of Science KeyUT 000868085500032
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000030997
FullText URL fulltext.pdf
Author Ogasahara, Tsubasa| Kouzai, Yusuke| Watanabe, Megumi| Takahashi, Akihiro| Takahagi, Kotaro| Kim, June-Sik| Matsui, Hidenori| Yamamoto, Mikihiro| Toyoda, Kazuhiro| Ichinose, Yuki| Mochida, Keiichi| Noutoshi, Yoshiteru|
Keywords Brachypodium distachyon monocotyledonous plant microbe-associated molecular pattern time-series transcriptome analysis reactive oxygen species pattern-triggered immunity
Published Date 2022-09-15
Publication Title Frontiers In Plant Science
Volume volume13
Publisher Frontiers Media S.A.
Start Page 1004184
ISSN 1664-462X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Ogasahara, Kouzai, Watanabe, Takahashi, Takahagi, Kim, Matsui, Yamamoto, Toyoda, Ichinose, Mochida and Noutoshi.
File Version publisher
PubMed ID 36186055
DOI 10.3389/fpls.2022.1004184
Web of Science KeyUT 000863600900001
Related Url isVersionOf https://doi.org/10.3389/fpls.2022.1004184
FullText URL fulltext.pdf
Author Takahara, Masahiro| Hiraoka, Sakiko| Ohmori, Masayasu| Takeuchi, Keiko| Takei, Kensuke| Yasutomi, Eriko| Igawa, Shoko| Yamamoto, Shumpei| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Harada, Keita| Ohnishi, Hideki| Okada, Hiroyuki|
Keywords bowel wall thickness Mayo endoscopic subscore classification transabdominal ultrasonography ulcerative colitis
Published Date 2022-09-15
Publication Title Internal Medicine
Volume volume61
Issue issue18
Publisher The Japanese Society of Internal Medicine
Start Page 2703
End Page 2709
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 35185047
DOI 10.2169/internalmedicine.8827-21
Web of Science KeyUT 000857218300001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.8827-21
FullText URL fulltext20220920-1.pdf
Author Takahashi, Yuiki| Baba, Masaaki| Enomoto, Katsunari| Hiramoto, Ayami| Iwakuni, Kana| Kuma, Susumu| Tobaru, Reo| Miyamoto, Yuki|
Published Date 2022-9-1
Publication Title The Astrophysical Journal
Volume volume936
Issue issue2
Publisher American Astronomical Society
ISSN 0004-637X
NCID AA00553242
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022. The Author(s).
File Version publisher
DOI 10.3847/1538-4357/ac87fb
Web of Science KeyUT 000850350600001
Related Url isVersionOf https://doi.org/10.3847/1538-4357/ac87fb
FullText URL fulltext.pdf
Author Matsuoka-Uchiyama, Natsumi| Tsuji, Kenji| Sang, Yizhen| Takahashi, Kensaku| Fukushima, Kazuhiko| Takeuchi, Hidemi| Inagaki, Kenichi| Uchida, Haruhito A.| Kitamura, Shinji| Sugiyama, Hitoshi| Wada, Jun|
Published Date 2022-09-02
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 14999
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36056164
DOI 10.1038/s41598-022-19226-0
Web of Science KeyUT 000849436000046
Related Url isVersionOf https://doi.org/10.1038/s41598-022-19226-0
JaLCDOI 10.18926/AMO/63906
FullText URL 76_4_465.pdf
Author Bekku, Kensuke| Tsugawa, Takuji| Tsuboi, Kazuma| Noda, Gaku| Inoue, Yousuke| Murao, Wataru| Ebara, Shin|
Abstract We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk.
Keywords metastatic renal cell carcinoma molecular-targeted therapy immuno-checkpoint inhibitor real-world setting
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 465
End Page 472
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123162
FullText URL fulltext.pdf
Author Kajiwara, Tsuyoshi| Sasaki, Toru| Otani, Yoji|
Keywords global stability two routes of infection two compartments type reproduction number lyapunov functional
Published Date 2022-08-02
Publication Title Mathematical Biosciences And Engineering
Volume volume19
Issue issue11
Publisher American Institute of Mathematical Sciences
Start Page 11047
End Page 11070
ISSN 1547-1063
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 the Author(s), licensee AIMS Press.
File Version publisher
DOI 10.3934/mbe.2022515
Web of Science KeyUT 000850188600006
Related Url isVersionOf https://doi.org/10.3934/mbe.2022515
JaLCDOI 10.18926/AMO/63887
FullText URL 76_4_359.pdf
Author Hiramatsu-Asano, Sumie| Wada, Jun|
Abstract Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE.
Keywords systemic lupus erythematosus miRNA miRNA targeting therapy
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 359
End Page 371
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123150
Web of Science KeyUT 000882167300002
FullText URL fulltext.pdf
Author Kawauchi, Satoshi| Yasuhara, Takao| Kin, Kyohei| Yabuno, Satoru| Sugahara, Chiaki| Nagase, Takayuki| Hosomoto, Kakeru| Okazaki, Yosuke| Tomita, Yousuke| Umakoshi, Michiari| Sasaki, Tatsuya| Kameda, Masahiro| Borlongan, Cesario, V| Date, Isao|
Keywords bone marrow stromal cells cerebral infarction encapsulated cell transplantation middle cerebral artery occlusion model neurogenesis
Published Date 2022-08-24
Publication Title Cns Neuroscience & Therapeutics
Publisher Wiley
ISSN 1755-5930
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 36000240
DOI 10.1111/cns.13947
Web of Science KeyUT 000846694400001
Related Url isVersionOf https://doi.org/10.1111/cns.13947
FullText URL fulltext.pdf
Author Komatsu, Yasuhiro| Shigeyasu, Kunitoshi| Yano, Shuya| Takeda, Sho| Takahashi, Kazutaka| Hata, Nanako| Umeda, Hibiki| Yoshida, Kazuhiro| Mori, Yoshiko| Yasui, Kazuya| Yoshida, Ryuichi| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Teraishi, Fuminori| Umeda, Yuzo| Kagawa, Shunsuke| Michiue, Hiroyuki| Tazawa, Hiroshi| Goel, Ajay| Fujiwara, Toshiyoshi|
Published Date 2022-08-08
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 13540
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © TheAuthor(s)2022
File Version publisher
PubMed ID 35941214
DOI 10.1038/s41598-022-17773-0
Web of Science KeyUT 000837764800013
Related Url isVersionOf https://doi.org/10.1038/s41598-022-17773-0
FullText URL fulltext20220810-2.pdf
Author Naito, Hidefumi| Okamoto, Ryuichi| Sumi, Tomonari| Koga, Kenichiro|
Note This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in (Hidefumi Naito, Ryuichi Okamoto, Tomonari Sumi, Kenichiro Koga; Osmotic second virial coefficients for hydrophobic interactions as a function of solute size. J. Chem. Phys. 14 June 2022; 156 (22): 221104. https://doi.org/10.1063/5.0097547) and may be found at (https://doi.org/10.1063/5.0097547).
This fulltext is available in June 2023.|
Published Date 2022-06-14
Publication Title The Journal of Chemical Physics
Volume volume156
Issue issue22
Publisher AIP Publishing
Start Page 221104
ISSN 0021-9606
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Author(s).
File Version publisher
PubMed ID 35705398
DOI 10.1063/5.0097547
Web of Science KeyUT 000832682400001
Related Url isVersionOf https://doi.org/10.1063/5.0097547
FullText URL fulltext20220720-2.pdf Tables20220720-2.pdf Figure20220720-2.pdf
Author Okazaki, Yuki| Furumatsu, Takayuki| Hiranaka, Takaaki| Zhang, Ximing| Kintaka, Keisuke| Higashihara, Naohiro| Tamura, Masanori| Kodama, Yuya| Kamatsuki, Yusuke| Ozaki, Toshifumi|
Keywords clinical outcome medial meniscus meniscal healing posterior root tear suture material
Note This is an Accepted Manuscript of an article published by Thieme Medical Publishers, Inc.
This fulltext is available in July 2023.|
Published Date 2022-07-07
Publication Title The Journal of Knee Surgery
Publisher Thieme Medical Publishers, Inc.
ISSN 1538-8506
NCID AA11604163
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022. Thieme.
File Version author
PubMed ID 35798342
DOI 10.1055/s-0042-1750047
Web of Science KeyUT 000821655400008
Related Url isVersionOf https://doi.org/10.1055/s-0042-1750047
FullText URL fulltext20220720-1.pdf figure20220720-1.pdf
Author Okazaki, Yuki| Furumatsu, Takayuki| Hiranaka, Takaaki| Kintaka, Keisuke| Higashihara, Naohiro| Tamura, Masanori| Ozaki, Toshifumi|
Note © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.knee.2022.02.004] .
This fulltext is available in Feb. 2023.|
Published Date 2022-03
Publication Title The Knee
Volume volume35
Publisher Elsevier BV
Start Page 71
End Page 80
ISSN 0968-0160
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Elsevier B.V.
File Version author
PubMed ID 35220135
DOI 10.1016/j.knee.2022.02.004
Web of Science KeyUT 000820232400009
Related Url isVersionOf https://doi.org/10.1016/j.knee.2022.02.004
FullText URL fulltext20220630-5.pdf figure20220630-5.pdf
Author Okazaki, Yuki| Furumatsu, Takayuki| Kodama, Yuya| Hiranaka, Takaaki| Kintaka, Keisuke| Kamatsuki, Yusuke| Ozaki, Toshifumi|
Keywords Anterior cruciate ligament Coronal inclination Knee kinematics Magnetic resonance imaging Medial meniscus Posterior root tear
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00590-022-03285-0
This fulltext is available in May 2023.|
Published Date 2022-05-20
Publication Title European Journal of Orthopaedic Surgery and Traumatology
Volume volume33
Issue issue4
Publisher Springer Science and Business Media LLC
Start Page 1255
End Page 1262
ISSN 1432-1068
NCID AA11622799
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature 2022
File Version author
PubMed ID 35593940
DOI 10.1007/s00590-022-03285-0
Web of Science KeyUT 000800795900002
Related Url isVersionOf https://doi.org/10.1007/s00590-022-03285-0