ID | 33023 |
FullText URL | |
Author |
Katsu, Takashi
Tsunamoto, Yumi
Komagoe, Keiko
Masuda, Kazufumi
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Abstract | S,S,S-Tris(2-ethylhexyl) phosphorotrithioate proved to be an effective solvent mediator for constructing a mexiletine-sensitive membrane electrode in combination with an ion-exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate. Among a series of phosphorus compounds containing phosphoryl (P=O) groups, this solvent mediator showed the highest sensitivity to mexiletine in phosphate-buffered physiological saline containing 0.15 mol L-1 NaCl and 0.01 mol L-1 NaH2PO4/Na2HPO4 (pH 7.4), giving a detection limit of 2 x 10(-6) mol L-1 with a slope of 58.8 mV decade(-1). This is the best reported detection limit of any mexiletine-sensitive electrode developed to date. Owing to its high selectivity toward inorganic cations, the electrode was used to determine the level of mexiletine in saliva, the monitoring of which is quite effective for controlling the dose of this drug noninvasively. The mexiletine concentrations determined with the mexiletine-sensitive electrode compared favorably with those determined by high-performance liquid chromatography.
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Keywords | Ion-selective electrode
Mexiletine determination
S,S,S-Tris(2-ethylhexyl) phosphorotrithioate
Solvent mediator
Drug monitoring
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Note | Published with permission from the copyright holder.
This is published in Analytical and Bioanalytical Chemistry, 2007 Vol.387 Issue.6 pp.2057-2064 Publisher URL: http://dx.doi.org/10.1007/s00216-006-1105-y Direct access to Thomson Web of Science record (C)2007 Springer-Verlag. |
Published Date | 2007-03
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Publication Title |
Analytical and Bioanalytical Chemistry
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Volume | volume387
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Issue | issue6
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Publisher | Springer Berlin / Heidelberg
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Start Page | 2057
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End Page | 2064
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ISSN | 1618-2642
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NCID | AA00524787
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Content Type |
Journal Article
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language |
English
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Copyright Holders | Springer-Verlag
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File Version | author
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Refereed |
True
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DOI | |
Web of Science KeyUT | |
Submission Path | analytical_chemistry/42
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