JaLCDOI 10.18926/AMO/54816
FullText URL 70_6_507.pdf
Author Torigoe, Hidejiro| Toyooka, Shinichi| Yamamoto, Hiromasa| Soh, Junichi| Miyoshi, Shinichiro|
Abstract We present the case of a 65-year-old Japanese man diagnosed with chronic empyema (without a bronchopleural fistula) that occurred 7 months after he underwent an extrapleural pneumonectomy for right malignant pleural mesothelioma (MPM). Following thoracic drainage and irrigation for 1 month, we performed surgery by a thoracoscopic approach, in light of his general condition. We performed debridement and removal of the Gore-Tex polytetrafluoroethylene (PTFE) patch that had been used for the reconstruction of the diaphragm and the pericardium. The empyema had not relapsed when he died from recurrence of the MPM at 4 months after the thoracoscopic surgery. This patientʼs case suggests that thoracoscopic debridement and patch removal can be a therapeutic option for not only early-stage (exudative or fibrinopurulent) empyema but also late-stage (organized and chronic) empyema without a bronchopleural fistula, particularly for patients in poor general condition.
Keywords empyema chronic extrapleural pneumonectomy thoracoscopic debridement patch removal
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2016-12
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 507
End Page 510
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003678
JaLCDOI 10.18926/AMO/65492
FullText URL 77_3_273.pdf
Author Shimizu, Yudai| Kuroda, Masahiro| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Yoshida, Suzuka| Fukumura, Yuka| Nakamura, Yoshihide| Kuroda, Kazuhiro| Kamizaki, Ryo| Imajoh, Satoshi| Tanabe, Yoshinori| Sugimoto, Kohei| Oita, Masataka| Sugianto, Irfan| Bamgbose, Babatunde O.| Yanagi, Yoshinobu| Asaumi, Junichi|
Abstract Diffusion kurtosis (DK) imaging (DKI), a type of restricted diffusion-weighted imaging, has been reported to be useful for tumor diagnoses in clinical studies. We developed a software program to simultaneously create DK images with apparent diffusion coefficient (ADC) maps and conducted an initial clinical study. Multi-shot echo-planar diffusion-weighted images were obtained at b-values of 0, 400, and 800 sec/mm2 for simple DKI, and DK images were created simultaneously with the ADC map. The usefulness of the DK image and ADC map was evaluated using a pixel analysis of all pixels and a median analysis of the pixels of each case. Tumor and normal tissues differed significantly in both pixel and median analyses. In the pixel analysis, the area under the curve was 0.64 for the mean kurtosis (MK) value and 0.77 for the ADC value. In the median analysis, the MK value was 0.74, and the ADC value was 0.75. The MK and ADC values correlated moderately in the pixel analysis and strongly in the median analysis. Our simple DKI system created DK images simultaneously with ADC maps, and the obtained MK and ADC values were useful for differentiating head and neck tumors from normal tissue.
Keywords simple diffusion kurtosis imaging mean kurtosis clinical trial head and neck tumor magnetic resonance imaging
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 273
End Page 280
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357628
Web of Science KeyUT 001026279600005
JaLCDOI 10.18926/AMO/62410
FullText URL 75_4_543.pdf
Author Yoshida, Ryuichi| Yagi, Takahito| Yasui, Kazuya| Umeda, Yuzo| Yoshida, Kazuhiro| Fuji, Tomokazu| Takagi, Kosei| Kumano, Kenjiro| Yoshimoto, Masashi| Fujiwara, Toshiyoshi|
Abstract The outcomes of pancreatectomy with resection and reconstruction of the involved arteries for locally advanced pancreatic cancer following chemotherapy have improved in recent years. In pancreatic head cancers in which there is contact with the common and proper hepatic arteries, margin-negative resection requires pancreati-coduodenectomy, with the resection of these arteries and the restoration of hepatic arterial flow. Here, we describe a middle colic artery transposition technique in hepatic arterial reconstruction during pancreatoduo-denectomy for an initially unresectable locally advanced pancreatic cancer. This technique was effective and may provide a new option for hepatic artery reconstruction in such cases.
Keywords hepatic artery locally advanced pancreatic cancer middle colic artery pancreatoduodenectomy reconstruction technique
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 543
End Page 548
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511625
Web of Science KeyUT 000696755800004
NAID 120007146036
JaLCDOI 10.18926/AMO/52656
FullText URL 68_3_157.pdf
Author Oozawa, Susumu| Sano, Shunji| Nishibori, Masahiro|
Abstract Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator. A previous study suggested that fibrinogen is an important factor associated with atherosclerosis progression. The present study was performed to examine the levels of plasma HMGB1 protein in atherosclerosis patients. We studied 24 patients with peripheral artery disease (PAD) with atherosclerosis, and 10 healthy controls. We found that the concentrations of HMGB1 were increased in the plasma of the patients with atherosclerosis, and there were significant correlations between the plasma HMGB1 and fibrinogen levels. Plasma HMGB1 may play a key role in the pathogenesis of clinical and experimental atherosclerosis.
Keywords HMGB1 fibrinogen atherosclerosis peripheral artery disease
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2014-06
Volume volume68
Issue issue3
Publisher Okayama University Medical School
Start Page 157
End Page 162
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24942794
Web of Science KeyUT 000337655600005
Related Url http://doi.org/10.18926/AMO/52792
JaLCDOI 10.18926/AMO/65751
FullText URL 77_4_407.pdf
Author Hotta, Kensuke| Kobayashi, Takaomi|
Abstract This study aimed to investigate the usefulness of force-controlled pelvic stress radiographs in the evaluation and treatment of fragility fractures of the pelvis (FFP) using a functional treatment strategy. We conducted a retrospective study of 55 geriatric patients with FFP who underwent pelvic stress radiographs on admission. The differences in the sacral width, pelvic ring width, and medial femoral head width between the radiographs with and without the Sam Sling II M size were defined as Δ sacral width, Δ pelvic ring width, and Δ medial femoral head width, respectively. We used Pearson’s correlation test to assess the relationship between the degree of radiographic instability and the Johns Hopkins highest level of mobility scale (JH-HLM) at 10-days postadmission. Conventional receiver-operating-characteristic curve analysis was used to identify cases requiring surgery using the best cutoff value for radiographic instability. The JH-HLM was significantly correlated with Δ sacral width (r=−0.401, p=0.017), but not with Δ pelvic ring width (r=−0.298, p=0.080) nor with Δ medial femoral head width (r= −0.261, p=0.128). The best cutoff value of Δ sacral width in identifying surgical cases was 10.7 mm (sensitivity 75.0%, specificity 98.0%). Force-controlled pelvic stress radiographs could be helpful in assessing the need for surgery on admission.
Keywords fragility fracture of the pelvis functional treatment strategy Sam Sling stress radiograph Johns Hopkins highest level of mobility scale
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 407
End Page 414
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635141
Web of Science KeyUT 001163659800001
JaLCDOI 10.18926/AMO/43828
FullText URL 65_1_33.pdf
Author Yanagawa, Youichi| Nishi, Kouichirou| Imamura, Tomonori| Sakamoto, Toshihisa|
Abstract Computed tomography (CT) is superior for the detection of substances with low radiolucency in comparison with abdominal roentgenograms. In the present study, medical chart review was retrospectively performed for patients who were admitted and underwent plain CT including the stomach on arrival to investigate whether CT is useful for diagnosing overdose (OD). The subjects were divided into patients with OD who did not undergo gastric lavage (OD group) and those without OD (Control group). The presence of a radiopaque area (Hounsfield number over 100 on a range of interest of 3mm2) in the stomach on CT was defined as a positive finding. The average Glasgow Coma Scale in the OD group (n=11) was significantly lower than that in the Control group (n=137). Positive findings on CT were found more frequently in the OD group than in the Control group (100 vs. 19.7%, p<0.0001). Based on the finding of a high-density deposition in the bottom of the stomach, the CT predicted OD with 98.5% specificity. Accordingly, CT findings of a high-density deposition in the stomach of a patient with a diminished consciousness may suggest the presence of a recent overdose.
Keywords overdose diagnosis CT
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2011-02
Volume volume65
Issue issue1
Publisher Okayama University Medical School
Start Page 33
End Page 39
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21339794
Web of Science KeyUT 000287620500005
JaLCDOI 10.18926/AMO/45269
FullText URL 65_2_105.pdf
Author Tsuzuki, Takao| Okada, Hiroyuki| Nasu, Junichiro| Takenaka, Ryuta| Inoue, Masafumi| Kawano, Seiji| Kita, Masahide| Hori, Keisuke| Yamamoto, Kazuhide|
Abstract The objectives of this study were to evaluate the accuracy of endoscopic ultrasonography (EUS) in local and regional staging of early gastric cancer, to analyze the factors influencing the accuracy of EUS, and to reveal the usefulness and problems of EUS in pre-treatment staging of gastric cancer. We examined 105 lesions in 104 patients with histologically confirmed gastric cancer and retrospectively evaluated them with EUS. The diagnostic accuracy, sensitivity, and specificity of EUS were determined by comparing the pre-treatment EUS with the postoperative histopathological findings. The overall diagnostic accuracy of EUS for the depth of cancer invasion was 86%. The overall sensitivity and specificity were 60% and 96%, respectively. The accuracy significantly declined in lesions located in the upper-third of the stomach (70%). Type 0-I lesions tended to be over-staged (12&), and the upper-third lesions tended to be under-staged (23%). The accuracy significantly declined in differentiated adenocarcinoma with massive submucosal invasion (56.5%). EUS is useful for evaluating the depth of gastric cancer invasion which determines the feasibility of endoscopic treatment. However, it is noteworthy that the diagnostic accuracy of the invasion depth diminished for lesions in the upper third of the stomach.
Keywords endoscopic ultrasonography early gastric cancer accuracy sensitivity specificity
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2011-04
Volume volume65
Issue issue2
Publisher Okayama University Medical School
Start Page 105
End Page 112
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21519368
Web of Science KeyUT 000289818800006
JaLCDOI 10.18926/AMO/32179
FullText URL fulltext.pdf
Author Murakami, Taiji| Ishino, Kozo| Nakayama, Hironobu| Kino, Koichi| Arai, Sadahiko| Nakayama, Yorikazu| Sugawara, Eiji| Senoo, Yoshimasa| Teramoto, Shigeru|
Abstract

Over the last three years, we have used ventricular assist devices (VAD) in 7 patients. Of these 7, four patients with combined aortic and mitral valvular disease underwent double valve replacement; one patient with annuloaortic ectasia underwent a Cabrol's operation; another had aortic valve replacement; the last patient had triple coronary artery bypass grafts. The only patient who could be weaned from CPB developed cardiogenic shock after the operation. LVADs supported 6 patients for 4 to 8 days and a BVAD supported one patient for 9 days. All patients survived the weaning procedure. Three were discharged from the hospital and survived 7 to 21 months. The 4 other patients died of multiple organ failure. Three of these four suffered from both renal failure and infection, while one patient had arrhythmia and died of ileus. These data suggest that renal failure and major infection can be serious detrimental complications to VAD support.

Keywords ventricular assist device postcaediotomy shock multiorgan failure
Amo Type Article
Publication Title Acta Medica Okayama
Published Date 1991-12
Volume volume45
Issue issue6
Publisher Okayama University Medical School
Start Page 433
End Page 440
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 1781299
Web of Science KeyUT A1991GX45300005
JaLCDOI 10.18926/AMO/30821
FullText URL fulltext.pdf
Author Sunami, Yoshifumi| Imai, Takeshi|
Abstract

Twenty-five cases of paraplegia due to fracture-dislocations of the thoracic and lumbar vertebrae were treated using the halo-pelvic apparatus. Thirteen of them only needed the apparatus, two underwent laminectomy, and ten had posterior spinal fusion in addition. The advantages of this method are that gentle reduction can be achieved without severe complications, and that posterior spinal fusion can be performed with this apparatus on, thus enabling an early start to the subsequent exercise program and minimal absence from work.

Amo Type Article
Publication Title Acta Medica Okayama
Published Date 1977-12
Volume volume31
Issue issue6
Publisher Okayama University Medical School
Start Page 361
End Page 368
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 147605
NAID 120002304995
JaLCDOI 10.18926/AMO/30785
FullText URL fulltext.pdf
Author Ohkawa, Motoomi| Katoh, Tsutomu| Nakano, Satoru| Fujiwara, Naomi| Mori, Yasutane| Hino, Ichiro| Tanabe, Masatada|
Abstract

Fluid-attenuated inversion recovery (FLAIR) imaging of hepatic hemangiomas (10 patients, 16 lesions) and hepatic cysts (8 patients, 10 lesions) was performed. All hemangiomas were hypointense on T1-weighted images and hyperintense on T2-weighted images. With Gd-DTPA (0.1 mmol/kg), all hemangiomas were enhanced but not all cysts. It was necessary to perform contrast enhanced imaging to differentiate hepatic hemangiomas from hepatic cysts. However, on FLAIR imaging, hepatic hemangiomas were strongly hyperintense and 9 of the 10 hepatic cysts were isointense. One of the hepatic cysts was slightly hyperintense. FLAIR images were useful in differential diagnosis of hepatic hemangiomas and hepatic cysts without using Gd-DTPA.

Keywords MRI FLAIR hepatic hemangioma hepatic cyst
Amo Type Article
Publication Title Acta Medica Okayama
Published Date 1997-10
Volume volume51
Issue issue5
Publisher Okayama University Medical School
Start Page 275
End Page 278
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 9359925
Web of Science KeyUT A1997YD65300006
JaLCDOI 10.18926/AMO/62778
FullText URL 75_5_641.pdf
Author Zulema Rosalia Arias Martinez| Jorge Luis Lopez Videla Montaño| Yamashiro, Keisuke| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Takashiba, Shogo|
Abstract This case report highlights the importance of using a dental operating microscope (DOM) and ultrasonic endodontic tips (UETs) to locate all root canals in the lower first premolar. A 53-year-old woman presented to our clinic with pain in the lower right first premolar. After a detailed search using a DOM and UETs, three root canals were found, prepared with rotary HyFlex endodontic files, and obturated using the lateral condensation technique. At the five-year follow-up after treatment, the tooth was completely restored and fulfilling its function, with no signs or symptoms of any post-treatment flare-up.
Keywords dental operating microscope lower first premolar multiple canals ultrasonic endodontic tips
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-10
Volume volume75
Issue issue5
Publisher Okayama University Medical School
Start Page 641
End Page 645
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34703048
Web of Science KeyUT 000711568400003
NAID 120007166663
JaLCDOI 10.18926/AMO/31844
FullText URL fulltext.pdf
Author Ohtsu, Tadahiro| Kokaze, Akatsuki| Shimada, Naoki| Kaneita, Yoshitaka| Shirasawa, Takako| Ochiai, Hirotaka| Ohida, Takashi|
Abstract

The structural deficits and problems associated with application of the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) were investigated. For this purpose, mortality statistics in Japan were examined for bias in the proportions of death causes classified using the ICD-10 four-character subcategory system, particularly the large distribution of cases classified under the .9 (unspecified) codes. The results showed that most deaths due to the 3 major causes were coded into the .9 subcategories. For example, 97.6% of the 607,065 deaths between 1995 and 2007 classified as I21 (acute myocardial infarction) were coded as I21.9 (acute myocardial infarction, unspecified). This suggests that the quality of the data recorded on many death certificates is poor. Thus, to ensure that the fourth-digit-level subcategories of the ICD-10 code system are effectively used to represent mortality data and actual causes of death in Japan, future studies should address the following objectives:(1) to minimize the discrepancy between the ICD classification terms and the names of diseases actually used in clinical practice, and (2) to actively raise awareness among physicians about the need to accurately record death causes on death certificates, since these records form the basis for determining mortality statistics in Japan.

Keywords ICD-10 four-character subcategories death certificate mortality statistics
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2009-10
Volume volume63
Issue issue5
Publisher Okayama University Medical School
Start Page 281
End Page 286
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 19893604
Web of Science KeyUT 000271132000008
JaLCDOI 10.18926/AMO/30567
FullText URL fulltext.pdf
Author Kimura, Ikuro| Yamana, Masatoshi| NNishishita, Akira| Sugiyama, Motoharu| Miyata, Akira|
Abstract

A urinary iron excretion test was carried out in 22 patients with iron deficiency anemia. The iron excretion index was significantly higher in patients with intractable iron deficiency anemia compared with normal subjects and anemic patients who were responsive to iron therapy. The findings suggest that iron excretion may be a factor that modulates the response of patients to iron therapy.

Keywords iron excretion iron deficiency anemia saccharated iron oxide.
Amo Type Article
Publication Title Acta Medica Okayama
Published Date 1980-02
Volume volume34
Issue issue1
Publisher Okayama University Medical School
Start Page 37
End Page 41
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 6446838
Web of Science KeyUT A1980JS13800005
JaLCDOI 10.18926/AMO/31637
FullText URL fulltext.pdf
Author Masatomi, Chie| Imai, Kaori| Wang, Da-Hong| Ikeda, Satoru| Taketa, Kazuhisa| Takata, Shinji| Kira, Shohei|
Abstract

The relationship between past and present lifestyle and urinary excretion of type I collagen cross-linked N-telopeptides (NTx) was studied in 61 Japanese females aged 34-59, with a view toward using NTx excretion rates as a predictor of future osteoporosis. Bone mineral density (BMD) of the lumbar spine, the speed of sound (SOS) and broadband ultrasound attenuation (BUA) of the os calcis, urinary NTx, serum osteocalcin (BGP) and bone-specific alkaline phosphatase (BAP) were measured. Stiffness index (stiffness) was calculated from SOS and BUA. The subjects were asked whether they took regular exercise in their childhood and teen years (in elementary, junior-high, senior-high school and college), the past (20-40 years of age) and present adulthood. Regular calcium intake, smoking habits, alcohol and other beverage consumption and milk consumption were also covered in the questionnaire. The mean NTx values of premenopausal and postmenopausal group were 22.2 and 56.0 nM bone collagen equivalents (BCE)/mM urinary creatinine (Cr), respectively. The group which did not exercise regularly between the ages of 20 and 40 had a higher mean NTx value (40.9 nMBCE/mMCr) than the group which did exercise regularly (22.7 nMBCE/mMCr). In multiple regression analyses, age, stiffness and exercise in past adulthood could explain 43.5% of the NTx variance. For prevention of bone metabolic increases around menopause, habitual exercise in early adulthood seems to be effective.

Keywords N-telopeptides bone turnover osteoporosis menopause lifestyle
Amo Type Article
Publication Title Acta Medica Okayama
Published Date 1999-06
Volume volume53
Issue issue3
Publisher Okayama University Medical School
Start Page 133
End Page 140
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
Web of Science KeyUT 000081201100006
JaLCDOI 10.18926/AMO/65150
FullText URL 77_2_199.pdf
Author Nagano, Tomohiro| Hosokawa, Shinobu| Miyahara, Hideaki| Yamada, Kotaro| Umeno, Takayuki| Kano, Hirohisa| Kayatani, Hiroe| Sakugawa, Makoto| Takehisa, Yasushi| Takenaka, Tadasu| Takeuchi, Makoto| Bessho, Akihiro|
Abstract Meningitis-retention syndrome (MRS) is the combination of aseptic meningitis and acute urinary retention that occurs in the absence of other neurological diseases. The cause(s) of MRS remain unclear. A 57-year-old Japanese woman was referred to our hospital for the evaluation of persistent fever and headache. The fever’s cause was initially unclear, but the presence of urinary retention raised concern about possible aseptic meningitis despite no physical indications of meningeal irritation. Only typical cases of MRS have been reported thus far to our knowledge, and it is important that clinicians are aware of MRS when it presents in this atypical form.
Keywords meningitis-retention syndrome aseptic meningitis acute urinary retention
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 199
End Page 201
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094958
Web of Science KeyUT 000982503800010
JaLCDOI 10.18926/AMO/32375
FullText URL fulltext.pdf
Author Taketa, Kazuhisa|
Abstract

An attempt was made to establish the method for the estimation of glucuronide formation in vivo using salicylamide and further to study the alteration in the glucuronide formation in liver disease. The results were as follows: 1. The method for the determination of free salicylamide separately from other conjugates of salicylamide in urine, without involving any hydrolysis of the other conjugates, was presented. When 1 g. of salicylamide was administered to the subjects with or without liver injuries, no free salicylamide was detected by the present method in the urine following the salicylamide administration. 2. The analytical method for the determination of salicylamide glucuronide was also devised by employing a hydrolysis with β-glucuronidase. The ratio of the salicylamide liberated by the enzymatic hydrolysis of the 10-hour urine following the administration of 1 g. of salicylamide to the total salicylamide excreted in the same urine was neither affected by the total recovery of the salicylamide nor by the urine volume. This ratio was thus used as a means of estimating the capacity of the glucuronide formation in vivo, although it was considered that the ratio might be affected to some extent by the competition between the glucuronide and other conjugate formations in vivo. 3. As a result of this salicylamide glucuronide excretion test, it was indicated that the in vivo formation of salicylamide glucuronide in the patients with postnecrotic cirrhosis was slightly decreased compared with that in normal controls.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1962-06
Volume volume16
Issue issue3
Publisher Okayama University Medical School
Start Page 129
End Page 136
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 13984681
NAID 120002312245
JaLCDOI 10.18926/AMO/63207
FullText URL 76_1_41.pdf
Author Miyahara, Hiroyuki| Miyai, Takayuki| Aya, Kunihiko| Tsukahara, Hirokazu|
Abstract High-dose steroids are required for the treatment of minimal change nephrotic syndrome (MCNS), especially for episodes of recurrence. Predicting and avoiding recurrence can help reduce the steroid dose, but prediction is currently difficult. We herein examined whether changes in laboratory data, especially the urinary protein- to-creatinine ratio (UTP/UCr), can predict clinical recurrence. We also assessed differences in clinical features between children and young adults. We included 36 patients with MCNS; for each case, we retrospectively studied laboratory data during stable remission and pre-recurrence, with the “stable” period defined as all but the 6 weeks before recurrence, and pre-recurrence defined as the 4±2 weeks before recurrence. UTP/UCr, serum albumin, etc. were measured every 5 years during stable periods. We divided patients into cohorts by age at recurrence, < 15 years and ≥ 15 years, and compared stable and pre-recurrence values for the two groups. UTP/UCr values during stable periods tended to be higher in younger patients. UTP/UCr and serum albumin showed statistically significant changes during pre-recurrence periods, but only in those aged ≥ 15 years. Thus, clinical features of recurrence differed depending on age. Signs of recurrence can be confirmed via UTP/UCr or serum albumin several weeks before recurrence in patients ≥ 15 years.
Keywords minimal change nephrotic syndrome recurrence urinary protein to creatinine ratio
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 41
End Page 49
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236997
Web of Science KeyUT 000762812700006
JaLCDOI 10.18926/AMO/54805
FullText URL 70_6_435.pdf
Author Yamashita, Miho| Hasegawa, Kosei| Higuchi, Yousuke| Miyai, Takayuki| Okada, Ayumi| Tanaka, Hiroyuki| Tsukahara, Hirokazu|
Abstract The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p<0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p<0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI.
Keywords bone resorption marker bone turnover bone mass
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-12
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 435
End Page 439
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003667
JaLCDOI 10.18926/AMO/32817
FullText URL fulltext.pdf
Author Erdil, Hayat| Mavi, Ayfer| Erdil, Sebati| Gumusburn, Erdem|
Abstract

Urethral duplication is a rare congenital anomaly. Although a number of theories have been proposed to describe the embryology of the condition, the actual mechanism of the disorder is still unclear. We report here a case of urethral duplication in a 11-year-old boy complaining of a double stream, and review the current literature on this rare entity.

Keywords urethra abnormalities duplication
Amo Type Article
Publication Title Acta Medica Okayama
Published Date 2003-04
Volume volume57
Issue issue2
Publisher Okayama University Medical School
Start Page 91
End Page 93
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 12866749
Web of Science KeyUT 000182520400007
JaLCDOI 10.18926/AMO/32371
FullText URL fulltext.pdf
Author Ida, Noriaki| Oda, Nobuo| Yoda, Tadao| Kiyama, Takashi|
Abstract

1. The objective of this investigation was to test the influence of mammary cancer tissue extract on the induction of various tumors by urethan. Three strains of female mice, Balb/c, Zb and Db, were used in this experiment. 2. It was found that urethan was a multipotential carcinogen in the induction of (a) lung tumor, ovarian hemorrhagic cyst, and hemorrhagic lesions in various tissue in Balb/c mice, (b) lung tumor, hepatoma, leukemia, mammary cancer, Harderian gland tumor and hemorrhagic lesions in various tissues such as spleen, mesenteric lymphnode, liver and ovary in Zb strain, and (c) lung tumor, mediastinal lymphoma, leukemia, hepatoma and hemorrhagic lesions in the liver and ovary in Db mice. 3. Mammary cancer tissue extract seemed to have a promotive effect on the generalization of the mediastinal lymphoma induced by urethan in Db female mice.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1962-10
Volume volume16
Issue issue5
Publisher Okayama University Medical School
Start Page 253
End Page 264
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
NAID 120002312307