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JaLCDOI 10.18926/AMO/55857
FullText URL 72_2_165.pdf
Author Yoshida, Aki| Fujiwara, Tomohiro| Uotani, Koji| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hasei, Joe| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Abstract Although there is considerable evidence indicating that the dysregulation of microRNAs (miRNAs) in malignant tumors plays a role in tumor development, the overall function of miRNAs and their clinicopathological significance are not well understood. In this retrospective analysis of 45 biopsy specimens from osteosarcoma (OS) patients, we investigated the functional and clinical significance of miR-25-3p in OS, which we previously identified as a highly expressed miRNA in OS patients’ serum. We observed that miR-25-3p dysregulation in human OS tissues was negatively correlated with the clinical prognosis, whereas the expression level of its target gene, Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3), was positively correlated with the clinical prognosis. Endogenous miR-25-3p upregulation promoted tumor growth, invasion, and drug resistance, which was consistent with DKK3 silencing in OS cells. In addition, secretory miR-25-3p was embedded in tumor-derived exosomes, where it promoted capillary formation and the invasion of vascular endothelial cells. Overall, our results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in OS, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease.
Keywords microRNA circulating microRNA osteosarcoma prognosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 165
End Page 174
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674765
JaLCDOI 10.18926/AMO/55856
FullText URL 72_2_153.pdf
Author Kumashiro, Masayuki| Kataoka, Takahiro| Yokota, Shinobu| Nakagawa, Shinobu| Otsuki, Keisuke| Miyake, Nobuyuki| Osumi, Shinji| Yamaoka, Kiyonori|
Abstract We examined the effects of a reduced exposure dose on the quality of images from an angiography device augmented with a noise reduction algorithm. Before its clinical application, we compared the diameter of the discrimination limit of the hole with that in the conventional method by a visual evaluation with a contrast-detail (C-D) phantom imaged using the target dose. Based on the results, a reducible dose was determined and applied clinically. The sample population consisted of patients being followed up after percutaneous coronary intervention (PCI) for coronary artery disease; we evaluated the effects of the exposure reduction on image quality. A significant dose reduction was observed by the noise-reduction method compared to the conventional method; the radiation dose to the flat panel detector (FPD) could be reduced to 70 nGy per frame. Clinically, a dose reduction of approx. 40% was obtained while maintaining image quality almost equal to that of the conventional method.
Keywords image quality radiation dose noise reduction percutaneous coronary intervention contrast-detail phantom
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 153
End Page 164
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674764
JaLCDOI 10.18926/AMO/55855
FullText URL 72_2_143.pdf
Author Shinohara, Yoshie| Nakatsuka, Mikiya|
Abstract We focus on Japanese individuals with gender identity disorder (GID), especially male-to-female (MTF) GID, who have experienced difficulty in adapting to social life. We clarify what gender dysphoria is, and we examine methods of intervention. Semi-structured interviews were conducted with 11 individuals with MTF-GID from August 2015 to April 2017. We categorized the subjects’experiences regarding dysphoria into the ‘Onset of gender dysphoria,’ ‘Experience of feeling gender dysphoria,’ and ‘Changes due to receiving medical care.’ The subjects reported experiencing great pain and distress because they did not fully understand that they were experiencing dysphoria and could not align their gender identity and their self-identity. All subjects described their experiences of dysphoria as negative. Additionally, all said that the dysphoria was alleviated by a medical intervention such as visiting a gender clinic, receiving a diagnosis and treatment, and changing their physical sex to the sex congruent with their gender identity. The provision of information at the gender clinic and the physical changes achieved by medical intervention exerted a positive effect both mentally and socially on the subjects, who suffered various physical, mental and social problems.
Keywords gender identity disorder gender dysphoria gender identity male to female
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 143
End Page 151
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674763
JaLCDOI 10.18926/AMO/55854
FullText URL 72_2_137.pdf
Author Takahashi, Yuko| Shien, Tadahiko| Sakamoto, Ai| Tsuyumu, Yuko| Yoshioka, Ryo| Uno, Maya| Hatono, Minami| Kochi, Mariko| Kawada, Kengo| Tsukioki, Takahiro| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Matsuoka, Junji| Nakatsuka, Mikiya| Doihara, Hiroyoshi|
Abstract Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy. Six (35%) patients underwent oocyte cryopreservation, and 11 (65%) married patients opted for embryo cryopreservation. There were no pregnancies among the patients undergoing oocyte cryopreservation, whereas 3 (27%) of the patients who opted for embryo cryopreservation became pregnant. Two (12%) patients stopped endocrine therapy after 2 years in an effort to become pregnant, but their breast cancers recurred. Though the problem of fertility loss for breast cancer patients is important and we should assess the infertility risk for all patients, we should also consider the prognosis. In June 2016, we launched a prospective multicenter cohort study to evaluate the efficacy and safety of fertility preservation in greater detail.
Keywords fertility preservation multidisciplinary breast cancer young patients
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 137
End Page 142
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674762
JaLCDOI 10.18926/AMO/55853
FullText URL 72_2_129.pdf
Author Okura, Tomohiro| Fujii, Masakuni| Shiode, Junji| Ito, Yuri| Kojima, Toru| Nasu, Junichiro| Niguma, Takefumi| Yoshioka, Masao| Mimura, Tetsushige| Yamamoto, Kazuhide|
Abstract The impact of body mass index (BMI) on postoperative survival in Japanese patients with pancreatic cancer is unclear. We examined the relationship between preoperative BMI and the prognosis of Japanese patients who underwent surgery for pancreatic cancer to determine whether BMI affects these patients’ prognosis. Of the patients who underwent pancreatectomy between January 2004 and August 2015 at our institution, 246 were pathologically diagnosed with pancreatic tubular adenocarcinoma; the cancer was located in the pancreatic head (n=161) and in the body and tail (n=85). We classified the patients by BMI: underweight (n=22), normal weight (n=190), and overweight/obese (n=34) groups. We retrospectively analyzed medical records for patient characteristics, lesion location, disease stage, postoperative complications, chemotherapy, and prognosis. Lesion location, disease stage, postoperative complications, and chemotherapy were not significantly different among the BMI groups. The median survival times were as follows (days): all patients, 686; underweight, 485; normal weight, 694; and overweight/obese, 839. In a multivariate analysis, after adjusting for competing risk factors, low BMI was associated with an increased risk of death (normal weight: HR 0.58, p=0.038; overweight/obese: HR 0.54, p=0.059). High BMI was not found to be a postoperative factor for poor prognosis in Japanese pancreatic cancer patients.
Keywords pancreatic cancer BMI prognosis surgery risk factor
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 129
End Page 135
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674761
JaLCDOI 10.18926/AMO/55852
FullText URL 72_2_121.pdf
Author Ochiai, Hirotaka| Shirasawa, Takako| Nanri, Hinako| Nishimura, Rimei| Hoshino, Hiromi| Kokaze, Akatsuki|
Abstract Several cross-sectional studies have shown that eating quickly is associated with overweight in children and adolescents. However, few cohort studies have examined this relationship. Here we investigated the relationship between eating quickly and overweight in a cohort study of fourth-grade schoolchildren (aged 9 or 10 years) who attended elementary schools in Ina-town, Japan. The children were followed for 3 years from 2001-2004 (at baseline) to 2004-2007. A questionnaire survey including information about eating speed (fast, medium, or slow) was administered, and height and weight measurements were obtained at baseline and follow-up. Overweight was defined according to the body mass index cutoff points proposed by the International Obesity Task Force. We used a Poisson regression model to examine the association between eating quickly at baseline and being overweight 3 years later. Data from 934 non-overweight children (465 boys, 469 girls) were analyzed. Eating quickly was not significantly associated with being overweight in the boys, whereas it was significantly associated with being overweight in the girls. Our analysis indicates that among girls, eating quickly leads to overweight, and that the modification of eating quickly could help prevent overweight in adolescents.
Keywords eating quickly overweight schoolchildren cohort study
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 121
End Page 128
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674760
JaLCDOI 10.18926/AMO/55851
FullText URL 72_2_115.pdf
Author Miyagi, Yasunari| Tada, Katsuhiko| Takayoshi, Riko| Oguni, Nobutsugu| Sato, Yasushi| Shibata, Maki| Kiyokawa, Machiko| Hashimoto, Tadashi| Takada, Tomoyoshi| Oda, Takashi| Miyake, Takahito|
Abstract We devised biomathematics-based formulae to estimate the standard values of fetal growth of Japanese after 22 weeks' gestation. The growth rates of bi-parietal diameter (BPD), abdominal circumference (AC), femur length (FL), and estimated fetal body weight (EFBW) at the time of gestation were assumed to be proportional to the product of the value at the time and the rest value of an unknown maximum value, respectively. The EFBW was also assumed to follow a multiple logistic function of BPD, AC and FL to fit the standard values of Japanese fetuses published by the Japan Society of Ultrasonics in Medicine. The Mann-Whitney test was used for statistical analysis. The values as a function of gestational day, t, were as follows: BPD(t)=99.6/(1+exp (2.725−0.01837*t)) (mm); AC(t)=39.7/(1+exp (2.454−0.01379*t)) (cm); FL(t)=79.6/(1+exp (2.851−0.01710*t)) (mm); EFBW(t)=8045.1/(1+exp (6.028−0.06582*BPD(t)−0.1469*AC(t)+ 0.07377*FL(t))) (g). EFBW as a function of BPD, AC and FL was as follows: EFBW=8045.1/(1+exp (4.747+ 0.02584*BPD+0.1010*AC−0.1416*FL)) (g). When the BPD, AC and FL were at −2 standard deviation (SD), −1SD, mean and + 2SD, the EFBW values calculated by the formula were statistically closer to the standard values than conventional formulas with p-values of 4.871×10−7, 4.228×10−7, 9.777×10−7 and 0.028, respectively. The formulae based on biomathematics might be useful to estimate the fetal growth standard values.
Keywords fetal growth formulae biomathematics Japanese ultrasound
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 115
End Page 119
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674759
JaLCDOI 10.18926/AMO/55850
FullText URL 72_2_105.pdf
Author Kato, Ryo| Iwamuro, Masaya| Hiraoka, Sakiko| Takashima, Shiho| Inokuchi, Toshihiro| Takahara, Masahiro| Kondo, Yoshitaka| Tanaka, Takehiro| Okada, Hiroyuki|
Abstract To analyze the clinical characteristics of patients with ulcerative colitis who have upper gastrointestinal lesions, we retrospectively reviewed the data of 216 patients with ulcerative colitis who underwent esophagogastroduodenoscopy at our institute in April 2008-March 2016. We investigated the endoscopic features and compared the clinical characteristics between the patients with and without upper gastrointestinal lesions. Forty-two patients (19.4%) had upper gastrointestinal lesions, including multiple erosions (n=18), bamboo joint-like appearance (n=17), mucosa with white spots (n=4), friable mucosa (n=2), ulcer (n=1), and purulent deposits within the mucosa (n=1) in the stomach and/or duodenum. Compared to the patients without upper gastrointestinal lesions, those with upper gastrointestinal lesions showed significantly more frequent extraintestinal manifestations (19.0% vs. 8.0%, p<0.05) and a significant history of colectomy (33.3% vs. 12.1%, p<0.01). There were no significant differences with regard to the sex ratio, age at esophagogastroduodenoscopy, gastrointestinal symptoms, time since the diagnosis of ulcerative colitis, type of colitis at the initial diagnosis of ulcerative colitis, or gastric atrophy between the groups. In conclusion, gastroduodenal lesions were identified in 19.4% of the patients with ulcerative colitis. Esophagogastroduodenoscopy is particularly recommended for ulcerative colitis patients who show extraintestinal manifestations and for those who have undergone a colectomy.
Keywords ulcerative colitis esophagogastroduodenoscopy gastritis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 105
End Page 113
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674758
JaLCDOI 10.18926/AMO/55849
FullText URL 72_2_99.pdf
Author Sugihara, Yuusaku| Harada, Keita| Kato, Ryo| Yamauchi, Kenji| Takashima, Shiho| Takei, Daisuke| Yamasaki, Yasushi| Inokuchi, Toshihiro| Takahara, Masahiro| Hiraoka, Sakiko| Okada, Hiroyuki|
Abstract Peroral endoscopic myotomy (POEM) for treatment of esophageal motility disorders has recently been reported to be highly effective and less invasive than other treatment. POEM was recently introduced in Okayama University Hospital under the supervision of a physician from a high-volume center. To verify the safety and efficacy of POEM during its introduction in our institution. We examined 10 cases in whom POEM was performed between January 2016 and April 2017. The patients included 7 men and 3 women, with a median age (range) of 49 years (17-74) and median symptom duration of 6 years (1-21). Seven patients had a straight esophagus, and the remaining 3 had a sigmoid esophagus. According to the Chicago classification, 6 patients were diagnosed with type I achalasia, 2 with type II achalasia, and 2 with distal esophagus spasm. Treatment outcomes and adverse events were evaluated. Treatment success was defined as a > 3 decrease in Eckardt score or a score of <3 at the time of discharge. The treatment success rate was 90%, with the average Eckardt score decreasing significantly, from 4.7 to 0.9 (p<0.05). No mucosal perforation, severe infection, mediastinitis, severe bleeding, or gastroesophageal reflux occurred intraoperatively or postoperatively. POEM was introduced to Okayama University Hospital, and the first 10 cases were accomplished safely and effectively under the supervision of an expert physician from a high-volume center.
Keywords achalasia Eckardt score peroral endoscopic myotomy (POEM)
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2018-04
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 99
End Page 104
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674757
Title Alternative Discovery Program for Global Learners at Okayama University and IB Education: Reflections on My University Experiences in Japan and the United States of America
FullText URL 2017_001_010_017.pdf
Author Chung, Haeng-ja|
Keywords 日米比較 文化人類学 振り返り Discovery Program for Global Learners at Okayama University グローバル・ディスカバリー・プログラム 国際バカロレア IB
Note 寄稿論文|
Published Date 2017-12
Publication Title 国際バカロレア教育研究
Issue issue1
Publisher 日本国際バカロレア教育学会
Start Page 10
End Page 17
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
File Version publisher
FullText URL hss_045_contents_eng.pdf
Author 岡山大学大学院社会文化科学研究科|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
FullText URL hss_045_colophon.pdf
Author 岡山大学大学院社会文化科学研究科|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
JaLCDOI 10.18926/55786
Title Alternative Toju NAKAE's Interpretation of '太虚(Taikyo)'
FullText URL hss_045_(1)_(16).pdf
Author Sun, Luyi|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
Start Page (1)
End Page (16)
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
NAID 120006416142
JaLCDOI 10.18926/55785
Title Alternative Die Subjektivität der Natur in Hegels Naturphilosophie : Insbesondere im Mechanismus
FullText URL hss_045_227_237.pdf
Author Takeshima, Naohito|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
Start Page 227
End Page 237
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
NAID 120006416141
JaLCDOI 10.18926/55784
FullText URL hss_045_209_226.pdf
Author Kawakami, Masahiro|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
Start Page 209
End Page 226
ISSN 1881-1671
language English
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
NAID 120006416140
JaLCDOI 10.18926/55783
Title Alternative The Statement on 'China' in the Magazine Kaizo Published in the 1920s
FullText URL hss_045_197_208.pdf
Author Xu, Danqing|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
Start Page 197
End Page 208
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
NAID 120006416139
JaLCDOI 10.18926/55782
Title Alternative On the Combination of Adjective and Noun Predication : The Case where the Subject Indicates a Human
FullText URL hss_045_175_195.pdf
Author Meng, Lingyi|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
Start Page 175
End Page 195
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
NAID 120006416138
JaLCDOI 10.18926/55781
Title Alternative Defamation by Reprint on the Internet and the Responsibility of the Reprinting Media
FullText URL hss_045_155_173.pdf
Author Zhang, Jing|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
Start Page 155
End Page 173
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
NAID 120006416137
JaLCDOI 10.18926/55780
Title Alternative On the Description of the Adverbial -ku form of Adjectives in Japanese Grammar
FullText URL hss_045_139_153.pdf
Author Kato, Kasumi|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
Start Page 139
End Page 153
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
NAID 120006416136
JaLCDOI 10.18926/55779
Title Alternative The Status of Subordinate Conjunctions in Japanese Grammar
FullText URL hss_045_121_137.pdf
Author Liu, Xiaomei|
Publication Title Journal of Humanities and Social Sciences
Published Date 2018-03-22
Volume volume45
Start Page 121
End Page 137
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2018 岡山大学大学院社会文化科学研究科
File Version publisher
NAID 120006416135