異種臓器抗体に関する研究 第2編 抗犬胃及び十二指腸粘膜家兎血清負荷犬の生体反応について

The serological and histological changes were observed on the administration of anti-canine gastric and duodenal mucosa-rabbit's serum, which was obtained from the sensitization of rabbit by the extracted solution of canine gastric and duodenal mucosa with physiological salt solution, into dog. And the results were as follows. 1. In the cases with the administration of comparative great amount of organic antiserum, other than the cases decreased within a short period by shock, the loss of weight, decrease of erythrocyte count and decline of hemoglobin value were generally found since the 1-5 day after the administration of both of the above organic antisera and it was supposed that there were the participation of one valued antibody in addition to the two valued antibody (hemolysin, erythrocyte agglutinin) included in both of the organic antisera, and the leukocyte count showed slight decrease since the 1-3rd day after the administration of both of the above antisera. The change in urine was not observed, but blood stool and occult blood in stool at the 1st. day after the administration were observed on the cases with the administration of anticanine stomach-serum and the cases with the administration of anti-canine duodenum-serum. 2. As for the change of antibody titer corresponding to the organic antigen, on the administration of anti-canine gastric and duodenal mucosa-rabbit's sera into healthy dog, the slight decline of the antibody titer was seen in many cases at the first period after the administration and the rise of both of the antibodies titers was seen at the 14th day from the 5th day after the administration. As for the vicissitude of complement titer at that time, the complement titer slightly declined at the first period after the administration and it showed the declining tendency with the rise of both organic antibodies' titers, after then. And the increase of γ-globulin, in the change of serum protein picture, was observed on the administration of both of the organic antisera, but the decrease of albumin was not remarkable and the total protein value showed the decreasing tendency, and the vicissitude of γ-globulin and both of the organic antibodies showed the same change. 3. The changes having the organic specificity, as the histological changes in the dog with the administration of anti-canine gastric and duodenal mucosa-rabbit's serum, were considerably observed on the gastric mucosa and duodenal mucosa of the dog as compared with the changes of other organs. Since the results of observation on the above histological changes and the vicissitude of the antibody and complement titer corresponding to both of the above organic antigens at that time, it was thought that the decrease of complement titer at the first period meaned the disturbed process of organ by the antigen-antibody reaction of both of the organic antisera in the organs corresponding to the antigen and the rise of both of the organic antibodies titers after the above period was due to the damage of the organ corresponding to the antigen and it was the auto-antibody which was secondarily produced in the self-body.