result 342 件
| JaLCDOI | 10.18926/AMO/65750 |
|---|---|
| FullText URL | 77_4_395.pdf |
| Author | Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana| |
| Abstract | We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia. |
| Keywords | tumor necrosis factor-alpha schizophrenia psychopathology immune system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 395 |
| End Page | 405 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635140 |
| Web of Science KeyUT | 001163659800010 |
| JaLCDOI | 10.18926/AMO/65748 |
|---|---|
| FullText URL | 77_4_377.pdf |
| Author | Morimoto, Kosaku| Takeuchi, Yasuto| Takaki, Akinobu| Wada, Nozomu| Oyama, Atsushi| Adachi, Takuya| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| |
| Abstract | Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker. |
| Keywords | NAFLD NASH liver fibrosis chemokine FIB-4 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 377 |
| End Page | 385 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635138 |
| Web of Science KeyUT | 001163659800009 |
| JaLCDOI | 10.18926/AMO/65740 |
|---|---|
| FullText URL | 77_4_347.pdf |
| Author | Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki| |
| Abstract | The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry. |
| Keywords | flow cytometry stem cell transplantation transplantation-associated microangiopathy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 347 |
| End Page | 357 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635134 |
| Web of Science KeyUT | 001163659800002 |
| JaLCDOI | 10.18926/AMO/65503 |
|---|---|
| FullText URL | 77_3_331.pdf |
| Author | Watanabe, Mototsugu| Yamamoto, Hiromasa| Miyoshi, Kentaroh| Sugimoto, Seiichiro| Toyooka, Shinichi| |
| Abstract | Masaoka stage I type A thymomas rarely recur. We report the case of an 82-year-old man who developed endobronchial metastasis after thymothymectomy for Masaoka stage I type A thymoma. Twenty years after surgery, the patient developed bloody sputum, and chest computed tomography revealed a neoplasm obstructing the right upper lobe bronchus of the lung with enlarged mediastinal lymph nodes. He underwent right upper lobectomy and mediastinal lymph node dissection. Although preoperative pathological diagnosis was squamous cell carcinoma of the lung, postoperative histopathology revealed endobronchial metastasis of the thymoma. Nine years later, at age 89, the patient is alive and well. |
| Keywords | endobronchial metastasis type A thymoma bloody sputum |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 331 |
| End Page | 334 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357635 |
| Web of Science KeyUT | 001026663400001 |
| JaLCDOI | 10.18926/AMO/65502 |
|---|---|
| FullText URL | 77_3_323.pdf |
| Author | Makino, Keigo| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro | Suruga, Yasuki| Washio, Kana| Nishida, Kenji| Yanai, Hiroyuki| Tomida, Shuta| Ennishi, Daisuke| Date, Isao| |
| Abstract | In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases. |
| Keywords | comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 323 |
| End Page | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357634 |
| Web of Science KeyUT | 001025850000001 |
| JaLCDOI | 10.18926/AMO/65496 |
|---|---|
| FullText URL | 77_3_311.pdf |
| Author | Miura, Takanori| Kijima, Hiroaki| Tazawa, Hiroshi| Miyakoshi, Naohisa| |
| Abstract | Japan’s hip fracture management guidelines now recommend the use of cemented stems in cases of bone fragility. However, the current stem selection practices in bipolar hemiarthroplasty (BHA) in a super-aging area in Japan remain unclear. This study aimed to examine the stem selection policies, the surgeons’ concerns about cemented stems, and factors affecting their confidence in their ability to coach others on cemented stem procedures. Ninety-four orthopedic surgeons (27 facilities) responded to our web-based questionnaire conducted in January/February 2022. Cementless stem was the first choice of 97.8% of the surgeons; <15% of the respondents expected to increase their use of cemented stems in the future. The cement technique was the greatest concern; almost half of the surgeons described having insufficient experience with cemented stems. The factor that most affected the surgeons’ expertise in using cemented stems is the number of surgeries they had conducted with a cemented stem (multivariable analysis odds ratio 8.42, p=0.001). Greater experience was associated with increased expertise of the surgeons in using cemented stems, with a threshold of 11 cases showing sensitivity of 41.7% and specificity of 98.3% for their confidence to instruct cemented stems. |
| Keywords | hip fracture arthroplasty bone cement questionnaire |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 311 |
| End Page | 318 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357632 |
| Web of Science KeyUT | 001026279600009 |
| JaLCDOI | 10.18926/AMO/65495 |
|---|---|
| FullText URL | 77_3_301.pdf |
| Author | Kato, Takahide| Miyoshi, Seigo| Hamada, Chizuru| Sano, Yoshifumi| Nogami, Naoyuki| Yamaguchi, Osamu| Hamaguchi, Naohiko| |
| Abstract | Acute exacerbation (AE) of interstitial lung disease (ILD) is a severe complication of lung resection in lung cancer patients with ILD (LC-ILD). This study aimed to assess the predictive value of comorbidities other than ILD for postoperative AE in patients with LC-ILD. We retrospectively evaluated 68 patients with LC-ILD who had undergone lung resection. We classified them into two groups: those who had developed postoperative AE within 30 days after resection and those who had not. We analyzed patient characteristics, high-resolution computed tomography findings, clinical data, pulmonary function, and intraoperative data. The incidence of postoperative AEs was 11.8%. In univariate analysis, performance status (PS), honeycombing, forced vital capacity (FVC), and high hemoglobin A1c (HbA1c) levels without comorbidities were significantly associated with postoperative AE. Patients were divided into two groups according to cutoff levels of those four variables as determined by receiver operating characteristic curves, revealing that the rates of patients without postoperative AE differed significantly between groups. The present results suggested that preoperative comorbidities other than ILD were not risk factors for postoperative AE in patients with LC-ILD. However, a high preoperative HbA1c level, poor PS, low FVC, and honeycombing may be associated with postoperative AE of LC-ILD. |
| Keywords | lung cancer interstitial lung disease acute exacerbation comorbidity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 309 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357631 |
| Web of Science KeyUT | 001026279600008 |
| JaLCDOI | 10.18926/AMO/65493 |
|---|---|
| FullText URL | 77_3_281.pdf |
| Author | Mukai, Yuko| Taira, Naruto| Kajiwara, Yukiko| Iwamoto, Takayuki| Kitaguchi, Yohei| Saiga, Miho| Watanabe, Satoko| Shien, Tadahiko| Doihara, Hiroyoshi| Kimata, Yoshihiro| |
| Abstract | Although immediate breast reconstruction following mastectomy has become increasingly common, its oncological safety has been debated. We enrolled patients with breast cancer who underwent surgery at Okayama University Hospital between 2007 and 2013. The primary outcome was relapse-free survival (RFS). Secondary outcomes were overall survival and the duration from the surgery to the initiation of adjuvant chemotherapy. We divided into immediate breast reconstruction, mastectomy alone, and breast conservative surgery groups. Outcomes were compared using Cox’s regression analysis. A total of 614 patients were included (reconstruction: 125, mastectomy: 128, breast conservative surgery: 361). The median follow-up duration was 79.0±31.9 months. The immediate-reconstruction patients were younger, had more lymph node metastases, and more often received postoperative chemotherapy. The RFS was better after the breast conservative surgery compared to after reconstruction (hazard ratio 0.33, 95% confidence interval: 0.144-0.763). The proportion of local recurrence was highest in the reconstruction group. No patients in the reconstruction group underwent postoperative radiation therapy. However, reconstruction did not affect overall survival or the time to the initiation of adjuvant chemotherapy. Surgeons should explain the risks of breast reconstruction to their patients preoperatively. Careful long-term follow-up is required after such procedures. |
| Keywords | immediate breast reconstruction oncological safety local recurrence postoperative radiation therapy time to initiation of adjuvant chemotherapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 281 |
| End Page | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357629 |
| Web of Science KeyUT | 001026279600006 |
| JaLCDOI | 10.18926/AMO/65492 |
|---|---|
| FullText URL | 77_3_273.pdf |
| Author | Shimizu, Yudai| Kuroda, Masahiro| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Yoshida, Suzuka| Fukumura, Yuka| Nakamura, Yoshihide| Kuroda, Kazuhiro| Kamizaki, Ryo| Imajoh, Satoshi| Tanabe, Yoshinori| Sugimoto, Kohei| Oita, Masataka| Sugianto, Irfan| Bamgbose, Babatunde O.| Yanagi, Yoshinobu| Asaumi, Junichi| |
| Abstract | Diffusion kurtosis (DK) imaging (DKI), a type of restricted diffusion-weighted imaging, has been reported to be useful for tumor diagnoses in clinical studies. We developed a software program to simultaneously create DK images with apparent diffusion coefficient (ADC) maps and conducted an initial clinical study. Multi-shot echo-planar diffusion-weighted images were obtained at b-values of 0, 400, and 800 sec/mm2 for simple DKI, and DK images were created simultaneously with the ADC map. The usefulness of the DK image and ADC map was evaluated using a pixel analysis of all pixels and a median analysis of the pixels of each case. Tumor and normal tissues differed significantly in both pixel and median analyses. In the pixel analysis, the area under the curve was 0.64 for the mean kurtosis (MK) value and 0.77 for the ADC value. In the median analysis, the MK value was 0.74, and the ADC value was 0.75. The MK and ADC values correlated moderately in the pixel analysis and strongly in the median analysis. Our simple DKI system created DK images simultaneously with ADC maps, and the obtained MK and ADC values were useful for differentiating head and neck tumors from normal tissue. |
| Keywords | simple diffusion kurtosis imaging mean kurtosis clinical trial head and neck tumor magnetic resonance imaging |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 273 |
| End Page | 280 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357628 |
| Web of Science KeyUT | 001026279600005 |
| JaLCDOI | 10.18926/AMO/65491 |
|---|---|
| FullText URL | 77_3_263.pdf |
| Author | Guo, Yusheng| Kosaka, Junko| Morimatsu, Hiroshi| |
| Abstract | Continuous renal replacement therapy (CRRT) is widely used to control fluid balance, but the optimal fluid balance to improve the prognosis of patients remains debated. Appropriate fluid management may depend on hemodynamic status. We investigated the association between 90-day mortality and fluid balance/mean arterial pressure (MAP) in patients receiving CRRT. This single-center retrospective study was conducted between May 2018 and March 2021. Based on the cumulative fluid balance at 72 h after initiation of CRRT, the cases were divided into negative (< 0 mL) and positive (> 0 mL) fluid balance groups. Ninety-day mortality was higher in the positive fluid balance group (p=0.009). At 4 h before and after CRRT initiation, the mean MAP was lower in the positive fluid balance group (p<0.05). After multivariate cox adjustment, 72-h positive fluid balance was independently associated with 90-day mortality (p=0.004). In addition, the cumulative fluid balance was associated with 90-day mortality (p<0.05) in cases without shock, high APACHE II score, sepsis, dialysis dependence, or vasopressor use. A 72-h positive fluid balance was associated with 90-day mortality in patients receiving CRRT. |
| Keywords | fluid management continuous renal replacement therapy mortality mean arterial pressure daily cumulative fluid balance |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 263 |
| End Page | 272 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357627 |
| Web of Science KeyUT | 001026279600004 |
| FullText URL | O0004546_abstract_review.pdf O0004546_fulltext.pdf |
|---|---|
| Author | JEONG, TAEJOO| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4546号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Pharmaceutical Sciences |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/65155 |
|---|---|
| FullText URL | 77_2_227.pdf |
| Author | Obayashi, Atsuto| Aoki, Kazuma| Wada, Tadayoshi| Furuie, Hiromi | Kuraoka, Kazuya| Hamamoto, Takao| Tatsukawa, Takaharu| |
| Abstract | We describe the use of the tyrosine kinase inhibitor lenvatinib in a patient with brain tumor metastases from anaplastic thyroid carcinoma (ATC). A 52-year-old Japanese male presented with consciousness loss. Imaging revealed a thyroid tumor and multiple brain lesions. After the brain tumor’s resection, pathology results provided the diagnosis of ATC. Total thyroidectomy was performed, followed by whole-brain irradiation. Additional brain lesions later developed, and lenvatinib therapy was initiated with no remarkable complications. However, the treatment effects were limited, and the patient died 2 months after starting lenvatinib, 202 days after the initial brain surgery. Relevant literature is discussed. |
| Keywords | anaplastic thyroid carcinoma brain metastasis lenvatinib |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-04 |
| Volume | volume77 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 232 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37094963 |
| Web of Science KeyUT | 000982563800006 |
| JaLCDOI | 10.18926/AMO/65154 |
|---|---|
| FullText URL | 77_2_221.pdf |
| Author | Iriyoshi, Hiroki| Sada, Ken-ei| Miyauchi, Atsushi| Yamamoto, Hirotaka| Hashimoto, Daisuke| Nojima, Shigeru| Yamanaka, Shingo| Kawamura, Masafumi| Oka, Satoshi| |
| Abstract | Several previous case reports have shown that patients with immunoglobulin D (IgD) multiple myeloma (MM) can be withdrawn from hemodialysis, however, the characteristics that can predict withdrawal in these patients have not yet been elucidated. A 57-year-old Japanese woman required hemodialysis because of renal dysfunction due to IgD-λ and Bence Jones protein-λ MM. Bortezomib-based chemotherapy nine days after admission led to her withdrawal from hemodialysis on Day 50. In our case-based review, younger age and early initiation of bortezomib-based chemotherapy emerged as possible predictors of successful hemodialysis withdrawal. |
| Keywords | IgD-type multiple myeloma acute renal dysfunction urinary protein hemodialysis bortezomib |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-04 |
| Volume | volume77 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 221 |
| End Page | 225 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37094962 |
| Web of Science KeyUT | 000982563800005 |
| JaLCDOI | 10.18926/AMO/65149 |
|---|---|
| FullText URL | 77_2_193.pdf |
| Author | Ikeda, Tomohiro| Noma, Kazuhiro| Okura, Kazuki| Katayama, Sho| Takahashi, Yusuke| Maeda, Naoaki| Tanabe, Shunsuke| Wakita, Akiyuki| Hamada, Masanori| Fujiwara, Toshiyoshi| Senda, Masuo| |
| Abstract | This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759). Furthermore, fewer patients whose CS-30 score was greater than 16 (the cutoff value defined based on 6MWT) experienced pneumonia in their postoperative course. These results suggest that exercise tolerance could be assessed using CS-30, and its cutoff value may be useful in predicting postoperative pneumonia risk. |
| Keywords | esophageal cancer exercise tolerance rehabilitation |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-04 |
| Volume | volume77 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 193 |
| End Page | 197 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37094957 |
| Web of Science KeyUT | 000982503800009 |
| JaLCDOI | 10.18926/AMO/65146 |
|---|---|
| FullText URL | 77_2_169.pdf |
| Author | Inoue, Kanae| Fujita, Rio| Nagahara, Takatoshi| Murakami, Shiho| Nagai, Yuta| Moriwake, Rina| Miyake, Nozomi| Wakuta, Akiko| Kariyama, Kazuya| Nishimura, Mamoru| Nouso, Kazuhiro| |
| Abstract | Alcoholic liver disease is a risk factor for non-virus-related hepatocellular carcinoma (HCC), which is increasing in prevalence. This study aimed to identify the factors for recovery from alcoholic liver failure. Sixty-two consecutive patients hospitalized for alcoholic liver failure at Okayama City Hospital were enrolled. The characteristics of patients who survived to the 1-month follow-up and whose liver function improved to Child–Pugh A at 3 months (CPA3) and 12 months (CPA12) were compared with the rest of the patients. The survivors at 1 month (50 patients) were significantly younger than the deceased patients and had better liver and renal function with higher levels of γ-glutamyl transferase (GGT). The same factors, except renal function, were correlated with achieving CPA3. High AST, ALT, and GGT levels as well as short spleen length, total abstinence, and good Child–Pugh scores at admission were identified as factors for achieving CPA12. The extent of alcohol intake before admission was not identified as a risk factor in any analysis. In conclusion, baseline liver function is crucial for survival and achieving CPA3, whereas high transaminase and γ-GTP levels, the absence of splenomegaly, and total abstinence are significant factors for achieving CPA12. |
| Keywords | alcoholic liver failure risk factors recovery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-04 |
| Volume | volume77 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 169 |
| End Page | 177 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37094954 |
| Web of Science KeyUT | 000982503800006 |
| JaLCDOI | 10.18926/AMO/65141 |
|---|---|
| FullText URL | 77_2_121.pdf |
| Author | Iguchi, Toshihiro| Matsui, Yusuke| Tomita, Koji| Uka, Mayu| Umakoshi, Noriyuki| Kawabata, Takahiro| Munetomo, Kazuaki| Nagata, Shoma| Araki, Motoo| Hiraki, Takao| |
| Abstract | Percutaneous cryoablation of renal tumors is widely used because of its high efficacy and safety. This high safety can be attributed, at least in part, to the visibility of the ablated area as an “ice ball”. This therapy has fewer complications (incidence, 0-7.2%) and is less invasive than surgery. Minor bleeding is inevitable in most kidney-related procedures, and indeed the most common complication of this therapy is bleeding (hematoma and hematuria). However, patients require treatment such as transfusion or transarterial embolization in only 0-4% of bleeding cases. Various other complications such as ureteral or collecting system injury, bowel injury, nerve injury, skin injury, infection, pneumothorax, and tract seeding also occur, but they are usually minor and asymptomatic. However, operators should know and avoid the various complications associated with this therapy. This study aimed to summarize the complications of percutaneous cryoablation for renal tumors and provide some techniques for achieving safe procedures. |
| Keywords | cryosurgery kidney neoplasms carcinoma renal cell complication |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-04 |
| Volume | volume77 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 121 |
| End Page | 129 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37094949 |
| Web of Science KeyUT | 000982503800001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Aly, Nagwa S. M.| Matsumori, Hiroaki| Dinh, Thi Quyen| Sato, Akira| Miyoshi, Shin-Ichi| Chang, Kyung-Soo| Yu, Hak Sun| Cao, Duc Tuan| Kim, Hye-Sook| |
| Keywords | transdermal N-89 mefloquine pyrimethamine antimalarials combination in vivo |
| Published Date | 2023-03-01 |
| Publication Title | Pathogens |
| Volume | volume12 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 398 |
| ISSN | 2076-0817 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 36986320 |
| DOI | 10.3390/pathogens12030398 |
| Web of Science KeyUT | 000958932800001 |
| Related Url | isVersionOf https://doi.org/10.3390/pathogens12030398 |
| JaLCDOI | 10.18926/64994 |
|---|---|
| FullText URL | biess_7_016_024.pdf |
| Author | Kim, Dong Kwang| Leih, Peodair| Teo, Ian| Freeman, Brigid| |
| Abstract | Scientific consensus agrees that over recent decades and generations, Earth has entered a new geological epoch, termed the Anthropocene. Whereas previous new epochs are postulated to have followed comet strikes and solar realignment, it is demonstrable that it is now human activity that most affects climate change, the release and transformation of chemicals, and general endangerment to life forms. At the same time, human societies throughout history can be seen to have adjusted to effects beyond their control. This is particularly clear in countries marked by frequent seismic activity, with Japan and Chile being prime examples. Particularly, changes in educational policy over the last hundred years appear to correlate to responses to major seismic catastrophes in these countries, with this article proposing to supplement understandings of educational policy evolution with consideration of the legacies of such cataclysms and the revised priorities they elicit. |
| Keywords | Higher Education in Emergencies Earthquakes Tsunamis Japan Chile |
| Publication Title | Bulletin of Institute for Education and Student Services, Okayama University |
| Published Date | 2023-03-14 |
| Volume | volume7 |
| Start Page | 16 |
| End Page | 24 |
| ISSN | 2432-9665 |
| language | English |
| File Version | publisher |
| JaLCDOI | 10.18926/bgeou/64980 |
|---|---|
| Title Alternative | A Comparative Study on the Japanese and Korean Children’s War Literature and its Introduction to Korean Elementary Education |
| FullText URL | bgeou_182_023_033.pdf |
| Author | Kimura, Isao| Kim, Jong Oh| |
| Abstract | 現在韓国の小学校国語教科書には，朝鮮戦争を内容とする戦争児童文学が採録されていない。過去の戦争から学べる惨状などを国語科の文学教育で教えることには意義がある。韓国の朝鮮戦争とは異なる，日本の戦争を描いた戦争児童文学を分析し，韓国の指導要領に基づいて日韓の戦争児童文学が韓国の小学校国語教育現場で扱われるようにしたい。これに関しての日本の戦争児童文学の導入の意義と，学年による作品配置案を考察した。 |
| Keywords | 戦争児童文学 文学教育 平和教育 韓国への導入 |
| Publication Title | Bulletin of Graduate School of Education, Okayama University |
| Published Date | 2023-02-24 |
| Volume | volume182 |
| Start Page | 23 |
| End Page | 33 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/64369 |
|---|---|
| FullText URL | 77_1_97.pdf |
| Author | Hoshijima, Mitsuhiro| Oka, Naoki| Matsumura, Tatsushi| Iida, Seiji| Kamioka, Hiroshi| |
| Abstract | Appropriate operations in severe anterior open bite (AOB) cases are extremely complicated to perform because of the multiple surgical procedures involved, the difficulty of predicting posttreatment aesthetics, and the high relapse rate. We herein report a 16-year-old girl with skeletal Class II, severe AOB malocclusion, and crowding with short roots, and aesthetic and functional problems. Four-piece segmental Le Fort I osteotomy with horseshoe osteotomy was performed for maxillary intrusion, and bilateral sagittal split ramus osteotomy (SSRO) and genioplasty were performed for mandibular advancement. The malocclusion and skeletal deformity were significantly improved by the surgical orthodontic treatment. Functional and aesthetic occlusion with an improved facial profile was established, and no further root shortening was observed. Acceptable occlusion and dentition were maintained after a two-year retention period. This strategy of surgical orthodontic treatment with a complicated operative procedure might be effective for correcting certain severe AOB malocclusion cases. |
| Keywords | anterior open bite short roots severe crowding four-piece segmental horseshoe Le Fort I osteotomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 97 |
| End Page | 104 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849153 |
| Web of Science KeyUT | 000952978000003 |
