result 18185 件
| FullText URL | K0006083_abstract_review.pdf K0006083_fulltext.pdf K0006083_summary.pdf |
|---|---|
| Author | Ishii, Kenzo| |
| Published Date | 2019-12-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6083号 |
| Granted Date | 2019-12-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0006081_abstract_review.pdf K0006081_summary.pdf K0006081_fulltext.pdf |
|---|---|
| Author | Ohbayashi, Yoshiaki| |
| Published Date | 2019-12-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6081号 |
| Granted Date | 2019-12-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/57959 |
|---|---|
| FullText URL | 74_1_89.pdf |
| Author | Kada, Akiko| Fukano, Reiji| Mori, Tetsuya| Kamei, Michi| Tanaka, Fumiko| Ueyama, Junichi| Sekimizu, Masahiro| Osumi, Tomoo| Mori, Takeshi| Koga, Yuhki| Ohki, Kentaro| Fujita, Naoto| Mitsui, Tetsuo| Saito, Akiko M.| Hashimoto, Hiroya| Kobayashi, Ryoji| |
| Abstract | No standard treatment for relapsed or refractory anaplastic large-cell lymphoma (ALCL) has been established. This study is a multicenter, open-label trial to examine the effectiveness and safety of transplantation with reduced-intensity conditioning (RIC) for patients under 20 years old with relapsed or refractory ALCL. We defined RIC as the administration of fludarabine (30 mg/m2/day) for five days plus melphalan (70 mg/m2/day) for two days and total body irradiation at 4 Gy, followed by allogeneic hematopoietic stem cell transplantation. |
| Keywords | anaplastic large-cell lymphoma relapsed/refractory fludarabine melphalan total body irradiation |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 89 |
| End Page | 94 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099255 |
| Web of Science KeyUT | 000516606200014 |
| NAID | 120006795626 |
| JaLCDOI | 10.18926/AMO/57958 |
|---|---|
| FullText URL | 74_1_83.pdf |
| Author | Sakurai, Toru| Watanabe, Toshiyuki| Manako, Kensuke| Komagoe, Syo| Mukai, Yuko| Kimata, Yoshiro| Namba, Yuzaburo| |
| Abstract | Nosaka, NobuyukiMastectomy is usually the first and most important surgical procedure in female-to-male (FTM) individuals with gender identity disorder. Nipple reduction is also important in the process of reconstructing the chest wall for a more male appearance. If the nipples remain large after a mastectomy, the results may be disappointing to many FTM transsexuals. Nipple reduction enables these individuals to go to the beach or Japanese public baths, where they may go topless in public. We therefore consider that nipple reduction is indicated for all FTM transsexuals who desire it. There are a variety of methods for the reduction of enlarged nipples for women or non-FTM patients, but only a few reports have described the process used to create masculine-appearing nipples for FTM transsexuals. We developed a novel technique called the Eryngii method for creating male-like nipples using a 4-mm diameter dermal punch knife. The name of the method refers to the Eryngii king trumpet mushroom, which the nipple resembles after the surgical process. The main strength of this method is that it permits the creation of ideal nipples without difficulty. Here we introduce the technique and discuss our history of surgical methods for nipple reduction, including improvements and elaborations. |
| Keywords | nipple reconstruction female-to-male transmen mastectomy top surgery |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 83 |
| End Page | 87 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099254 |
| Web of Science KeyUT | 000516606200013 |
| NAID | 120006795625 |
| JaLCDOI | 10.18926/AMO/57957 |
|---|---|
| FullText URL | 74_1_77.pdf |
| Author | Endo, Hirosuke| Akazawa, Hirofumi| Yashiro, Masato| Yamada, Kazuki| Sanki, Tomoaki| Tetsunaga, Tomonori| Nishida, Keiichiro| Furumatsu, Takayuki| Ozaki, Toshifumi| |
| Abstract | Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up. |
| Keywords | idiopathic chondrolysis hip joint medication bump arthroscopy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 77 |
| End Page | 81 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099253 |
| Web of Science KeyUT | 000516606200012 |
| NAID | 120006795624 |
| JaLCDOI | 10.18926/AMO/57956 |
|---|---|
| FullText URL | 74_1_73.pdf |
| Author | Yamane, Masaomi| Mandai, Yasuhiro| Ino, Hideo| Matsukawa, Akihiro| Toyooka, Shinichi| |
| Abstract | In 2016, Gunma University Hospital’s Medical Accident Investigation Committee released a report reiterating the necessity of medical education and the need for surgeons to master non-technical skills. We designed a 17-h training course for surgical instructors, designed to teach participants how to sufficiently educate surgeon trainees and encourage their professional identity formation. A post-training survey showed that participants improved their awareness, and their behavioral changes led to favorable team performances. We then began offering a 3-h workshop focusing on the participants’ experiences. We propose that the training course using participant narratives is required and effective to establish surgeons’ self-reflection and professional identity as surgeons. |
| Keywords | professional identity instructor training narrative |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 73 |
| End Page | 76 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099252 |
| Web of Science KeyUT | 000516606200011 |
| NAID | 120006795623 |
| JaLCDOI | 10.18926/AMO/57955 |
|---|---|
| FullText URL | 74_1_65.pdf |
| Author | Akiyama, Tomoyuki| Saigusa, Daisuke| Hyodo, Yuki| Umeda, Keiko| Saijo, Reina| Koshiba, Seizo| Kobayashi, Katsuhiro| |
| Abstract | To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine. |
| Keywords | antiepileptic drugs gas chromatography-tandem mass spectrometry metabolome analysis metabolomics |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 65 |
| End Page | 72 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099251 |
| Web of Science KeyUT | 000516606200010 |
| NAID | 120006795622 |
| JaLCDOI | 10.18926/AMO/57954 |
|---|---|
| FullText URL | 74_1_59.pdf |
| Author | Owari, Yutaka| Miyatake, Nobuyuki| Suzuki, Hiromi| |
| Abstract | Few studies have considered the causal relationship between psychological distress and social participation in elderly people. Here we investigated this relationship based on an initial survey and a follow-up survey. In 2016, a survey was distributed to 86 participants. A follow-up survey of 80 of those participants was performed in 2017. We adopted the following variables: psychological distress and social participation as represented by the Kessler psychological distress scale and social participation scores, respectively. By using cross-lagged and synchronous effects models, we found that the 2016 Kessler psychological distress scale had a significant influence on the 2017 social participation scores (standardization factor=−0.221, p=0.020) and the 2017 Kessler psychological distress scale significantly influenced the 2017 social participation scores (standardization factor=−0.345, p=0.039). The results suggest that psychological distress may affect social participation one year later. |
| Keywords | causal relationship elderly people psychological distress social participation structural equation modeling (SEM) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 59 |
| End Page | 63 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099250 |
| Web of Science KeyUT | 000516606200009 |
| NAID | 120006795621 |
| JaLCDOI | 10.18926/AMO/57953 |
|---|---|
| FullText URL | 74_1_53.pdf |
| Author | Kubota, Risa| Araki, Motoo| Wada, Koichiro| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Ariyoshi, Yuichi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Kano, Yuzuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken out through the GelPort® and irrigated on ice with Ringer’s solution. In 2 cases, a complete intracorporeal robotic RAT was performed. An end-to-side anastomosis was performed between the renal vein and the external iliac vein and between the renal artery and the external iliac artery. Ureteroneocystostomy was also performed in 2 cases. All cases were performed robotically without open conversion. The median (IQR) console time was 3.1 (0.7) h, and the operative time was 3.8 (1.1) h. The estimated blood loss was 30 (0) ml. The warm ischemia time was 4.0 (0.2) min, and the cold ischemia time was 97 (17) min. Intracorporeal transarterial hypothermic renal perfusion was feasible in the 2 complete intracorporeal robotic RAT cases by using a perfusion catheter through a laparoscopic port. Robotic RAT has the potential to be a new minimally invasive substitute for conventional open surgery. |
| Keywords | renal autotransplantation robotic porcine model transplantation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 53 |
| End Page | 58 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099249 |
| Web of Science KeyUT | 000516606200008 |
| NAID | 120006795620 |
| JaLCDOI | 10.18926/AMO/57952 |
|---|---|
| FullText URL | 74_1_49.pdf |
| Author | Takeuchi, Takashi| Okumura, Yasuyuki| Ichikura, Kanako| |
| Abstract | The use of alcohol or drug(s) prior to self-injury is a possible inducing factor for suicidal self-injuries among patients with adjustment disorder. We analyzed the cases of 175 individuals who were admitted to the intensive care unit (ICU) of Tokyo Medical and Dental University Medical Hospital for suicidal self-injury to determine whether alcohol consumption or an excessive use of prescribed psychotropic medications prior to self-injury is more common in patients with adjustment disorder. During a 7-year period (July 2006 to June 2013) following their deliberate self-injuries, 971 patients were admitted to the ICU. Our study sample (n=175) was restricted to patients with adjustment disorder (n=48), major depressive disorder (n=90), or schizophrenia (n=37). The outcome variable was alcohol consumption or excessive use of medications prior to suicidal self-injury. A logistic regression analysis revealed that the patients with adjustment disorder more commonly showed alcohol consumption or excessive medication use prior to their suicidal self-injury compared to those with schizophrenia (odds ratio: 8.10; 95%CI: 2.97-24.60). To inhibit suicidal self-injury among patients with adjustment disorder, it is important to continue efforts to provide psychoeducation about alcohol use and to instruct the patients to take their prescribed medication(s) only as directed by their physician. |
| Keywords | alcohol psychotropic medications self-injury adjustment disorder |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 49 |
| End Page | 52 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099248 |
| Web of Science KeyUT | 000516606200007 |
| NAID | 120006795619 |
| JaLCDOI | 10.18926/AMO/57951 |
|---|---|
| FullText URL | 74_1_41.pdf |
| Author | Amano, Hoichi| Fujimoto, Kenichi| Fujimori, Makoto| Saka, Natsumi| Nomura, Kyoko| Tanihara, Shinichi| |
| Abstract | We aimed to clarify the prevalence of polypharmacy among elderly individuals in Japan. We used the data obtained from a large-scale population-based representative database of health insurance claims in a single prefecture in Japan. We examined all of the outpatient and pharmaceutical health insurance claims for National Health Insurance and those for Late-stage Elderly Health Insurance in Nagasaki Prefecture, Japan between April and June 2016. When two or more claim forms were issued for a patient in a single month, we combined the data and identified the number of prescribed drugs for each person. The definition of polypharmacy is a the prescription of six or more drugs per month. We investigated the prevalence of polypharmacy among the beneficiaries of the two insurance systems. Of the 605,406 beneficiaries of the 2 insurance systems, 121,033 (20.0%) patients with polypharmacy were identified. The prevalence of polypharmacy increased with age, especially among the beneficiaries aged > 85 years, with about half of the beneficiaries having polypharmacy status. About half of the people aged > 85 years in the database had polypharmacy status. When a drug is prescribed to an elderly individual, it is necessary to consider the possibility of polypharmacy-related problems. |
| Keywords | health insurance claims late-stage elderly health insurance national health insurance Japan polypharmacy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 41 |
| End Page | 48 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099247 |
| Web of Science KeyUT | 000516606200006 |
| NAID | 120006795618 |
| JaLCDOI | 10.18926/AMO/57950 |
|---|---|
| FullText URL | 74_1_33.pdf |
| Author | Honda, Hiroyuki| Hanayama, Yoshihisa| Obika, Mikako| Hasegawa, Kou| Hamahara, Jun| Kishida, Masayuki| Hagiya, Hideharu| Ogawa, Hiroko| Kataoka, Hitomi| Otsuka, Fumio| |
| Abstract | A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients’ gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups’ characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients’ SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients’ PPG levels were correlated with GERD-related symptoms, diabetic patients’ blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful |
| Keywords | blood glucose type 2 diabetes mellitus gastroesophageal reflux depressive status postprandial plasma glucose |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 33 |
| End Page | 40 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099246 |
| Web of Science KeyUT | 000516606200005 |
| NAID | 120006795617 |
| JaLCDOI | 10.18926/AMO/57949 |
|---|---|
| FullText URL | 74_1_27.pdf |
| Author | Toda, Kazukiyo| Yagata, Yukihisa| Kikuchi, Takeshi| Takigawa, Tomoyuki| Ito, Yasuo| |
| Abstract | Pelvic fractures occur with high-energy trauma, and the patient’s clinical status is unstable. Although a number of surgical methods for unstable pelvic fractures are available, none can achieve strong fixation with minimal invasiveness. We describe a surgical transiliac rod and screw fixation (TIF) procedure that provides minimally invasive fixation using a spinal implant for unstable pelvic ring fractures, and we retrospectively analyzed the procedure’s outcomes in 27 patients with type B or C1 fractures (based on the AO/ATO classification system). Small skin incisions are made above the posterior superior iliac spines on both sides. The ilium is partially resected, and two iliac screws are inserted on each side. The spinous process of the sacral spine is then shaved, and the iliac screws are connected to 2 rods, one placed caudal to the other. Corrective manipulation is performed at the fracture site, and the rods are connected with connectors. Favorable fracture reduction, defined as a rating of ‘excellent’ or ‘good,’ was achieved in 77.8% of the patients. Transiliac rod and screw fixation (TIF) will be a useful therapeutic option for unstable pelvic ring fractures. |
| Keywords | pelvic ring fractures sacral fracture transiliac rod and screw fixation spinal fixation system minimally invasive surgery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 27 |
| End Page | 32 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099245 |
| Web of Science KeyUT | 000516606200004 |
| NAID | 120006795616 |
| JaLCDOI | 10.18926/AMO/57948 |
|---|---|
| FullText URL | 74_1_17.pdf |
| Author | Ishii, Kenzo| Morimatsu, Hiroshi| Ono, Kazumi| Miyasho, Koji| |
| Abstract | We performed a retrospective cohort study of 911 high-energy trauma patients who underwent chest CT scans at least twice after admission. We hypothesized that in high-energy trauma patients, a high-inspired oxygen concentration delivered after admission results in dorsal atelectasis. The study’s primary outcome was dorsal atelectasis formation diagnosed based on CT images. We defined dorsal atelectasis as the presence of atelectasis at ≥ 10 mm thick on CT images. We defined high-inspired oxygen concentration as >60% oxygen delivered between two CT scans. Four hundred sixty-five patients (51.0%) developed atelectasis according to the second CT scan, and 338 (37.1%) received a high-inspired oxygen concentration. A univariate analysis showed that the rate of the high-inspired oxygen concentration in the atelectasis group was significantly higher than that in the non-atelectasis group (43.4% vs. 30.1%, p<0.001). However, a logistic regression analysis showed that there was no significant relationship between the oxygen concentration and the formation of dorsal atelectasis (OR: 1.197, 95%CI: 0.852-1.683, p=0.30). Age, the Injury Severity Score, BMI, and smoking were found to be risk factors of dorsal atelectasis formation in high-energy trauma patients. There was no relationship between the oxygen concentration and atelectasis formation in our series of high-energy trauma patients. |
| Keywords | trauma patient dorsal atelectasis oxygen concentration |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 17 |
| End Page | 26 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099244 |
| Web of Science KeyUT | 000516606200003 |
| NAID | 120006795615 |
| JaLCDOI | 10.18926/AMO/57947 |
|---|---|
| FullText URL | 74_1_7.pdf |
| Author | Sanki, Tomoaki| Endo, Hirosuke| Tetsunaga, Tomonori| Furumatsu, Takayuki| Yamada, Kazuki| Ozaki, Toshifumi| |
| Abstract | We investigated the relationship between the initial contact status and stress shielding in total hip arthroplasty (THA) using fit-and-fill type straight-stem implants. In addition we evaluated the clinical and radiographic outcomes. Subjects were 100 hips of 94 patients who underwent THA and were followed-up for ≥10 years. Contact areas with the femoral cortical bone were investigated according to the zonal distribution of Gruen using postoperative CT images. Depending on the number of contact areas, the patients were classified into high contact [HC], medium contact [MC], and low contact [LC] groups. Radiographic and clinical outcomes were evaluated. In the HC group (20 hips), severe stress shielding was observed in 12 hips, which was statistically significant (p=0.008). In the LC group (29 hips), mild stress shielding was observed in 27 hips which was statistically significant (p<0.001). No significant differences were observed among the 3 groups in clinical outcomes, Harris hip score (p=0.719) or Japanese Orthopedic Association (JOA) score (p=0.301). In insertion of cementless collared fit-and-fill type straight-stem implants, severe late stress shielding of the femoral bone may occur if high contact of the femoral component is achieved. However, the degree of stress shielding does not result in adverse clinical outcomes. |
| Keywords | fit-and-fill stress shielding cementless straight stem total hip arthroplasty |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099243 |
| Web of Science KeyUT | 000516606200002 |
| NAID | 120006795614 |
| JaLCDOI | 10.18926/AMO/57946 |
|---|---|
| FullText URL | 74_1_1.pdf |
| Author | Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro| |
| Abstract | Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings. |
| Keywords | cancer stem cell stemness iron chelation chemotherapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099242 |
| Web of Science KeyUT | 000516606200001 |
| NAID | 120006795613 |
| FullText URL | CORR477_8_1892.pdf |
|---|---|
| Author | Kunisada, Toshiyuki| Fujiwara, Tomohiro| Hasei, Joe| Nakata, Eiji| Senda, Masuo| Ozaki, Toshifumi| |
| Published Date | 2019-08 |
| Publication Title | Clinical Orthopaedics and Related Research |
| Volume | volume477 |
| Issue | issue8 |
| Publisher | Lippincott, Williams & Wilkins |
| Start Page | 1892 |
| End Page | 1901 |
| ISSN | 0009-921X |
| NCID | AA00607942 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30985613 |
| DOI | 10.1097/CORR.0000000000000764 |
| Web of Science KeyUT | 000509664400024 |
| Related Url | isVersionOf https://doi.org/10.1097/CORR.0000000000000764 |
| FullText URL | PJAB95_4_165.pdf |
|---|---|
| Author | Nakamura, Eizo| Kunihiro, Tak| Ota, Tsutomu| Sakaguchi, Chie| Tanaka, Ryoji| Kitagawa, Hiroshi| Kobayashi, Katsura| Yamanaka, Masahiro| Shimaki, Yuri| Bebout, Gray E.| Miura, Hitoshi| Yamamoto, Tetsuo| Malkovets, Vladimir| Grokhovsky, Victor| Koroleva, Olga| Litasov, Konstantin| |
| Keywords | ordinary chondrite chronology geochemistry impact melting asteroid comet |
| Published Date | 2019-04-11 |
| Publication Title | Proceedings of the Japan Academy, Ser. B Physical and Biological Sciences |
| Volume | volume95 |
| Issue | issue4 |
| Start Page | 165 |
| End Page | 177 |
| ISSN | 0386-2208 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Japan Academy |
| File Version | publisher |
| PubMed ID | 30971619 |
| DOI | 10.2183/pjab.95.013 |
| Web of Science KeyUT | 000470804000002 |
| Related Url | isVersionOf https://doi.org/10.2183/pjab.95.013 |
| FullText URL | BS69_4_633.pdf |
|---|---|
| Author | Kuya, Noriyuki| Sun, Jian| Iijima, Ken| Venuprasad, Ramaiah| Yamamoto, Toshio| |
| Keywords | QTL anaerobic germination anoxic water direct seeding genetic resources phenotyping method rice |
| Publication Title | Breeding Science |
| Volume | volume69 |
| Issue | issue4 |
| Publisher | Japanese Society of Breeding |
| Start Page | 633 |
| End Page | 639 |
| ISSN | 1344-7610 |
| NCID | AA11353132 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by JAPANESE SOCIETY OF BREEDING |
| File Version | publisher |
| PubMed ID | 31988627 |
| DOI | 10.1270/jsbbs.19003 |
| Web of Science KeyUT | 000504401200009 |
| Related Url | isVersionOf https://doi.org/10.1270/jsbbs.19003 |
| FullText URL | IM58_2_311.pdf |
|---|---|
| Author | Nishimura, Yoshito| Yasuda, Miho| Hasegawa, Kou| Otsuka, Fumio| |
| Keywords | adrenal medullary hyperplasia stroke hypertension and catecholamines |
| Published Date | 2019-01-15 |
| Publication Title | Internal Medicine |
| Volume | volume58 |
| Issue | issue2 |
| Start Page | 311 |
| End Page | 311 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | 2019 (c) The Japanese Society of Internal Medicine |
| File Version | author |
| PubMed ID | 30146579 |
| DOI | 10.2169/internalmedicine.1182-18 |
| Web of Science KeyUT | 000455930700027 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.1182-18 |
