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JaLCDOI 10.18926/AMO/64362
FullText URL 77_1_57.pdf
Author Katsumata, Ryo| Manabe, Noriaki| Monobe, Yasumasa| Ayaki, Maki| Suehiro, Mitsuhiko| Fujita, Minoru| Kamada, Tomoari| Kawamoto, Hirofumi| Haruma, Ken|
Abstract Melanosis coli (MC) is an acquired colorectal disorder visualized as colonic mucosa pigmentation. Disease severity is confirmed based on MC depth, shape, and coloration, although the clinical course is not fully understood. This study sought to clarify characteristics of MC development and disappearance and to investigate its clinical course and severity. Contributors to MC grade progression were explored. This study reviewed MC cases discovered via colonoscopy at a single institution over a 10-year period. Of all 216 MC cases, 17 developing and 10 disappearing cases were detected. Anthranoid laxative use was a key factor: 29.4% of the developing cases had used such agents before the initial MC diagnosis, whereas 40% of disappearing cases had discontinued anthranoids prior to detection of MC disappearance. Among 70 grade I cases, progression to grade II occurred in 16 cases during a mean follow-up of 3.67±2.1 years (rate of progression=22.8%). Males more commonly showed progressive than stable grade I cases, and the probability of progression was higher for male than for female cases. An association between anthranoid administration and MC presence was presumed, and grade I MC was found to progress in severity over 5 years.
Keywords melanosis sex characteristics laxatives colorectal neoplasms colonoscopy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 57
End Page 64
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849146
Web of Science KeyUT 000952992100003
JaLCDOI 10.18926/AMO/64361
FullText URL 77_1_45.pdf
Author Takeuchi, Kazuhiro| Ide, Yasuhiro| Mori, Yuichiro| Uehara, Yusuke| Sukeishi, Hiroshi| Goto, Sachiko|
Abstract Novel deep learning image reconstruction (DLIR) reportedly changes the image quality characteristics based on object contrast and image noise. In clinical practice, computed tomography image noise is usually controlled by tube current modulation (TCM) to accommodate changes in object size. This study aimed to evaluate the image quality characteristics of DLIR for different object sizes when the in-plane noise was controlled by TCM. Images acquisition was performed on a GE Revolution CT system to investigate the impact of the DLIR algorithm compared to the standard reconstructions of filtered-back projection (FBP) and hybrid iterative reconstruction (hybrid-IR). The image quality assessment was performed using phantom images, and an observer study was conducted using clinical cases. The image quality assessment confirmed the excellent noise- reduction performance of DLIR, despite variations due to phantom size. Similarly, in the observer study, DLIR received high evaluations regardless of the body parts imaged. We evaluated a novel DLIR algorithm by replicating clinical behaviors. Consequently, DLIR exhibited higher image quality than those of FBP and hybrid-IR in both phantom and observer studies, albeit the value depended on the reconstruction strength, and proved itself capable of providing stable image quality in clinical use.
Keywords computed tomography deep learning image reconstruction tube current modulation object size
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 45
End Page 55
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849145
Web of Science KeyUT 000952992100002
JaLCDOI 10.18926/AMO/64360
FullText URL 77_1_37.pdf
Author Yamanouchi, Kosho| Maeda, Shigeto|
Abstract Systemic therapy for stage IV breast cancer is usually an initial treatment and is based on findings regarding biomarkers (e.g., hormone receptors and human epidermal growth factor receptor-2 [HER2]). However, the response to therapy and outcomes sometime differ among patients with similar prognostic factors including grade, hormone receptor, HER2, and more. We conducted retrospective analyses to evaluate the correlations between the overall survival (OS) of 46 stage IV breast cancer patients and (i) the peripheral absolute lymphocyte count (ALC) and (ii) composite blood cell markers. The peripheral blood cell markers included the neutrophil- to-lymphocyte ratio (NLR), the monocyte-to-lymphocyte ratio (MLR), the systemic immune-inflammation index (SII), the systemic inflammation response index (SIRI), and the most recently introduced indicator, the pan-immune-inflammatory value (PIV). The SIRI and PIV showed prognostic impacts on the patients: those with a low SIRI or a low PIV showed significantly better OS than those with a high SIRI (5-year, 66.0% vs. 35.0%, p<0.05) or high PIV (5-year, 68.1% vs. 38.5%, p<0.05), respectively. This is the first report indicating the possible prognostic value of the PIV for OS in patients with stage IV breast cancer. Further studies with larger numbers of patients are necessary for further clarification.
Keywords breast cancer pan-immune-inflammatory value prognosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 37
End Page 43
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849144
Web of Science KeyUT 000952992100001
FullText URL fulltext.pdf
Author Nose, Keito| Yoshioka, Kaito| Yamaji, Minoru| Tani, Fumito| Goto, Kenta| Okamoto, Hideki|
Published Date 2023-01-30
Publication Title RSC Advances
Volume volume13
Issue issue6
Publisher The Royal Society of Chemistry
Start Page 4096
End Page 4101
ISSN 2046-2069
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Author(s).
File Version publisher
PubMed ID 36756556
DOI 10.1039/d2ra07771j
Web of Science KeyUT 000923434600001
Related Url isVersionOf https://doi.org/10.1039/d2ra07771j
JaLCDOI 10.18926/AMO/64358
FullText URL 77_1_29.pdf
Author Yamamoto, Shusei| Sato, Ikumi| Fujii, Moe| Kakimoto, Mai| Honma, Koki| Akiyama, Natsumi| Sakai, Miku| Fukuhama, Natsuki| Kumazaki, Shota| Hirohata, Satoshi| Kitamori, Kazuya| Yamori, Yukio| Watanabe, Shogo|
Abstract The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased.
Keywords SHRSP5/Dmc nonalcoholic steatohepatitis cardiovascular disease glycine-conjugated bile acids unconjugated bile acids
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 29
End Page 36
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849143
Web of Science KeyUT 000953019200001
JaLCDOI 10.18926/AMO/64357
FullText URL 77_1_21.pdf
Author Homma, Daisuke| Minato, Izumi| Imai, Norio| Miyasaka, Dai| Sakai, Yoshinori| Horigome, Yoji| Suzuki, Hayato| Dohmae, Yoichiro| Endo, Naoto|
Abstract We measured the muscle mass and phase angle of each body part to evaluate the relationship between balance and gait functions in individuals with a pre-frailty status. This cross-sectional observational study determined the skeletal muscle mass-to-body weight ratio and phase angles of 21 control (robust) and 29 pre-frail subjects. Their Brief-Balance Evaluation Systems Test, Timed Up-and-Go (TUG) test, Life-Space Assessment, and Modified Fall Efficacy Scale scores plus the relationship between muscle mass, phase angle, and motor function were evaluated. In the pre-frailty group (three males, 26 females, aged 75.58±7.60 years), significant correlations were noted between the Brief-Balance Evaluation Systems Test score and lower-limb (r=0.614) and wholebody (r=0.557) phase angles, and between the TUG test score and lower-limb muscle mass-to-body weight ratio (r=−0.616), lower-limb phase angle (r=−0.616), and whole-body phase angle (r=−0.527). Evaluating the phase angle of the lower extremities of pre-frail patients and intervening accordingly may help clinicians maintain and improve these patients’ balance and gait functions.
Keywords bioelectrical impedance analysis motor function muscle quality muscle volume
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 21
End Page 27
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849142
Web of Science KeyUT 000953663800003
JaLCDOI 10.18926/AMO/64356
FullText URL 77_1_11.pdf
Author Watanabe, Satoko| Saiga, Miho| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Kimata, Yoshihiro|
Abstract The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction.
Keywords breast reconstruction mastectomy brassiere professional bra fitter
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 11
End Page 19
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849141
Web of Science KeyUT 000953663800002
JaLCDOI 10.18926/AMO/64355
FullText URL 77_1_1.pdf
Author Nahar, Lutfun| Hagiya, Hideharu| Nada, Takahiro| Iio, Koji| Gotoh, Kazuyoshi| Matsushita, Osamu| Otsuka, Fumio|
Abstract Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA.
Keywords antimicrobial resistance clindamycin erm D-zone test inducible MLSB
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 9
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849140
Web of Science KeyUT 000953663800001
Title Alternative Annual report / Institute of Plant Science and Resources, Okayama University
FullText URL IPSR_30.pdf
Author Institute of Plant Science and Resources, Okayama University|
Publication Title Annual Report, Institute of Plant Science and Resources Okayama University
Published Date 2023-03-31
Volume volume30
Start Page 1
End Page 68
ISSN 2186-4918
language Japanese
File Version publisher
FullText URL fulltext20230221-1.pdf
Author Kawada, Koki| Furumatsu, Takayuki| Tamura, Masanori| Xue, Haowei| Higashihara, Naohiro| Kintaka, Keisuke| Yokoyama, Yusuke| Ozaki, Toshifumi|
Keywords Fixed-flexion view Medial joint space Medial meniscus extrusion Meniscus Posterior root tear Pullout of repair
Published Date 2023-01-30
Publication Title International Orthopaedics
Publisher Springer Science and Business Media LLC
ISSN 0341-2695
NCID AA0068148X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023, corrected publication 2023
File Version publisher
PubMed ID 36715713
DOI 10.1007/s00264-023-05701-4
Web of Science KeyUT 000921741800003
FullText URL fulltext.pdf correction.pdf
Author Yabuno, Satoru| Yasuhara, Takao| Nagase, Takayuki| Kawauchi, Satoshi| Sugahara, Chiaki| Okazaki, Yosuke| Hosomoto, Kakeru| Sasada, Susumu| Sasaki, Tatsuya| Tajiri, Naoki| Borlongan, Cesar V.| Date, Isao|
Keywords Cerebral ischemic infarct Rehabilitation Regenerative medicine SB623 Voluntary exercise
Published Date 2023-01-24
Publication Title STEM Cell Research & Therapy
Volume volume14
Issue issue1
Publisher BMC
Start Page 10
ISSN 1757-6512
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 36691091
DOI 10.1186/s13287-023-03236-4
Web of Science KeyUT 000920132500001
Related Url isVersionOf https://doi.org/10.1186/s13287-023-03236-4
FullText URL srfa_112_cover_e.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_colophon.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
ISSN 2186-7755
language Japanese
File Version publisher
Title Alternative The List of Published by Members of the Faculty From January to December 2022
FullText URL srfa_112_023_036.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 23
End Page 36
ISSN 2186-7755
language Japanese
File Version publisher
Title Alternative Sexual Dimorphism of Arginine Vasotocin Neuron in Birds
FullText URL srfa_112_019_022.pdf
Author Saito, Noboru|
Abstract Arginine vasotocin (AVT) is one of neurohypophysial peptides in birds and is well known both as an antidiuretic and oxytocic hormone. AVT is produced in the hypothalamus and mainly synthesized in magnocellular neurons, supraoptic nucleus (SON) and paraventricular nucleus (PVN). Recent, immunocytochemistry and in situ hybridization results indicate that AVT is also synthesized in parvocellular neurons corresponding to mammalian stria terminalis (nST). The AVT neurons in nST in the male are more numerous than those in the female. Therefore, these data suggest that there is sexual dimorphism in the distribution of AVT neurons. Several experiments involving electrical lesion, testosterone implantation, and the detection of the immediately-early gene expression in birds expressing copulatory behavior suggested that nST and nucleus praeopticus medialis (POM) were related to the reproductive behavior. When male embryo was treated with estradiol, the distribution of AVT neurons assumes the same distribution as found in the female, and reproductive behavior was abolished, suggesting that AVT in the brain has an important role in reproductive behavior.
Keywords arginine vasotocin sexual dimorphism reproductive behavior parvocellular neurons bird
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 19
End Page 22
ISSN 2186-7755
language Japanese
File Version publisher
Title Alternative Studies on l-Glutamate Oxidase with Strict Substrate Specificity from Streptomyces sp.
FullText URL srfa_112_013_018.pdf
Author Nakayama, Natsume| Inagaki, K.|
Abstract l-glutamate oxidase (LGOX) from Streptomyces sp. is a heterohexameric flavin enzyme that catalyzes the oxidative deamination of l-glutamate to form α-ketoglutarate with ammonia and hydrogen peroxide. LGOX shows strict substrate specificity for l-Glu. In addition, it is highly thermostable and pH stable. Because of these properties, LGOX is currently used as a biosensor for the trace determination of l-Glu in the food industry and clinical laboratories. The full-length cDNA is 2103 bp and is encoded by a single polypeptide chain consisting of 701 residues including subunits α-γ-β. The LGOX gene was heterologously expressed in Escherichia coli JM109. The LGOX precursor expressed in E. coli is a homodimer with weak enzymatic activity and becomes a heterohexamer upon activation by protease treatment. X-ray crystallography and docking studies of purified recombinant LGOX suggest that the Arg305 residue is a key residue for substrate recognition. Mutant analysis showed that Arg305 is essential for substrate recognition, as the activity toward l-Glu was greatly reduced and substrate specificity was changed in some enzymes. The functional analysis of R305E-LGOX, which is an l-Arg oxidase, revealed that R305E-LGOX can be used as a enzyme biosensor for l-Arg.
Keywords l-glutamate oxidase biosensor substrate recognition X-ray crystallography modification of substrate specificity
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 13
End Page 18
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_007_012.pdf
Author Thao Thu Phan| Fukushima, Keigo| Tanaka, Yoshiyuki| Yasuba, Ken-ichiro| Yoshida, Yuichi| Goto, Tanjuro|
Abstract This study aimed to investigate whether seed cold priming by PEG‒6000, followed by re‒drying would affect the germination, growth, and flowering of Eustoma ‘Exe Lavender’ raised seedling under high temperatures. Seeds of control treatment were not treated with cold‒priming or re‒drying. In experiment 1, seeds were cold‒primed with water and PEG‒6000 at ‒0.75 and ‒1.5 MPa for 5 weeks at 10°C in the dark and then subjected to re‒dried and storage for 30 days at 10°C. The results showed that cold‒primed seeds germinated earlier than those of the control. Compared to water treatment, plants grown from PEG‒6000 treatments and re‒drying showed similar germination rate, bolting rate, days to bolting, bolting node and flowering rate. In experiment 2, cold priming periods by water and ‒1.5 MPa PEG‒6000 were investigated for 4, 5, 6, 7, and 8 weeks. ‘Exe Lavender’ seeds treated with cold water and in the dark for longer than 5 weeks increased their percentage of radicle emergence and decreased germination rate after 30 days of re‒drying and storage. Meanwhile, those treated with cold-PEG did not protrude the radicle even for 8 weeks of priming and maintained the germination rate after re‒drying and storage. Days to bolting and days to flowering tended to decrease when the priming period decreased. The results suggest that the seed cold priming treatment by ‒1.5 MPa PEG‒6000 and subsequent re‒drying improved germination rate and maintained bolting rate and flowering rate in Eustoma compared to cold priming treatment by water raised seedling under high temperature conditions.
Keywords bolting chilling dehydrate PEG-6000 storage
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 7
End Page 12
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_001_006.pdf
Author Yoshida, Yuichi| Hanada, Atsushi| Ooguma, Keita| Yoshida, Kenta| Goto, Tanjuro| Tanaka, Yoshiyuki| Yasuba, Ken-ichiro|
Abstract Long day (LD) treatment is frequently applied for horticultural crops, including strawberry, and sufficient effect similar to 4 to 6hours of day time elongation in the evening can be achieved by 1 to 3hours of night break in the mid night. Incandescent lamps (IC) have long been an important light source, but the general incandescent lamps are out of production and have been replaced with LED or florescent lamps (FL). Thus, we compared light sources and their color temperature (2,800K, warm white similar to IC; 6,500K, daylight) in different lighting programs. The effectiveness of 3 and 4cycles of alternate intermittent lighting, 30min on/30min off, were equal to and larger than 2hours of night break, respectively. Measured intensity of illumination (lux) at the canopy surface by 2,800K LED (6.9W) and FL (12W) was 1.50 and 0.95times as large as IC (54W), but leaf growth under LED and FL was similar to and less vigorous than IC, respectively. On the other hand, intensity values of illumination by 6,500K LED (6.9W) and FL (12W) were both 1.20times as large as 2,800K ones, but 6,500K light sources were much less effective compared to 2,800K ones. Daylight type LED and FL which have higher luminance efficiency but emit less red light compared to warm white ones, are not suitable as alternative light sources for IC.
Keywords daylight Fragaria ×ananassa Duch. intermittent lighting luminance efficiency warm white
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 1
End Page 6
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_contents.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_cover.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
ISSN 2186-7755
language Japanese
File Version publisher