Conditions

close

result 18185 件

JaLCDOI 10.18926/OER/55230
Title Alternative A Study of the Principle of Taxation on Actual Beneficiary in Japanese Income Tax Act : The meaning of Economic Substance Approach in Taxation
FullText URL oer_049_1_023_039.pdf
Author Morishita, Mikio|
Abstract The purpose of this paper is to consider the meaning of "economic substance" in taxation.  In Japanese Income Tax Act (Article 12), where a person to whom the revenue is legally imputed is merely nominal and other person enjoys it, the tax shall be imposed on the person who actually enjoys the revenue. This is called "the Principle of taxation on Actual Beneficiary". But it is not always easy to determine the person who actually enjoys the revenue from assets or business. In such a case, there are two ways of thinking. The first is a way of thinking in which a valid private-law contract is considered more important than economic substance. The second is a way of thinking in which economic substance is considered more important than a private-law contract.  This provision( Article 12) was enacted in 1950's, but opinions are divided among scholars on this point and there is room for further consideration. This paper will be considered this subject from legal and economic viewpoints.
Publication Title Okayama Economic Review
Published Date 2017-07-03
Volume volume49
Issue issue1
Start Page 23
End Page 39
ISSN 2433-4146
language Japanese
Copyright Holders Copyright © 2017 岡山大学経済学会
File Version publisher
NAID 120006313606
JaLCDOI 10.18926/OER/55229
Title Alternative New leader builds a strategy to recover the performance
FullText URL oer_049_1_001_021.pdf
Author Kita, Masanobu|
Abstract In this paper, focusing on the management crisis, we analyzed the judgments and actions taken by a new leader entrusted to reconstruction and the relationship with the organization members who responded to it, and examined the behavioral style of the leader.  As a result of case study, we were able to confirm the following points.  Under the influence of the representative heuristic, the new leader decided in a top-down style the rationalization plan that overestimated the start dash to survive the company. For the members, this will give rise to a situation where it is not convincing. Subsequent actions of the leader are consistent with behavior of innovative leadership such as role modeling, schema transformation. It is linked to the characteristics of heuristics such as easy remembrance (recallability) and affinity. If such behavior is taken, there is a possibility of showing synchronicity. Also, leaders will take care to treat everyone equally through specific actions and express sincerity to rationalization measures substantially. In response to such attitudes, members feel strongly about interpersonal justice.  It was suggested that the behavior and attitude of the leader mentioned above will make a stepping stone toward recovery of business performance.
Keywords Innovative leadership Heuristics Cognitive bias Synchronicity Interpersonal justice
Publication Title Okayama Economic Review
Published Date 2017-07-03
Volume volume49
Issue issue1
Start Page 1
End Page 21
ISSN 2433-4146
language Japanese
Copyright Holders Copyright © 2017 岡山大学経済学会
File Version publisher
NAID 120006313605
FullText URL K0005440_other1.pdf
Author Hiroshi, Umemura| Yamasaki, Osamu| Kaji, Tatsuya| Otsuka, Masaki| Asagoe, Kenji| Takata, Minoru| Iwatsuki, Keiji|
Keywords 5-S-cysteinyl-dopa biomarker lactate dehydrogenase malignant melanoma serum 5-S-CD
Note 学位審査副論文|
Published Date 2017-04
Publication Title Journal of Dermatology
Volume volume44
Issue issue4
Publisher Wiley-Blackwell
Start Page 449
End Page 454
ISSN 03852407
NCID AA00696658
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 27786364
DOI 10.1111/1346-8138.13651
Web of Science KeyUT 000398690600029
Related Url isVersionOf https://doi.org/10.1111/1346-8138.13651
FullText URL Nature_543_7643_131.pdf
Author Suga, Michihiro| Akita, Fusamichi| Sugahara, Michihiro| Kubo, Minoru| Nakajima, Yoshiki| Nakane, Takanori| Yamashita, Keitaro| Umena, Yasufumi| Nakabayashi, Makoto| Yamane, Takahiro| Nakano, Takamitsu| Suzuki, Mamoru| Masuda, Tetsuya| Inoue, Shigeyuki| Kimura, Tetsunari| Nomura, Takashi| Yonekura, Shinichiro| Yu, Long-Jiang| Sakamoto, Tomohiro| Motomura, Taiki| Chen, Jing-Hua| Kato, Yuki| Noguchi, Takumi| Tono, Kensuke| Joti, Yasumasa| Kameshima, Takashi| Hatsui, Takaki| Nango, Eriko| Tanaka, Rie| Naitow, Hisashi| Matsuura, Yoshinori| Yamashita, Ayumi| Yamamoto, Masaki| Nureki, Osamu| Yabashi, Makina| Ishikawa, Tetsuya| Iwata, So| Shen, Jian-Ren|
Published Date 2017-03
Publication Title Nature
Volume volume543
Issue issue7643
Publisher Nature Publishing Group
Start Page 131
End Page 135
ISSN 0028-0836
NCID AA00752384
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28219079
DOI 10.1038/nature21400
Web of Science KeyUT 000395671500047
Related Url https://doi.org/10.1038/nature21400
FullText URL K0005478_other1.pdf
Author Matsuzono, Kosuke| Ikeda, Yoshio| Liu, Wentao| Kurata, Tomoko| Deguchi, Shoko| Deguchi, Kentaro| Abe, Koji|
Keywords Prion disease Novelgene mutation 2bp deletion in codon 178 stopcodon at codon 195 Sensoryneuropathy HSAN Pan-autonomicfailure Familial case
Note 岡山大学審査学位副論文|
Published Date 2013-05
Publication Title European journal of neurology
Volume volume20
Issue issue5
Publisher Wiley
Start Page e67
End Page e69
ISSN 1351-5101
NCID AA11015934
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja
File Version author
PubMed ID 23577609
Web of Science KeyUT 000317609800003
Related Url https://doi.org/10.1111/ene.12089 http://ousar.lib.okayama-u.ac.jp/55031
FullText URL K0005463_other1.pdf
Author Higuchi, Yuji | Uchitomi, Yosuke| Fujimori, Maiko| Koyama, Toshihiro| Kataoka, Hitomi| Kitamura, Yoshihisa| Sendo, Toshiaki| Inagaki, Masatoshi|
Keywords Empathy Hospital pharmacist Japan Pharmaceutical care
Note The final publication is available at Springer| 岡山大学審査学位副論文|
Published Date 2015-12
Publication Title International Journal of Clinical Pharmacy
Volume volume37
Issue issue6
Publisher Springer
Start Page 1258
End Page 1266
ISSN 2210-7703
NCID AA12633112
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 26441314
DOI 10.1007/s11096-015-0204-2
Web of Science KeyUT 000363490100042
Related Url https://doi.org/10.1007/s11096-015-0204-2 http://ousar.lib.okayama-u.ac.jp/55016
FullText URL JRNC_313_1_169.pdf
Author Kudo, Ken-ichi| Hanafusa, Tadashi| Ono, Toshiro|
Keywords Monoterpenes Linalool X-ray irradiation Reactive oxygen species SSB
Note The final publication is available at Springer|
Published Date 2017-07
Publication Title Journal of Radioanalytical and Nuclear Chemistry
Volume volume313
Issue issue1
Publisher Springer
Start Page 169
End Page 174
ISSN 0236-5731
NCID AA11120189
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1007/s10967-017-5268-0
Related Url https://doi.org/10.1007/s10967-017-5268-0
FullText URL Chem_Mater_29_5_2150.pdf
Author Morimoto, Naoki| Suzuki, Hideyuki| Takeuchi, Yasuo| Kawaguchi, Shogo| Kunisu, Masahiro| Bielawski, Christopher W.| Nishina, Yuta|
Published Date 2017-03-02
Publication Title Chemistry of Materials
Volume volume29
Issue issue5
Publisher American Chemical Society
Start Page 2150
End Page 2156
ISSN 15205002
NCID AA12096771
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2017 American Chemical Society
File Version author
DOI 10.1021/acs.chemmater.6b04807
Web of Science KeyUT 000396639400027
Related Url isVersionOf https://doi.org/10.1021/acs.chemmater.6b04807
JaLCDOI 10.18926/AMO/55210
FullText URL 71_3_259.pdf
Author Kawana, Shinichi| Yamamoto, Hiromasa| Maki, Yuho| Sugimoto, Seiichiro| Toyooka, Shinichi| Miyoshi, Shinichiro|
Abstract  Primary sternal chondrosarcoma is a rare malignant tumor that is refractory to chemotherapy and radiation. Effective therapy is radical resection of the tumor. We present two patients with primary sternal chondrosarcoma who underwent a radical resection of the lower half of the sternum and bilateral ribs, followed by reconstruction with 2 sheets of polypropylene mesh layered orthogonally. The patients have maintained almost the same pulmonary function as preoperative values, with stability of the chest wall. Although there are various ways to reconstruct the anterior chest wall, reconstruction with polypropylene mesh layered orthogonally is an easy-to-use and sufficient method.
Keywords chondrosarcoma sternum reconstruction polypropylene mesh
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2017-06
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 259
End Page 262
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655947
JaLCDOI 10.18926/AMO/55209
FullText URL 71_3_255.pdf
Author Kumase, Fumiaki| Morizane, Yuki| Kimura, Shuhei| Toshima, Shinji| Shiraga, Fumio|
Abstract  Parafoveal retinal holes (PRHs) are one of the complications that can occur after internal limiting membrane (ILM) peeling during macular surgery. Here we describe a patient in whom an exceptionally large PRH (1,069-μm dia.) was successfully closed by repeated autologous ILM transplantation.
Keywords autologous internal limiting membrane transplantation parafoveal retinal hole, macular surgery
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2017-06
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 255
End Page 257
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655946
JaLCDOI 10.18926/AMO/55208
FullText URL 71_3_249.pdf
Author Washio, Kana| Muraoka, Michiko| Kanamitsu, Kiichiro| Oda, Megumi| Shimada, Akira|
Abstract  We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.
Keywords langerhans cell histiocytosis (LCH) hemophagocytic lymphohistiocytosis (HLH) hematopoietic stem cell transplantation (HSCT) reduced-intensity conditioning (RIC) refractory
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2017-06
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 249
End Page 254
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655945
JaLCDOI 10.18926/AMO/55207
FullText URL 71_3_241.pdf
Author Iwamuro, Masaya| Tanaka, Shouichi| Moritou, Yuki| Inaba, Tomoki| Higashi, Reiji| Kusumoto, Chiaki| Yunoki, Naoko| Ishikawa, Shin| Okamoto, Yuko| Kawai, Yoshinari| Kitada, Ken-ichi| Takenaka, Ryuta| Toyokawa, Tatsuya| Okada, Hiroyuki|
Abstract  Most gastric bezoars can be treated with endoscopic fragmentation combined with or without cola dissolution, whereas laparotomy or laparoscopic surgery is generally inevitable for small intestinal bezoars because they cause small bowel obstruction. Therefore, early diagnosis and management of gastric bezoars are necessary to prevent bezoar-induced ileus. To investigate the incidence of overlooked gastric bezoars during the initial esophagogastroduodenoscopy, we retrospectively reviewed the cases of 27 patients diagnosed with gastrointestinal bezoars. The bezoars were diagnosed using esophagogastroduodenoscopy (n=25), abdominal ultrasonography (n=1), and barium follow-through examination (n=1). Bezoars were overlooked in 9/25 patients (36.0%) during the initial endoscopy examination because the bezoars were covered with debris in the stomach. Of the 9 patients, 8 had concomitant gastric ulcers, and the other patient had gastric lymphoma. Although a computed tomography (CT) scan was performed before the second-look endoscopy in 8 of the 9 patients, the bezoars were mistaken as food debris on CT findings and were overlooked in these patients. In conclusion, gastric bezoars may not be discovered during the initial esophagogastroduodenoscopy and CT scan. In cases with debris in the stomach, second-look endoscopy is essential to detect bezoars.
Keywords bezoar gastric ulcer foreign bodies phytobezoar
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-06
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 241
End Page 247
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655944
JaLCDOI 10.18926/AMO/55203
FullText URL 71_3_209.pdf
Author Xin, Zhao| Tsuda, Toshihide| Doi, Hiroyuki|
Abstract We evaluated how exposure to airborne volatile organic compounds emitted from a plastic recycling facility affected nearby residents, in a cross-sectional study. Individuals>10 years old were randomly sampled from 50 households at five sites and given questionnaires to complete. We categorized the subjects by distance from the recycling facility and used this as a proxy measure for pollutant exposure. We sought to improve on a preceding study by generating new findings, improving methods for questionnaire distribution and collection, and refining site selection. We calculated the odds of residents living 500 or 900 m away from the facility reporting mucocutaneous and respiratory symptoms using a reference group of residents 2,800 m away. Self-reported nasal congestion (odds ratio=3.0, 95% confidence interval=1.02-8.8), eczema (5.1, 1.1-22.9), and sore throat (3.9, 1.1-14.1) were significantly higher among residents 500 m from the facility. Those 900 m away were also considerably more likely to report experiencing eczema (4.6, 1.4-14.9). Air pollution was found responsible for significantly increased reports of mucocutaneous and respiratory symptoms among nearby residents. Our findings confirm the effects of pollutants emitted from recycling facilities on residents’ health and clarify that study design differences did not affect the results.
Keywords air pollutants volatile organic compounds recycling facility mucocutaneous symptoms respiratory symptoms
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-06
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 209
End Page 217
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655940
JaLCDOI 10.18926/AMO/55202
FullText URL 71_3_201.pdf
Author Matsuda, Miwa| Sasaki, Aiko| Shimizu, Keiko| Kamada, Yasuhiko| Noguchi, Soichi| Hiramatsu, Yuji| Nakatsuka, Mikiya|
Abstract  Vascular dysfunction has been reported in women with recurrent pregnancy loss (RPL). We investigated the severity of vascular dysfunction in non-pregnant women with RPL and its correlation with anti-heat shock protein (HSP) antibodies that are known to induce arteriosclerosis. We measured the serum anti-HSP60 antibodies, anti-HSP70 antibodies, and anti-phospholipid antibodies (APA) in 68 women with RPL and 29 healthy controls. Among the women with RPL, 14 had a diagnosis of antiphospholipid syndrome (APS), and in the remaining 54, the causes for RPL were unexplained. Compared to the controls, the brachial-ankle pulse wave velocity (baPWV), carotid augmentation index (cAI), and uterine artery pulsatility index (PI) were all significantly higher in the women with both APS and unexplained RPL. Compared to the controls, the anti-HSP60 antibody levels were significantly higher in the APA-positive group of women with unexplained RPL, and the anti-HSP70 antibody levels were significantly higher in APS and APA-positive group of women with unexplained RPL. However, the anti-HSP60 and anti-HSP70 antibody levels did not correlate with the values of baPWV or cAI. Our results demonstrated anti-HSP60 and anti-HSP70 antibodies are increased in women with unexplained RPL. Further studies are needed to elucidate the roles of anti-HSP antibodies and their pathophysiology in unexplained RPL.
Keywords recurrent pregnancy loss autoantibody heat shock protein pulse wave velocity arterial stiffness
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-06
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 201
End Page 208
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655939
JaLCDOI 10.18926/AMO/55201
FullText URL 71_3_191.pdf
Author Kobayashi, Katsuhiro| Akiyama, Tomoyuki| Agari, Takashi| Sasaki, Tatsuya| Shibata, Takashi| Hanaoka, Yoshiyuki| Akiyama, Mari| Endoh, Fumika| Oka, Makio| Date, Isao|
Abstract  Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
Keywords fast oscillations, epilepsy electroencephalogram time-frequency analysis
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2017-06
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 200
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655938
FullText URL K0005453_other1.pdf
Author Nobumoto, Etsuko| Masuyama, Hisashi| Hiramatsu, Yuji| Sugiyama, Takashi| Kusaka, Hideto| Toyoda, Nagayasu|
Keywords New GDM criteria Perinatal complications Obesity 75-g oral glucose tolerance test
Note The final publication is available at Springer| 学位審査副論文|
Published Date 2015-09
Publication Title Diabetology International
Volume volume6
Issue issue3
Publisher Springer Japan
Start Page 226
End Page 231
ISSN 21901678
NCID AA12503387
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
DOI 10.1007/s13340-014-0193-8
Web of Science KeyUT 000366631000009
Related Url http://doi.org/10.1007/s13340-014-0193-8 http://ousar.lib.okayama-u.ac.jp/55005
FullText URL J_Comp_Neurol_525_7_1586.pdf
Author Tamura, Kei| Kobayashi, Yasuhisa| Hirooka, Asuka| Takanami, Keiko| Oti, Takumi| Jogahara, Takamichi| Oda, Sen-ichi| Sakamoto, Tatsuya| Sakamoto, Hirotaka|
Keywords RRID AB_2060157 RRID: AB_2571636 RRID: AB_626757 Suncus murinus (suncus) gastrin-releasing peptide male reproductive function sexual dimorphism spinal cord
Note This is the peer reviewed version of the following article: Tamura K. Kobayashi Y. Hirooka A. et al. Identification of the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function in the mouse and Asian house musk shrew (Suncus murinus). J Comp Neurol. 2017;525:1601–1613. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.| 2018年5月公開予定|
Published Date 2017-05-01
Publication Title Journal of Comparative Neurology
Volume volume525
Issue issue7
Publisher Wistar Institute of Anatomy and Biology
Start Page 1586
End Page 1598
ISSN 0021-9967
NCID AA00695917
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 27804131
DOI 10.1002/cne.24138
Web of Science KeyUT 000397559700004
Related Url https://doi.org/10.1002/cne.24138
FullText URL JoAmChemSoc_2017_139_12_4376.pdf
Author Niho, Akiko| Yoshizawa, Susumu| Tsukamoto, Takashi| Kurihara, Marie| Tahara, Shinya| Nakajima, Yu| Mizuno, Misao| Kuramochi, Hikaru| Tahara, Tahei| Mizutani, Yasuhisa| Sudo, Yuki|
Note This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher.|
Published Date 2017-03-29
Publication Title Journal of the American Chemical Society
Volume volume139
Issue issue12
Publisher American Chemical Society
Start Page 4376
End Page 4389
ISSN 00027863
NCID AA00692602
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 28257611
DOI 10.1021/jacs.6b12139
Web of Science KeyUT 000398247100034
Related Url isVersionOf https://doi.org/10.1021/jacs.6b12139
FullText URL Acta_Biomater_2017_5.pdf
Author Okada, Masahiro| Nakai, Akira| Hara Emilio, Satoshi| Taguchi, Tetsushi| Nakano, Takayoshi| Matsumoto, Takuya|
Keywords Hydroxyapatite Nanoparticle Solid adhesive Wet adhesion
Published Date 2017-05
Publication Title Acta Biomaterialia
Volume volume57
Publisher Elsevier B.V.
Start Page 404
End Page 413
ISSN 1742-7061
NCID AA12033647
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
File Version author
PubMed ID 28483692
DOI 10.1016/j.actbio.2017.05.014
Web of Science KeyUT 000405041900035
Related Url https://doi.org/10.1016/j.actbio.2017.05.014
Title Alternative Identification of Marker Gene of Pars Tuberalis Morphogenesis in Chicken Embryo. The expression of Cytokine-like 1 and Gap junction protein alpha 5 in the pars tuberalis
FullText URL poalas_033_031_034.pdf
Author Aizawa, Sayaka | Higaki, Yuriko| Ogoshi, Maho| Takeuchi, Sakae| Takahashi, Sumio|
Abstract Adenohypophysis delivered from oral ectoderm consists of pars distalis (PD), pars intermedia and pars tuberalis (PT). The mechanisms of development of PD has been well studied, and the cell differentiation of PD has been well understood. However, the morphogenesis and the differentiation of PT are still unclear, and the gene expression during the PT development remains largely unknown. In this study, we explored the specifically expressing genes in PT during development and analyzed its spatiotemporal expressions pattern. Microarray analysis on laser-captured PT and PD tissues obtained from chicken embryos on embryonic day 10 (E10.0) showed high expressing genes, Cytokine-like 1 (CYTL1) and Gap junction protein alpha 5 (GJA5) in PT. A detail analysis of spatiotemporal expressions pattern during chick embryo development by in situ hybridization revealed that CYTL1 mRNA was first detected in lateral head ectoderm and ventral head ectoderm in E1.5. The CYTL1 expressions moved into Rathke’s pouch at E2.5, then it was localized in PT primordium and continuously expressed in PT primordium until E12.0. On the other hand, GJA5 mRNA was transiently detected in PT primordium from E6 to E14.0, while the expression was not detected in PD during development. These results suggested that these genes may be involved in the regulation mechanism of PT development and could be a useful marker in the PT development.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2017-04
Volume volume33
Start Page 31
End Page 34
language Japanese
File Version publisher