result 47530 件
| JaLCDOI | 10.18926/15001 |
|---|---|
| Title Alternative | アトピー型および非アトピー型気管支喘息の発作発症機序の差異について･･･ロイコトリエンC4の役割について |
| FullText URL | 067_021_027.pdf |
| Author | Ashida, Kozo| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tsugeno, Hirofumi| Tanizaki, Yoshiro| |
| Abstract | Concentrations of main bronchoconstricting chemical mediators, histamine and leukotriene C4 (LTC4), were measured in bronchoalveolar lavage (BAL) fluid, and when cells (peripheral leukocytes and BAL cells) were stimulated by Ca ionophore A23187, in 7 atopic and 7 nonatopic asthma patients. 1. The proportion of basophilic cells was significantly larger in atopic than in nonatopic asthma (p<0.05), however no significant difference was present in the other BAL cells between the two asthma types. 2. Concentration of histamine in BAL fluid was significantly higher in atopic than that in nonatopic asthma, however, difference in that of LTC4 was not found between them. 4. The release of LTC 4 from BAL cells was higher in nonatopic than that in atopic asthma, but this was not significant. In contrast, the release of histamine was significantly higher in atopic compared to that in nonatopic asthma (p<0.001) when the cells were stimulated by Ca ionophore A23187. These results suggest that both histamine and LTC4 participate in the onset mechanism of atopic asthma, and only LTC4 in that of nonatopic asthma. |
| Keywords | Histamine LTC4 atopic nonatopic BAL cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 21 |
| End Page | 27 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307446 |
| JaLCDOI | 10.18926/15000 |
|---|---|
| Title Alternative | Ⅱ型(細気管支閉塞)喘息と閉塞性細気管支炎における細気管支領域の炎症反応の差 |
| FullText URL | 067_014_020.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine| |
| Abstract | Ventilatory function and inflammatory cells in airways were compared between patients with type Ⅱ (bronchiolar obstruction) asthma and those with obstructive bronchiolitis. 1. Age and age at onset were higher in patients with type Ⅱ asthma than in those with obstructive bronchiolitis. IgE-mediated allergic reaction was observed in patients with type Ⅱ asthma, but not in those with obstructive bronchiolitis. 2. In ventilatory function tests, all ventilatory parameters examined were lower in patients with type Ⅱ asthma compared to those with obstructive bronchiolitis, and the differences were significant in FEV1.0% (p<0.001), % MMF (p<0.02), and V50 (p<0.01). 3. The proportion of BAL neutrophils was very high in type Ⅱ asthma (55.7%) and obstructive bronchiolitis (74.4%), however, this was not significant. 4. Absolute numbers/BAL fluid of total cells, BAL macrophages and BAL neutrophils were significantly higher in patients with obstructive bronchiolitis than in those with type Ⅱ asthma. 5. The results on absolute number/mℓ of BAL cells demonstrated that number of BAL neutrophils markedly larger in patients with obstructive bronchiolitis compared to those with type Ⅱ asthma. These results show that high proportion of BAL neutrophils was observed in the two respiratory diseases, however, the degree of inflammation in airways was markedly greater in obstructive bronchiolitis. |
| Keywords | Ⅱ型喘息 (Type Ⅱasthma) 閉塞性細気管支炎 (Obstructive bronchiolitis) 換気機能 (Ventilatory function) BAL好中球 (BAL neutrophiIs) IgE系反応 (IgE-mediated allergy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 14 |
| End Page | 20 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307471 |
| JaLCDOI | 10.18926/14999 |
|---|---|
| Title Alternative | 肺活量(FVC)低値を示す気管支喘息の臨床的特徴 |
| FullText URL | 067_008_013.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Clinical features of asthma patients with a low % FVC (<75%) were studied in relation to clinical asthma type and disease severity. 1. The value of % FVC was not related to patient age. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type Ⅱ asthma (bronchiolar obstruction) than in those with type Ia-1 and type Ia-2 (simple bronchoconstriction) (p<0.001). 3. % FVC value significantly correlated with disease severity. The value in the subjects tended to decrease as their asthma conditions were more severe. 4. The % FVC value in the subjects was improved after treatment (complex spa therapy). These results demonstrate that a significant correlation is present between low % FVC and disease severity in asthma patients with a low % FVC. |
| Keywords | % FVC低値 (Low % FVC) 気管支喘息 (Bronchial asthma) 臨床病型 (Clinical asthma type) 重症度 (asthma severity) 温泉療法 (Spa therapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 8 |
| End Page | 13 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308511 |
| JaLCDOI | 10.18926/14998 |
|---|---|
| Title Alternative | BAL液中好中球増加をともなわないⅡ型喘息について |
| FullText URL | 067_001_007.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Tsuji, Takao| |
| Abstract | Clinical features of asthma patients with bronchiolar obstruction (type Ⅱ asthma) were studied in relation to the proportion of neutrophils in bronchoalveolar lavage (BAL) fluid. Of 13 subjects studied, 7 were accompanied with BAL neutrophilia (53.5%) (BALn(+)) and 6 were without BAL neutrophilia (3.5%) (BALn(-)). 1. The mean age was higher in BALn(-) (66.0 years) than in BALn(+) patients (55.0 years). 2. Bronchial reactivity to methacholine was slightly higher in BALn(-) patients than in those with BALn(+). 3. The value of FEV1.0% was significantly lower in BALn(+) patints than in those with BALn(-) (p<0.01). 4. The proportion of BAL lymphocytes was signicantly more decreased in BALn(+) patients compared to the proportion in those with BALn(-) (p<0.001). 5. the values of serum IgG, IgA, and IgM were not significantly different between BALn(+) and BALn(-) patients, however, the value of IgG was more decreased in BALn(+) patients than in those with BALn(-). These results suggest that two kinds of type Ⅱ asthma ; one is with BAL neutrophilia related to suppressed immunity, and another is without BAL neutrophilia in part due to aging. |
| Keywords | 気管支喘息 (Bronchial asthma) 細気管支閉塞 (Bronchiolar obstruction) BAL好中球 (BAL neutrophilia) 免疫能低下 (Suppressed immunity) 加齢 (Aging) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 1 |
| End Page | 7 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308171 |
| Author | 岡山大学医学部附属病院三朝分院| |
|---|---|
| Published Date | 1997-12 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume68 |
| Content Type | Others |
| Author | Matsubara, Fumie| lnoue, Taeko| Mifune, Takashi| Tanizaki, Yoshiro| |
|---|---|
| Published Date | 1997-12 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume68 |
| Content Type | Data or Dataset |
| JaLCDOI | 10.18926/14995 |
|---|---|
| FullText URL | 068_115_120.pdf |
| Author | Terasaki, Kayo| 石田 三枝子| Yoshio, Keiko| Yamamoto, Sadae| Nakamura, Akemi| 福井 由美| 坂本 香須美| |
| Abstract | 入院時の情報収集は患者の苦痛,疲労が最小限になるよう,短時間で聴取でき,適切な問題把握かできることが望ましい｡しかし,当院の入院事情と重なり情報収集が円滑に進まず時間を要していた｡そこで,入院前にデーターベースを患者に渡し自己記入してもらうことを試みた結果,聴取･記録時間の短縮かでき,問題点のしぼりこみも早くできるようになった｡ |
| Keywords | データベース 自己記入 時間短縮 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 115 |
| End Page | 120 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308127 |
| JaLCDOI | 10.18926/14994 |
|---|---|
| Title Alternative | Three cases of rheumatoid arthritis with biliary tract cancer |
| FullText URL | 068_107_114.pdf |
| Author | Iwagaki, Naofumi| Tsugeno, Hirofumi| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Okamoto, Makoto| Tanizaki, Yoshiro| |
| Abstract | 一般的に,慢性関節リウマチには悪性腫瘍の合併は少ないと言われている｡特に,消化器系あるいは胆道系悪性腫瘍を合併したという報告は極めて少ない｡我々は慢性関節リウマチの経過中,胆道系悪性腫瘍を合併した3例を経験した｡3症例はそれぞれ胆嚢癌,肝内胆管癌,乳頭部癌を合併していた｡非常に稀な症例であり,文献的考案を含め報告する｡ |
| Keywords | 慢性関節リウマチ (rheumatoid arthritis) 胆道系悪性腫瘍 (biliary tract cancer) 胆嚢癌 (gall bladder cancer) 胆管癌 (bile duct cancer) 乳頭部癌 (cancer of papilla of Vater) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 107 |
| End Page | 114 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308182 |
| JaLCDOI | 10.18926/14993 |
|---|---|
| Title Alternative | Diet therapy with α-linolenic acid-enriched perilla seed oil on pulmonary emphysema. |
| FullText URL | 068_099_106.pdf |
| Author | Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Mifune, Takashi| Okamoto, Makoto| Iwagaki, Naofumi| Hosaki, Yasuhiro| Tsuji, Takao| Tanizaki, Yoshiro| |
| Abstract | 症例は67歳,男性｡主訴は労作時呼吸困難｡【第一回目入院】平成7年9月から12月まで入院し,薬物療法,複合温泉療法を行なった｡自覚症状はやや改善がみられたが,呼吸機能検査所見の改善は得られなかった｡【第二回目入院】平成8年8月から12月まで入院｡n-3系脂肪酸強化食事療法も併用した｡自覚症状および,呼吸機能検査上,FVC,FEV(1.0),PEFなどに改善を認めた｡n-3系脂肪酸はアラキドン酸代謝を通してロイコトリエン合成に関与すると推定されるが,経過中に白血球のLTB(4)産生能の減少を認めた。この症例は肺気腫に対するn-3系脂肪酸強化食事療法の有用性が示唆され,病態を考える上でも興味深いと考えられたので報告する。 |
| Keywords | 肺気腫 (pulmonary emphysema) n-3系脂肪酸 (n-3 fatty acid) 食事療法 (diet therapy) ロイコトリエン合成 (leukotriene) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 99 |
| End Page | 106 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308310 |
| JaLCDOI | 10.18926/14992 |
|---|---|
| Title Alternative | Endoscopic aspiration of pure pancreatic juice is useful in diagnosis and treatment of chronic pancreatitis. |
| FullText URL | 068_094_098.pdf |
| Author | Ochi, Koji| Matsumura, Naoki| Kato, Tadahiro| Mizushima, Takaaki| Ichimura, Mitsuko| Harada, Hideo| Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hasuoka, Hideaki| Tsurumi, Tetsuya| |
| Abstract | 内視鏡的純粋膵液採取法の慢性膵炎診療における意義を検討した｡本法を用い,セクレパン100単位静注後10分間膵液を採取するintaraductal secretin test(IDST,膵管内セクレチン試験)はこれまで膵外分泌機能検査のgold standardである十二指腸液を採取するセクレチン試験に代用ができ,しかも10分間の採取時間で終了する利点を有する｡本法を施行することにより,蛋白栓が除去され,痔痛の消失に有用である｡また,慢性膵炎と鑑別を要する膵癌を除外診断するために,本法によって採取した膵液の細胞診,腫瘍マーカー,癌遺伝子の検出は有用である｡ |
| Keywords | 慢性膵炎 (chronic pancreatitis) 膵液 (pancreatic juice) 内視鏡 (endoscopy) 膵外分泌機能検査 (exocrine pancreatic function test) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 94 |
| End Page | 98 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308491 |
| JaLCDOI | 10.18926/14991 |
|---|---|
| Title Alternative | 呼吸器疾患のリハビリテーション.気管支喘息の病態的特徴と関連した温泉療法の効果 |
| FullText URL | 068_080_093.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Iwagaki, Naofumi| Yamamoto, Kazuhiko| |
| Abstract | The number of patients with respiratory disease in the elderly has been increasing in recent years. Pathophysiological characteristic of respiratory diseases in older patients is clearly different from that in younger patients. In this study, rehabilitation for patients with respiratory disease, particularly bronchial asthma, in the elderly was discussed in relation to pathophysiology of asthma. Complex spa therapy has two kinds of actions, direct and indirect actions. Subjective and objective symptoms of patients with asthma are improved by spa therapy for 1-2 months, accompanied with improvement of ventilatory function, and decrease in bronchial hyperresponsiveness and respiratory resistance. In addition to these direct action of spa therapy, increase in strength of respiratory muscle, stability of autonomic nerve syetem, psychical relaxation, and inprovement of suppressed function of adrenocortical glands are observed as indirect action of spa therapy. Regarding clinical asthma type classified by pathophysiological changes of the airways, spa therapy was more effective in patients with hypersecretion and bronchiolar obstruction. These results suggest that complex spa therapy is available as rehabilitation and/or treatment for patients with respiratory disease. |
| Keywords | 気管支喘息 (Bronchial asthma) リハビリテーション (rehabilitation) 複合温泉療法 (complex spa therapy) 換気機能 (ventilatory function) 副腎皮質 (adrenocortical glands) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 80 |
| End Page | 93 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308151 |
| JaLCDOI | 10.18926/14990 |
|---|---|
| Title Alternative | Application of hot spring pool training in outpatients with chronic diseases and its clinical evaluation |
| FullText URL | 068_071_079.pdf |
| Author | Nishimura, Nobuko| Kasui, Hayako| Yoshio, Keiko| Nakamura, Akemi| Ikeda, Akiko| Fukui, Yumi| Iga, Mayumi| Kuroda, Akiko| |
| Abstract | 1996年4月より6月までの3ヵ月間に,三朝分院内の温泉プールで水泳ないし歩行訓練を受けた内科外来患者は延べ2109例(実数213例)で,外来患者総数(延べ6848例)に対する利用率は30.8%であった｡これらの対象症例について,リハビリテーション受診カードにより,性別,年令別,疾患別の検討を行った｡その結果,性別では女性が多く(72.3%),年齢別では50才以上の患者が多い(80.3%)傾向が見られた｡また,地域別検討では,鳥取県内からの患 者が多い(88.3%)傾向であった。さらに,1996年12月より1997年1月へかけて,アンケート調査を行い(集計数;64例)継続期間,利用回数,効果を感じた期間,効果のあった症状などについて疾患別に比較検討した｡その結果,慢性閉塞性肺疾患を主とした呼吸器疾患では,週に1～2回の利用回数(50.0%)で長期間(3年以上:52.9%)続けている患者が多い傾向であった｡また慢性関節リウマチ,腰痛などの慢性疼痛性疾患では,訓練期間は比較的短期間であっ たが（3年以下:52.9%),利用回数は週に3～5回(38.0%)と多い傾向が見られた。温泉プール訓練では,疾患本来の症状改善に加えて,全身状態の改善,精神的リラックス,気分転換などを感じていることが示唆された｡ |
| Keywords | 温水プール水泳訓練 (swimming training in a hot spring pool) 呼吸器疾患 (respiratory disease) 慢性疼痛性疾患 (chronic pain disease) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 71 |
| End Page | 79 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308283 |
| JaLCDOI | 10.18926/14989 |
|---|---|
| Title Alternative | A case of eosinophilic gastroenteritis with stenosis in the colon |
| FullText URL | 068_064_070.pdf |
| Author | Mizushima, Takaaki| Ochi, Koji| Matsumura, Naoki| Kato, Tadahiro| Seno, Toshinobu| Harada, Hideo| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | 大腸に全周性狭窄をきたした好酸球性胃腸炎の1例を報告した｡症例は54才の女性で,腹痛と下痢を主訴に来院した｡上部消化管検査では異常を認めなかったが,下部消化管造影検査と大腸内視鏡検査で横行結腸の全周性狭窄を認め,生検にて大腸粘膜の好酸球浸潤を認めた｡貝料理の摂取にて腹痛発作が出現したが,原因抗原は同定できなかった｡貝類の摂取を避けることにより,症状は消失し,末梢血液中の好酸球増多は消失した｡本邦ではこれまでに124例 の報告があるが,大腸に全周性の狭窄をきたす症例は稀であり,文献的考察を加え報告する｡ |
| Keywords | 好酸球性胃腸炎 (eosinophilic gastroenteropathy) 大腸 (colon) 狭窄 (stenosis) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 64 |
| End Page | 70 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308243 |
| JaLCDOI | 10.18926/14988 |
|---|---|
| Title Alternative | 慢性膵炎患者の全消化管通過に関する研究 |
| FullText URL | 068_059_063.pdf |
| Author | Mizushima, Takaaki| Ochi, Koji| Matsumura, Naoki| Seno, Toshinobu| Harada, Hideo| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | Abnormalities of whole gut transit could contribute to the maldigestion and digestive symptoms of chronic pancreatitis patients. Whole gut transit was measured by radiopaque markers method. Fifteen chronic pancreatitis patients (2 females, 13 males; age range 40-78 years) and 17 controls (4 females, 13 males, 32-73 years) were studied. Additionally, we also looked for evidence of autonomic neuropathy in the chronic pancreatitis patients by using cardiovascular tests. In chronic pancreatitis, whole gut transit was shorter than controls. These abnormalities were not influenced by the degree of autonomic neuropathy. We conclude that whole gut transit is shorter in chronic pancreatitis patients. |
| Keywords | 慢性膵炎 (Chronic pancreatitis) 全消化管通過 (Whole gut transit) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 59 |
| End Page | 63 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308490 |
| JaLCDOI | 10.18926/14987 |
|---|---|
| Title Alternative | Clinical effect of spa therapy on lumbargo |
| FullText URL | 068_051_058.pdf |
| Author | Okamoto, Makoto| Ashida, Kozo| Yamamoto, Kazuhiko| Iwagaki, Naofumi| Tsugeno, Hirofumi| Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine| |
| Abstract | 腰痛症患者12例を対象に温泉療法の臨床効果について検討した｡臨床効果の判定は,日本整形外科学会の腰痛治療成績判定基準に基づき,自覚症状,他覚症状,及び日常生活動作などの項目を中心に,治療前後で比較検討した｡その結果,自覚症状,日常生活動作,総計では,治療前に比べ治療後に有意の改善がみられた｡また改善指数や改善率での検討でも温泉療法の有効性が示唆された｡年齢別(60才以上と60才未満),入院期間(80日以上と80日未満)別の 検討では,65才未満の症例,80日以上の入院の症例において,改善指数,改善率が,有意差はみられなかったもののより高い傾向がみられた｡ |
| Keywords | 腰痛症 (lumbargo) 温泉療法 (spa therapy) 腰痛治療判定基準 (scoring system based on the standard judgement of therapy for lumbargo) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 51 |
| End Page | 58 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308321 |
| JaLCDOI | 10.18926/14986 |
|---|---|
| Title Alternative | 気管支喘息患者における腰椎海綿骨骨塩量と脊椎圧迫骨折の臨床的特徴 |
| FullText URL | 068_045_050.pdf |
| Author | Tsugeno, Hirofumi| Nakai, Mutsuro| Okamoto, Makoto| Mifune, Takashi| Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Akiyama, Tsuneo| Tsuji, Takao| Tanizaki, Yoshiro| |
| Abstract | Clinical risk factors associated with the development of osteoporosis and vertebral fractures were evaluated in patients with asthma in relation to sex, age, and dose of glucocorticoids (GC). In 75 asthmatic patients including 44 steroid-dependent asthma, the bone mineral density (BMD) of the lumber spines was measured by quantitative computed tomography (QCT). Thirty five patients of them were followed up with radiographs over a period of 0.5 to 4 years (average: 2.6±1.3 years). The BMD was significantly lower in older (p |
| Keywords | 気管支喘息 (bronchial asthma) 骨粗鬆症 (osteoporosis) 椎体骨折 (vertebral fracture) ステロイド療法 (glucocorticoid therapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 45 |
| End Page | 50 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308467 |
| JaLCDOI | 10.18926/14985 |
|---|---|
| Title Alternative | Dietary supplementation in bronchial asthma. Suppression of the generation of leukotrienes by N-3 fatty acids. |
| FullText URL | 068_041_044.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Iwagaki, Naofumi| Tanizaki, Yoshiro| Tsuji, Takao| Yamamoto, Junko| Okita, Misako| |
| Abstract | N-3系脂肪酸の気管支喘息に対する有用性が示唆されているが,その評価は定まっていない｡今回,5人の気管支喘息患者に対しN-3系脂肪酸であるαリノレン酸を豊富に含有するエゴマ油を用いた食事療法を行い,臨床症状,ピークフロー値,末梢白血球からのロイコトリエン産生能,血漿リン脂質中の脂肪酸組成につき検討を行った｡2週間の食事療法の前後でピークフロー値は有意な改善を示し(p<0.05),カルシウムイオノファー刺激によるロイコトリエン(LT)産生能は治療前後でLTB4が77.6ng/5×106cellsから41.6ng/5×10(6)cells(p<0.05)に,LTC4は64.0ng/5×10(6)cellsから38･8ng/5×10(6)cells(p<0.05)とともに有意な改善を認めた。また血漿リン脂質中のN-3系脂肪酸(αリノレン酸,エイコサペンタエン酸,ドコサヘキサエン酸)も有意な上昇を認めた。以上よりN-3系脂肪酸(エゴマ油)を用いた食事療法の有用性が示唆された｡ |
| Keywords | シソ油 (perilla seed oil) 気管支喘息 (bronchial asthma) ロイコトリエンB4 (LTB4) ロイコトリエンC4 (LTC4) 脂肪酸 (fatty acids) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 41 |
| End Page | 44 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308166 |
| Author | Yoneyama, Kiichiro| |
|---|---|
| Published Date | 2007-03-31 |
| Publication Title | 文化共生学研究 |
| Volume | volume7 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/14984 |
| Author | 傅 穹| |
|---|---|
| Published Date | 2007-03-31 |
| Publication Title | 文化共生学研究 |
| Volume | volume7 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/14983 |
| Author | 谷 凌| |
|---|---|
| Published Date | 2007-03-31 |
| Publication Title | 文化共生学研究 |
| Volume | volume7 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/14982 |
