result 318 件
| FullText URL | JRNC_313_1_169.pdf |
|---|---|
| Author | Kudo, Ken-ichi| Hanafusa, Tadashi| Ono, Toshiro| |
| Keywords | Monoterpenes Linalool X-ray irradiation Reactive oxygen species SSB |
| Note | The final publication is available at Springer| |
| Published Date | 2017-07 |
| Publication Title | Journal of Radioanalytical and Nuclear Chemistry |
| Volume | volume313 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 169 |
| End Page | 174 |
| ISSN | 0236-5731 |
| NCID | AA11120189 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1007/s10967-017-5268-0 |
| Related Url | https://doi.org/10.1007/s10967-017-5268-0 |
| JaLCDOI | 10.18926/AMO/55204 |
|---|---|
| FullText URL | 71_3_219.pdf |
| Author | Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira| |
| Abstract | Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery. |
| Keywords | oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-06 |
| Volume | volume71 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 226 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28655941 |
| Author | Ono, Miho| |
|---|---|
| Published Date | 2016-09-30 |
| Content Type | Thesis or Dissertation |
| Author | Iwamuro, Masaya| Okada, Hiroyuki| Harada, Keita| Kanzaki, Hiromitsu| Hori, Keisuke| Kita, Masahide| Kawano, Seiji| Kawahara, Yoshiro| Tanaka, Takehiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2016-12-01 |
| Publication Title | Journal of Okayama Medical Association |
| Volume | volume128 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Mizukawa, Nobuyoshi| Onoda, Tomoo| Matsumoto, Hiroshi| Takeda, Seiko| Noda, Youhei| Onoda, Satoshi| Fukushima, Mai| Tsumura, Munechika| Takeuchi, Tetsuo| Sugiyama, Narushi| Kimata, Yoshihiro| |
|---|---|
| Published Date | 2016-12-01 |
| Publication Title | Journal of Okayama Medical Association |
| Volume | volume128 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54420 |
|---|---|
| FullText URL | 70_3_205.pdf |
| Author | Kozaki, Ken-ichi| Kawakami, Shigehisa| Konishi, Takayuki| Ohta, Keiji| Yano, Jitsuro| Onoda, Tomoo| Matsumoto, Hiroshi| Mizukawa, Nobuyoshi| Kimata, Yoshihiro| Nishizaki, Kazunori| Iida, Seiji| Gofuku, Akio| Abe, Masanobu| Minagi, Shogo| Okayama Dream Speech Project| |
| Abstract | A palatal augmentation prosthesis (PAP) is used to facilitate improvement in the speech and swallowing functions of patients with tongue resection or tongue movement disorders. However, a PAPʼs effect is limited in cases where articulation disorder is severe due to wide glossectomy and/or segmental mandibulectomy. In this paper, we describe speech outcomes of a patient with an articulation disorder following glossectomy and segmental mandibulectomy. We used a palatal plate (PP) based on a PAP, along with an artificial tongue (KAT). Speech improvement was evaluated by a standardized speech intelligibility test consisting of 100 syllables. The speech intelligibility score was significantly higher when the patient wore both the PP and KAT than when he wore neither (p＝0.013). The conversational intelligibility score was significantly improved with the PP and KAT than without PP and KAT (p＝0.024). These results suggest that speech function can be improved in patients with hard tissue defects with segmental mandibulectomy using both a PP and a KAT. The nature of the design of the PP and that of the KAT will allow these prostheses to address a wide range of tissue defects. |
| Keywords | palatal augmentation prosthesis artificial tongue articulation disorder glossectomy mandibulectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-06 |
| Volume | volume70 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 205 |
| End Page | 211 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27339210 |
| Web of Science KeyUT | 000379406100008 |
| Author | Onoda, Satoshi| |
|---|---|
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Title Alternative | Drug-induced liver injury due to the long-term oral administration of rosuvastatin |
|---|---|
| FullText URL | 127_219.pdf |
| Author | Oonishi, Ayano| Kariyama, Kazuya| Wakuta, Akiko| Nishimura, Mamoru| Nouso, Kazuhiro| |
| Abstract | A 67-year-old man was admitted to our hospital presenting with a liver injury. He had used several types of oral medication for the prior 2 years, including rosuvastatin calcium for hypertension, hyperlipidemia, and prostatic hypertrophy. His liver dysfunction was noted for the first time in February 2013, and at re-examination in March 2013 he showed exacerbation of the liver dysfunction, he was admitted to our hospital at that time. We stopped all of his oral medications, and his liver function improved steadily. We conducted a drug-induced lymphocyte transformation test (DLST), and the rosuvastatin calcium result was positive. He was diagnosed as having a drug-induced (by rosvastatin calcium) liver injury. He resumed oral medications other than rosuvastatin calcium from the time of discharge, with no exacerbation of liver dysfunction since then. Reports of drug-induced liver injury due to drugs with a long-term oral administration are extremely rare. We discuss the relevant literature herein. |
| Keywords | 薬物性肝障害（drug induced liver injury） ロスバスタチンカルシウム（Rosuvastatin） スタチン（statin） DLST |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-12-01 |
| Volume | volume127 |
| Issue | issue3 |
| Start Page | 219 |
| End Page | 222 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.127.219 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.219 |
| NAID | 130005116815 |
| Author | Nishiyama, Yuichi| Hanafusa, Tadashi| Yamashita, Jun| Yamamoto, Yoko| Ono, Toshiro| |
|---|---|
| Published Date | 2015-06-20 |
| Publication Title | Journal of Radioanalytical and Nuclear Chemistry |
| Content Type | Journal Article |
| Author | Yamashita, Koji| Hamamoto, Yuji| Yasuda, Yuto| Ono, Tomoko| |
|---|---|
| Published Date | 2015-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume31 |
| Content Type | Journal Article |
| FullText URL | K0005071_abstract_review.pdf K0005071_fulltext.pdf |
|---|---|
| Author | Onoda, Akihisa| |
| Published Date | 2014-12-31 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5071号 |
| Granted Date | 2014-12-31 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0005018_abstract_review.pdf K0005018_fulltext.pdf |
|---|---|
| Author | Ono, Tetsuichiro| |
| Published Date | 2014-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5018号 |
| Granted Date | 2014-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| Title Alternative | Drug interaction (29. drug interaction of steroids) |
|---|---|
| FullText URL | 126_59.pdf |
| Author | Hayashi, Youko| Nawa, Hideki| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 59 |
| End Page | 63 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.59 |
| Title Alternative | Concept and management of pancreaticobiliary maljunction |
|---|---|
| FullText URL | 126_17.pdf |
| Author | Noda, Takuo| |
| Keywords | 膵・胆管合流異常 先天性胆道拡張症 分流手術胆道癌 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 17 |
| End Page | 24 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.17 |
| Author | 高橋 敏雄| 黒崎 東洋郎| 洲脇 史朗| 川上 公一| 大月 一泰| 平野 圭一| 秋山 真| 小野 仁美| 桐野 彰子| 山本 真道| 景山 勝| 小林 武則| 高木 理行| 高杉 衣美| 林 俊雄| 村上 有希子| 佐官 尚宏| |
|---|---|
| Published Date | 1999-06-12 |
| Publication Title | 岡山大学算数・数学教育学会誌 : パピルス |
| Volume | volume6 |
| Content Type | Departmental Bulletin Paper |
| Author | 高橋 敏雄| 黒崎 東洋郎| 洲脇 史郎| 大月 一泰| 平野 圭一| 川上 公一| 秋山 真| 小野 大| 字津見 雅美| 林 俊雄| 桐野 彰子| |
|---|---|
| Published Date | 2000-06-10 |
| Publication Title | 岡山大学算数・数学教育学会誌 : パピルス |
| Volume | volume7 |
| Content Type | Departmental Bulletin Paper |
| Author | 高橋 敏雄| 黒崎 東洋郎| 洲脇 史郎| 大月 一泰| 平野 圭一| 木村 善生| 秋山 真| 宇津見 雅英| 林 俊雄| 小野 大| 桐野 彰子| |
|---|---|
| Published Date | 2001-06-09 |
| Publication Title | 岡山大学算数・数学教育学会誌 : パピルス |
| Volume | volume8 |
| Content Type | Departmental Bulletin Paper |
| Author | Kurata, Yasuko| Fujiwara, Satoko| Kajizono, Makoto| Aoyagi, Megumu| Kitamura, Yoshihisa| Sendo, Toshiaki| |
|---|---|
| Published Date | 2013-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | 小野寺 伊勢之助| |
|---|---|
| Published Date | 1930-02-01 |
| Publication Title | 農学研究 |
| Volume | volume14 |
| Content Type | Departmental Bulletin Paper |
| Author | 小野寺 伊勢之助| |
|---|---|
| Published Date | 1930-02-01 |
| Publication Title | 農学研究 |
| Volume | volume14 |
| Content Type | Departmental Bulletin Paper |
