result 940 件
| Author | Kojima, Toru| Hashimoto, Yuuri| Watanabe, Yuichi| Kagawa, Shunsuke| Uno, Futoshi| Kuroda, Shinji| Tazawa, Hiroshi| Kyo, Satoru| Mizuguchi, Hiroyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2009-10-01 |
| Publication Title | The Journal of Clinical Investigation |
| Volume | volume119 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Muro, Takayuki| Kato, yukako| Matsushita, Tomohiro| Kinoshita, Toyohiko| Watanabe, Yoshio| Okazaki, Hiroyuki| Yokoya, Takayoshi| Sekiyama, Akira| Suga, higemasa| |
|---|---|
| Published Date | 2011-11 |
| Publication Title | Journal of Synchrotron Radiation |
| Volume | volume18 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Baba, T| Yokoya, T| Tsuda, S| Watanabe, T| Nohara, M| Takagi, H| Oguchi, T| Shin, S| |
|---|---|
| Published Date | 2010-05-17 |
| Publication Title | Physical Review B |
| Volume | volume81 |
| Issue | issue18 |
| Content Type | Journal Article |
| Author | Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ma, Shaobo| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nakao, Miyuki| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Yagi, Takahito| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Sasaki, Tsuyoshi| Tazawa, Hiroshi| Hasei, Jo| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Yano, Shuya| Yoshida, Ryosuke| Uno, Futoshi| Kagawa, Shunsuke| Morimoto, Yuki| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Watanabe, Makiko| |
|---|---|
| Published Date | 2012-03-23 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Watanabe, Kae| |
|---|---|
| Published Date | 2012-03-23 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Okamura, Yosiyuki| |
|---|---|
| Published Date | 1936-07-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume48 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | 渡邊 佳成| |
|---|---|
| Published Date | 2012-03-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume19 |
| Content Type | Research Paper |
| JaLCDOI | 10.18926/AMO/48264 |
|---|---|
| FullText URL | 66_2_143.pdf.pdf |
| Author | Watanabe, Makiko| Ueno, Hiroshi| Suemitsu, Shunsuke| Yokobayashi, Eriko| Matsumoto, Yosuke| Usui, Shinichi| Sujiura, Hiroko| Okamoto, Motoi| |
| Abstract | Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin- containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV. |
| Keywords | parvalbumin fast-spiking interneurons FcγRllB barrel cortex sensory deprivation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-04 |
| Volume | volume66 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 143 |
| End Page | 154 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22525472 |
| Web of Science KeyUT | 000303175300007 |
| JaLCDOI | 10.18926/CTED/48199 |
|---|---|
| Title Alternative | Results and Issues in Student Teaching Program for Freshman at Okayama University on 2011 |
| FullText URL | cted_002_112_119.pdf.pdf |
| Author | Mishima, Tomotaka| Yamasaki, Mitsuhiro| Takahata, Hiroshi| Sekine, Masami| Watanabe, Masakatsu| Akazaki, Tetsuya| Shibata, Yasuko| Kishi, Akiko| Ohta, Yasuko| Kaga, Masaru| |
| Abstract | 本研究の目的は，岡山大学教育学部における1年次の教育実習プログラムの成果と課題の検討であった。そのため，平成23年度の教育実習Ⅰ受講生294名を対象に実習後に調査を行った。その結果，（１）教育実践力を構成する4つの力や附属学校園における実習目的の多くが達成されている，（２）4つの力のうち「コーディネート力」「生徒指導力」の達成度が特に高く，「学習指導力」の学校種ごとの学習指導の特徴や違いを説明することは達成度が低い，（３）附属学校園が掲げる目的のうち，観察して学ぶことの達成度が高いが，実際に児童生徒 と関わって学ぶことの達成度は低い傾向である，（４）実習中の実習生の取り組みに関しては，授業観察において事実を観察，記録することは取り組めているが，解釈的な授業観察や，協議会での発言は十分取り組めていない，の4点が主に示唆され，実習Ⅰの課題や不安に対する学生の自由記述と併せて結果が考察された。 |
| Keywords | 教育実習 教職志望学生 学部1年生 教員養成 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Published Date | 2012-03-19 |
| Volume | volume2 |
| Start Page | 112 |
| End Page | 119 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2012 岡山大学教師教育開発センター |
| File Version | publisher |
| NAID | 120003987704 |
| JaLCDOI | 10.18926/CTED/48193 |
|---|---|
| Title Alternative | Teacher education for raising the understanding capability about acts of violence in schools.―Development of the educational contents for in-service teachers and prospective teachers.― |
| FullText URL | cted_002_050_059.pdf.pdf |
| Author | Watanabe, Junichi| |
| Abstract | ここ数年児童生徒の暴力行為の増加が続き喫緊の課題となっている。暴力行為を予防し適切な指導・援助をするためには言語的な攻撃等も含めた攻撃行動自体を対象にし、その行為に及ぶ児童生徒を十分に理解することが基本となる。このような考えのもと、教員養成段階にある学生と現職教員の、児童生徒の攻撃行動に対する理解の実態を事例を用いて調査した。その結果、攻撃行動の理解の基盤となる四つの理論的視座―精神力動的、行動主義的、認知主義的、神経生理学的―のいずれからの理解にも課題のあることが明らかになった。また、児童生徒の攻撃行動を理解するための学習機会は、教員養成段階にある学生にも現職教員にも必ずしも多くないことが想定された。そこで、両者の理解力を養成・高度化するために、四つの理論的視座にコミュニケーションの視座を加えた教育・研修内容を開発し提案した。 |
| Keywords | 暴力行為 攻撃行動 教師教育 教員養成 生徒指導 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Published Date | 2012-03-19 |
| Volume | volume2 |
| Start Page | 50 |
| End Page | 59 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2012 岡山大学教師教育開発センター |
| File Version | publisher |
| NAID | 120003987710 |
| JaLCDOI | 10.18926/AMO/48078 |
|---|---|
| FullText URL | 66_1_23.pdf |
| Author | Watanabe, Toyohiko| Inoue, Miyabi| Ishii, Ayano| Yamato, Toyoko| Yamamoto, Masumi| Sasaki, Katsumi| Kobayashi, Yasuyuki| Araki, Motoo| Uehara, Shinya| Saika, Takashi| Kumon, Hiromi| |
| Abstract | Polypropylene mesh implants for the correction of pelvic organ prolapse (POP) are now available in Japan. We developed an innovative approach for correcting POP by placing polypropylene mesh transvaginally with laparoscopic assistance. From June 2007 through March 2010, sixteen consecutive patients with symptomatic stage 2 or 3 pelvic organ prolapse underwent the laparoscopic-assisted tension-free vaginal mesh procedure at Okayama University Hospital. All patients were evaluated before and at 1, 3, 6, and 12 months after surgery. Female sexual function was also evaluated with the Female Sexual Function Index (FSFI). The procedure was performed successfully without significant complications. Fifteen of 16 patients were considered anatomically cured (93.8%) at 12 months postoperatively. One patient with a recurrent stage 3 vaginal vault prolapse required sacral colpopexy six months postoperatively. Total FSFI scores improved significantly from 10.3±1.3 at baseline to 18.0±1.2 at 12 months after surgery. The laparoscopic-assisted trans-vaginal mesh is a safe, effective, and simple procedure for POP repairs. The procedure not only restores anatomic relationships but also improves sexual function. |
| Keywords | tension-free vaginal mesh pelvic organ prolapse laparoscopic female urology sexual function |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 23 |
| End Page | 29 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358136 |
| Web of Science KeyUT | 000300800700004 |
| JaLCDOI | 10.18926/AMO/48076 |
|---|---|
| FullText URL | 66_1_7.pdf |
| Author | Kawauchi, Keiichiro| Watanabe, Masami| Kaku, Haruki| Huang, Peng| Sasaki, Kasumi| Sakaguchi, Masakiyo| Ochiai, Kazuhiko| Huh, Nam-ho| Nasu, Yasutomo| Kumon, Hiromi| |
| Abstract | The preclinical safety and therapeutic efficacy of adenoviral vectors that express the REIC/Dkk-3 tumor suppressor gene (Ad-REIC) was examined for use in prostate cancer gene therapy. The Ad-human (h) and mouse (m) REIC were previously demonstrated to induce strong anti-cancer effects in vitro and in vivo, and we herein report the results of two in vivo studies. First, intra-tumor Ad-hREIC administration was examined for toxicity and therapeutic effects in a subcutaneous tumor model using the PC3 prostate cancer cell line. Second, intra-prostatic Ad-mREIC administration was tested for toxicity in normal mice. The whole-body and spleen weights, hematological and serum chemistry parameters, and histological evaluation of tissues from throughout the body were analyzed. Both experiments indicated that there was no significant difference in the examined parameters between the Ad-REIC-treated group and the control (PBS- or Ad-LacZ-treated) group. In the in vitro analysis using PC3 cells, a significant apoptotic effect was observed after Ad-hREIC treatment. Confirming this observation, the robust anti-tumor efficacy of Ad-hREIC was demonstrated in the in vivo subcutaneous prostate cancer model. Based on the results of these preclinical experiments, we consider the adenovirus-mediated REIC/Dkk-3 in situ gene therapy to be safe and useful for the clinical treatment of prostate cancer. |
| Keywords | REIC Dickkopf-3 gene therapy prostate cancer preclinical study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 16 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358134 |
| Web of Science KeyUT | 000300800700002 |
| Author | Watanabe, Naomi| |
|---|---|
| Published Date | 2011-12-31 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| JaLCDOI | 10.18926/bgeou/47110 |
|---|---|
| Title Alternative | A Study on the Development of the Practice in Early Childhood Care and Education to Improve Both the Way to Grasp Its Goals and the Practice Itself Qualitatively |
| FullText URL | bgeou_147_125_133.pdf |
| Author | Yokomatsu, Tomoyoshi| Watanabe, Yuzo| Mori, Hideko| Ise, Makoto| Toyoike, Rie| Saito, Kenji| |
| Abstract | 今日の保育園には，保育課程経営の実現が求められている。保育課程経営とは，保育課程開発の各段階とそれに対応する経営活動をPDCAサイクルにのせて推進し，より豊かな園の保育を実現しようとする営みであるといえる。その実現のためのアクション・リサーチが，私立御南保育園において実施されている。同リサーチでは，実効のある保育目標の明確化過程をとおして，保育目標の明確化手順を開発し､その上で，所属保育士有志が，実効のある保育目標を達成するためのより発展的な保育実践を開発しようとする取り組みを行っている。本研究では，その過程の分析をとおして，実効のある保育目標を前提にした保育実践開発が，保育目標のとらえ方と保育実践の両者を質的に向上させる可能性があることとその実現のための課題について考察している。 |
| Keywords | 保育目標のとらえ方 保育実践 質的向上 保育課程開発 保育課程経営 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2011-06-25 |
| Volume | volume147 |
| Start Page | 125 |
| End Page | 133 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120003551001 |
| Author | Satoh, Daisuke| Yagi, Takahito| Sadamori, Hiroshi| Umeda, Yuzo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
