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Author 岡山大学温泉研究所|
Published Date 1954-03
Publication Title 岡山大学温泉研究所報告
Volume volume14
Content Type Others
JaLCDOI 10.18926/40322
Title Alternative THE CLINICAL STUDIES OF RHEUMATOID ARTHRITIS (I)
FullText URL 016_035_048.pdf
Author Morinaga, Hiroshi|
Abstract The value of spa treatment of rheumatic disease is an established feature of medical management based on experiences for many centuries. The author has been practising the balneotherapy of rheumatic diseases at Misasa Spa for several years, and has found this therapy efficacious in many cases in relieving the anemia that accompanies rheumatoid arthritis. For this reason, the author is investigating the metabolism of iron in rheumatic anemia, which is expected to occur in the course of the spa treatment. In this report, the results of clinical examinations of 24 patients with rheumatoid arthritis, of the type (2. 2. 2.) Polyarthritis systemica chronica (in Prof. Kodama's classification of arthritis), are described. I. Some observations of anemia in rheumatoid arthritis 1. The peripheral blood The number of erythrocytes is 266×10(4)~455×10(4)/c. mm. (average: (381±32)×10(4)/c. mm.), Hb-content : 55~90% (average : 76±5.8%), and the color index is about 1.0. The anemia of rheumatic disease treated is mostly normochromic. The white blood count is between 3240 and 13300/c. mm. (average: 6421±955/c. mm. ), and the number of the leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed in 15% of the cases. 2. Anemia-producing substance in the serum of rheumatoid arthritis When serum from rheumatoid arthritis patients was injected into rabbits, the number of erythrocytes and the hemoglobin -content of the rabbits was found to decrease markedly for 2~6hours after the injection. But no such effect was observed when the serum of healthy subjects was injected. From this, the author presumes the presence of an anemia-producing substance in the serum of rheumatoid arthritis. The nature of this substance in now under investigation. II. Clinical-biochemical studies 3. Gastric acidity of rheumatic patients Of 7 cases examined, anacidity of gastric juice was observed in 2 cases, subacidity in other 2 cases and normacidity in the remaining 3 cases. Thus, a decrease in the gastric acidity was found to occur in 57% of the cases. 4. Takata-serum-test and sedimentation rate It is said that the sedimentation rate and the Weltmann-reaction are very sensitive indicators of the extent of the activity of rheumatic disease. The Takata-serum-test was applied in 18 cases and was found to give positive results in 10 cases (55%). The sedimentation rate was found to increase in 17 of 20 cases (85%). 5. Blood uric acid As is well known, the concentration of uric acid is abnormally high in the blood of patients with gout; while, according to the literature, the blood uric acid levels of patients with rheumatoid arthritis range within the normal limits. The author, using the method of Benedict, obtained the following results for blood uric acid in 14 normal subjects in fasting state: Range - 2.30~3.47mg./dl. , 5% rejection limit -- 1.97~3.68mg./dl. In 5 of 7 cases of rheumatoid arthritis, the blood uric acid levels were shown to be above the upper limit of the normal range, but the concentrations of blood uric acid of non-rheumatic joint diseases and neuralgias were mostly within the normal range. 6. Blood sugar The fasting blood sugar levels of rheumatoid patients ranged from 82 to 1l0mg./dl. (average : 100mg./dl.), higher than the levels of healthy subjects (78~108mg./dl., average : 90mg./dl.). The intravenously injected glucose load test was applied to 8 rheumatoid patients. A solution of 40 ml. of 20% glucose was injected into a fasting subject for 2 minutes. Blood samples were taken before the injection, 3 minutes after the injection, and at each subsequent 10 minute-interval for 70 minutes. The glucose tolerance curves in 5 of these cases were found to be out of the normal range. It is to be noticed that the average blood sugar for rheumatoid arthritis is similar to the curve for liver disease. 7. Serum alkaline phosphatase activity and serum phosphorus The method of Taussky-Shorr was used for the determination of the level of alkaline phosphatase activity and inorganic phosphate in the serum. The alkaline phosphatase activity of 11 normal individuals ranged from 1.4 to 6.4 Shinowara-Jones-Rheinhart units/dl. (5% rejection limit), while in 4 of 8 cases of rheumatoid arthritis, it was of abnormally high levels. The concentration of inorganic phosphate in the serum of 12 normal subjects ranged from 2.9 to 5.0mg. /dl. (5% rejection limit), while in 3 cases of rheumatoid patients, it showed higher levels than normal. 8. Total cholesterol in serum The total cholesterol in the serum of fasting normal individuals was measured by Bloor's method, and the concentration was found to range from 124 to 188mg./dl. (rejection limit of 5% level of significance), and the total cholesterol in the serum of rheumatoid arthritis to be abnormally high in concentration in 6 of 7 cases. The liver function was evaluated by the Takata-serum-test, the test of fasting blood sugar levels, the glucose load test, and the test of serum alkaline phosphatase activity; and from this the hepatic dysfunction was found to occur in rheumatoid arthritis patients in about 50% of the cases examined. Disturbances in the protein, fat, and carbohydrate metabolism were also found to occur. The above-mentioned findings indicate that rheumatoid arthritis is not only a disease of the joints, but also a general and systemic illness. Attention must accordingly be given to the general condition of the patient in the treatment of rheumatic disease.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-01
Volume volume16
Start Page 35
End Page 48
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40318
language Japanese
File Version publisher
NAID 40017532470
JaLCDOI 10.18926/40319
Title Alternative REPORT OF THE CHEMICAL ANALYSIS OF MISASA HOT SPRINGS, TOTTORI PREFECTURE
FullText URL 016_001_018.pdf
Author Oshima, Yoshio| Mifune, Masaaki| Yamada, Naoharu| Ueyama, Akiko|
Abstract The water samples of 55 springs of Misasa were analysed in the years 1950~1951. The temperatures of the waters ranged from 44° to 85° C. Radon content ranged from 34.1 to 2360×10(-10) curies per liter. pH 6.2~7.5. Evaporation residue: 534~1940 mg/kg. K(+) :10.4~47.3mg/kg. Na(+) : 140.4~574mg/kg. Ca(2+) : 7.56~49.06mg/kg. Mg(2+) : 0.11~15.3mg/kg.. Fe(2+) : 0.10~0.67mg/kg. Cl(-) : 138~854mg/kg. SO(4)(2-) : 29.2~187mg/kg. HCO(3)(-) : 74.8~370mg/kg. HBO(2)(-) : 1.80~19.6mg/kg. S(2)O(3)(2-) : o.62~3.69mg/kg. Radon sources seem to exist at shallow places under the ground and the radon in the thermal wacer is supposed to have been derive partly from the ground water which also contains considerable amount of radon. A close linear correlation (r=0.751) was proved between the sulfate and the chloride ion contents.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-01
Volume volume16
Start Page 1
End Page 18
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40318
language Japanese
File Version publisher
NAID 40017532473
Author 岡山大学温泉研究所|
Published Date 1956-01
Publication Title 岡山大学温泉研究所報告
Volume volume16
Content Type Others
JaLCDOI 10.18926/40315
Title Alternative OUR EXPERIENCES OF INTRAARTICULAR HYDROCORTISONE INJECTION AND SPA TREATMENT FOR RHEUMATOID ARTHRITIS AND ARTHROSISDEFORMANS
FullText URL 017_019_032.pdf
Author Nakahara, Yasuhiro| Izumi, Tomokuni|
Abstract 1. We classified 89 cases of rheumatoid arthritis and arthrosis deformans according to Prof. T. Kodama's criteria as follows: 33 cases of (222) polyarthritis systemica (37%), 15 cases of (221) polyarthritis non systemica (16.8%) 22 cases of (111) monoarthrosis non systemica (24%), and others. 2. We analysed their symptoms following the criteria recommended by the New York Rheumatism Association and Prof. T. Kodama. In many cases of (222), their local and general symptoms were found to belong to Class III or IV, and in many cases of (111) and (221), to Class I or II. This shows that (222), here treated, was severer than (111) and (221) in both local and general conditions. The hepatic disorder and anemia were found to occur in patients with (222). 3. We treated these 89 cases chiefly by spa therapy and intraarticular injection of hydrocortisune, and evaluated the results by the criteria recommended by N. Y. R. A. and Prot. T. Kodama. Each of these treatments was more effective on (111), (121), and (221) than on (222). In all cases, the combined treatment with the said two measures was more efficacious than the separate treatment with each of the two. 4. The effects of the intraarticular hydrocortisone injections, 686 in total and mostly into knee joints, were examined. The most efficacious of these were obtained when the injection was made into fingers, toes or hip joints. In our experiences, the post-injection flare ups and the adverse effects of the treatments were observed in 2.8% of the cases treated, but they lasted only for a few days. 5. Of five cases of (222), where the combined treatment of hydrocortisone intraarticular injection and spa therapy was given for 5-14 months, detailed descriptions are given. By this treatment the physical abilities in joints of patients were improved remarkably and their general conditions were ameliorated gradually without any adverse effects.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-03
Volume volume17
Start Page 19
End Page 32
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40311
language Japanese
File Version publisher
NAID 40017532476
JaLCDOI 10.18926/40314
Title Alternative BALNEOTHERAPEUTIC EXPERIENCES IN GYNECOLOGY (6) A STATISTICAL INVESTIGATION ON CHANGE OF SUBJECTIVE SYMPTOMS OF 30 GYNECOLOGIC PATIENTS IN THE COURSE OF BALNEOTHERAPY IN MISASA SPA
FullText URL pitsr_017_013_018.pdf
Author Tanaka, Yosinori| Hosokawa, Ryukai|
Abstract 1. The chief complaints of the patients were lower abdominal pain (33%), menstrual disorder (23%), infertility (20%), etc. 2. As disease, adnexitis (17%), retroflexio uteri (23%), vaginitis (13%), etc. were noted. 3. As balneotherapy they took thermal bath on an average 4 times a day for three weeks in Misasa radioactive spa. 4. Various "Fäder-reaktionen" were noted on 70% of the patients. They were fatigue (33%), dulling of the appetite (23%), small uterine bleeding (20%), lower abdomimal pain (17%), fever (11%), vaginal discharge (7%), etc. 5. The above-mentioned small uterine bleeding occured about 7 th day of the cure, and continued for 2 days on an average. In most cases, it was accompanied by the lower abdominal pain. 6. A temporary change of menstrual cycles after the cure was noted in 30% of the patients. 7. In 62% of the cases treated. the spa treatment gave curative effects paticularly on various pains and vegetative disharmony, but none on infertility.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-03
Volume volume17
Start Page 13
End Page 18
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40311
language Japanese
File Version publisher
NAID 120002462899
JaLCDOI 10.18926/40313
Title Alternative EFFECT OF INTERNAL USE OF THERMAL WATER OF YUMURA AND MUSASHI HOT SPRINGS UPON THE ALIMENTARY HYPERGLYCEMIA IN RABBITS
FullText URL pitsr_017_008_012.pdf
Author Morinaga, Hiroshi|
Abstract The author investigated the effect of the internal use of thermal water of Yumura (weak alkaline spring, Hyogo Prefecture) and Musashi (weak common salt spring, Fukuoka Prefecture) Springs upon the alimentary hyperglycemia in rabbits. Sixty ml. of spring water, and of plain water as control, with 10% glucose in solution was administered to rabbits by stomach tube, and the blood sugar level was determined before and 1/2, 1, 2 and 3 hours after the administration. In all cases, the thermal water was revealed to inhibit the alimentary hyperglycemia significantly by comparing the results obtained with the thermal water and those with the plain water control.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-03
Volume volume17
Start Page 8
End Page 12
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002462898
JaLCDOI 10.18926/40312
Title Alternative o-PHENANTHROLINE METHOD APPLIED TO THE DETERMINATION OF IRON IN NATURAL WATERS
FullText URL pitsr_017_001_007.pdf
Author Tanaka, Shigeo|
Abstract The o-phenanthroline method was tested as to its applicability to the separate determination of iron in natural water: ionic ferrous iron, reducible iron, snd colloidally dispersed iron. In connection with this, the results of the following experiments are given in this paper. 1. Determination of the absorption curve of o-phenanthroline ferrous complex. (Figure 1.) 2. Construction of the calibration curve for a Purfrich's photometer with filter S 50, 15 cm cuvettes. (Figure 2.) 3. Examination of the effects of coexisting anions on the determination of iron by the method of three way layout. (Table 1., Table 2.) 4. Trial determinations of iron in three different states in solution. (Table 3., Table 4. ) 5. Test of the applicability of this method to the determination of ionic ferrous iron and reducible iron in thermal water. (Table 5., Table 6.) From the above, it was revealed that ionic ferrous iron and reducible iron in natural water are separately determinable with sufficient accuracy by the o-phenanthroline method, and that ionic iron and colloidally dispersed iron are also separately determinable, when the dispersed iron is present in amount more than 1.3% of the total iron.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-03
Volume volume17
Start Page 1
End Page 7
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40311
language Japanese
File Version publisher
NAID 120002462897
Author 岡山大学温泉研究所|
Published Date 1956-03
Publication Title 岡山大学温泉研究所報告
Volume volume17
Content Type Others
Author 山口 鎌次|
Published Date 1957-03
Publication Title 岡山大学温泉研究所報告
Volume volume18
Content Type Others
Author 岡山大学温泉研究所|
Published Date 1957-03
Publication Title 岡山大学温泉研究所報告
Volume volume18
Content Type Others
Author 鈴木 篁|
Published Date 1957-09
Publication Title 岡山大学温泉研究所報告
Volume volume19
Content Type Conference Paper
Author 片山 信夫|
Published Date 1957-09
Publication Title 岡山大学温泉研究所報告
Volume volume19
Content Type Others
Author Yamaguchi, Kenji|
Published Date 1957-09
Publication Title 岡山大学温泉研究所報告
Volume volume19
Content Type Conference Paper
Author 沼野 忠之|
Published Date 1957-09
Publication Title 岡山大学温泉研究所報告
Volume volume19
Content Type Conference Paper
Author 岡山大学温泉研究所|
Published Date 1957-09
Publication Title 岡山大学温泉研究所報告
Volume volume19
Content Type Others
JaLCDOI 10.18926/40273
Title Alternative On the Underground Temperatures and Radioactivities at One Meter Depth in the Misasa Hot Spring Area
FullText URL pitsr_020_055_061.pdf
Author Soma, Tokuzo|
Abstract Methods and Results of Measurements:-- A stick of steel was driven into the ground down to one meter depth, and a narrow pipe of aluminum or brass, closed at the upper end, was inserted and the hole covered by a board and earth. (See Fig.3.) In Fig.2 the locations for the experiments are shown by x. Fig.1 gives the atmospheric temperatures at noon, October4-21,1955, when the experiments were carried out. About three hours after the above setting had been done, the gas in the hole was replaced by a bottle of water, and was collected, by driving sprayer for five minutes with apparatus as shown in Fig.5, in a can in which an autoradiographic plate was set. (See Fig.6.) The temperature in the hole was read by means of a maximum thermometer hung in the hole for ten minutes at one meter depth. Fig.7 shows the distribution of temperatures at one meter depth thus observed. Exactly twenty four hours after the above setting, the autoradiographic plate in the can (a quarter sized Fuji ET-2E plate, 15μ thick, for contact method) was developed. For developing, the plate was immersed in Ilford D-19 for fifteen minutes, then fixed with Fuji-fix for fifteen minutes, washed with running water for forty minutes, and dried. Then those autoradiographic plate was examined under the microscope of magnification ×280, to count the number of tracks of a-particles. The results obtained are shown in Fig.8. Underground Temperature Distribution:-- On the basis of the distribution of temperatures at one meter depth (Fig.7) and of other available boring data, the distribution of undergound temperatures is estimated as shown in Fig.9 (vertical section along the Misasa river).
Publication Title 岡山大学温泉研究所報告
Published Date 1958-01
Volume volume20
Start Page 55
End Page 61
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002462896
JaLCDOI 10.18926/40272
Title Alternative THE CHANGE IN CONCENTRATION OF FERROUS IRON AND REDUCIBLE IRON, DISSOLVED IN SPRING WATER AT MISASA HOT SPRINGS, JAPAN, DURING PRESERVATION OF THE WATER SAMPLE IN A SEALED BOTTLE
FullText URL pitsr_020_048_054.pdf
Author Tanaka, Shigeo|
Abstract The two sprigns called "Tanaka-no-Yu" and "Hisui-no-Yu" at Misasa Hot Springs, japan (Fig. 1), suitable for sampling the unpolluted water, the locations of which, are shown in Fig. 2, were chosen for this study. The o-phenanthroline method, details of which were discussed in the previous report by the author (Repts. Balneol. Lab. Okyama Univ., 17, 1, (1956)) was used for the determination of ferrous iron, ferrous iron + reducible iron, and ferrous iron + reducible iron + colloidally dispersed iron (to be referred to as "total irons" in this report). For comparison, the change in concentratin of iron dissolved in distilled water during preservation in a sealed bottle was observed, and the results obtained for the solutions with the pH values of 5.4 and 5.8 are illustrated in Fig.3 and Fig.5, rspectively. Both ferrous and reducible iron disappear within 5 minutes, when the pH of the solution is 6.4. The hydrogen ion concentration was thus seen to give a sensitive effects on the speed of diminution of ferrous and reducible iron dissolved in the distilled water. It should be noticed that no appreciable diminution was observed during the period from 60 min. to 120 min,. It is probable that the diminution of total iron is caused by the adsorption of colloidal iron hydroxides on the wall of glass bottle. The effects of charged anion (SO(4)(--)) on the change in concentration of iron during preservation was also investigated, but no appreciable effect was found. (Fig. 5 and Fig. 6). Fig.7, Fig.8, and Fig.9 show the change in concentration of iron during preservation of the spring water at "Tanaka-no-Yu". The content of iron in the spring water is about 0.3 mg/l, and its pH value is about 7.1. For the first 30 minutes, ferrous iron diminishes rapidly, the slope of the diminution curve being sharp and almost straight. Thereafter the slope becomes gentler, and, after an hour, the slope approaches nearly zero. On the other hand, ferrous iron dissolved in distilled water disappears in a moment at the same pH 7.1. Fig.10, Fig.11, and Fig.12 show the change in concentration of iron during preservation of the spring water at "Hisui-no-Yu". The content of iron in the spring water is about 1.0 mg/l, and its pH value is about 6.4. In this case, the diminution of ferrous iron is not remarkable, and only 20% of the initial quantity diminishes within 2 days. Whereas, in the case of distilled water, the diminution is very rapid at the same pH 6,4, and the ferrous iron disappears completely within 5 minutes. In Fig.13 the speed of diminution of iron in distilled water and that in spring water are compared. The difference here seen may probably be due either to that the ferrous iron in spring water is in a certain complex form not easily oxidizable, or to that the spring water contains some reducing substances.
Publication Title 岡山大学温泉研究所報告
Published Date 1958-01
Volume volume20
Start Page 48
End Page 54
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002462895
JaLCDOI 10.18926/40270
Title Alternative DIE KLINISCHEN UND EXPERIMENTELLEN UNTERSUCHUNGEN ÜBER DIE PELOIDTHERAPIE BEI GYNÄKOLOGISCHEN ENTZÜNDUNGEN
FullText URL 020_001_041.pdf
Author Okada, Toshio|
Abstract Die resortive Behandlung bei schwerheilbaren chronischen Entzündungen der Adnexe und des Uterus besteht aus verschiedenen Wärmeapplikationsmethoden. Effekt der Peloidtherapie als eine von diesen Methoden wurde untersucht. Die Untersuchung besteht aus klinischer Beobachtung über die Peloidpackung und tier experimentellem Studium über Peloidbad. A) Über die Peloidpackung. 1. Heileffekt der Packung. 35 Fälle, die an chronischer Entzündung der Adnexe und des Uterus gelitten hatten, wurden mit warmer Peloidpackung an Lenden oder Unterbauch täglich einmal für 2 oder 3 Wochen behandelt. Bei den 28 Fällen von diesen 35 Fällen wurde die gute Folge, wie zum Beispiel Nachlass der Schmerzen und der Induration, bemerkt, Da einige Fälle von diesen 28 Fällen schwache Reaktion auf die anderen verschiedenen Therapie wie Ultrakurzwellenbestrahlung gezeigt hatten, Packung mit Peloid muss eine erfolgreichste Therapie in besonderen Fällen sein, 2, Physiologische Untersuchungen über den Einfluss der Packung bei obigen Kranken, Gesteigerte Blutsenkungsgeschwindigkeit normalisierte sich, und Leukozytenzahl zeigte keine Zeichen der Verschlechteung während der Kur, Keine nennenswerte Veränderung des Elektrokardiogramms wurde während und nach Applikation der Peloid gefunden, und bei Kranken mit hohem Blutdruck fiel der Blutdruck vorübergehend während Applikation der Peloid, Steigerung der Hauttemperatur und der Uterustemperatur bei Packung waren grösser als bei Ultrakurzwellenbestrahlung und Heissluftbad, und diese Erscheinungen wurden auch von tierexperimentellen Untersuchungen festgestellt, Ausscheidung der Phenolsulfonphthalein, die in die Bauchhöhle des Kaninchens sich eingespritzt hatte, wurde von Packung an Unterbauch beschleunigt, So stellt diese klinischen und tierexperimentellen Untersuchungen fest, dass Peloidpackung stark resorptiv durch ihre hyperämisierenden Wirkung nach die Tiefe des Krankheitsherdes ist, und zwar es den Kranken zu keiner Last in verschiedenen Seiten fallt, B) Über das Peloidbad, Verfasser hatte ein Stückchen der spongiOsen Gelatine, die üblich als blutstillendes Material bei Operation gebraucht wird, an Peritoneum der Ratten angenäht, und liess diese Ratten die Peloidbäder täglich einmal 20 minutenlang für 4 Wochen nehmen Inzwischen wurden die Ratten wöchentlich getötet, und die spongiöse Gelatine wurde mit umgebener Granulation aus Bauchhöhle herausgenommen, und dann wurde histologisch untersucht. Gleichzeitig wurden Arten der freien Zellen in der Bauchhöhle und die Neutralrotfärbung:::intensität der Hystiozyten in lockerem Bindegewebe der Unterhaut als Merkmal für Abwehrkraft des Organismus untersucht, Es war festgestellt, dass bei Peloidbädern der Verlauf der durch spongiöse Gelatine hervorgerufene Entzündung sich verkürzt, und das Stückchen der Gelatine wird schnell abgesorviert, und zugleich Abwehrkraft sich steigert, Bei diesen Experimente wurden die stark sauere sulfurhaltge Quellenschlamme (Konyajigoku zu Beppu) und die neutrale Schlamme der Seeboden (Toogooike zu Tottoriken) gebraucht, aber kein wesentlicher Wirkungsunterschied zwischen beide Schlamme wurde gefunden.
Publication Title 岡山大学温泉研究所報告
Published Date 1958-01
Volume volume20
Start Page 1
End Page 41
ISSN 0369-7142
language Japanese
File Version publisher
NAID 40017532504
Author 岡山大学温泉研究所|
Published Date 1958-01
Publication Title 岡山大学温泉研究所報告
Volume volume20
Content Type Others