result 48648 件
| JaLCDOI | 10.18926/AMO/52012 |
|---|---|
| FullText URL | 67_6_385.pdf |
| Author | Tanaka, Masato| Arataki, Shinya| Sugimoto, Yoshihisa| Takigawa, Tomoyuki| Tetsunaga, Tomoko| Ozaki, Toshifumi| |
| Abstract | Craniometaphyseal dysplasia is a rare genetic condition characterized by progressive thickening of bones in the skull and metaphyseal abnormalities in the long bones. This disorder often causes progressively symptomatic cranial nerve compression, but in rare cases foramen magnum stenosis may lead to quadriplegia. Chiari I malformation with craniometaphyseal dysplasia is extremely rare. The authors report on a 25-year-old woman with myelopathy due to Chiari I malformation along with craniometaphyseal dysplasia. There are only four previous case reports of this condition. The authors present here the fifth case report of this rare condition and summarize its characteristics. |
| Keywords | craniometaphyseal dysplasia Chiari malformation cervicomedullary compression |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 385 |
| End Page | 389 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356723 |
| Web of Science KeyUT | 000328915700007 |
| JaLCDOI | 10.18926/AMO/52011 |
|---|---|
| FullText URL | 67_6_377.pdf |
| Author | Sakoma, Yoshimasa| Sano, Hirotaka| Shinozaki, Nobuhisa| Itoigawa, Yoshiaki| Yamamoto, Nobuyuki| Itoi, Eiji| |
| Abstract | The pathogenetic roles of the coracoacromial arch in the development of rotator cuff tears are still controversial. This study compared the anteroposterior coverage of the humeral head by the coracoacromial arch between shoulders with and without full-thickness rotator cuff tears. Forty-two shoulders from 21 embalmed cadaveric specimens were macroscopically examined. Specimens were divided into 2 groups:shoulders with full-thickness cuff tears (tear group) and those with intact cuff tendons (normal group). The coverage angle of each component of the coracoacromial arch was measured using true lateral photographs. We also measured the angle of the total arc of the coracoacromial arch, as well as the angle of the anterior acromial projection. These data were compared between the tear group and the normal group. Although no significant differences were observed in the total arc of the coracoacromial arch between the groups, the tear group had significantly less coverage by the coracoacromial ligament than did the normal group (p＜0.05). Moreover, greater anterior acromial projection was observed in the tear group (p＜0.05). These results suggest that greater coverage of the bony structures on the rotator cuff may correlate with the development of rotator cuff tears. |
| Keywords | rotator cuff tear coracoacromial arch humeral head anatomy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 377 |
| End Page | 383 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356722 |
| Web of Science KeyUT | 000328915700006 |
| JaLCDOI | 10.18926/AMO/52010 |
|---|---|
| FullText URL | 67_6_369.pdf |
| Author | Yu, Shaonan| Wang, Xiaozhen| Liu, Guifeng| Zhu, Xuewei| Chen, Yan| |
| Abstract | Despite high sensitivity to chemotherapy, the prognosis for triple-negative breast cancer (TNBC) remains poor because of its high rate of metastasis and low sensitivity to endocrine therapy. CXCR4 expression has been reported in many subtypes of human breast cancers, but it remains unknown whether CXCR4 is expressed in TNBC and whether CXCR4 expression in TNBC could be a prognostic indicator. TNBCs tissues were formalin fixed, paraffin embedded and hematoxylin-eosin (H&E) stained. Immunohistochemical staining was utilized to determine the CXCR4 expression in those specimens. Statistical analyses were performed using SPSS16.0 software to reveal the correlation of CXCR4 expression in TNBC specimens and cancer recurrence and cancer-related death. Our results showed that there was a strong association between CXCR4 overexpression and both menopause and the histological cancer grade of TNBC patients (p values were separately 0.004 and 0.001). The 5-y disease-free survival (DFS) and the 5-y overall survival (OS) were 57.69% and 58.33% for the low-CXCR4 group versus 42.11% and 44.74% for the high-CXCR4 group, respectively (p＝0.031 and 0.048). CXCR4 overexpression plays an important role in triple-negative breast cancers, and may be a predictor of poor prognosis. |
| Keywords | CXCR4 immunohistochemical staining triple-negative breast cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 369 |
| End Page | 375 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356721 |
| Web of Science KeyUT | 000328915700005 |
| JaLCDOI | 10.18926/AMO/52009 |
|---|---|
| FullText URL | 67_6_359.pdf |
| Author | Katashima, Kazunori| Kuroda, Masahiro| Ashida, Masakazu| Sasaki, Takanori| Taguchi, Takehito| Matsuzaki, Hidenobu| Murakami, Jun| Yanagi, Yoshinobu| Hisatomi, Miki| Hara, Marina| Kato, Hirokazu| Ohmura, Yuichi| Kobayashi, Tomoki| Kanazawa, Susumu| Harada, Sosuke| Takemoto, Mitsuhiro| Ohno, Seiichiro| Mimura, Seiichi| Asaumi, Junichi| |
| Abstract | It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30sec. Heating at 42℃ was used to induce apoptosis while heating at 48℃ was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3μm. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30msec might be optimal to distinguish between apoptosis and necrosis. |
| Keywords | ADC apoptosis necrosis hyperthermia cell density |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 367 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356720 |
| Web of Science KeyUT | 000328915700004 |
| JaLCDOI | 10.18926/AMO/52008 |
|---|---|
| FullText URL | 67_6_351.pdf |
| Author | Yokoyama, Yusuke| Abe, Nobuhiro| Fujiwara, Kazuo| Suzuki, Masahiko| Nakajima, Yoshikazu| Sugita, Naohiko| Mitsuishi, Mamoru| Nakashima, Yoshio| Ozaki, Toshifumi| |
| Abstract | A computer-assisted navigation system to be used for total knee arthroplasties (TKAs) was reported to improve the accuracy of bone resection and result in precise implant placement, but the concomitant surgical invasion and time consumption are clinical problems. We developed a computed tomography (CT)-based navigation system (NNS) to be used for minimally invasive TKA. It requires only the reference points from a small limited area of the medial femoral condyle and proximal tibia through a skin incision to obtain optical images. Here we evaluated the usefulness and accuracy of the NNS in comparison with the commercially available BrainLAB image-free navigation system (BLS). In a clinical experiment, the registration times obtained with the NNS tended to be shorter than those obtained with the BLS, but not significantly so. The NNS group tended to be in the extended position in the sagittal plane of the distal femur within 3 degrees, and the BLS group showed rather flexed deviation in the sagittal plane of the anterior femur. |
| Keywords | total knee arthroplasty navigation system minimally invasive surgery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 351 |
| End Page | 358 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356719 |
| Web of Science KeyUT | 000328915700003 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52515 |
| JaLCDOI | 10.18926/AMO/52007 |
|---|---|
| FullText URL | 67_6_343.pdf |
| Author | Yamane, Kentaro| Takigawa, Tomoyuki| Tanaka, Masato| Osaki, Syuhei| Sugimoto, Yoshihisa| Ozaki, Toshifumi| |
| Abstract | Cervical spinal schwannoma is benign, and outcomes after surgical resection are generally excellent. A surgical dilemma sometimes arises as to whether to perform total tumor removal, which carries a risk of sacrificing the nerve root, or subtotal removal, where the risk can be tumor recurrence. The purpose of this study was to identify factors with the potential to predict clinical impairment after surgery for cervical spinal schwannomas. Thirty cases of cervical schwannomas treated surgically in our institute were retrospectively reviewed;initial symptoms, tumor location, Eden classification, surgical method, functional outcome, and tumor recurrence were investigated. All permanent motor deficits were the result of resecting functionally relevant nerve roots (i.e., C5-8). The rate of permanent sensory deficit was 11% after C1-4 nerve root resection, and 67% after C5-8 nerve root resection. Permanent neurological deficits occurred in 14% of patients younger than 40 years and 38% of those older than 40. Dumbbell tumors were associated with the need for total or ventral nerve root transection, as well as with a high incidence of tumor recurrence. The incidence of permanent neurological deficit was significantly higher in patients undergoing C5-8 nerve root resection, and tended to be higher in those over 40. |
| Keywords | cervical spinal schwannoma neurological deficit nerve root resection tumor resection tumor recurrence |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 343 |
| End Page | 349 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356718 |
| Web of Science KeyUT | 000328915700002 |
| JaLCDOI | 10.18926/AMO/52006 |
|---|---|
| FullText URL | 67_6_333.pdf |
| Author | Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses. |
| Keywords | oncolytic adenovirus autophagy E2F1 microRNA |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 333 |
| End Page | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356717 |
| Web of Science KeyUT | 000328915700001 |
| FullText URL | O0004409_abstract_review.pdf O0004409_fulltext.pdf |
|---|---|
| Author | Kusumoto, Masahiko| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4409号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | O0004408_abstract_review.pdf O0004408_fulltext.pdf |
|---|---|
| Author | Osawa, Fuminori| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4408号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Pharmaceutical Sciences |
| Grantor | 岡山大学 |
| language | Japanese |
| Author | 岡山大学大学院法務研究科| |
|---|---|
| Published Date | 2013-11 |
| Publication Title | 臨床法務研究 |
| Volume | volume12 |
| Content Type | Others |
| Author | Yoshioka, Fumio| |
|---|---|
| Published Date | 2012-07-25 |
| Publication Title | 岡山大学文学部紀要 |
| Volume | volume57 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/okadai-bun-kiyou/52002 |
| Author | Yoshioka, Fumio| |
|---|---|
| Published Date | 2011-07-25 |
| Publication Title | 岡山大学文学部紀要 |
| Volume | volume55 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/okadai-bun-kiyou/52001 |
| Author | Yoshioka, Fumio| |
|---|---|
| Published Date | 2010-07-30 |
| Publication Title | 岡山大学文学部紀要 |
| Volume | volume53 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/okadai-bun-kiyou/52000 |
| Author | Kaneda, Noriko| |
|---|---|
| Published Date | 2013-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| FullText URL | K0004871_abstract_review..pdf K0004871_fulltext.pdf |
|---|---|
| Author | Furukawa, Yoko| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4871号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Law |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0004870_abstract_review.pdf K0004870_fulltext.pdf |
|---|---|
| Author | Toyota, Teruaki| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4870号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Health Sciences |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Harimoto, Takashi| |
|---|---|
| Published Date | 2013-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Eguchi, Hitomi| |
|---|---|
| Published Date | 2013-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| FullText URL | K0004867_abstract_review.pdf K0004867_fulltext.pdf |
|---|---|
| Author | Hartwig, Claudia| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4867号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004866_abstract_review.pdf K0004866_fulltext.pdf |
|---|---|
| Author | Siti Norbaizura Binti MD. Rejab| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4866号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese English |
