Remarkable Efficacy of Capmatinib in a Patient with Cancer of Unknown Primary with MET Amplification

Tanaka, Takaaki; Makimoto, Go; Sumii, Ryohei; Omote, Rika; Ando, Yayoi; Ninomiya, Kiichiro; Ichihara, Eiki; Ohashi, Kadoaki; Maeda, Yoshinobu; Tabata, Masahiro

doi:10.2169/internalmedicine.5028-24

Permalink : http://escholarship.lib.okayama-u.ac.jp/69790

ID	69790
フルテキストURL	fulltext.pdf 896 KB
著者	Tanaka, Takaaki Department of Respiratory Medicine, Okayama University Hospital Makimoto, Go Department of Respiratory Medicine, Okayama University Hospital Sumii, Ryohei Department of General Internal Medicine, NHO Fukuyama Medical Center Omote, Rika Department of Pathology, NHO Fukuyama Medical Center Ando, Yayoi Clinical Research Support Office, National Cancer Center Hospital Ninomiya, Kiichiro Center for Comprehensive Genomic Medicine, Okayama University Hospital Kaken ID Ichihara, Eiki Center for Clinical Oncology, Okayama University Hospital Kaken ID publons Ohashi, Kadoaki Department of Respiratory Medicine, Okayama University Hospital ORCID Kaken ID researchmap Maeda, Yoshinobu Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Kaken ID researchmap Tabata, Masahiro Center for Clinical Oncology, Okayama University Hospital Kaken ID researchmap
抄録	This case report describes a 70-year-old female with cancer of unknown primary origin (CUP) who exhibited multiple distant lymph node metastases. Despite conventional chemotherapy (carboplatin and paclitaxel) and immunotherapy (nivolumab), disease progression was noted. Genomic profiling revealed MET amplification, leading to the administration of capmatinib, a selective MET tyrosine kinase inhibitor. The patient experienced substantial tumor reduction with dose adjustments due to adverse effects, indicating the potential efficacy of capmatinib in treating CUP with MET amplification.
キーワード	MET amplification capmatinib MET inhibitors cancer of unknown primary MET exon 14 skipping
発行日	2025-12-01
出版物タイトル	Internal Medicine
巻	64巻
号	23号
出版者	Japanese Society of Internal Medicine
開始ページ	3460
終了ページ	3464
ISSN	0918-2918
NCID	AA10827774
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 by The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	40399079
DOI	10.2169/internalmedicine.5028-24
Web of Science KeyUT	001494122100001
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.5028-24
ライセンス	https://creativecommons.org/licenses/by-nc-nd/4.0/