ID | 61999 |
FullText URL | |
Author |
Morichika, Daisuke
Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Taniguchi, Akihiko
Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Oda, Naohiro
Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Fujii, Utako
Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Senoo, Satoru
Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Itano, Junko
Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kanehiro, Arihiko
Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kitaguchi, Yoshiaki
First Department of Internal Medicine, Shinshu University School of Medicine
Yasuo, Masanori
First Department of Internal Medicine, Shinshu University School of Medicine
Hanaoka, Masayuki
First Department of Internal Medicine, Shinshu University School of Medicine
Satoh, Takashi
Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center (WPI‑IFReC), Osaka University
Akira, Shizuo
Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center (WPI‑IFReC), Osaka University
Kiura, Katsuyuki
Department of Allergy and Respiratory Medicine, Okayama University
Maeda, Yoshinobu
Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Miyahara, Nobuaki
Department of Allergy and Respiratory Medicine, Okayama University
|
Abstract | Background IL-33, which is known to induce type 2 immune responses via group 2 innate lymphoid cells, has been reported to contribute to neutrophilic airway inflammation in chronic obstructive pulmonary disease. However, its role in the pathogenesis of emphysema remains unclear. Methods We determined the role of interleukin (IL)-33 in the development of emphysema using porcine pancreas elastase (PPE) and cigarette smoke extract (CSE) in mice. First, IL-33(-/-) mice and wild-type (WT) mice were given PPE intratracheally. The numbers of inflammatory cells, and the levels of cytokines and chemokines in the bronchoalveolar lavage (BAL) fluid and lung homogenates, were analyzed; quantitative morphometry of lung sections was also performed. Second, mice received CSE by intratracheal instillation. Quantitative morphometry of lung sections was then performed again. Results Intratracheal instillation of PPE induced emphysematous changes and increased IL-33 levels in the lungs. Compared to WT mice, IL-33(-/-) mice showed significantly greater PPE-induced emphysematous changes. No differences were observed between IL-33(-/-) and WT mice in the numbers of macrophages or neutrophils in BAL fluid. The levels of hepatocyte growth factor were lower in the BAL fluid of PPE-treated IL-33(-/-) mice than WT mice. IL-33(-/-) mice also showed significantly greater emphysematous changes in the lungs, compared to WT mice, following intratracheal instillation of CSE. Conclusion These observations suggest that loss of IL-33 promotes the development of emphysema and may be potentially harmful to patients with COPD.
|
Keywords | Chronic obstructive pulmonary disease
COPD
HGF
VEGF
|
Published Date | 2021-05-15
|
Publication Title |
Respiratory Research
|
Volume | volume22
|
Issue | issue1
|
Publisher | BMC
|
Start Page | 150
|
ISSN | 1465-993X
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | © The Author(s) 2021.
|
File Version | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.1186/s12931-021-01705-z
|
License | http://creativecommons.org/licenses/by/4.0/
|