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ID 33023
フルテキストURL
著者
Katsu, Takashi Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Tsunamoto, Yumi Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Hanioka, Nobumitsu Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Komagoe, Keiko Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Masuda, Kazufumi Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Narimatsu, Shizuo Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
抄録
S,S,S-Tris(2-ethylhexyl) phosphorotrithioate proved to be an effective solvent mediator for constructing a mexiletine-sensitive membrane electrode in combination with an ion-exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate. Among a series of phosphorus compounds containing phosphoryl (P=O) groups, this solvent mediator showed the highest sensitivity to mexiletine in phosphate-buffered physiological saline containing 0.15 mol L-1 NaCl and 0.01 mol L-1 NaH2PO4/Na2HPO4 (pH 7.4), giving a detection limit of 2 x 10(-6) mol L-1 with a slope of 58.8 mV decade(-1). This is the best reported detection limit of any mexiletine-sensitive electrode developed to date. Owing to its high selectivity toward inorganic cations, the electrode was used to determine the level of mexiletine in saliva, the monitoring of which is quite effective for controlling the dose of this drug noninvasively. The mexiletine concentrations determined with the mexiletine-sensitive electrode compared favorably with those determined by high-performance liquid chromatography.
キーワード
Ion-selective electrode
Mexiletine determination
S,S,S-Tris(2-ethylhexyl) phosphorotrithioate
Solvent mediator
Drug monitoring
備考
Published with permission from the copyright holder.
This is published in Analytical and Bioanalytical Chemistry, 2007 Vol.387 Issue.6 pp.2057-2064
Publisher URL: http://dx.doi.org/10.1007/s00216-006-1105-y
Direct access to Thomson Web of Science record
(C)2007 Springer-Verlag.
発行日
2007-03
出版物タイトル
Analytical and Bioanalytical Chemistry
387巻
6号
出版者
Springer Berlin / Heidelberg
開始ページ
2057
終了ページ
2064
ISSN
1618-2642
NCID
AA00524787
資料タイプ
学術雑誌論文
言語
English
著作権者
Springer-Verlag
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT
Submission Path
analytical_chemistry/42