result 9002 件
| JaLCDOI | 10.18926/15150 |
|---|---|
| Title Alternative | Study of the preparation with sodium picosulfate and PEG intestinal lavage solution for total colonoscopy. |
| FullText URL | 065_022_026.pdf |
| Author | Ochi, Koji| Harada, Hideo| Chowdhury, Riaz| Tanaka, Juntaro| Matsumoto, Shuji| Seno, Toshinobu| Mizushima, Takaaki| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Akiyama, Tsuneo| Nakai, Mutsuo| Hasuoka, Hideaki| Kato, Tadahiro| |
| Abstract | Total colonoscopyの前処置における被検者の負担軽減と良好な腸管洗浄を得る目的で,50例の大腸内視鏡検査において,前日の食事制限せず, sodium picosulfate 20mℓ前夜服用,検査当日PEG腸管洗浄液1ℓ以上服用する前処置法の有用性について検討した。本前処置法によってPEG腸管洗浄液平均1230mℓの服用により,50例中48例で観察可能な腸管洗浄が得られ,PEG腸管洗浄液の服用量の減量が可能であった｡腹痛,嘔気,腹鳴などの症状出現例は認めたが,重篤な副作用は認めなかった｡腸管洗浄度の点で,高齢者の大腸内視鏡検査の前処置として有用である｡以上よりSodium Picosulfate 20mℓをPEG腸管洗浄液と併用することにより,優れた腸管洗浄度を得られると同時にPEG腸管洗浄液服用量の減量か可能であり,total colonoscopyの前処置として有用であることが示された。 |
| Keywords | 大腸内視鏡検査 (colonoscopy) 前処置 (preparation) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1994-09 |
| Volume | volume65 |
| Start Page | 22 |
| End Page | 26 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307186 |
| JaLCDOI | 10.18926/15149 |
|---|---|
| Title Alternative | A case report of severe allergic reactionsinduced by black fly bites |
| FullText URL | 065_017_021.pdf |
| Author | Kitani, Hikaru| Takata, Ichiro| Yokota, Satoshi| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro| |
| Abstract | 多数のブユに刺されたのを契機に重症反応を呈するようになった29歳男性例について,アレルギー学的検討を行った。血清IgE値が高値(4591U/ml)であったが,免疫グロブリン,抗核抗体,血清補体価,CD4,CD8陽性リンパ球出現頻度などいずれも正常であり,またハウスダスト,カンジダその他16種類の吸入性抗原,ミツバチ,スズメバチ,アシナガバチ,ゴキブリ,ヤブカ,ユスリカなどの昆虫抗原に対する特異的IgE抗体はいずれも陰性であった｡一方ニッポンヤマブユ抗原による好塩基球からのヒスタミン遊離は陰性であったが,皮膚反応,IgE抗体は陽性を示したことから,本症例における重症化因子としてIgE系反応の関与が示唆された｡なおEBウイルス抗体価の検討では,EBV-EADR抗体はすべて陰性,EBNA-EIA抗体はIgG抗体のみ陽性であり,EBウイルスの既感染状態と判断されたが,病因との関連は明らかではなかった｡ |
| Keywords | 昆虫アレルギー (lnsect allergy) ブユ (Black fly) IgE系反応 (lgE-mediated reaction) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1994-09 |
| Volume | volume65 |
| Start Page | 17 |
| End Page | 21 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307240 |
| JaLCDOI | 10.18926/15148 |
|---|---|
| Title Alternative | 気管支喘息における末梢血白血球および気管支肺胞洗浄液中の細胞からのヒスタミンおよびロイコトリエンC(4),B(4)遊離と気道過敏性 |
| FullText URL | 065_009_016.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine| |
| Abstract | The proportions of cells in bronchoalveolar lavage (BAL) fluid, the release of histamine, leukotrienes C(4) and B(4) from leucocytes and BAL cells, and bronchial reactivity to methacholine were examined in 40 patients with asthma in relation to patient age. 1. The proportions of lymphocytes and neutrophils in BAL fluid were higher in older patients over age 60 than in younger patients between 20 and 49. The proportions of eosinophils and basophilic cells in BAL fluid were higher in younger patients than in older patients, and the difference in the proportion of BAL basophilic cells was significant between the two groups (p<0.05). 2. The release of histamine from BAL cells was significantly higher in younger patients than in older patients (p<0.001). The release of LTC(4) from BAL cells was higher in older patients compared to younger patients. 3. Bronchial reactivity to methacholine was higher in younger patients than in older patients. The number of patients reactive to low concentration of methacholine (390μg/mℓ or less) was larger in younger patients (12/16 ; 75.0%) than in older patients (5/14 ; 35.7%). These results suggest that bronchial hyperresponsiveness changes with aging, accompanied by changes in the release of chemical mediators from BAL cells and in the proportion of BAL cells. |
| Keywords | BAL cells (BAL細胞) histamine (ヒスタミン) leukotrienes (ロイコトリエン) bronchial hyperresponsiveness (気道過敏性) asthma (気管支喘息） |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1994-09 |
| Volume | volume65 |
| Start Page | 9 |
| End Page | 16 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307646 |
| JaLCDOI | 10.18926/15147 |
|---|---|
| Title Alternative | 気管支喘息における複合温泉療法と気道炎症反応 |
| FullText URL | 065_001_008.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine| |
| Abstract | Efficacy of complex spa therapy was studied in 55 patients with bronchial asthma. Complex spa therapy was effective in 47 (85.5%) of the 55 patients with bronchial asthma : marked efficacy was observed in 15 (27.3%), moderate in 32 (58.2%), slight in 6 (10.9%) and no efficacy in 2 patients (3.6%). Improvement of clinical symptoms and findings by complex spa therapy was more clearly observed in patients with an increased proportion of BAL lymphocytes, neutrophils and eosinophils. These findings suggest that complex spa therapy more affects cell infiltration in the airways than bronchoconstriction induced by chemical mediators. Improvement of ventilatory function represented by FEV1.0% value was higher in patients with a low proportion of BAL neutrophils, suggesting that patients with increased number of BAL neutrophils require longer complex spa therapy than those without BAL neutrophilia. |
| Keywords | complex spa therapy (複合温泉療法) airway inflammation (気道炎症反応) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1994-09 |
| Volume | volume65 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307726 |
| JaLCDOI | 10.18926/15129 |
|---|---|
| FullText URL | 066_085_091.pdf |
| Author | Chowdhury Riaz| Ochi, Koji| Harada, Hideo| Tanaka, Juntaro| Mizushima, Takaaki| Matsumoto, Shuji| Seno, Toshinobu| Ichimura, Mitsuko| Akiyama, Tsuneo| Yokota, Satoshi| |
| Abstract | Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress. |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 85 |
| End Page | 91 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307190 |
| JaLCDOI | 10.18926/15128 |
|---|---|
| Title Alternative | Collagen degradation and in the pathogenesis of dieseases |
| FullText URL | 066_078_084.pdf |
| Author | Ochi, Koji| Harada, Hideo| Chowdhury Riaz| Yamashita, Haruhiro| Ichimura, Mitsuko| Tanaka, Juntaro| Seno, Toshinobu| Matsumoto, Shuji| Mizushima, Takaaki| Yokota, Satoshi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | 組織のコラーゲン沈着にはコラーゲン合成系と分解系の不均衡によって生ずる｡従来,主としてコラーゲン合成系が注目されていたが,最近の研究の進歩により,コラーゲン分解系が重要な役割を演ずることが明らかになってきた｡コラーゲンの分解系には細胞内と細胞外の二つの経路が存在する｡それぞれcollagenolytic cathepsinおよびmatrix metalloproteinases( MMP)がコラーゲン分解能を有する重要な酵素である｡その調節因子については細胞外の経路についての解明か進んでいる｡MMPの遺伝子の発現にはサイトカインや成長因子が関与し,IL-1やTNF-αは強力な誘導因子である｡一旦,遺伝子か発現すれば,MMPは合成され,細胞外に不活性型(latent form)で分泌される｡不活性型のMMPが活性化する過程にはplasminogen activator inhibitorやtissue inhibitors of metalloproteinases(TIMP)などの阻害因子が存在し,MMP活性を調節する｡TIMPの遺伝子の発現にもサイトカインや成長因子が関与する｡MMPがTIMPを上回るような病態では組織破壊が,逆にTIMPがMMPを上回るような病態では綿維化が生ずる｡コラーゲン分解能の障害が線維化の維持や不可逆性に関与することが推察される。 |
| Keywords | 線維化 (Fibrosis) コラーゲン (Collagen) TIMP (tissue inhibitor of metalloproteinase) MMP (matrix metalloproteinase) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 78 |
| End Page | 84 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307516 |
| JaLCDOI | 10.18926/15127 |
|---|---|
| Title Alternative | Spa therapy and quality of life in patients with bronchial asthma |
| FullText URL | 066_072_077.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | 気管支喘息のなかでも,ステロイド依存性重症難治性喘息では,気管支拡張薬その他の抗喘息薬のみでは発作のコントロ-ルが極めて困難であり,したがって副腎皮質ホルモンの長期投与を余儀なくされる｡そして,投与薬剤,特に気管支拡張薬の心臓刺激作用や副腎皮質ホルモンの副作用,さらには運動誘発喘息がひき起こされやすいなどの理由により,体動制限が加えられることが多い｡このことが,また精神活動の低下へとつながる｡したがって,重症難治性喘息患者のQuality of life (QOL)を高めるためには,薬剤の副作用をできるだけ低くするための投与薬剤の減量をはかるとともに,十分な運動のもとに治療を行い全身状態の改善,それにともなう精神活動の活性化をはかる必要がある｡かかる観点からすれば,温泉療法は最も理想的な治療法であり,その直接作用(気道への作用:気道浄化作用,気道粘膜正常化作用)により,白,他覚症状の改善,換気機能の改善,気道過敏性の低下などが観察される｡また,間接作用(気道以外への作用)により,全身状態の改善,自律神経系の安定化作用,副腎皮質機能の改善作用などが見られる｡すなわち,重症難治性喘息に対する温泉療法では,十分な運動のもとに,精神活動の活性化をともなった喘息症状の改善がはかられるため,患者のQOLをより一層高めることができると判断される｡ |
| Keywords | 温泉療法 (spa therapy) 重症難治性喘息 (lntractable asthma) 運動 (exercise) 精神活動 (phychical activity) QOL |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 72 |
| End Page | 77 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307919 |
| JaLCDOI | 10.18926/15126 |
|---|---|
| Title Alternative | Pelvimetry with smaller radiation field by CC･DR system- An examination on applying to lateral radiography of the pelvis (Guthmann) ― |
| FullText URL | 066_062_071.pdf |
| Author | Nakai, Mutsuo| Akiyama, Tsuneo| Nakagiri, Yoshiyasu| Kobayashi, Yasuaki| |
| Abstract | 100万画素CCDカメラを用いたI.I.-DR装置(CC･DRシステム)をX線骨盤計測に適用するため,被曝線量をはじめとするいくつかの点を検討した｡照射野内の被曝線量は従来の高感度Screen-Film システムであるG12/HRSと同等以下に抑えることが可能であった｡また,CC･DRシステムの9インチ円形照射野は一般的に用いられている大角フィルム面積の1/3であり,胎位の95%を占めるといわれている頭位の撮影においては胎児の生殖腺はもちろん, 赤色骨髄を多く含む脊椎への被曝を大幅に低減できた｡また,新たに開発された距離計測ソフトウェアーの正確度は良好で,通常lmm以下の誤差で測定が可能であることを確認した。その他,装置に標準装備されている自動露出機構の特性についても報告し,最後に撮影時の留意点についても検討した｡ |
| Keywords | 骨盤計測 (Pelvimetry) グースマン法 (Guthmann Position) デジタルラジオグラフィー (digital radiography) 被曝線量 (exposure dose) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 62 |
| End Page | 71 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307350 |
| JaLCDOI | 10.18926/15125 |
|---|---|
| Title Alternative | Spa therapy for chronic respiratory disease. Recent trends of therapy for patients from distant area. |
| FullText URL | 066_057_061.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| |
| Abstract | 1995年1月から6月までの半年間に当院へ入院し,温泉療法を受けた慢性呼吸器疾患患者77例について,その地域分布を中心に最近の動向を検討した1.77例中鳥取県内から来院した患者は28例(36.4%)であった｡一方,遠隔地(鳥取県外)からの患者は49例(63.6%)であり,遠隔地から入院してくる患者が増加する傾向か見られた｡2.遠隔地からの入院患者では,兵庫県からの12例(15.6%)が最も多く,次で岡山県8例(10.4%),大阪府7例(9.1%),山口 県5例(6.5%)の順であった｡3.入院患者の年齢分布では,鳥取県内の患者では70才以上の症例が最も多く,次で60-69才の年齢層の順であったが,遠隔地からの患者では,60-69才が最も多く,次で50-59才,40-49才の順であり,鳥取県内に比べ年齢層がやや低い傾向か見られた｡4.慢性呼吸器疾患のうちわけは,気管支喘息が62例と最も多く,全体の80.5%を占め,次で慢性閉塞性細気管支炎6例,肺気腫4例,慢性気管支炎3例の順であった｡ |
| Keywords | 慢性呼吸器疾患 (chronic respiratory disease) 温泉療法 (spa therapy) 遠隔地医療 (therapy for patients from distant area) 年齢 (patient age) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 57 |
| End Page | 61 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307808 |
| JaLCDOI | 10.18926/15124 |
|---|---|
| Title Alternative | Evaluation of airway response to salbutamol sulfate and disodium cromoglycate in bronchial asthma by use of body pletysmograph |
| FullText URL | 066_049_056.pdf |
| Author | Yokota, Satoshi| Mifune, Takashi| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | サルブタモール,クロモグリク酸ナトリウム(クロモリン)吸入液を,気管支喘息(以下BA)11例,肺病変のない対照群9例に吸入させ,吸入前および吸入後30分に,sRaw(specific airway resistance)とsGaw(specific airway conductance)を,定容積型体プレチスモグラフ(Sensor Medics Corporation, Anaheim, California, U.S.A.)を用いて測定した。サルブタモールの場合,BAでは吸入後に有意な改善(p<0.01)を認め,対照群でも有意な変化(p<0.05)があったが,改善率(%)はBA が対照群に比べて有意に高かった(p<0.01)｡クロモリンの場合,吸入前後での比較では有意差は認めなかったが,吸入後にBAでは改善,対照群では悪化する傾向があり,改善率(%)はBA が対照群に比べて有意に高値(p<0.01)であった｡ |
| Keywords | 体プレチスモグラフ (body pletysmograph) 気管支喘息 (bronchial asthma) サルブタモール (salbutamol) クロモリン (disodium cromoglycate) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 49 |
| End Page | 56 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307959 |
| JaLCDOI | 10.18926/15123 |
|---|---|
| Title Alternative | T cell subpopulation and asthma classification |
| FullText URL | 066_044_048.pdf |
| Author | Mifune, Takashi| Yokota, Satoshi| Hosaki, Yasuhiro| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | 気管支喘息症例の臨床病型に対するTリンパ球の役割を明らかにするために,気管支肺胞洗浄液中のCD3,CD4,CD8陽性細胞の比率を検討した｡1.Ia気管支攣縮型におけるCD3陽性細胞は75.6±6.52%,Ib:過分泌型では75.4±16.5%,Ⅱ:細気管支閉塞型では61.0±12.5%であり,いずれの病型においても有意な差は認められなかった｡2.CD4陽性細胞についてはIa型47.4±6.11%,Ib型39.5±8.70%,Ⅱ型46.3±6.91%,CD8陽性細胞についてはIa型28.3±8.77%,Ib型35.5±12.3%,Ⅱ型29.4±11.5%と過分泌型 で他の2病型とは違う傾向を示したが,有意ではなかった｡3.活性化を示すHLA-DR陽性細胞はCD4,CD8陽性細胞とも気管支攣縮型で高い傾向が認 められたが有意ではなかった｡以上,今回の検討では各臨床病型間でTリンパ球の関与に明らかな差は見られなかったが,気管支攣縮型に対する活性型Tリンパ球より強い関与の可能性が示唆された｡ |
| Keywords | 気管支喘息臨床病型 (clinical type of beonchial asthma) Tリンパ球 (T-lymphocyte) CD4陽性リンパ球 (CD4+lymphocyte) CD8陽性リンパ球 (CD8+lymphocyte) 活性化リンパ球 (activated lymphocyte) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 44 |
| End Page | 48 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307211 |
| JaLCDOI | 10.18926/15122 |
|---|---|
| Title Alternative | Study on the relationship between the bone mineral densities measured by QCT and biochemical parameters. |
| FullText URL | 066_037_043.pdf |
| Author | Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Yokota, Satoshi| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Nakai, Mutsuro| Akiyama, Tsuneo| |
| Abstract | 当院内科に通院または入院中の女性患者24例(57～89才,平均71.8才)を対象とし,定量的QCT法による骨塩量測定と同時に血中骨代謝マーカーを測定し検討を行った｡年齢についての検討では,カルシウム(Ca)が70才台で60才台に比べ有意に高値であった以外は年代による有意差は認められなかった｡オステオカルシン(OC)とイオン化Ca(Ca(2+))との間にr=-0.50,p<0.01の有意の逆相関を認め,OCとBody mass indexとの間に有意の正の相関(r=0.41,p<0.05)を認めた｡平均骨塩量と各生化学parameterとの間には有意な相関はみられなかった｡副腎皮質ステロイド剤(ステロイド)投与群では非投与群に比べ,投与群でALP骨型アイソザイム(ALP3)高値,OC低値の傾向がみられた｡またステロイド投与症例はすべてOC値が8.4ng/mℓ以下であり,ステロイドによる骨粗鬆症誘発の機序として骨形成の抑制が関与している可能性が考えられた｡今後骨塩量と骨代謝マーカーとの関連について,若年者を含めた検討が必要と考えられた｡ |
| Keywords | 骨粗鬆症 (Osteoporosis) 骨塩量 (Bone mineral desity) オステオカルシン (Osteocalcin) 骨型アルカリフォスファターゼ (alkaline phosphatase (bone type isozyme)) イオン化カルシウム (ionized calcium) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 37 |
| End Page | 43 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307374 |
| JaLCDOI | 10.18926/15121 |
|---|---|
| Title Alternative | 気管支喘息患者の血清コーチゾール値について. 副腎皮質ホルモン投与および年齢との関連 |
| FullText URL | 066_030_036.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Serum cortisol levels were examined in 94 patients with bronchial asthma in relation to dose of glucocorticoids and age. 1. The level of serum cortisol was significantly lower in group A patients, treated with glucocorticoids (prednisolone of 5mg/day or more) for more than 2 years, (2.4±1.2mcg/㎗) than in group B, treated with glucocorticoids (prednisolone of 5mg or less) for less than 2 years, (6.8±3.7mcg/㎗) (p<0.001) and in group C, treated without glucocorticoids, (12.6±3.9mcg/㎗) (p<0.001). The serum cortisol level was also significantly lower in group B than in group C (p<0.001). 2. The level of serum cortisol was significantly lower in patients over the age of 70 compared to that in those aged between 0 and 39 years (p<0.01) and those between 40 and 49 (p<0.05), and those between 50 and 59 (p<0.02). The level was also lower in patients between 60 and 69 compared to that in those between 0 and 39, however, this was not significant. These results demonstrate that the level of serum cortisol decreases by long-term glucocorticoid regimen and with aging. |
| Keywords | serum cortisol level (血清コーチゾール) bronchial asthma (気管支喘息) clinical asthma type (臨床病型) glucocorticoids (副腎皮質ホルモン) aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 30 |
| End Page | 36 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307345 |
| JaLCDOI | 10.18926/15120 |
|---|---|
| Title Alternative | 老年者気管支喘息の各臨床病型における換気機能の特徴 |
| FullText URL | 066_021_029.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Ventilatory function was examined in 55 patients with asthma (25 older patients over the age of 60 and 30 younger patients under the age of 59) in relation to four clinical types classified by clinical symptoms and signs. 1. Regarding cellular composition of bronchoalveolar lavage (BAL) fluid, number of BAL neutrophils was significantly increased in type II, bronchiolar obstruction type, of older and younger patients compared to that in type la-1 and type la-2 of same patients. In contrast, BAL eosinophilia was observed in type la-2 of both older and younger patients and in type Ib of younger patients. 2. The values of % FVC, FEV(1.0%) and % PEFR were not significantly different among four clinical types of asthma and between older and younger patients, although the values of these ventilatory parameters in type II asthma showed a tendency to be lower compared to other clinical types. 3. The values of % MMF, % V(50), and % V(25), showing ventilatory dysfunction of small airways, were lowest in type II asthma of both older and younger patients among four clinical types. A significant difference in these ventilatory parameters of type II asthma compared to type la-1 asthma was observed in younger patients, but not in older patients. These results show that ventilatory dysfunction of small airways is related to clinical asthma types in younger patients, and to aging rather than asthma types in older patients. |
| Keywords | Ventilatory function (換気機能) Clinical asthma type (臨床病型) BAL cells (BAL細胞) aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 21 |
| End Page | 29 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308008 |
| JaLCDOI | 10.18926/15119 |
|---|---|
| Title Alternative | 気管支喘息患者の気管支肺胞細胞からのヒスタミンとロイコトリエンC4遊離 ―アトピー性喘息におけるヒスタミンの役割について― |
| FullText URL | 066_014_020.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | To clarify the main humoral triggering factor (histamine and/or leukotriene) of the early stage of asthma attacks, the release of histamine and leukotriene C4 (LTC4) from bronchoalveolar lavage (BAL) cells stimulated with Ca ionophore A23187 was examined in 7 patients with atopic asthma, and the results were compared to those in 7 nonatopic asthma patients. 1. The proportion of BAL basophilic cells was significantly higher in atopic patients than in nonatopic patients (p<0.05). 2. The content of histamine in BAL fluid was significantly higher in atopic (2.3mcg/mℓ) comparted to that in nonatopic patients (0mcg/mℓ)(p<0.001). The content of LTC4 was high in nonatopic (2.4ng/mℓ) than in atopic patients (0.5ng/ mℓ), however, this was not significant. 3. The release of histamine from BAL cells was 32.6% in atopic and 0% in nonatopic patients, and this was significant (p<0.001). The release of LTC4 from BAL cells was significantly higher in nonatopic (11.3ng/10(6)cell) than in atopic (3.5ng/10(6)cell)(p<0.02). The results demonstrate that histamine play more important role in atopic patients as a main triggering factor of attacks than LTC4. In contrast, in nonatopic patients, LTC4 is more predominant than histamine during early stage of asthma attacks. |
| Keywords | Histamine LTC4 BAL cells atopic asthma |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 14 |
| End Page | 20 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307251 |
| JaLCDOI | 10.18926/15118 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性気管支喘息患者の血清コルチゾールに対する温泉療法の影響 |
| FullText URL | 066_008_013.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| |
| Abstract | Serum cortisol levels before and after spa therapy were compared in 30 patients with steroid-dependent intractable asthma (SDIA) in relation to clinical asthma types. 1. The mean level of serum cortisol in patients with type la-1 asthma was 2.0±0.7mcg/dℓ before spa therapy, and significantly increased to 9.0±3.1mcg/dℓ (p<0.001). The serum cortisol level of patients with type la-2 also significantly increased from 3.3±1.5mcg/dℓ before spa therapy to 5.9±3.1 mcg/dℓ after the therapy (p<0.05). 2. The level of serum cortisol in patients with type Ib increased from 4.0±1.6mcg/dℓ to 7.8±1.4mcg/ dℓ after spa therapy (p<0.001). In contrast, the serum cortisol levels in patients with type II were not significantly different before (2.7±1.3mcg/dℓ) and after spa therapy (3.5±3.0mcg/dℓ). The results showed that an increase in the levels of serum cortisol by spa therapy was more clearly observed in patients with type la-1 asthma compared to that in type la-2 or type Ib, and that, in contrast, the serum cortisol levels in patients with type II asthma did not significantly increase by spa therapy, since their asthma attacks were always severe and chronic in spite of long-term glucocorticoid regimen. |
| Keywords | Serum cortisol level (血清コルチゾール値) SDIA (ステロイド依存性重症難治性気管支喘息) clinical asthma type (気管支喘息臨床病型) spa therapy (温泉療法) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 8 |
| End Page | 13 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307485 |
| JaLCDOI | 10.18926/15117 |
|---|---|
| Title Alternative | ダニ喘息における気道遊走細胞からのヒスタミン遊離の加齢による減少 |
| FullText URL | 066_001_007.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Histamine release from bronchoalveolar cells induced by house dust mite (HDm) was compared in patients with atopic asthma sensitive to HDm in relation to age. 1. Total cell number in bronchoalveolar lavage (BAL) fluid was larger in patients over the age of 40 years (9.10×10(6)) than in those aged between 20 and 39 years (6.25×10(6)), however, this was not significant. 2. Number of BAL eosinophils was not significantly different between the two age groups. 3. Number of BAL basophilic cells was significantly higher in younger patients (20-39 years) (1.85±1.03×10(2)/mℓ) than in older patients (40+ years) (0.39±0.24×10(2)/mℓ) (p<0.001). 4. Histamine release from BAL cells induced by HDm was significantly higher in younger patients (38.1±24.8%) than in older patients (0%) (p<0.001). These results suggest that histamine release from BAL cells in patients with HDm allergy decreases with aging. |
| Keywords | Bronchial asthma House dust allergy Histamine release Bronchoalveolar cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 1 |
| End Page | 7 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307845 |
| JaLCDOI | 10.18926/15111 |
|---|---|
| FullText URL | 067_134_146.pdf |
| Author | 寺崎 佳代| 山田 修子| 坂本 香須美| |
| Abstract | 私達はロイ看護モデルで事例を看護過程にそって展開することにした｡急性疾患では生命の危険があるものも少なくはなく,早期に治療とフォローが必要とされる｡それに加えて重要なことは患者自身病気に対し,恐怖にも近い不安を持つ｡患者は個人の中にある調節器対処機制と認知器対処機制によって環境の変化に対処していく｡対処した行動が適応行動か非効果的行動かは,四つの適応様式,つまり生理的,自己概念,役割機能,相互依存によって示される｡患者は自分に必要な行動を認知し,様々な環境に適応していかなければならない｡看護婦は効果的なコミュニケーションを用いて急性期の患者の行動をアセスメントし,適応行動か非効果的行動かを判定する｡その結果として四つの適応様式,それぞれに個人的特徴が強く現れる｡成人期の患者は個人の人生目標もあり,人生経験もある｡あるいは治療中に死に至ることもある｡そこで心理,社会的様式のアセスメントは特に個人の背景や価値観を理解した上でされなければならない｡患者の四つの適応様式,各々の適応を促進するために必要な介助を行うことは看護婦の役割であり,その人の健康や生活の質に貢献することができるものである｡ |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 134 |
| End Page | 146 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307386 |
| JaLCDOI | 10.18926/15110 |
|---|---|
| FullText URL | 067_126_133.pdf |
| Author | 中村 寿美江| 細田 つる子| 中村 あけみ| 寺崎 佳代| 吉尾 慶子| 伊賀 真由美| 土海 智穂| |
| Keywords | 外来看護 記録 データベース |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 126 |
| End Page | 133 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307403 |
| JaLCDOI | 10.18926/15109 |
|---|---|
| Title Alternative | A case of multiple pancreatic cysts with K-ras point mutation in pure pancreatic juice |
| FullText URL | 067_121_125.pdf |
| Author | Yamamoto, Ryoichi| Ochi, Koji| Matsumura, Naoki| Tanaka, Juntaro| Kato, Tadahiro| Mizushima, Takaaki| Chowdhury Riaz| Harada, Hideo| Hasuoka, Hideaki| Yokota, Satoshi| Tanizaki, Yoshiro| |
| Abstract | 膵癌の早期診断を行うために,最近の進歩の著しい遺伝子診断を用いて,膵液中のK-ras遺伝子の点突然変異の検討がなされている｡われわれは膵液の細胞診は陰性であるが,K-ras遺伝子の点突然変異を認め,膵全体に多発する膵嚢胞の1例を経験した｡本例は悪性であるとの確診が得られないことや切除するとなれば膵全摘となることなどのために,経過観察を行っているが,18カ月後の現在,嚢胞の増大など認めていない｡膵癌の遺伝子診断の文献的考察を含め,報告する｡ |
| Keywords | 膵嚢胞 (pancreatic cyst) 膵液 (pancreatic juice) K-ras遺伝子 (K-ras oncogene) 点突然変異 (point mutation) 細胞診 (cytology) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 121 |
| End Page | 125 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307457 |
