ID | 32940 |
FullText URL | |
Author |
Uchida, Naohiko
Ujike, Hiroshi
Nakata, Kenji
Nomura, Akira
Katsu, Takeshi
Tanaka, Yuji
Imamura, Takaki
Sakai, Ayumu
Kuroda, Shigetoshi
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Abstract | Background: Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia.
Methods: A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies. |
Note | Digital Object Identifier: 10.1186/1471-244X-3-13
Published with permission from the copyright holder. This is the institute's copy, as published in BMC Psychiatry, 21 October 2003, 3:13. Publisher URL:http://dx.doi.org/10.1186/1471-244X-3-13 Copyright © 2003 Uchida et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
Published Date | 2003-10-21
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Publication Title |
BMC Psychiatry
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Volume | volume3
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Publisher | BioMed Central
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NCID | AA12072671
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Content Type |
Journal Article
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language |
English
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Copyright Holders | Uchida et al; licensee BioMed Central Ltd.
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File Version | publisher
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Refereed |
True
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DOI | |
PubMed ID | |
Submission Path | internal_medicine/3
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