result 47559 件
| FullText URL | K0005801_abstract_review.pdf K0005801_fulltext.pdf K0005801_summary.pdf |
|---|---|
| Author | Haruma, Tomoko| |
| Published Date | 2018-09-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5801号 |
| Granted Date | 2018-09-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005800_abstract_review.pdf K0005800_fulltext.pdf K0005800_Supplementary material.pdf K0005800_summary.pdf |
|---|---|
| Author | Takagi, Kosei| |
| Published Date | 2018-09-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5800号 |
| Granted Date | 2018-09-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005799_abstract_review.pdf K0005799_fulltext.pdf K0005799_summary.pdf |
|---|---|
| Author | Aoyama, Katsuyuki| |
| Published Date | 2018-09-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5799号 |
| Granted Date | 2018-09-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005798_abstract_review.pdf K0005798_fulltext.pdf K0005798_summary.pdf |
|---|---|
| Author | Ueoka, Akira| |
| Published Date | 2018-09-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5798号 |
| Granted Date | 2018-09-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005797_abstract_review.pdf K0005797_summary.pdf K0005797_fulltext.pdf K0005797_other1.pdf K0005797_other2.pdf |
|---|---|
| Author | Miyamoto, Tomoyuki| |
| Published Date | 2018-09-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5797号 |
| Granted Date | 2018-09-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005796_abstract_review.pdf K0005796_fulltext.pdf K0005796_summary.pdf |
|---|---|
| Author | Muto, Noriko| |
| Published Date | 2018-09-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5796号 |
| Granted Date | 2018-09-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | PhysRevB_97_184510.pdf |
|---|---|
| Author | Maeda, S.| Matano, K.| Zheng, Guo-qing| |
| Note | This is an article published by American Physical Society| |
| Published Date | 2018-05-21 |
| Publication Title | Physical Review B |
| Volume | volume97 |
| Issue | issue18 |
| Start Page | 184510 |
| ISSN | 01631829 |
| NCID | AA11187113 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©2018 American Physical Society |
| File Version | publisher |
| DOI | 10.1103/PhysRevB.97.184510 |
| Web of Science KeyUT | 000433012300004 |
| Related Url | isVersionOf https://doi.org/10.1103/PhysRevB.97.184510 |
| JaLCDOI | 10.18926/AMO/56254 |
|---|---|
| FullText URL | 72_5_535.pdf |
| Author | Sato, Daisuke| Gohda, Tomohito| Kihara, Masao| Kanaguchi, Yasuhiko| Kobayashi, Takashi| Mano, Satoshi| Sasaki, Yu| Nohara, Nao| Murakoshi, Maki| Nakata, Junichiro| Suzuki, Hitoshi| Ueda, Seiji| Horikoshi, Satoshi| Suzuki, Yusuke| |
| Abstract | Some patients with chronic kidney disease (CKD) receiving hemodialysis develop erythropoietin-resistant anemia, possibly due to zinc deficiency. The frequency of zinc deficiency in CKD (stages 1-5 and 5D) and CKD improvement via zinc supplementation are not completely verified. Here 500 CKD patients (Stage 1/2, n=100; Stage 3, n=100; Stage 4, n=100, Stage n=5, 100; Stage 5D, n=100) will be recruited to determine the frequency of serum zinc deficiency at each CKD stage. Patients with serum zinc concentrations <80 μg/dL will be treated with zinc acetate dihydrate (NobelzinR) to evaluate its effects on hypozincemia, taste disturbances, and anemia. |
| Keywords | zinc acetate dihydrate anemia chronic kidney disease |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 535 |
| End Page | 538 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369613 |
| JaLCDOI | 10.18926/AMO/56253 |
|---|---|
| FullText URL | 72_5_531.pdf |
| Author | Kondo, Naoki| Fujisawa, Junichi| Arai, Katsumitsu| Kakutani, Rika| Endo, Naoto| |
| Abstract | A 60-year-old Japanese woman with severe osteoporosis presented with a history of right buttock pain and right lateral lower leg pain in an L5 distribution. She had been treated with methotrexate and methylprednisolone for rheumatoid arthritis (RA) and interstitial pneumonia. Computed tomography demonstrated a sacral stress fracture in the right sacral ala. The right L5 nerve root was compressed by the fracture site. This case is rare in that L5 radiculopathy was complicated by a sacral stress fracture. Clinicians should suspect sacral stress fractures when RA or osteoporosis is present in women who experiences lumbar pain and lumbar radiculopathy. |
| Keywords | lumbar 5 radiculopathy sacral stress fracture osteoporosis rheumatoid arthritis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 531 |
| End Page | 534 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369612 |
| JaLCDOI | 10.18926/AMO/56252 |
|---|---|
| FullText URL | 72_5_525.pdf |
| Author | Kakutani, Rika| Kondo, Naoki| Mochizuki, Tomoharu| Fujisawa, Junichi| Endo, Naoto| |
| Abstract | The bilateral shoulder pain of an 81-year-old Japanese woman due to falls persisted despite celecoxib treatment, and plain X-rays later showed bilateral collapsed humeral heads. After ruling out osteoarthritis, infectious arthritis, crystal-induced arthritis, neuropathic arthropathy, and osteonecrosis, we diagnosed bilateral shoulder joint rapidly destructive arthrosis (RDA). Lumbar bone mineral density showed very low T-score (−4.1). Primary osteoporosis was observed. Histology of biopsied humeral head indicated the features of fracture healing process: callus formation and osteoclasts without empty lacunae. Her history thus included an insufficiency fracture due to severe osteoporosis. Bilateral humeral head replacement was performed; her shoulder joint function improved. This case is extremely rare in that RDA was caused by simultaneous bilateral shoulder joint collapse within a very short time, with minimal or low mechanical stress and severe osteoporosis. |
| Keywords | rapidly destructive arthrosis differential diagnosis humeral head replacement osteoporosis shoulder joint |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 525 |
| End Page | 530 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369611 |
| JaLCDOI | 10.18926/AMO/56251 |
|---|---|
| FullText URL | 72_5_519.pdf |
| Author | Miyahara, Hiroyuki| Tokumasu, Hironobu| Chin, Masaki| Waki, Kenji| Arakaki, Yoshio| |
| Abstract | Cases of recurrent meningitis in elderly patients with a spontaneous cerebrospinal fistula have been reported, and in some of these patients, cystic lesions were thought to be the underlying cause. We report a case of recurrent meningitis in an 11-year-old Japanese girl with an arachnoid cyst in the petrous apex. Pulsation of the cystic lesion was thought to cause bone erosion, leading to the formation of a fistula. Magnetic resonance imaging was useful in evaluating the arachnoid cyst and fistula. During 2 years of follow-up, the osteolytic lesion enlarged and the rate of bone erosion was higher than expected. |
| Keywords | magnetic resonance imaging pulsation of cystic lesion bone erosion fistula |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 519 |
| End Page | 523 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369610 |
| JaLCDOI | 10.18926/AMO/56250 |
|---|---|
| FullText URL | 72_5_515.pdf |
| Author | Kanamitsu, Kiichiro| Chayama, Kousuke| Washio, Kana| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Shimada, Akira| |
| Abstract | Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living-donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient’s bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis. |
| Keywords | hepatitis-associated aplastic anemia impaired hematopoiesis liver transplantation immunosuppressive therapy abnormal immune reaction |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 515 |
| End Page | 518 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369609 |
| JaLCDOI | 10.18926/AMO/56249 |
|---|---|
| FullText URL | 72_5_507.pdf |
| Author | Ogata, Takeshi| Katsui, Kuniaki| Yoshio, Kotaro| Ihara, Hiroki| Katayama, Norihisa| Soh, Junichi| Kuroda, Masahiro| Kiura, Katsuyuki| Maeda, Yoshinobu| Toyooka, Shinichi| Kanazawa, Susumu| |
| Abstract | To clarify the relationship between dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) after surgery in cases of non-small cell lung cancer (NSCLC) treated with induction concurrent chemoradiotherapy (CCRT). Patients with NSCLC treated with induction CCRT (chemotherapy: cisplatin and docetaxel; radiotherapy: 2.0 Gy fractions once daily for a total of 46 Gy) before surgery were reviewed. We calculated the percentage of lung volume receiving at least 20 Gy (V20) and the mean lung dose (MLD) for the total lung volume and the lung remaining after resection. Factors affecting the incidence of RP at grade 2 or higher (≥ G2 RP) were analyzed. Eighteen of 49 patients (37%) experienced ≥G2 RP. The V20 and MLD for the lung remaining after resection (V20r and MLDr) were significant predictors according to the multivariate analysis (p=0.007 and 0.041, respectively). The incidence of ≥G2 RP was 8% in patients with V20r<10%, and 13% in patients with MLDr<5.6 Gy, respectively. The optimal approach to reduce the rate of postoperative RP in patients with induction CCRT for NSCLC is to keep the V20r below 10% and/or the MLDr below 5.6 Gy in the radiotherapy planning. |
| Keywords | radiation pneumonitis V20 mean lung dose induction chemoradiotherapy non-small cell lung cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 507 |
| End Page | 513 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369608 |
| JaLCDOI | 10.18926/AMO/56248 |
|---|---|
| FullText URL | 72_5_499.pdf |
| Author | Kodama, Yuya| Furumatsu, Takayuki| Maehara, Ami| Ozaki, Toshifumi| |
| Abstract | Cell clusters, or groups of cells sharing a single chondron-like structure, are frequently found in degenerated areas of the osteoarthritic (OA) meniscus. However, little is known about these meniscal clusters in humans. The aim of our study was to determine the composition of the extracellular matrix deposition around cell clusters in human OA menisci. Twenty-six menisci were obtained through total knee arthroplasty from patients with OA knee joints. The specimens were subjected to safranin O staining and immunostaining for Sry-type HMG box 9 (SOX9), type II collagen, and aggrecan. Their signal density after staining was assessed using ImageJ software. Five regions of interest were analyzed within each tissue sample. The SOX9, type II collagen, and aggrecan densities were considerably higher in cluster areas than in intact superficial layers of the meniscus. In addition, a substantial difference was detected between cluster areas and degenerative areas without cell clusters. We demonstrated that cell clusters localized near fissures and clefts showed remarkable uniformity in menisci exposed to a broad range of injuries. In addition, the chondrogenic proteins SOX9, type II collagen, and aggrecan were highly expressed in these tissues. |
| Keywords | cell cluster meniscus osteoarthritis Sry-type HMG box 9 type II collagen |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 499 |
| End Page | 506 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369607 |
| JaLCDOI | 10.18926/AMO/56247 |
|---|---|
| FullText URL | 72_5_493.pdf |
| Author | Okazaki, Yuki| Furumatsu, Takayuki| Masuda, Shin| Miyazawa, Shinichi| Kodama, Yuya| Kamatsuki, Yusuke| Hino, Tomohito| Okazaki, Yoshiki| Ozaki, Toshifumi| |
| Abstract | Medial meniscus (MM) posterior root tear (PRT) results in joint overloading and degenerative changes in the knee. MM root repair is recommended to prevent subsequent cartilage degeneration following MMPRT. Favorable clinical outcomes have been reported after transtibial pullout repair of MMPRT. However, it is unclear whether pullout repair can cause compositional change in the MM posterior segment. We examined this question in 14 patients who underwent MMPRT pullout repair. Magnetic resonance imaging examinations were performed preoperatively and 3 months postoperatively at 10° knee flexion. The region-of-interest was marked along the MM posterior segment edge. Intra-meniscal signal intensity (IMSI) was expressed as the signal intensity ratio of the repaired MM to the intact lateral meniscus, which was used as a control. MMPRT pullout repair reduced IMSI from 1 to 0.915±0.096 (range, 0.760-1.074) 3 months postoperatively (p=0.006, power=0.90). Meniscal degeneration causes high proton density-weighted imaging signal intensity of the meniscal body. In our study, MMPRT pullout repair reduced IMSI contrary to other tears. This technique may decrease the MM posterior segment signal intensity by restoring the hoop tension mechanism. Measuring IMSI may be useful to assess the effect of MMPRT pullout repair on meniscal healing. |
| Keywords | medial meniscus posterior root tear magnetic resonance imaging signal intensity arthroscopic surgery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 493 |
| End Page | 498 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369606 |
| JaLCDOI | 10.18926/AMO/56246 |
|---|---|
| FullText URL | 72_5_487.pdf |
| Author | Hamasaki, Ichiro| Shibata, Kiyo| Shimizu, Takehiro| Morisawa, Shin| Toshima, Shinji| Miyata, Manabu| Furuse, Takashi| Hasebe, Satoshi| Ohtsuki, Hiroshi| Morizane, Yuki| Shiraga, Fumio| |
| Abstract | We investigated variances in the stability and amount of postoperative exodrift among age groups of intermittent exotropia (XPT) patients who underwent unilateral lateral rectus muscle recession and medial rectus muscle resection. We analyzed the cases of 110 consecutive patients who underwent the surgery in 2004-2011, dividing the patients into groups by their age at surgery: <10, 10-19, and ≥20 years. We performed a regression analysis (dependent variable: postoperative exodrift (°); independent variable: number of days post-surgery) using the formula of curve lines. When the tangent line slope was = 0.01 (°/days) for each group, we defined the numbers of days until alignment became stable as the ‘stable days.’ We evaluated the between-group differences in the amount of exodrift calculated for the stable days. The coefficients and coefficients of determination for the fitting curves were: <10 year group: f(x)=12.2 (1−e−0.0183x) (r2=0.588, p<0.05); 10-19 year group: f(x)=10.0 (1−e−0.0178x) (r2=0.453, p<0.05); ≥20 year group: f(x)=3.40 (1−e−0.0382x) (r2=0.217, p<0.05). There were 389 , 388, and 153 stable days, and the estimated postoperative exodrift with long-term follow-up was 11.5±3.7°, 9.3±4.4°, and 4.1±3.6° for the < 10 year, 10-19 year, and ≥ 20 year groups, respectively (≥20 year vs. other 2 groups, p<0.05). Longer periods and more postoperative exodrift were associated with younger age at surgery. The postoperative evaluation was approx. ≥ 1 year post-surgery in patients aged < 20. These findings may contribute to evaluating XPT’s success rate and prognoses. |
| Keywords | intermittent exotropia postoperative exodrift recession resection procedure strabismus surgery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 487 |
| End Page | 492 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369605 |
| JaLCDOI | 10.18926/AMO/56245 |
|---|---|
| FullText URL | 72_5_479.pdf |
| Author | Tanaka, Ken-ichi| Yagi, Takao| Nanba, Takeshi| Asanuma, Masato| |
| Abstract | We tried to clarify the applicability of a single prolonged stress (SPS) protocol as post-traumatic stress disorder (PTSD) model in mice. To investigate PTSD pathophysiology, we conducted hypothalamo-pituitary-adrenal (HPA) negative feedback testing at 1, 4, 8 and 12 weeks after the SPS by administrating a dexamethasone (DEX) suppression test. The SPS induced over-suppression of the HPA system by DEX treatment at 8 and 12 weeks. To investigate PTSD-like behavioral characteristics, we subjected mice to testing in a light/dark box (to assess anxiety), a Y-maze (working memory), a cliff avoidance (visual cognition), and an open field (locomotor activity) at 1, 4, 8 and 12 weeks after the SPS. In the light/dark box test, the SPS-applied mice spent significantly less time in the light box at 8 or 12 weeks. In the cliff avoidance test, the SPS-applied mice spent significantly less time in the open area at 1 week. However, in both the Y-maze test and the open field test, SPS-applied mice tended toward slight decreases in a time-dependent manner until 12 weeks. Therefore, SPS-applied mice may thus be useful for assessing characteristics relevant to PTSD that coincide with changes in the HPA axis. |
| Keywords | PTSD single prolonged stress corticosterone mouse |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 479 |
| End Page | 485 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369604 |
| JaLCDOI | 10.18926/AMO/56244 |
|---|---|
| FullText URL | 72_5_467_n.pdf |
| Author | Vika Fatafehi Hala’ufia Lemoto| Sugimoto, Kentaro| Kanazawa, Tomoyuki| Matsuzaki, Takashi| Morimatsu, Hiroshi| |
| Abstract | We investigated the incidence of desaturation during general anesthesia in preoperatively hypoxic (< 92%), and nonhypoxic (≥ 92%) pediatric (n=1,090) and adult (n=5,138) patients. We plotted the patients’ SpO2 value time-courses and assessed desaturation in 6,228 patients. The crude overall incidence (95%CI) for desaturation was 11.1% (9.4-13.1) in the pediatric patients and 0.9% (0.6-1.2) in the adults. The crude incidence of desaturation in the hypoxic pediatric patients was 2.5 times the risk in the nonhypoxic patients: risk ratio (RR) 2.5 (1.8-3.5), p<0.001. The risk of desaturation in the hypoxic adult patients was 20.1 times the risk in the nonhypoxic adult patients: RR 20.1 (10.3-39.2), p<0.001. When the patients were separately stratified by American Society of Anesthesiologists Physical Status (ASA-PS) and by age, the directly adjusted risk-ratio (RRS) showed that the hypoxic pediatric patients had 1.8 and 1.6 times the risk in the nonhypoxic pediatric patients: ASA-PS adjusted RRS 1.6 (1.8-2.2), p<0.001; age-adjusted RRS 1.8 (1.3-2.5), p<0.001, and the hypoxic adult patients had 13.8 times the risk in the nonhypoxic adult patients: RRS 13.8 (6.9-27.6), p<0.001. A pulse-oximeter check before the start of general anesthesia could ensure timely preparation to avoid intraoperative desaturation. |
| Keywords | desaturation incidence pulse oximetry general anesthesia adult pediatric |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 467 |
| End Page | 478 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369603 |
| JaLCDOI | 10.18926/AMO/56243 |
|---|---|
| FullText URL | 72_5_457.pdf |
| Author | Muto, Noriko| Matsuoka, Yoshikazu| Arakawa, Kyosuke| Kurita, Masako| Omiya, Hiroki| Taniguchi, Arata| Kaku, Ryuji| Morimatsu, Hiroshi| |
| Abstract | Quercetin is a flavonoid widely found in plants and marketed to the public as a supplement. Several studies have reported its effect on glial cells. This study aimed to examine the effect of quercetin on the development of neuropathic pain and the underlying mechanism in a spared nerve injury (SNI) rat model. Male Sprague-Dawley rats randomly assigned to the control or the quercetin group were subjected to SNI of the sciatic nerve. We measured pain behaviors on the hind paw and glial fibrillary acidic protein (GFAP) in the dorsal root ganglion (DRG) and spinal cord. Oral administration of 1% quercetin, begun before surgery, attenuated mechanical allodynia compared to the control group at days 7 and 10 after SNI. On the other hand, established pain was not attenuated in a post-dose group in which quercetin was begun 7 days after SNI. Quercetin inhibited GFAP in the satellite glial cells of the ipsilateral L5 DRG on day 7 compared to the control group. Quercetin suppressed the development of neuropathic pain through a mechanism partly involving the inhibition of satellite glial cells. As its safety is well established, quercetin has great potential for clinical use in pain treatment. |
| Keywords | flavonoid dorsal root ganglion glial fibrillary acidic protein alternative medicine |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 457 |
| End Page | 465 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369602 |
| JaLCDOI | 10.18926/AMO/56242 |
|---|---|
| FullText URL | 72_5_447.pdf |
| Author | Oka, Kosuke| Hanayama, Yoshihisa| Sato, Asuka| Omura, Daisuke| Yasuda, Miho| Hasegawa, Ko| Obika, Mikako| Otsuka, Fumio| |
| Abstract | We retrospectively analyzed the cases of 148 febrile patients whose body temperature (BT) was ≥ 37.5°C at our hospital. We categorized them into seven groups; those with bacterial and viral infection, nonspecific inflammation, neoplasm, connective tissue disease (CTD), drug-induced disease, and unidentified causes. Our analysis revealed that the patient’s BT at the 1st visit (BT-1st visit) and highest BT during the febrile period (BT-max) differed significantly among all categories except neoplasm. The greatest difference between BT-1st visit and BT-max was highest in the CTD group (1.5°C). Positive correlations of heart rate and C-reactive protein (CRP) level with BT-max and a negative correlation between serum sodium level with BT-max were uncovered. The serum thyroid-stimulating hormone (TSH) level and the ratio of TSH/free thyroxine were negatively correlated with BT-max, especially in the viral infection group, suggesting the existence of occult thyrotoxicosis in accord with a febrile condition, possibly leading to febrile tachycardia. A febrile gap between BT-1st visit and BT-max (except in the neoplasm group) was shown, in which BT-max was correlated with thyroid function. Clinicians should recognize the fluctuation of BT when diagnosing febrile patients, and tachycardia in such febrile patients may be, at least in part, associated with subclinical thyroid dysfunction. |
| Keywords | body temperature C-reactive protein fever of unknown origin tachycardia thyroid dysfunction |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 447 |
| End Page | 456 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369601 |
