result 18634 件
| Author | Inoue, Taeko| Ikegami, Tadaoki| Morinaga, Hiroshi| |
|---|---|
| Published Date | 1970-03-30 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume39 |
| Content Type | Data or Dataset |
| JaLCDOI | 10.18926/40170 |
|---|---|
| Title Alternative | Study on the conbined therapy of spa and gold salt in rheumatoid arthritis Part II. An experience of granulocytopenia possibly caused by gold salt preparation |
| FullText URL | pitsr_039_037_042.pdf |
| Author | Ikegami, Tadaoki| Yahata, Takaaki| Kitayama, Minoru| Morinaga, Hiroshi| |
| Abstract | A thirty seven years old woman with rheumatoid arthritis was instituted gold salt intramuscularly twice a week on the nineteenth hospital day. On the fifty fourth day, however, it was discontinued at the total dosis of 180 mg because of the skin rush. In about ten days after stopping gold injection appeared high fever with shivering and granulocytopenia was demonstrated. With immediate administration of ACTH, adrenocortical hormons etc. including blood transfusion the abnormal findings of the blood pictures returned to normal and the patient became well. Recently, gold salts are so widely used in treatment of rheumatoid arthritis as one of specific antirheumatic agents that the possible severe side effect such as granulocytopenia, if quite rare, should always be considered in the course of gold therapy. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1970-03-30 |
| Volume | volume39 |
| Start Page | 13 |
| End Page | 35 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/40169 |
|---|---|
| Title Alternative | Clinical studies on electromyographic changes in rheumatoid arthritis Part II. Electromyographic changes in treated rheumatoid arthritis during 3 months after admission |
| FullText URL | 039_013_035.pdf |
| Author | Ikegami, Tadaoki| |
| Abstract | Electromyograms were recorded on 15 patients with rheumatoid arthritis (12 cases of classical rheumatoid arthritis and 3 cases of definite rheumatoid arthritis) and 5 cases of healthy controls. The muscles selected were the biceps brachii, opponens pollicis and abductor pollieis brevis, and following results were obtained: 1) The amplitude and mean potential duration in rheumatoid arthritis were less than controls, the differences being statistically significant. 2) Electromyographic evidence of myogenic atrophy was demonstrated in the small hand muscles and proximal muscles. 3) Myogenic atrophy due to steroid therapy was considered in proximal muscles, while the small hand muscles were affected more rarely. 4) Myogenic atrophy in stage III-IV were less than those in stage I-II, but in the m. opponens pollicis there were little differences. 5) Myogenic atrophy in inactive rheumatoid arthritis were significantly less than those in active, but in the m. opponens pollicis no marked changes were observed. 6) Myogenic atrophy of the m. opponens pollicis were more than that of m. abductor pollicis brevis. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1970-03-30 |
| Volume | volume39 |
| Start Page | 13 |
| End Page | 35 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002398497 |
| JaLCDOI | 10.18926/40168 |
|---|---|
| Title Alternative | Clinical studies on electromyographic changes in rheumatoid arthritis Part I. Electromyographic changes in rheumatoid arthritis |
| FullText URL | pitsr_039_001_012.pdf |
| Author | Ikegami, Tadaoki| |
| Abstract | Electromyograms were recorded on 15 patients with rheumatoid arthritis (12 cases of classical rheumatoid arthritis and 3 cases of definite rheumatoid arthritis) and 5 cases of healthy controls. The muscles selected were the biceps brachii, opponens pollicis and abductor pollieis brevis, and following results were obtained: 1) The amplitude and mean potential duration in rheumatoid arthritis were less than controls, the differences being statistically significant. 2) Electromyographic evidence of myogenic atrophy was demonstrated in the small hand muscles and proximal muscles. 3) Myogenic atrophy due to steroid therapy was considered in proximal muscles, while the small hand muscles were affected more rarely. 4) Myogenic atrophy in stage III - IV were less than those in stage I·II, but in the m. opponens pollicis there were little differences. 5) Myogenic atrophy in inactive rheumatoid arthritis were significantly less than those in active, but in the m. opponens pollicis no marked changes were observed. 6) Myogenic atrophy of the m. opponens pollicis were more than that of m. abductor pollicis brevis. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1970-03-30 |
| Volume | volume39 |
| Start Page | 1 |
| End Page | 12 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002398496 |
| JaLCDOI | 10.18926/40161 |
|---|---|
| Title Alternative | Studies on the uptake of (75)Se-selenomethionine by the pancreas Attempt to augment by the effects of protocols |
| FullText URL | pitsr_040_019_031.pdf |
| Author | Tokunou, Tsuneo| |
| Abstract | Since the introduction of the pancreatic scanning using (75)Se-selenomethionine, there has been various protocols proposed to increase the pancreatic uptake of this isotope. In this experiment several protocols; as diets high carbohydrate meal, high protein meal, high fat meal, and as medicaments pancreozymin, secretin and phydroxyphenylsalicylamide (PHPS), were tested for determining the effects on the uptake of (75)Se-selenomethionine by the pancreas and the liver of the dog. The animals given protocols were sacrified at each of a number of selected times to compare P/L ratio on a percentper-gram concentration of (75)Se-selenomethionine and the total organ concentration of (75)Se-selenomethionine in the pancreas and in the liver. A controlled group of animals were fasted for 24-hour and sacrificed at each of same times. On P/L ratio basis it was found that animals with high carbohydrate meal had better ratio than those with no preparation during first 4-hour post administration. However, animals with each of high protein meal. fat meal and PI-IPS had lower ratio than those with no preparation. On the blood concentration, animals with each of high carbohydrate meal and secretin had lower variation of blood concentration than controlled group. Thus, from the results mentioned above, the protocol by high carbohydrate meal is proved to be useful in pancreatic scanning. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1971-03-26 |
| Volume | volume40 |
| Start Page | 19 |
| End Page | 31 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002398153 |
| JaLCDOI | 10.18926/40160 |
|---|---|
| Title Alternative | Clinical studies on electromyographic changes in rheumatoid arthritis Part III. Effect of radioactive hot spring baths |
| FullText URL | pitsr_040_001_017.pdf |
| Author | Ikegami, Tadaoki| |
| Abstract | The author observed the changes in electromyographic patterns of 14 patients with rheumatoid arthritis (13 cases of classical rheumatoid arthritis and one case of definite rheumatoid arthritis) bathed 2 or 3 times daily in hot spring water at Misasa Spa, at a temperature of 40±1℃, 5-10 minutes. The electromyographic examination was performed on the biceps brachii, opponens pollicis and the abductor pollicis brevis. Intramuscular temperature was measured in the deltoid muscle. The results were as follows. 1) The intramuscular temperature in cases of rheumatoid arthritis did not deviate from normal subjects. 2) After the general spring bathing the intramuscular temperature increased about 1℃ and it had no difference between the patients with rheumatoid arthritis and normal subjects. 3) With increasing intramuscular temperature by the general spring bathing in cases of active rheumatoid arthritis the mean potential amplitude decreased and the mean potential duration increased. 4) With increasing intramuscular temperature by the general spring bathing in cases of inactive rheumatiod arthritis the mean amplitude increased and the mean duration decreased. 5) The patterns of potential duration and amplitude before and after a bath on re-examination, one month after a series of the general spring baths, showed a tendency of reverse of the initial patterns. 6) After two months of a series of the general spring baths, the patterns of electromyographic changes of patients with rheumatoid arthritis following the bathing were similar to the initial patterns. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1971-03-26 |
| Volume | volume40 |
| Start Page | 1 |
| End Page | 17 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002398152 |
| JaLCDOI | 10.18926/40155 |
|---|---|
| Title Alternative | Esophagus hiatal hernia with special reference to the early stage |
| FullText URL | pitsr_041_063_068.pdf |
| Author | Noishiki, Yasuharu| Komoto, Yoshiaki| Nakahara, Yasuhiro| |
| Abstract | In the aged, hiatal hernia should be recognized as it has developed; it develops progressively. Special attention should be given to the early stage of hiatal hernia from the genetic point of view. Like other organs in the aged, aging changes around a hiatus are inevitable; relaxing of esophageal diaphragmatic ligament and weakening of muscle power of diaphragmatic vertebral part move on with age. After all, valve structure at hiatus, Goubaroff's valve, is so weakened its function and in the stomach, "His angle" is so widened, that the stomach becomes wedge shaped against the hiatus. The more the pressure in the stomach increases, the larger the wedge shapes. Under these conditions, when the abdominal pressure rises by the acts of coughing or defecation, hiatus may be widened and the wedge may be pushed into the hiatus. There are no strong valve and or ligament enough to keep the wedge part of stomach in peritoneal cavity. In the stomach, the pressure of the expelling meal is equal to that of the widening wedge. On the other hand, in the peritoneal cavity, pressure produced by the act of defecation is equal to that of ejecting the wedge through hiatus. These are self-evident from the Pascal's principle. Hiatal hernia is produced under these conditions. We, therefore, should call the attention to the early genetic stage of hiatal hernia. In Japan, hiatal hernia has been recognized when it gets larger and fixes out of the peritoneal cavity. But in the early stage, it also must be noted as hiatal hernia. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1972-03-25 |
| Volume | volume41 |
| Start Page | 63 |
| End Page | 68 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002398151 |
| JaLCDOI | 10.18926/40154 |
|---|---|
| Title Alternative | Report of a case of severe mechanical joundice -Successfully treated by jejuno-hepatic ducts anastomoses |
| FullText URL | 041_057_062.pdf |
| Author | Noishiki, Yasuharu| Kotakemori, Michiaki| Komoto, Yoshiaki| Nakahara, Yasuhiro| |
| Abstract | Jejuno hepatic ducts anastomoses were successfully performed by carefull managements. Because of dense adhesion at hilus of liver, around the gall bladder and choledocus, dissection of common duct, cystic duct, hepatic ducts and even gall bladder was very difficult anatomically. Resecting a inflammatory granulative tumor, including gall bladder, choledocus, lesser omentum and hepatocluodenal ligament en mass, we found that only very short hepatic ducts with inflammatory granulation tissue were remained open. Reconstruction of biliary passages was done using Roux. Y. method with loop jejunum. It needed very carefull procedure to avoid suture failure, ascending infection (cholangitis) and postoperative stenoses at the site of the anastomoses. The anastomoses were performed using atraumatic 3-0 Tefdek ; interrupted and each big bite of duct wall together with surrounding thickend granulative tissue, in order to keep capillary blood supply effective and to minimize the anastomotic trauma which were very important for wound healing. Patient is healthy, enjoying his normal life and his liver function tests are within normal range, 1 1/2 years postoperatively. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1972-03-25 |
| Volume | volume41 |
| Start Page | 57 |
| End Page | 62 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532304 |
| JaLCDOI | 10.18926/40153 |
|---|---|
| Title Alternative | Absorption of Medium-chain triglyceride (MCT) in isolated intestinal loops of dog and its effect upon the lipids of serum aud adipose tissue |
| FullText URL | pitsr_041_049_056.pdf |
| Author | Kotakemori, Michiaki| |
| Abstract | The absorption of medium chain triglyceride (MCT) has been investigated with intestinal loop of dog without both bile and pancreatic juce. On optimal state, the average coefficient of fat absorption was 78.1±7.4%. The use of medium chain triglyceride diet for 4 weeks in dogs had some effecton lipids of serum and adipose tissue but minimal change on clinical evidence was found. There was a prompt reduction in the proportion of arachidonic acid and a sustained increase in the proportion of oleic acid and linoleic acid in serum lipid. Analysis on lipids of adipose tissue showed prompt reduction in the proportion of oleic acid and linoleic acid. Neither clinical evidence nor side effect induced with medium chain triglyceride was found. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1972-03-25 |
| Volume | volume41 |
| Start Page | 49 |
| End Page | 56 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002398150 |
| JaLCDOI | 10.18926/40152 |
|---|---|
| Title Alternative | Studies on chrysotherapy in rheumatoid arthritis, III. Gold determination by the atomic absorption spectrophotometry |
| FullText URL | 041_035_048.pdf |
| Author | Takahashi, Kazue| |
| Abstract | The gold concentration in serum, synovial fluid and urine has been determined using a HITACHI MODEL 207 atomic absorption spectrophotometer. Flow rate of acetylene was setted at 2.0l/min. and lamp current was setted at 8mA. The samples were pretreated by the determination of gold. Serum was diluted with deionized water by two to ten-fold. To O.2ml. of synoival fluid 50units/ml of hyaluronidase was added and then incubated for 20 minutes at 37℃. This sample was then treated the procedure for serum given previously. Urine was treated using the modification method of Christions procedure. The recovery rates with gold sodium thiomalate in serum, synovial fluid and urine were 99.9%, 102.5% and 93.6% respectively. When gold sodium thiomalate was injected in rabbits, the maximum serum gold level was attained 1 hour after injection and then gradually decreased at about 50% of the maximum level 24 hours after injection. In the observations of changes in the gold levels in the serum of patients with rheumatoid arthritis after injection of gold sodium thiomalate and gold thioglucose, its peak level after gold thioglucose injection tended to be slightly lower as compared with the same amount of gold sodium thiomalate injection. In those patients who had been given 300 mg. or more of gold salt-preparation, one additional injection of 25 mg. of gold salt could attain the gold level of around 200μg/100ml, in serum a week later, and this level was very nearly the same with that after 3-4 days of one additional injection of 1Omg. of gold salt. The amount of gold excreted in the urine varied from patient to patient, and the mean excretion rates of gold sodium thiomalate and gold thioglucose in the urine within 24 hours after intramuscular administralion were 9.8% and 6.5% respectively. The simple, rapid and accurate method for analysis in biological specimens using atomic absorption spectrophotometer would offer one of the excellent measures in the clinical management of patients with rheumatoid arthritis. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1972-03-25 |
| Volume | volume41 |
| Start Page | 35 |
| End Page | 48 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532302 |
| Author | Inoue, Taeko| Morinaga, Hiroshi| |
|---|---|
| Published Date | 1972-03-25 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume41 |
| Content Type | Data or Dataset |
| JaLCDOI | 10.18926/40143 |
|---|---|
| Title Alternative | Rheumatoid arthritis and Sjögren's syndrome |
| FullText URL | 042_031_045.pdf |
| Author | Ichikawa, Yukinobu| |
| Abstract | 1. Parotid Sialography Parotid sialograms were investigated in 29 patients with classical or definite RA according to the criteria of the American Rheumatism Association (one of whom had scleroderma), 5 patients with SLE (according to the Dubois's criteria, three were definite, one probable and another possible SLE), 3 patients with other autoimmune diseases (Hashimoto's thyroiditis, colitis ulcerosa and undiagnosed collagen disease), 3 patients with polyarthralgia and 10 patients with nonautoimmune diseases. Sialographic technique was performed by modified Rubin's Method using contrast medium Conray-400. Sialectasis which is pathognomonic of Sjögren's syndrome (SS) alone was observed in 6 patients with RA (20.7%) (3 punctate and 3 globular patterns) and 2 patients with SLE (one punctate and another globular pattern). Retention of the contrast medium in the duct for at least 5 minutes after the injection was observed in patients with RA, one patient with SLE and one patient with colitis ulcerosa. Sial ectasis and retention almost always existed together, and were observed in patients from young to older one. Although dilatation of the Stensen's duct and subalveolar dissection also existed together, they were observed in only older patients. It appeared that the former is the specific findings of SS and the latter is the non-specific findings according to the aging. Dry mouth was complained in 7 sialectasis (87.5%), 3 subalveolar dissection (60.0%), 10 retention (62.5%) and 9 normal sialogram (37.5%). Salivary hyposecretion (less than 10 ml/10min) was observed in 4 sialectasis (50%), one subalveolar dissection (20%), 6 dilatation of the Stensen's duct (37.5%), 5 retention (45.5%) and one normal sialogram (4.2%). These results show that sialectasis and retention are well correlated with salivary hyposecretion, but dry mouth is not so diagnostic in SS. Two patients with SLE had sialectasis were young women and showed normal salivary and lacrimal secretion. These cases may be supported by Heaton's hypothesis that SS is a benign and chronic form of SLE, or thay may be a subclinical state of SS. 2. Schirmer test Sixty seven patients (36RA, 6SLE, 3 other autoimmune diseases, 3 polyarthralgia and 19 non-autoimmune diseases) were examined by Schirmer test. Besides lacrimal hyposecretion was observed in RA and other autoimmune diseases, it began in younger age. These results show that autoimmune diseases have a sicca element in themselves. Compared with the results of sialography, Schirmer test was not correlated with sialectasis and retention. Dry eye was complained in only 4 patients (13.3%) with lacrimal hyposecretion (less than 10mm/5min) and all patients with dry eye had keratoconjunctivitis sicca (KCS). Dry eye is more diagnostic than Schirmer test. 3. Corneal staining by 1% rose bengal solution Twenty five patients with RA or SLE were examned corneal staining (Holm's type A) was observed in 5 patients with RA (20%). Staining of the medial and lateral bulbar conjunctiva (Holm's type B and C) were observed in 6 patients with RA (24%) and one patient with SLE. Nine patients with positive staining (type A, B and C) (75%) showed lacrimal hyposecretion. Dry eye was complained in 4 patients with type A staining (80%), but no patient with type B and C complained dry eye. Dry eye appears to be specific for the diagnosis of SS as sialectasis on the sialogram. 4. Salivary secretion All amount of saliva was collected during ten minutes chewing two pieces of gum. All of 21 patients with non-autoimmune diseases showed more than 10 ml/10min, and slight degree of salivary hyposecretion was observed with aging. Nine patients with RA (25.7%) showed salivary hyposecretion (less than 10ml/10min), besides it began in younger age. It was also observed in patients with other autoimmune diseases. Only 36.4% patients with salivary hyposecretion showed sialectasis on the sialogram. It can be supposed that patients with sialectasis and good salivary secretion are subclinical states of SS, and that this state is depends on the compensative function of the glands. Therefore, it is impossible to suppose the salivary dysfunction from the complaints of patients alone. It is required that saliva must be analysed not only quantitativly but also qualitativly (such as RA factor, complement and lysozome). Dry mouth was not only complained in 9 patients who showed salivary hyposecretion (81.8%). but in 10 patients showed normal secretion (50%). Dry mouth appears to be less specific for the diagnosis of SS than dry eye. 5. Diagnosis of SS Vanslow's criteria of SS was modified as follows. (1) Major : ① Sialectasis or salivary gland enlargement ② Positive corneal staining (type A) ③ Classical or definite RA (according to the criteria of the ARA) (2) Minor : ① Arthritis ② History ot salivary gland swelling ③ Dry mouth or salivary hyposecretion (less than 10ml/10min) ④ Dry eye or positive Schirmer test (less than 10mm/5min). Three major was diagnosed as definite, 2 major as probable and one major with one or more minor as possible SS. Of 35 patients with RA, definite (8.6%), probable (17.1%) and possible SS (54.3%) were obserevd. Two of SLE (33.3%) were possible SS. One patients with undiagnosed collagen disease was possible SS. Clinically, definite and probable SS may be diagnosed as Sjögren's syndrome. Two possible SS with SLE may be supporsed as subclinical states of SS who do not yet exhibite full criteria. Compared with the clinical and laboratory findings of these definite, probable and possible SS with RA, it was supporsed that positive antinuclear factor or positive LE cells in RA patients almost always represents SS, drug allergy, especially to gold therapy may be a manifestation of SS. Hypergammaglobulinemia, extreme elevation of erythrocyte sedimentation rate, struma, lymphnode enlargement in RA patients must be suspected of SS. Although one possible SS with SLE and one probable SS with RA showed positive ANF (peripheral pattern), it is impossible to differentiate SS from SLE by ANF alone. Because Suzuki et al. reported that 15.4% of SS had showed positive ANF (peripheral pattern). Examinations of salivary glands including sialography must be performed in patients with SLE in the future. To detect a subclinical SS, sialography and corneal staining must be performed even in patients with no sicca symptom, because of the compensatory functions of salivary and lacrimal glands. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1973-03-25 |
| Volume | volume42 |
| Start Page | 31 |
| End Page | 45 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532309 |
| JaLCDOI | 10.18926/40142 |
|---|---|
| Title Alternative | A case of systemic lupus erythematosus with idiopathic thrombocytopenic purpura |
| FullText URL | pitsr_042_025_029.pdf |
| Author | Ichikawa, Yukinobu| Ikegami, Tadaoki| Kitayama, Minoru| Morinaga, Hiroshi| |
| Abstract | A 24-year-old woman was presented in whom thrombocytopenic purpura appeared during antiinflammatory drugs therapy for arthralgia. At that time she had a positive LE cell preparation, positive antinuclear factor and false positive serum test for syphilis. Steroid hormon and ACTH therapy were started under the diagnosis of systemic lupus erythematosus. In the 23-rd hospital days, she had a negative LE cell preparation, negative antinuclear factor and negative serum test for syphilis. In the 28-th days after stopping steroid hormon and ACTH therapy, positive LE cell preparation and positive antinuclear factor appeared again. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1973-03-25 |
| Volume | volume42 |
| Start Page | 25 |
| End Page | 29 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002398146 |
| JaLCDOI | 10.18926/40137 |
|---|---|
| Title Alternative | Two cases of bile duct anomalies |
| FullText URL | 044_047_053.pdf |
| Author | Murakami, Naoki| Tokioka, Masaaki| Ichikawa, Yukinobu| Ikegami, Tadaoki| Takasugi, Kiyoshi| Kitayama, Minoru| |
| Abstract | We reported two cases of biIe duct anomalies detected by percutaneons transhepatic cholangiography. The first case was a 53-years-old woman who had a long cystic duct running paralleI to, and apparently adhered to a common hepatic duct distally, thus forming one large duct separated by a thin membrane within. Stenosis of the lower bile duct and subsequent dilatation of the proximal part of the duct were also demonstrated. In the second case, 5-years-old girl, the most conspicuous findings include stenosis of the extrahepatic duct with the resultant dilatation of the proximal par t of the common hepatic duct and bilateral hepatic ducts. Distally displaced opening of the common biIe duct to the duodenum and aberrant run of the duodenum were also disrcovered radiographically. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1975-03-25 |
| Volume | volume44 |
| Start Page | 47 |
| End Page | 53 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/40129 |
|---|---|
| FullText URL | 64_4_219.pdf |
| Author | Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa| |
| Abstract | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH. |
| Keywords | ACTH imipramine lithium proliferation Ki-67 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-08 |
| Volume | volume64 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20802538 |
| Web of Science KeyUT | 000281384400002 |
| Author | Inoue, Seiji| |
|---|---|
| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Hosokawa, Shinobu| |
|---|---|
| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Isobe, Midori| |
|---|---|
| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kojo, Shoichiro| |
|---|---|
| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kikumoto, Yoko| |
|---|---|
| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
