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JaLCDOI 10.18926/AMO/53562
FullText URL 69_4_255.pdf
Author Miyahara, Hiroyuki| Maruyama, Hidehiko| Kanazawa, Akane| Iwasaki, Yuka| Shigemitsu, Yusuke| Watanabe, Hirokazu| Tokorodani, Chiho| Miyazawa, Mari| Nishiuchi, Ritsuo| Kikkawa, Kiyoshi|
Abstract Since the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7) in 2007, invasive pneumococcal disease has declined, but the incidence of Streptococcus pneumoniae serotype 19A has risen worldwide. The present study examined changes in the features of invasive pneumococcal disease since the introduction of the PCV7 in Kochi, Japan. Pediatric cases of invasive pneumococcal disease were investigated before and after vaccine introduction (January 2008 to December 2013). Cases of invasive pneumococcal disease tended to decrease after PCV7 introduction. In addition, before introduction of the vaccine, most serotypes causing invasive pneumococcal disease were those included in the vaccine. However, after the introduction, we found cases infected by serotypes not covered by vaccine. Penicillin-resistant S. pneumoniae was the predominant serotype causing invasive pneumococcal disease before introduction of the PCV7, and the susceptibility of this serotype to antibiotics improved after vaccine introduction. Serotype isolates identified after vaccine introduction were also relatively susceptible to antibiotic therapy, but decreased susceptibility is expected.
Keywords seven-valent pneumococcal conjugate vaccine (PCV7) invasive pneumococcal disease (IPD)
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 255
End Page 260
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289917
Web of Science KeyUT 000365519100009
JaLCDOI 10.18926/AMO/53561
FullText URL 69_4_245.pdf
Author Aoki, Kana| Sakuma, Mayumi| Ogisho, Noriyuki| Nakamura, Kozo| Chosa, Etsuo| Endo, Naoto|
Abstract Exercise is essential for maintaining quality of life (QOL) in elderly individuals. However, adherence to exercise programs is low. Here, we assessed the effectiveness of a self-directed home exercise program with serial telephone contacts to encourage exercise adherence among elderly individuals at high risk of locomotor dysfunction. We recruited community-dwelling adults (ァ65 years) in Niigata, Japan, who were targets of the long-term care prevention project for locomotor dysfunction but did not participate in the government-sponsored prevention programs. The study was conducted from November 2011 to October 2012. Participants received exercise instruction and performed exercises independently for 3 months with serial telephone contacts. The single-leg stance and five-times sit-to-stand tests were used to assess physical function. The SF-8 was used to measure health-related QOL. Ninety-seven participants were enrolled in the study, representing 2.5オ of eligible people;87 completed the intervention. Scores from physical function tests were significantly improved by the intervention, as were 7 of eight SF-8 subscales. Adherence was 85.4オ for the single-leg standing exercise and 82.1オ for squatting. Thus, self-directed home exercise with serial telephone contacts improved physical function and health-related QOL, representing a promising model for preventing the need for long-term care due to locomotor dysfunction.
Keywords locomotor dysfunction self-home exercise single-leg stance test five-times sit-to-stand test SF-8
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 245
End Page 253
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289916
Web of Science KeyUT 000365519100008
JaLCDOI 10.18926/AMO/53560
FullText URL 69_4_237.pdf
Author Nanba, Shintarou| Ikeda, Fusao| Fujioka, Shin-ichi| Araki, Yasuyuki| Takaguchi, Kouichi| Hashimoto, Noriaki| Seki, Hiroyuki| Takaki, Akinobu| Iwasaki, Yoshiaki| Yamamoto, Kazuhide|
Abstract The effectiveness of extending treatment duration as response guided therapy was previously reported for chronic hepatitis C (CHC) genotype 1, but is still controversial for genotype 2. The present study is a retrospective cohort study to investigate the effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for patients with CHC genotype 2 by focusing on the timing at which patients obtained undetectable HCV RNA. A total of 306 patients who obtained undetectable HCV RNA by week 24 of treatment and completed 24 weeks of treatment were enrolled. Rapid virological response (RVR) to standard therapy was achieved by 122 patients (51オ), and 89オ of them obtained sustained virological response (SVR), while 69オ of non-RVR patients achieved SVR. Non-RVR patients with undetectable HCV RNA at week 8, and insufficient adherence<80オ pegylated interferon and ribavirin during the first 24 weeks, significantly improved their SVR rate by extended therapy. Among patients receiving extended therapy, drug adherences did not differ between SVR and non-SVR patients, indicating that extending treatment duration might compensate for insufficient antiviral effects due to insufficient drug adherences. This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2.
Keywords hepatitis C virus interferon genotype 2 response-guided therapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 237
End Page 244
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289915
Web of Science KeyUT 000365519100007
JaLCDOI 10.18926/AMO/53559
FullText URL 69_4_227.pdf
Author Nakagawa, Naohisa| Koda, Hiromi| Nitta, Noriko| Nakahara, Yukie| Uno, Jiro| Hashimoto, Toru| Nakahori, Takashi| Hasegawa, Masaaki| Kataoka, Mikio|
Abstract Previous reports have shown that some ovarian endometrioid adenocarcinomas and ovarian clear cell adenocarcinomas derive from ovarian endometriosis (OE), and that endocervical-like mucinous borderline ovarian tumors are associated with OE. We examined the relationship between the staging and histological subtypes of OE or epithelial ovarian tumors (EOT) and the serum levels of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) to evaluate the potential of these markers for preoperative diagnosis. First, we analyzed the preoperative serum levels of CA19-9 and CA125 in 195 patients who were histopathologically diagnosed with OE or EOT. We then performed a case-control study in which 308 women were enrolled, the 195 women described above and 113 healthy women as control subjects. Serum CA19-9 and CA125 levels were found to be useful in differentiating between OE and serous adenocarcinoma, but not between OE and other EOT. Moreover, serum CA19-9 levels were useful for preoperative assessment between OE and stage I mucinous borderline ovarian tumors, with or without the interstitial infiltration. In addition, considering that the serum CA19-9 levels in stage I mucinous borderline ovarian tumors were elevated via the interstitial infiltration of leukocytes and that precancerous lesions are associated with a cancerous glycosylation disorder in the process of inflammatory carcinogenesis, the CA19-9 level may be considered a suitable biomarker for estimating drug susceptibility.
Keywords ovarian endometriosis epithelial ovarian tumors histological subtype carbohydrate antigen 19-9 carbohydrate antigen 125
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 227
End Page 235
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289914
Web of Science KeyUT 000365519100006
JaLCDOI 10.18926/AMO/53558
FullText URL 69_4_219.pdf
Author Toshimori, Junichi| Nouso, Kazuhiro| Nakamura, Shinichiro| Wada, Nozomu| Morimoto, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Kuwaki, Kenji| Ohnishi, Hideki| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Yamamoto, Kazuhide|
Abstract We conducted a retrospective cohort study to investigate the predisposing factors for local recurrence and complications after percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). HCC patients (n=397) consecutively treated with RFA (256 males, 141 females, median age 69 years) were enrolled. In these patients, 1,455 nodules (median size 17mm) were ablated. Predisposing factors for overall recurrence and local recurrence in the context of tumor location and complications were examined. Local recurrence was observed for 113 of the 1,455 nodules. The 1-, 3- and 5-year local recurrence rates were 2.2オ, 7.4オ and 9.5オ, respectively. A multivariate Cox proportional hazard analysis revealed that large tumor size (>2cm), tumor location (adjacent to the major portal branch or hepatic vein), and small ablated margin (<3mm) were independent predisposing factors for local recurrence after RFA (HR=1.70-2.81). Tumor location (adjacent to the major portal branch, hepatic vein, or diaphragm) was also revealed as a risk factor for liver damage due to RFA. HCC adjacent to the major portal vein or hepatic vein was associated with a higher risk for local recurrence and for complications;therefore, special precautions are necessary when applying RFA to HCC near vessels even when the tumors are located at an easy-to-puncture site.
Keywords hepatocellular carcinoma radiofrequency ablation ablated margin tumor location
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 226
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289913
Web of Science KeyUT 000365519100005
JaLCDOI 10.18926/AMO/53557
FullText URL 69_4_213.pdf
Author Yumoto, Tetsuya| Sato, Keiji| Ugawa, Toyomu| Ichiba, Shingo| Ujike, Yoshihito|
Abstract Hyponatremia, a common electrolyte disorder associated with traumatic brain injuries (TBIs), has high mortality and morbidity rates. The aim of this study was to identify the risk factors for hyponatremia associated with TBI. We retrospectively analyzed the cases of TBI patients who were admitted to the emergency intensive care unit at Okayama University Hospital between October 2011 and September 2014. A total of 82 TBI patients were enrolled. The incidences of hyponatremia (serum sodium level of<135mEq/L) and severe hyponatremia (serum sodium level of<130mEq/L) within the first 14 days after admission were 51オ (n=42) and 20オ (n=16), respectively. After admission, hyponatremia took a median period of 7 days to develop and lasted for a median of 3 days. Multivariate analysis demonstrated that higher fluid intake from days 1 to 3 and the presence of cranial fractures were risk factors for hyponatremia. The 58 patients with hyponatremia experienced fewer ventilator-free days, longer intensive care unit stays, and less favorable outcomes compared to the 24 patients without hyponatremia;however, these differences were not significant. Further studies are needed to determine the optimal management strategy for TBI-associated hyponatremia in the intensive care unit setting.
Keywords traumatic brain injury hyponatremia cranial fracture fluid intake
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 213
End Page 218
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289912
Web of Science KeyUT 000365519100004
JaLCDOI 10.18926/AMO/53556
FullText URL 69_4_205.pdf
Author Okada, Yoshiki| Endo, Hirosuke| Mitani, Shigeru| Fujiwara, Kazuo| Tetsunaga, Tomonori| Kagawa, Yohei| Fujii, Yosuke| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Abstract Total hip arthroplasty (THA) is the most effective treatment for advanced or end-stage hip osteoarthritis. However, venous thromboembolism (VTE) remains one of its unresolved complications. We reviewed the records of 322 patients undergoing primary THA and investigated the efficacy of anticoagulant prophylaxis for VTE. Our study cohort consisted of 60 patients who received no anticoagulants, 100 patients who received a factor Xa inhibitor (fondaparinux), 100 patients who received low molecular weight heparin (enoxaparin), and 62 patients who selectively received no anticoagulant prophylaxis due to perioperative bleeding, weight, and/or hemoglobin concentration. Enhanced 64-slice multidetector row computed tomography was performed postoperatively for 7 days in all cases. The incidence of VTE in the four groups was 15オ, 9.0オ, 6.0オ, and 6.4オ, respectively. The incidence of VTE was significantly lower in the groups receiving anticoagulant prophylaxis and the group selectively receiving no anticoagulant prophylaxis than in the group receiving no anticoagulants. Complications of fondaparinux therapy included hepatic dysfunction in 4 cases (4.0オ), minor bleeding in 2 cases (2.0オ), persistent wound drainage in 3 cases (3.0オ), and eruption in 1 case (1.0オ). The complications of enoxaparin therapy were persistent wound drainage in 1 case (1.0オ) and progression of anemia in 1 case (1.0オ). The incidence of VTE was low in patients who selectively received no anticoagulant prophylaxis, so we conclude that anticoagulant prophylaxis should be used selectively in THA cases.
Keywords total hip arthroplasty venous thromboembolism anticoagulant prophylaxis complications
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 205
End Page 212
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289911
Web of Science KeyUT 000365519100003
Related Url http://doi.org/10.18926/AMO/53680
JaLCDOI 10.18926/AMO/53555
FullText URL 69_4_197.pdf
Author Ishibashi, Naoki| Miyasho, Koji| Kitamura, Tetsuhisa| Ookuma, Takaaki| Kashitani, Nobuhiro| Beika, Nobuhiko| Yamashita, Takahiro| Ujike, Yoshihito|
Abstract We evaluated the hemodynamics and outcomes of septic shock (SS) patients who did not respond to fluid resuscitation, after treatment with or without intravenous calcium. We retrospectively collected information on 154 eligible SS patients who were admitted to Fukuyama City Hospital Emergency Medical Center and did not respond to fluid resuscitation. To compare their degree of hemodynamic impairment, we compared the changes in the vasoactive-inotropic score (VIS) in the calcium-treated group (n=112) and the noncalcium-treated group (n=42). We compared the length of stay in the intensive care unit (ICU) and hospital, in-hospital deaths, 28-day deaths, and changes in the Sequential Organ Failure Assessment score within 72h of ICU admission between the 2 groups. Changes in the VIS at 1h after the baseline time were significantly greater in the calcium-treated group than in the noncalcium-treated group (1.41 vs. -1.25, respectively;p<0.001). However, the changes in the VIS at 3, 6, 24, 48, and 72h did not differ between the 2 groups. The secondary outcomes also did not differ between the groups. Our findings indicate that calcium administered to SS patients might reduce their hemodynamic stabilization, but only for a short time after its administration.
Keywords hemodynamics calcium shock sepsis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 197
End Page 204
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289910
Web of Science KeyUT 000365519100002
JaLCDOI 10.18926/AMO/53554
FullText URL 69_4_189.pdf
Author Yamashita, Mako| Katayama, Norihisa| Waki, Takahiro| Katsui, Kuniaki| Himei, Kengo| Takemoto, Mitsuhiro| Kanazawa, Susumu|
Abstract This study compared field-in-field (FIF) radiotherapy with conformal radiotherapy with physical wedges for the treatment of unilateral cervical malignant lymphoma. Two treatment plans, the FIF technique and conformal RT, were generated for each of 32 patients with unilateral cervical malignant lymphoma. To compare the 2 treatment plans, dose-volume histograms of the planning target volume (PTV), the thyroid, submandibular gland, carotid artery, mucosa, spinal cord, and surrounding normal tissue, and monitor unit (MU) were analyzed. The FIF technique showed significant reduction in the mean dose of thyroid, submandibular gland, carotid artery and mucosa, the maximum dose of the spinal cord and PTV, and the volume receiving>107% of the prescribed dose of surrounding normal tissue (p<0.001). In addition, there were gains in the homogeneity index of the PTV for FIF. Furthermore, the total MU was also lower for the FIF technique than for the wedge technique (p<0.001). Compared with the wedge technique, the FIF technique improved the dose homogeneity of the PTV, reduced the dose to normal structures, and was associated with fewer MUs in the treatment of patients with cervical malignant lymphoma.
Keywords field-in-field technique wedge lymphoma monitor units dose-volume histogram
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 189
End Page 195
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289909
Web of Science KeyUT 000365519100001
JaLCDOI 10.18926/OER/53553
Title Alternative J. H. Clapham, An Economic History of Modern Britain, vol. , Book 3, Free Trade and Steel, 1850-1886 (1st ed., 1932), Outline, Chap. 8, Chap. 9
FullText URL oer_047_1_081_111.pdf
Author Ichinose, Atsushi|
Publication Title 岡山大学経済学会雑誌
Published Date 2015-07-02
Volume volume47
Issue issue1
Start Page 81
End Page 111
ISSN 0386-3069
language Japanese
Copyright Holders Copyright © 2015 岡山大学経済学会
File Version publisher
NAID 120005627389
JaLCDOI 10.18926/OER/53552
Title Alternative Local Development by University Reform: “Investments for the future” Program and University-Community Partnerships
FullText URL oer_047_1_071_079.pdf
Author Iwabuchi, Yasushi|
Publication Title 岡山大学経済学会雑誌
Published Date 2015-07-02
Volume volume47
Issue issue1
Start Page 71
End Page 79
ISSN 0386-3069
language Japanese
Copyright Holders Copyright © 2015 岡山大学経済学会
File Version publisher
NAID 120005627388
JaLCDOI 10.18926/OER/53551
Title Alternative Report on the Questionary Survey Research about the Effects that Team Medical Care Gives for the Organizational Change in the Hospital
FullText URL oer_047_1_045_069.pdf
Author Matsuda, Yoichi| Kawakami, Sachiko|
Publication Title 岡山大学経済学会雑誌
Published Date 2015-07-02
Volume volume47
Issue issue1
Start Page 45
End Page 69
ISSN 0386-3069
language Japanese
Copyright Holders Copyright © 2015 岡山大学経済学会
File Version publisher
NAID 120005627387
JaLCDOI 10.18926/OER/53550
Title Alternative The Development of Studies for Accounting Anomalies and Market Efficiency
FullText URL oer_047_1_031_043.pdf
Author Nakagawa, Toyotaka|
Publication Title 岡山大学経済学会雑誌
Published Date 2015-07-02
Volume volume47
Issue issue1
Start Page 31
End Page 43
ISSN 0386-3069
language Japanese
Copyright Holders Copyright © 2015 岡山大学経済学会
File Version publisher
NAID 120005627386
JaLCDOI 10.18926/OER/53549
Title Alternative Entrepreneurial Initiatives to the Paradigm Shift towards Sound Material Cycle Economy: A Case Study of Japanese Plastic Food Container Industry
FullText URL oer_047_1_015_030.pdf
Author Fujii, Daiji|
Publication Title 岡山大学経済学会雑誌
Published Date 2015-07-02
Volume volume47
Issue issue1
Start Page 15
End Page 30
ISSN 0386-3069
language Japanese
Copyright Holders Copyright © 2015 岡山大学経済学会
File Version publisher
NAID 120005627385
JaLCDOI 10.18926/OER/53548
Title Alternative Looking Back on the History of International Student Support Network Peach (The First Half) −For Further Improvements of the Short-term Homestay Programme-
FullText URL oer_047_1_001_014.pdf
Author Hirota, Yoko| Oka, Masumi|
Publication Title 岡山大学経済学会雑誌
Published Date 2015-07-02
Volume volume47
Issue issue1
Start Page 1
End Page 14
ISSN 0386-3069
language Japanese
Copyright Holders Copyright © 2015 岡山大学経済学会
File Version publisher
NAID 120005627384
Title Alternative The 114th General Assembly of the Okayama Medical Association
FullText URL 127_169.pdf
Author 岡山医学会|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 169
End Page 174
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.169
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.169
NAID 130005096243
Title Alternative Advances in Diabetology, The 49th Annual Post Graduate Course
FullText URL 127_167.pdf
Author Makino, Hirofumi|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 167
End Page 168
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.167
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.167
NAID 130005096244
Title Alternative The 56th Annual Meeting of the Japanese Society of Pediatric Hematology/Oncology
FullText URL 127_163.pdf
Author Oda, Megumi|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 163
End Page 166
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.163
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.163
NAID 130005096245
Title Alternative The 26th Annual Meeting of the Japanese Society of Cerebral Blood Flow and Metabolism
FullText URL 127_161.pdf
Author Abe, Koji|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 161
End Page 162
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.161
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.161
NAID 130005096246
FullText URL 127_159.pdf
Author 小松原 正吉|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 159
End Page 160
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher