検索結果 369 件
| JaLCDOI | 10.18926/AMO/66915 |
|---|---|
| フルテキストURL | 78_2_123.pdf |
| 著者 | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
| 抄録 | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
| キーワード | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 123 |
| 終了ページ | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688830 |
| Web of Science KeyUT | 001229151800004 |
| JaLCDOI | 10.18926/AMO/66914 |
|---|---|
| フルテキストURL | 78_2_115.pdf |
| 著者 | Nakamura-Maruyama, Emi| Irie, Keiichiro| Narita, Kazuhiko| Himi, Naoyuki| Miyamoto, Osamu| Nakamura, Takehiro| |
| 抄録 | Brain edema causes abnormal fluid retention and can be fatal in severe cases. Although it develops in various diseases, most treatments for brain edema are classical. We analyzed the impacts of age and gender on the characteristics of a water intoxication model that induces pure brain edema in mice and examined the model’s usefulness for research regarding new treatments for brain edema. C57BL/6J mice received an intraperitoneal administration of 10% body weight distilled water, and we calculated the brain water content by measuring the brain-tissue weight immediately after dissection and after drying. We analyzed 8-OHdG and caspase-3 values to investigate the brain damage. We also applied this model in aquaporin 4 knockout (AQP4−) mice and compared these mice with wild-type mice. The changes in water content differed by age and gender, and the 8-OHdG and caspase-3 values differed by age. Suppression of brain edema by AQP4− was also confirmed. These results clarified the differences in the onset of brain edema by age and gender, highlighting the importance of considering the age and gender of model animals. Similar studies using genetically modified mice are also possible. Our findings indicate that this water intoxication model is effective for explorations of new brain edema treatments. |
| キーワード | brain edema water intoxication model age gender AQP4 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 115 |
| 終了ページ | 122 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688829 |
| Web of Science KeyUT | 001229151800003 |
| JaLCDOI | 10.18926/AMO/66913 |
|---|---|
| フルテキストURL | 78_2_107.pdf |
| 著者 | Han, Dongxiang| Du, Jianxiu| Wang, Wei| Wang, Cui| |
| 抄録 | Vertical transmission of hepatitis B virus (HBV), especially in Asia, is a key target in the global elimination of HBV. This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. There were no significant differences in liver function markers, including alanine aminotransferase, total bilirubin, blood creatinine, and blood urea nitrogen levels before and after TDF treatment. The serum HBV DNA viral load of the TDF-treated group became significantly lower than those of the control group and their own pre-medication levels. Infants showed no significant difference in body growth, including weight, height, head size, and five-min Apgar score. At 7 months after birth, 94.29% of infants in the TDF group and 86.54% of control-group infants had protective HBsAb levels ≥ 10 mIU/ml (p>0.05). The HBV infection rate of infants in the TDF-treated group was lower than that in the non-treated group. In high-HBV-DNA-load pregnant women, TDF administered from 28 weeks gestational age to delivery was associated with a lower risk of mother-to-infant transmission of HBV. |
| キーワード | mother-to-infant transmission tenofovir disoproxil fumarate hepatitis B virus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 107 |
| 終了ページ | 113 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688828 |
| Web of Science KeyUT | 001229151800002 |
| JaLCDOI | 10.18926/AMO/66912 |
|---|---|
| フルテキストURL | 78_2_095.pdf |
| 著者 | Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| 抄録 | The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. |
| キーワード | neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 95 |
| 終了ページ | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688827 |
| Web of Science KeyUT | 001229151800001 |
| JaLCDOI | 10.18926/AMO/66675 |
|---|---|
| フルテキストURL | 78_1_085.pdf |
| 著者 | Miyake, Keisuke| Tanikawa, Tomohiro| Haruma, Ken| Kawada, Mayuko| Ishii, Katsunori| Urata, Noriyo| Nishino, Ken| Suehiro, Mitsuhiko| Kawanaka, Miwa| Manabe, Noriaki| Kawamoto, Hirofumi| |
| 抄録 | A 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential efficacy of TM in treating IPUD and the importance of considering hypercontractility as the underlying cause in cases of IPUD. |
| キーワード | gastric ulcer idiopathic peptic ulcerative disease trimebutine maleate |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-02 |
| 巻 | 78巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 85 |
| 終了ページ | 88 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38419319 |
| Web of Science KeyUT | 001204421300002 |
| JaLCDOI | 10.18926/AMO/66672 |
|---|---|
| フルテキストURL | 78_1_063.pdf |
| 著者 | Murakami, Daizo| Nishimoto, Kohei| Takao, Soshi| Miyamaru, Satoru| Kadowaki, Tomoka| Saito, Haruki| Takeda, Hiroki| Ise, Momoko| Suyama, Koichi| Orita, Yorihisa| |
| 抄録 | The tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated with a <8 mg/day mean dose of lenvatinib was significantly better than that of the patients treated with 8-24 mg/day (hazard ratio [HR] 0.38 for 1.14-4.54 mg/day, and HR 0.01 for 4.56-7.97 mg/day) adjusted for various factors (e.g., sex, age, drug interruption period). The cumulative dose of lenvatinib administered tended to be higher in the patients treated with low doses (< 8 mg/day) than in the patients treated with relatively high doses (8-24 mg/day). Considering its adverse events, the continuation of lenvatinib treatment with an adequate daily dose and drug interruption may help prolong the survival of patients with unresectable thyroid carcinoma. |
| キーワード | thyroid carcinoma lenvatinib adverse effect survival |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-02 |
| 巻 | 78巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 63 |
| 終了ページ | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38419316 |
| Web of Science KeyUT | 001203658200007 |
| JaLCDOI | 10.18926/AMO/66671 |
|---|---|
| フルテキストURL | 78_1_053.pdf |
| 著者 | Ichikawa, Yukiko| Ogino, Tetsuya| |
| 抄録 | Ice bags are frequently used in medical care settings for pain relief, comfort, and in some cases, whole-body cooling. This study quantifies heat energy transfer capacity of ice bags and evaluates their cooling effects on body temperature. Forty-eight healthy adults in their 20s were recruited. An ice bag wrapped in two layers of dry towel was applied to the forehead, neck, or palm of each participant for 10 min. The skin surface temperature, heat flow, and core temperature were recorded during the cooling and non-cooling periods, with energy transfer calculated by integrating heat flow over time. Over the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling period, the range increased to 180.0-218.7 kJ·m-2 over 10 min. Skin surface temperature decreased by 3.2-5.7°C, whereas core temperature was unchanged. Ice bag use augmented energy transfer by about 150-180 kJ·m-2 over 10 min, but this was insufficient for rapid whole body cooling due to the small skin-surface area in contact with the ice bag. The measured energy transfer indicated that topical ice bag application absorbs insufficient energy to affect core temperature. Quantitative assessment of energy transfer was shown to inform the safe and appropriate use of thermotherapy. |
| キーワード | cold compress fever hyperthermia thermal conductivity thermoregulation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-02 |
| 巻 | 78巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 53 |
| 終了ページ | 61 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38419315 |
| Web of Science KeyUT | 001203658200009 |
| JaLCDOI | 10.18926/AMO/66669 |
|---|---|
| フルテキストURL | 78_1_037.pdf |
| 著者 | Tanaka, Masato| Meena, Umesh| Taoka, Takuya| Fujiwara, Yoshihiro| Yokomizo, Daiichiro| Bashyal, Santosh Kumar| Sake, Naveen| Arataki, Shinya| |
| 抄録 | In adult spinal deformity (ASD) surgery, one of the key factors working to prevent proximal junctional kyphosis is the proximal anchor. The aim of this study was to compare clinical and radiographic outcomes of triangular fixation with conventional fixation as proximal anchoring techniques in ASD surgery. We retrospectively evaluated 54 patients who underwent corrective spinal fusion for ASD. Fourteen patients underwent proximal triangular fixation (Group T; average 74.6 years), and 40 patients underwent the conventional method (Group C; average 70.5 years). Clinical and radiographic outcomes were assessed using visual analogue scale (VAS) values for back pain and the Oswestry disability index (ODI). Radiographic evaluation was also collected preoperatively and postoperatively. Surgical times and intraoperative blood loss of the two groups were not significantly different (493 vs 490 min, 1,260 vs 1,173 mL). Clinical outcomes such as VAS and ODI were comparable in the two groups. Proximal junctional kyphosis in group T was slightly lower than that of group C (28.5% vs 47.5%, p=0.491). However, based on radiology, proximal screw pullout occurred significantly less frequently in the triangular fixation group than the conventional group (0.0% vs 22.5%, p=0.049). Clinical outcomes in the two groups were not significantly different. |
| キーワード | adult spinal deformity proximal junctional kyphosis triangular fixation minimally invasive surgery C arm free |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-02 |
| 巻 | 78巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 37 |
| 終了ページ | 46 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38419313 |
| Web of Science KeyUT | 001203658200003 |
| JaLCDOI | 10.18926/AMO/66668 |
|---|---|
| フルテキストURL | 78_1_029.pdf |
| 著者 | Kitayama, Takahiro| Tanaka, Takashi| Kanie, Yuichiro| Marukawa, Yohei| Kojima, Katsuhide| Tanaka, Takehiro| Takao, Soshi| Hiraki, Takao| |
| 抄録 | This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD. |
| キーワード | methotrexate lymphoproliferative disorder computed tomography necrosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-02 |
| 巻 | 78巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 29 |
| 終了ページ | 36 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38419312 |
| Web of Science KeyUT | 001203658200001 |
| JaLCDOI | 10.18926/AMO/66667 |
|---|---|
| フルテキストURL | 78_1_021.pdf |
| 著者 | Tamura, Masanori| Furumatsu, Takayuki| Yokoyama, Yusuke| Kintaka, Keisuke| Higashihara, Naohiro| Kawada, Koki| Ozaki, Toshifumi| |
| 抄録 | The use of various strategies for arthroscopic meniscal repairs to save the meniscus and prevent the progression of knee osteoarthritis has gradually increased. We investigated the frequency of various arthroscopic treatments and the short-term clinical outcomes of symptomatic isolated medial meniscus (MM) injuries. This retrospective observational study included 193 patients (197 knees) who underwent arthroscopic meniscal treatment for isolated MM injuries between January 2016 and April 2019. Arthroscopic meniscal repairs were divided into two groups: transtibial pullout repairs of MM posterior root tears (MMPRTs) and arthroscopic meniscal repairs for other types of MM injuries. MMPRT pullout repair, other meniscal repairs, and partial meniscectomy were performed in 71.0%, 16.8%, and 12.2% of the knees, respectively. The ratio of women to men and the patient age were higher in the pullout-repair group than the meniscal-repair group. The Preoperative Knee Injury and Osteoarthritis Outcome Score subscale (as an index of daily living activities) was significantly lower in the pullout-repair group than the meniscus-repair group. However, no significant differences were observed in these scores among the two groups postoperatively. Our results suggest that familiarity with the diagnosis and treatment of MMPRTs is necessary for orthopedic surgeons to manage isolated MM injuries. |
| キーワード | knee medial meniscus posterior root tear arthroscopy pullout repair |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-02 |
| 巻 | 78巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 21 |
| 終了ページ | 27 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38419311 |
| Web of Science KeyUT | 001203658200002 |
| JaLCDOI | 10.18926/AMO/66665 |
|---|---|
| フルテキストURL | 78_1_009.pdf |
| 著者 | Akagi, Naoki| Kanematsu, Akihiro| Shigesaka, Koji| Shimatani, Kimihiro| Yamamoto, Shingo| |
| 抄録 | Bacillus Calmette-Guérin (BCG) treatment for non-muscle-invasive bladder cancer frequently causes an intraprostatic BCG granuloma. We investigated the optimal timing for a prostate biopsy after BCG treatment by retrospectively analyzing the cases of 22 patients with non-muscle-invasive bladder cancer who underwent a prostate biopsy after BCG treatment at our institute (2013-2017). Biopsies were indicated for a rising prostate-specific antigen (PSA) level, positive digital rectal examination findings, or the appearance of de novo low apparent diffusion coefficient lesions on MRI. The control group was comprised of 28 age- and PSA-matched patients. The relationships among the cancer detection rate and the patients’ PSA levels and MRI findings were analyzed. Prostate cancer was detected by biopsy in only 13.9% (3/22) of the patients in the BCG group but in 78.5% (22/28) of the control patients (p=0.0001). The three patients in the BCG group in whom prostate cancer was detected had all undergone the biopsy > 1 year after their BCG treatment. The remaining biopsies were performed within 1 year after BCG treatment and resulted in no diagnoses of prostate cancer. We suggest that performing a prostate biopsy early after BCG treatment is not informative or useful. |
| キーワード | bacillus Calmette-Guérin prostate granuloma prostate cancer bladder cancer prostate biopsy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-02 |
| 巻 | 78巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 9 |
| 終了ページ | 13 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38419309 |
| Web of Science KeyUT | 001203658200010 |
| JaLCDOI | 10.18926/AMO/66664 |
|---|---|
| フルテキストURL | 78_1_001.pdf |
| 著者 | Sun, Cuiming| Matsukawa, Akihiro| |
| 抄録 | Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis. |
| キーワード | ERK-MAPK SPRED2 fibrosis macrophages |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-02 |
| 巻 | 78巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38419308 |
| Web of Science KeyUT | 001203658200006 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kato, Yusuke| Kuroda, Hiroshi| Ozawa, Shin-Ichiro| Saito, Keisuke| Dogra, Vivek| Scholz, Martin| Zhang, Guoxian| de Vitry, Catherine| Ishikita, Hiroshi| Kim, Chanhong| Hippler, Michael| Takahashi, Yuichiro| Sakamoto, Wataru| |
| キーワード | post-translational modification Arabidopsis thaliana protein degradation photosystem II photo-oxidative damage tryptophan oxidation Chlamydomonas reinhardtii |
| 発行日 | 2023-11-21 |
| 出版物タイトル | eLife |
| 巻 | 12巻 |
| 出版者 | eLife Sciences Publications |
| 開始ページ | RP88822 |
| ISSN | 2050-084X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Kato, Kuroda, Ozawa et al. |
| 論文のバージョン | publisher |
| PubMed ID | 37986577 |
| DOI | 10.7554/eLife.88822 |
| Web of Science KeyUT | 001134641800001 |
| 関連URL | isVersionOf https://doi.org/10.7554/eLife.88822 |
| JaLCDOI | 10.18926/AMO/66160 |
|---|---|
| フルテキストURL | 77_6_665.pdf |
| 著者 | Sakurai, Atsunobu| Uka, Mayu| Iguchi, Toshihiro| Tomita, Koji| Matsui, Yusuke| Kakiuchi, Yoshihiko| Kuroda, Shinji| Fujiwara, Toshiyoshi| Hiraki, Takao| |
| 抄録 | We report the case details of a 65-year-old Japanese man with an omental abscess that was discovered 43 days after he underwent a laparoscopic proximal gastrectomy for gastric cancer. His chief complaint was mild abdominal pain that had persisted for several days. The abscess was diagnosed as a rare postoperative complication. We hesitated to perform a reoperation given the invasiveness of general anesthesia and surgery, plus the possibility of postoperative adhesions and because the patient’s general condition was stable and he had only mild abdominal pain. Percutaneous drainage using a 10.2-F catheter was performed with the patient under conscious sedation and computed tomography–fluoroscopy guidance, with no complications. After the procedure, the size of the abscess cavity was remarkably reduced, and 23 days later the catheter was withdrawn. |
| キーワード | drainage omental abscess omental infarction proximal gastrectomy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 665 |
| 終了ページ | 669 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145942 |
| Web of Science KeyUT | 001164631200013 |
| JaLCDOI | 10.18926/AMO/66155 |
|---|---|
| フルテキストURL | 77_6_627.pdf |
| 著者 | Hibino, Yumi| Okazawa-Sakai, Mika| Yokoyama, Takanori| Fujimoto, Etsuko| Okame, Shinichi| Teramoto, Norihiro| Takehara, Kazuhiro| |
| 抄録 | To explore the incidence of abnormal vaginal cytology after total laparoscopic hysterectomy for the treatment of cervical intraepithelial neoplasia 3, we retrospectively analyzed the medical records of patients treated at NHO Shikoku Cancer Center (Japan) in 2014-2019. The cases of 99 patients who underwent a laparoscopic (n=36) or open (n=63) hysterectomy and postoperative follow-up were examined. Abnormal vaginal cytology was detected in 13.9% (5/36) of the laparoscopic-surgery (LS) group and 14.3% (9/63) of the open-surgery (OS) group. A vaginal biopsy was performed at the physicians’ discretion; one LS patient and six OS patients were diagnosed with vaginal intraepithelial neoplasia. The cumulative incidence of abnormal vaginal cytology at 3 years post-hysterectomy was 21.4% (LS group) and 20.5% (OS group), a nonsignificant difference. A multivariate analysis showed that age > 50 years was the only independent risk factor for abnormal vaginal cytology among the covariates examined including age; body mass index; histories of vaginal delivery, abdominal surgery, and smoking; and surgical approach (hazard ratio 8.11; 95% confidence interval 1.73-37.98; p=0.01). These results suggest that the occurrence of abnormal vaginal cytology after a hysterectomy may not be influenced by the laparoscopic procedure but is associated with older age. |
| キーワード | total laparoscopic hysterectomy vaginal intraepithelial neoplasia cervical intraepithelial neoplasia vaginal cytology risk factor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 627 |
| 終了ページ | 634 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145937 |
| Web of Science KeyUT | 001164631200008 |
| JaLCDOI | 10.18926/AMO/66153 |
|---|---|
| フルテキストURL | 77_6_613.pdf |
| 著者 | Miyake, Yoshiaki| Namba, Yoshifumi| Mitani, Shigeru| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro| |
| 抄録 | The relationship between osteoarthritis (OA) of the lower extremity and shoulder OA has not been established. This study evaluated the prevalence of shoulder OA in patients with knee OA. We collected contrast-enhanced computed tomography (CECT) images of the shoulder joints of 105 patients with knee OA that were taken 1 week after they underwent primary knee arthroplasty to check for venous thromboembolism (VTE). The images were compared with CECT images of 110 control-group patients that were taken for the purpose of differentiating VTE. Shoulder OA was present in a significantly higher percentage of patients with knee arthroplasty than controls (29% versus 15%), and the difference was particularly pronounced in patients in their 70s (33%) compared to age-matched controls (11%). Patients with knee OA often use arm support to stand up or walk due to knee joint pain and muscle weakness, which places the weight-bearing shoulder at risk of developing OA. |
| キーワード | shoulder osteoarthritis knee osteoarthritis weight-bearing shoulder knee arthroplasty |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 613 |
| 終了ページ | 618 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145935 |
| Web of Science KeyUT | 001164631200006 |
| JaLCDOI | 10.18926/AMO/66152 |
|---|---|
| フルテキストURL | 77_6_607.pdf |
| 著者 | Tani, Yasunari| Kashima, Saori| Mitsuhashi, Toshiharu| Suzuki, Etsuji| Takao, Soshi| Yorifuji, Takashi| |
| 抄録 | Many studies have shown an association between long-term exposure to particulate matter having an aerodynamic diameter of 2.5 μm or less (PM2.5) and diabetes mellitus (DM), but few studies have focused on Asian subjects. We thus examined the association between long-term exposure to PM2.5 and DM prevalence in Okayama City, Japan. We included 76,591 participants who had received basic health checkups in 2006 and 2007. We assigned the census-level modeled PM2.5 data from 2006 and 2007 to each participant and defined DM using treatment status and the blood testing. PM2.5 was associated with DM prevalence, and the prevalence ratio (95% confidence interval) was 1.10 (1.00-1.20) following each interquartile range increase (2.1 μg/m3) in PM2.5. This finding is consistent with previous results and suggests that long-term exposure to PM2.5 is associated with an increased prevalence of DM in Okayama City, Japan, where the PM2.5 level is lower than in other cities in Asian countries. |
| キーワード | air pollution diabetes mellitus epidemiology glycosylated hemoglobin particulate matter |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 607 |
| 終了ページ | 612 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145934 |
| Web of Science KeyUT | 001164631200005 |
| JaLCDOI | 10.18926/AMO/66151 |
|---|---|
| フルテキストURL | 77_6_595.pdf |
| 著者 | Bando, Takashi| Chuma, Masayuki| Hamano, Hirofumi| Niimura, Takahiro| Okada, Naoto| Kondo, Masateru| Izumi, Yuki| Ishida, Shunsuke| Yoshioka, Toshihiko| Asada, Mizuho| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Miyata, Koji| Yagi, Kenta| Izawa-Ishizawa, Yuki| Azuma, Momoyo| Yanagawa, Hiroaki| Tasaki, Yoshikazu| Ishizawa, Keisuke| |
| 抄録 | There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN. |
| キーワード | vancomycin-associated nephrotoxicity polypharmacy nephrotoxin spontaneous adverse event reporting database electronic medical records |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 595 |
| 終了ページ | 605 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145933 |
| Web of Science KeyUT | 001164631200004 |
| JaLCDOI | 10.18926/AMO/66148 |
|---|---|
| フルテキストURL | 77_6_567.pdf |
| 著者 | Matsumoto, Naomi| Higuchi, Chigusa| Miyaji, Chikara| Mitsuhashi, Toshiharu| Hagiya, Hideharu| Takao, Soshi| Yorifuji, Takashi| |
| 抄録 | This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic. |
| キーワード | coronavirus disease 2019 adverse reactions mRNA vaccine antibody titers young adults |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 567 |
| 終了ページ | 575 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145930 |
| Web of Science KeyUT | 001164631200001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Taketa, Shin| Kim, June-Sik| Takahashi, Hidekazu| Yajima, Shunsuke| Koshiishi, Yuichi| Sotome, Toshinori| Kato, Tsuneo| Mochida, Keiichi| |
| キーワード | genetic diversity Hordeum vulgare RNA-sequencing seed transcriptome single nucleotide polymorphism virus disease resistance genes |
| 発行日 | 2023 |
| 出版物タイトル | Breeding Science |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Japanese Society of Breeding |
| 開始ページ | 435 |
| 終了ページ | 444 |
| ISSN | 1344-7610 |
| NCID | AA11353132 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Japanese Society of Breeding. |
| 論文のバージョン | publisher |
| DOI | 10.1270/jsbbs.23031 |
| Web of Science KeyUT | 001101195500001 |
| 関連URL | isVersionOf https://doi.org/10.1270/jsbbs.23031 |