Remarkable Efficacy of Capmatinib in a Patient with Cancer of Unknown Primary with MET Amplification

Tanaka, Takaaki; Makimoto, Go; Sumii, Ryohei; Omote, Rika; Ando, Yayoi; Ninomiya, Kiichiro; Ichihara, Eiki; Ohashi, Kadoaki; Maeda, Yoshinobu; Tabata, Masahiro

doi:10.2169/internalmedicine.5028-24

Permalink : http://escholarship.lib.okayama-u.ac.jp/69790

ID	69790
FullText URL	fulltext.pdf 896 KB
Author	Tanaka, Takaaki Department of Respiratory Medicine, Okayama University Hospital Makimoto, Go Department of Respiratory Medicine, Okayama University Hospital Sumii, Ryohei Department of General Internal Medicine, NHO Fukuyama Medical Center Omote, Rika Department of Pathology, NHO Fukuyama Medical Center Ando, Yayoi Clinical Research Support Office, National Cancer Center Hospital Ninomiya, Kiichiro Center for Comprehensive Genomic Medicine, Okayama University Hospital Kaken ID Ichihara, Eiki Center for Clinical Oncology, Okayama University Hospital Kaken ID publons Ohashi, Kadoaki Department of Respiratory Medicine, Okayama University Hospital ORCID Kaken ID researchmap Maeda, Yoshinobu Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Kaken ID researchmap Tabata, Masahiro Center for Clinical Oncology, Okayama University Hospital Kaken ID researchmap
Abstract	This case report describes a 70-year-old female with cancer of unknown primary origin (CUP) who exhibited multiple distant lymph node metastases. Despite conventional chemotherapy (carboplatin and paclitaxel) and immunotherapy (nivolumab), disease progression was noted. Genomic profiling revealed MET amplification, leading to the administration of capmatinib, a selective MET tyrosine kinase inhibitor. The patient experienced substantial tumor reduction with dose adjustments due to adverse effects, indicating the potential efficacy of capmatinib in treating CUP with MET amplification.
Keywords	MET amplification capmatinib MET inhibitors cancer of unknown primary MET exon 14 skipping
Published Date	2025-12-01
Publication Title	Internal Medicine
Volume	volume64
Issue	issue23
Publisher	Japanese Society of Internal Medicine
Start Page	3460
End Page	3464
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	40399079
DOI	10.2169/internalmedicine.5028-24
Web of Science KeyUT	001494122100001
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.5028-24
License	https://creativecommons.org/licenses/by-nc-nd/4.0/