result 18185 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Gion, Yuka| Okano, Mitsuhiro| Koyama, Takahisa| Oura, Tokie| Nishikori, Asami| Orita, Yorihisa| Tachibana, Tomoyasu| Marunaka, Hidenori| Makino, Takuma| Nishizaki, Kazunori| Sato, Yasuharu| |
| Keywords | mast cell eosinophilic chronic rhinosinusitis c-kit IgE |
| Published Date | 2020-03-07 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1843 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32155995 |
| DOI | 10.3390/ijms21051843 |
| Web of Science KeyUT | 000524908500294 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21051843 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oka, Takashi| Matsuoka, Ken-Ichi| Utsunomiya, Atae| |
| Keywords | ATL HTLV-1 PDT PDD chemotherapy allogeneic hematopoietic cell transplantation immunotherapy GVHD ALA-PDT/PDD |
| Published Date | 2020-02-02 |
| Publication Title | Cancers |
| Volume | volume12 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 335 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32024297 |
| DOI | 10.3390/cancers12020335 |
| Web of Science KeyUT | 000522477300081 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers12020335 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kubota, Satoshi| Ishikawa, Takanori| Kawata, Kazumi| Hattori, Takako| Nishida, Takashi| |
| Keywords | retrotransposon endogenous retrovirus chondrocyte cartilage skeletal development |
| Published Date | 2020-02-25 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1564 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32106563 |
| DOI | 10.3390/ijms21051564 |
| Web of Science KeyUT | 000524908500015 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21051564 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Otani, Yoshihiro| Fujimura, Atsushi| Fujii, Kentaro| Tomita, Yusuke| Hattori, Yasuhiko| Uneda, Atsuhito| Tsuboi, Nobushige| Kaneda, Keisuke| Makino, Keigo| Date, Isao| |
| Keywords | ANXA2 OSMR Invasion Mesenchymal transition Glioblastoma |
| Published Date | 2020-04-05 |
| Publication Title | Acta Neuropathologica Communications |
| Volume | volume8 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 42 |
| ISSN | 2051-5960 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 32248843 |
| DOI | 10.1186/s40478-020-00916-7 |
| Web of Science KeyUT | 000524286500001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40478-020-00916-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hassan, Ghmkin| Afify, Said M.| Nair, Neha| Kumon, Kazuki| Osman, Amira| Du, Juan| Mansour, Hager| Abu Quora, Hagar A.| Nawara, Hend M.| Satoh, Ayano| Zahra, Maram H.| Okada, Nobuhiro| Seno, Akimasa| Seno, Masaharu| |
| Keywords | Induced pluripotent stem cells Cancer stem cells differentiation tumor microenvironment hematopoietic cells |
| Published Date | 2019-12-29 |
| Publication Title | Cancers |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | MDPI |
| Start Page | 82 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31905766 |
| DOI | 10.3390/cancers12010082 |
| Web of Science KeyUT | 000516826700082 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers12010082 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sogawa, Chiharu| Eguchi, Takanori| Tran, Manh Tien| Ishige, Masayuki| Trin, Kilian| Okusha, Yuka| Taha, Eman Ahmed| Lu, Yanyin| Kawai, Hotaka| Sogawa, Norio| Takigawa, Masaharu| Calderwood, Stuart K.| Okamoto, Kuniaki| Kozaki, Ken-Ichi| |
| Keywords | drug repositioning/repurposing three-dimensional (3D) culture tumoroids dopamine transporter (DAT) benztropine signal transducer and activator of transcription (STAT) circulating tumor cell (CTC) |
| Published Date | 2020-02-24 |
| Publication Title | Cancers |
| Volume | volume12 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 523 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32102440 |
| DOI | 10.3390/cancers12020523 |
| Web of Science KeyUT | 000522477300269 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers12020523 |
| JaLCDOI | 10.18926/AMO/58279 |
|---|---|
| FullText URL | 74_2_179.pdf |
| Author | Abe, Yoshiyuki| Fujibayashi, Kazutoshi| Nishizaki, Yuji| Yanagisawa, Naotake| Nojiri, Shuko| Kon, Takayuki| Tada, Kurisu| Yamaji, Ken| Tamura, Naoto| |
| Abstract | Glucocorticoids (GCs) have long played a central role in the treatment of systemic lupus erythematosus (SLE), but these drugs have many adverse effects. We will determine whether rapid weekly GC tapering is non-inferior to conventional biweekly tapering in patients with severe SLE. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the relapse-free survival rate at 52 weeks. The main secondary outcome is the prevalence of the Lupus Low Disease Activity State at 52 weeks. The trial will determine the optimal method of tapering GCs in patients with severe SLE. |
| Keywords | systemic lupus erythematosus relapse-free survival rate glucocorticoid, tapering Lupus Low Disease Activity State |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 179 |
| End Page | 183 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341595 |
| Web of Science KeyUT | 000528278500014 |
| NAID | 120006839458 |
| JaLCDOI | 10.18926/AMO/58278 |
|---|---|
| FullText URL | 74_2_175.pdf |
| Author | Yu, Zhikang| Lin, Wenfeng| Xu, Abai| Liu, Chunxiao| Li, Hulin| Huang, Peng| |
| Abstract | Urolithiasis, a common condition in patients with spinal deformity, poses a challenge to surgical procedures and anesthetic management. A 51-year-old Chinese male presented with bilateral complex renal calculi. He was also affected by severe kyphosis deformity and spinal stiffness due to ankylosing spondylitis. Dr. Li performed the percutaneous nephrolithotomy under local infiltration anesthesia with the patient in a kneeling prone position, achieving satisfactory stone clearance with no severe complications. We found this protocol safe and effective to manage kidney stones in patients with spinal deformity. Local infiltration anesthesia may benefit patients for whom epidural anesthesia and intubation anesthesia are difficult. |
| Keywords | percutaneous nephrolithotomy local infiltration anesthesia kneeling prone position spinal deformity |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 175 |
| End Page | 178 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341594 |
| Web of Science KeyUT | 000528278500013 |
| NAID | 120006839457 |
| JaLCDOI | 10.18926/AMO/58277 |
|---|---|
| FullText URL | 74_2_171.pdf |
| Author | Okita, Atsushi| Yoshida, Osamu| Murakami, Masakazu| |
| Abstract | A 76-year-old Japanese man was transferred to our hospital to undergo rehabilitation after traffic accident-related injuries. Seven days post-admission, he presented with abdominal pain and an 8-cm lump in the right inguinal region. He was diagnosed with an incarcerated inguinal hernia and underwent elective surgery the day after manual reduction. He had a normal vermiform appendix which was observed to have adhered to the right indirect hernia sac. An appendectomy and hernia repair using lightweight mesh were performed. We discuss the surgical management of this rare incarcerated Amyand’s hernia and the relevant literature. |
| Keywords | Amyand’s hernia incarcerated inguinal hernia appendectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 171 |
| End Page | 174 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341593 |
| Web of Science KeyUT | 000528278500012 |
| NAID | 120006839456 |
| JaLCDOI | 10.18926/AMO/58276 |
|---|---|
| FullText URL | 74_2_165.pdf |
| Author | Umemura, Hiroshi| Miura, Katsuhiro | Naruse, Hiromu| Hatta, Yoshihiro| Takei, Masami| Nakayama, Tomohiro| |
| Abstract | Hereditary hemorrhagic telangiectasia (HHT; also known as Osler-Weber-Rendu disease) is an autosomal dominant genetic disorder that causes frequent epistaxis, mucocutaneous telangiectasia, and visceral arteriovenous malformations. Four genes (ENG, ACVRL1, SMAD4, and GDF2) have been identified as pathogenic in HHT. We describe the case of a 50-year-old Japanese man highly suspected of having HHT due to recurrent epistaxis, mucocutaneous telangiectasia, and a family history. Genomic analysis revealed a novel missense mutation of c.100T>A, p.Cys34Ser in the patient’s ACVRL1 gene. We used 6 freeware programs to perform an in silico analysis of this mutation. The results demonstrated the mutation’s high pathogenicity. |
| Keywords | ACVRL1 hereditary hemorrhagic telangiectasia in silico analysis missense mutation Osler-Weber- Rendu disease |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 165 |
| End Page | 169 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341592 |
| Web of Science KeyUT | 000528278500011 |
| NAID | 120006839455 |
| JaLCDOI | 10.18926/AMO/58275 |
|---|---|
| FullText URL | 74_2_159.pdf |
| Author | Thar Htet San| Ota, Yoko| Fushimi, Soichiro| Fujisawa, Masayoshi| Yanai, Hiroyuki| Toda, Hiroko| Kunitomo, Tadayoshi| Kodama, Keisuke| Matsukawa, Akihiro| |
| Abstract | Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (～97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested. |
| Keywords | juvenile granulosa cell tumor late recurrence adult granulosa cell tumor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 159 |
| End Page | 163 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341591 |
| Web of Science KeyUT | 000528278500010 |
| NAID | 120006839454 |
| JaLCDOI | 10.18926/AMO/58274 |
|---|---|
| FullText URL | 74_2_151.pdf |
| Author | Yamamoto, Norio| Dan’ura, Tomoyuki| Noda, Tomoyuki| Ozaki, Toshifumi| |
| Abstract | This is the second report of an atypical peri-implant femoral fracture occurring at the distal screw after intramedullary nail fixation of a pertrochanteric fracture. A 94-year-old Japanese female with a 5-year history of alendronate intake presented with prodromal pain in her right thigh after intramedullary nail fixation. Plain radiographs showed an incomplete noncomminuted transverse fracture at the distal screw, suggesting an atypical peri-implant femoral fracture. The pathogenesis of an atypical peri-implant femoral fracture could be a combined systemic bone metabolism disorder and repetitive overloading at the screw, similar to the pathogenesis of an atypical periprosthetic femoral fracture around stem implantation. |
| Keywords | atypical femoral fracture insufficiency fracture bisphosphonate atypical peri-implant femoral fracture, atypical periprosthetic femoral fracture |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 157 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341590 |
| Web of Science KeyUT | 000528278500009 |
| NAID | 120006839453 |
| JaLCDOI | 10.18926/AMO/58273 |
|---|---|
| FullText URL | 74_2_145.pdf |
| Author | Otsuki, Hideo| Yamasaki, Tomoya| Hori, Shunsuke| Aoki, Hiroshi| Kosaka, Takeo| Uehara, Shinya| Fujio, Kei| |
| Abstract | To investigate the efficacy of mirabegron for lower urinary tract symptoms in patients with an indwelling ureteral stent after ureterorenoscopic lithotripsy. This was a prospective follow-up study of 76 patients with stent-related symptoms (SRSs). Patients with upper urinary calculi who were pre-stented for > 2 weeks before lithotripsy were examined for the presence of SRSs by tests including the International Prostate Symptom Score (IPSS), OAB Symptom Score (OABSS), and urinary bother and pain measured by a Visual Analogue Scale (VAS) before lithotripsy. Mirabegron (50 mg/day) was prescribed post-lithotripsy for 2 weeks. SRSs were assessed at the time of stent removal. The IPSS scores improved significantly from 16.2 to 14.3 (p<0.001) and the IPSS-QoL scores decreased significantly from 5.0 to 4.6 (p=0.012). The OABSS scores improved significantly from 7.7 to 6.8 (p=0.006), and the urinary urgency scores (OABSS-Q3) decreased significantly from 3.24 to 2.68 (p<0.001). The number of nocturia episodes decreased significantly from 2.5 to 2.2 (p=0.045). Urinary bother and pain assessed by the VAS declined from 4.2 and 3.1 to 3.8 (p=0.15) and 2.5 (p=0.075), respectively. Mirabegron significantly improved SRSs and the number of nocturia episodes due to a ureteral stent. |
| Keywords | stent-related symptoms overactive bladder mirabegron ureterorenoscopic lithotripsy ureteral stent |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 145 |
| End Page | 150 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341589 |
| Web of Science KeyUT | 000528278500008 |
| NAID | 120006839452 |
| JaLCDOI | 10.18926/AMO/58272 |
|---|---|
| FullText URL | 74_2_137.pdf |
| Author | Isozaki, Hiroshi| Yamamoto, Yasuhisa| Sakai, Kunihiko| Sho, Tatuo| Ishihara, Kiyohiro| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro| |
| Abstract | Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer. |
| Keywords | breast cancer mucinous carcinoma clinicopathological features long-term prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 137 |
| End Page | 143 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341588 |
| Web of Science KeyUT | 000528278500007 |
| NAID | 120006839451 |
| reference | Clayton F: Pure mucinous carcinomas of breast: morphologic features and prognostic correlates. Hum Pathol (1986) 17: 34-38.| Avisar E, Khan MA, Axelrod D and Oza K: Pure mucinous carcinoma of the breast: a clinicopathologic correlation study. Ann Surg Oncol (1998) 5: 447-451.| Komenaka IK, El-Tamer MB, Troxel A, Hamele-Bena D, Joseph KA, Horowitz E, Ditkoff BA and Schnabel FR: Pure mucinous carcinoma of the breast. Am J Surg (2004) 187: 528-532.| Barkley CR, Ligibel JA, Wong JS, Lipsitz S, Smith BL and Golshan M: Mucinous breast carcinoma: a large contemporary series. Am J Surg (2008) 196: 549-551.| André S, Cunha F, Bernardo M, Meneses e Sousa J, Cortez F and Soares J: Mucinous carcinoma of the breast: a pathologic study of 82 cases. J Surg Oncol (1995) 58: 162-167.| Skotnicki P, Sas-Korczynska B, Strzepek L, Jakubowicz J, Blecharz P, Reinfuss M and Walasek T: Pure and Mixed Mucinous Carcinoma of the Breast: A Comparison of Clinical Outcomes and Treatment Results. Breast J (2016) 22: 529-534.| Di Saverio S, Gutierrez J and Avisar E: A retrospective review with long term follow up of 11,400 cases of pure mucinous breast carcinoma. Breast Cancer Res Treat (2008) 111: 541-547.| Fu J, Wu L, Jiang M, Li D, Jiang T, Hong Z, Wang F and Li S: Clinical Nomogram for Predicting Survival Outcomes in Early Mucinous Breast Cancer. PLoS One (2016) 11: e0164921.| Japanese Breast Cancer Society: General Rules for Clinical and Pathological Recording of Breast Cancer, 18th Ed, Kanehara & Co., Ltd., Tokyo, (2018) (in Japanese).| American College of Radiology: Breast Imaging Reporting and Data System-Mammography. fourth edition, (2003).| UICC (Union for International Cancer Control): TNM classification of malignant tumors, 8th Ed, John Wiley & Sons, Ltd., (2017).| Kanda Y: Investigation of the freely available easy-to-use software ʻEZRʼ for medical statistics. Bone Marrow Transplant (2013) 48: 452-458.| Bae SY, Choi MY, Cho DH, Lee JE, Nam SJ and Yang JH: Mucinous carcinoma of the breast in comparison with invasive ductal carcinoma: clinicopathologic characteristics and prognosis. J Breast Cancer (2011) 14: 308-313.| Park S, Koo J, Kim JH, Yang WI, Park BW and Lee KS: Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified. Korean Med Sci (2010) 25: 361-368.| Komaki K, Sakamoto G, Sugano H, Morimoto T and Monden Y: Mucinous carcinoma of the breast in Japan. A prognostic analysis based on morphologic features. Cancer (1988) 61: 989-996.| Wilson TE, Helvie MA, Oberman HA and Joynt LK: Pure and mixed mucinous carcinoma of the breast: pathologic basis for differences in mammographic appearance. AJR Am J Roentgenol (1995) 165: 285-289.| |
| JaLCDOI | 10.18926/AMO/58271 |
|---|---|
| FullText URL | 74_2_129.pdf |
| Author | Fukuma, Shogo| Shinya, Takayoshi| Soh, Junichi| Fukuhara, Ryuichiro| Ogawa, Nanako| Higaki, Fumiyo| Tanaka, Takehiro| Ichihara, Eiki| Hiraki, Takao| Toyooka, Shinichi| Kanazawa, Susumu| |
| Abstract | The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal–Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types. |
| Keywords | differentiation dynamic computed tomography primary lung cancer enhancement pattern |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 135 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341587 |
| Web of Science KeyUT | 000528278500006 |
| NAID | 120006839450 |
| JaLCDOI | 10.18926/AMO/58270 |
|---|---|
| FullText URL | 74_2_123.pdf |
| Author | Fukuhara, Ryuichiro| Shinya, Takayoshi| Fukuma, Shogo| Ogawa, Nanako| Masaoka, Yoshihisa| Tanaka, Takehiro| Marunaka, Hidenori| Arioka, Tadashi| Hiraki, Takao| Kaji, Mitsumasa| Kanazawa, Susumu| |
| Abstract | The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly. |
| Keywords | 18F-fluorodeoxyglucose positron emission tomography/computed tomography extranodular spread metastasis oral squamous cell carcinoma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 128 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341586 |
| Web of Science KeyUT | 000528278500005 |
| NAID | 120006839449 |
| JaLCDOI | 10.18926/AMO/58269 |
|---|---|
| FullText URL | 74_2_115.pdf |
| Author | Kotani, Sayoko| Kamada, Yasuhiko| Shimizu, Keiko| Sakamoto, Ai| Nakatsuka, Mikiya| Hiramatsu, Yuji| Masuyama, Hisashi| |
| Abstract | Thrombosis in decidual vessels is one of the mechanisms of pregnancy loss. However, few studies have assessed the relation between platelet activation, which is known to cause of thrombosis, and recurrent pregnancy loss (RPL). We investigated platelet activation in women with RPL compared to controls by measuring plasma levels of platelet factor 4 (PF4) and β-thromboglobulin (βTG), and assessed correlations between PF4/βTG and coagulative risk factors associated with RPL. The study group included 135 women who had experienced two or more consecutive pregnancy losses. The control group included 28 age-matched healthy women who had never experienced pregnancy loss. PF4 and βTG plasma levels were significantly higher in the women with RPL than controls (PF4: 14.0 [8.0-20.0] vs. 9.0 [6.0-12.0] ng/ml, p=0.043; βTG: 42.0 [24.3-59.8] vs. 31.5 [26.6-36.4] ng/ml, p=0.002). There was a significant association between βTG and anti-phosphatidylethanolamine antibody immunoglobulin M (aPE IgM) (p=0.048). Among the women with RPL, 18 of those who were positive for PF4 (45%) and 18 of those who were positive for βTG (37%) were negative for all known coagulative risk factors associated with RPL. Measurements of PF4 and βTG may be important because they help identify women who are at risk of RPL. |
| Keywords | recurrent pregnancy loss platelet factor 4 β-thromboglobulin platelet activation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 115 |
| End Page | 122 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341585 |
| Web of Science KeyUT | 000528278500004 |
| NAID | 120006839448 |
| JaLCDOI | 10.18926/AMO/58268 |
|---|---|
| FullText URL | 74_2_109.pdf |
| Author | Ogawa, Chikako| Nakamura, Keiichiro| Matsuoka, Hirofumi| Matsubara, Yuko| Haraga, Junko| Masuyama, Hisashi| |
| Abstract | This study aimed to determine whether the risk conferred by gynecologic cancer (GC) as second primary cancer (SPC) differs from that associated with GC as first primary cancer (FPC). We investigated the correlations between FPC/SPC and the characteristics and prognoses of 1,645 GC patients (701 with cervical cancer [CC], 641 with endometrial cancer [EM], and 303 with ovarian cancer [OV]). The χ2 test and the Kaplan–Meier method were used to determine whether FPC/SPC and the characteristics and prognoses of GC patients. Of the SPC patients, 26 (3.7%) had CC, 53 (8.3%) had EM, and 31 (10.2%) had OV. The most common previous cancer type in SPC of GC patients was breast cancer, which was observed in 13 patients (50.0%) with CC, 23 (43.4%) with EM, and 16 (51.6%) with OV. In all patients with CC, EM, and OV as SPC, the stage was significantly associated with recurrence. There were no significant differences in the morbidity or mortality of CC, EM, or OV patients between those with FPC and those with SPC. The risk of SPC development in GC patients varied, ranging from 3.5% (CC) to 10.3% (OV) of patients. |
| Keywords | second primary cancer gynecologic cancer prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 109 |
| End Page | 114 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341584 |
| Web of Science KeyUT | 000528278500003 |
| NAID | 120006839447 |
| JaLCDOI | 10.18926/AMO/58267 |
|---|---|
| FullText URL | 74_2_103.pdf |
| Author | Kawada, Yasumasa| Kubo, Toru| Baba, Yuichi| Hirota, Takayoshi| Tanioka, Katsutoshi| Yamasaki, Naohito| Kitaoka, Hiroaki| |
| Abstract | This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal dose of single-pill therapy, whereas low-density lipoprotein (LDL) cholesterol levels significantly decreased after the medication was switched from 94±24 mg/dl to 89±17 mg/dl (p=0.015). A switch from medication with two separate pills of amlodipine and atorvastatin to an equal dose of single-pill therapy resulted in an overall decrease in LDL cholesterol. The results indicated that the switch to single-pill therapy might be a useful treatment. |
| Keywords | hypertension dyslipidemia single-pill therapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 103 |
| End Page | 108 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341583 |
| Web of Science KeyUT | 000528278500002 |
| NAID | 120006839446 |
| JaLCDOI | 10.18926/AMO/58266 |
|---|---|
| FullText URL | 74_2_95.pdf |
| Author | Kuba, Sayaka| Yamanouchi, Kosho| Morita, Michi| Sakimura, Chika| Inamasu, Eiko| Hatachi, Toshiko| Otsubo, Ryota| Matsumoto, Megumi| Yano, Hiroshi| Miyamoto, Junya| Sato, Shuntaro| Nakagawa, Hiroo| Kanetaka, Kengo| Takatsuki, Mitsuhisa| Nagayasu, Takeshi| Eguchi, Susumu| |
| Abstract | We assessed the usefulness of ChemoCalc, a software package for calculating drug costs, in helping patients understand these costs. We randomly assigned, in a 1 : 1 ratio, 20 women who had undergone surgery for early breast cancer to a group that discussed adjuvant treatment with their physicians using the ChemoCalc software (ChemoCalc group) or a group that discussed adjuvant treatment without ChemoCalc (Usual Explanation group). The participants completed a five-grade evaluation questionnaire after these discussions. The primary endpoint was the intergroup comparison of the questionnaire scores regarding participants’ understanding of their treatment-associated drug costs. Median age was not significantly different between the ChemoCalc group and Usual Explanation group (57 vs. 50, respectively; p=0.27). Patients in the ChemoCalc group had a significantly higher perceived level of understanding of the drug cost than those in the Usual Explanation group (5 [4-5] vs. 2.5 [1-5], respectively; p=0.002). Scores related to the patients’ perception that understanding drug costs is an important part of breast cancer treatment were also higher in the ChemoCalc group than the Usual Explanation group (5 [2-5] vs. 3 [1-5], respectively; p=0.049). ChemoCalc was found to be useful for understanding drug costs. |
| Keywords | breast cancer drug costs ChemoCalc |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 101 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341582 |
| Web of Science KeyUT | 000528278500001 |
| NAID | 120006839445 |
