| JaLCDOI | 10.18926/19683 |
|---|---|
| Title Alternative | Studies on anti-allergic actions of tranilast (Rizaben®) |
| FullText URL | 057_042_045.pdf |
| Author | Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Morinaga, Hiroshi| Ohtani, Jun| Kimura, Ikuro| |
| Abstract | 抗アレルギー剤（脱顆粒抑制剤）の1つであるtranilastの肥満細胞の遊離機序に対する抑制作用について検討を加えた。1．抗原刺激時の肥満細胞の(45)Ca uptakeおよびヒスタミン遊離に対して，tranilastは有意の抑制作用を示したが，comp.48/80刺激時にはtranilastの(45)Ca uptake，ヒスタミン遊離に対する抑制作用はほとんどみられなかった。2．phosphatidylserine添加時には，(45)Ca uptakeに対するtranilastの抑制作用は減弱傾向を示し，この傾向はヒスタミン遊離に対する作用に比べより高度であった。3．抗原および抗ヒトIgEによる好塩基球からのヒスタミン遊離に対して，tranilastは明らかな抑制作用を示さなかった。 |
| Keywords | トラニラスト (tranilast) (45)Ca取り込み ((45)Ca uptake) ヒスタミン遊離 (histamine release) 肥満細胞 (mast cell) 好塩基球 (basophils) |
| Publication Title | 環境病態研報告 |
| Published Date | 1986-07 |
| Volume | volume57 |
| Start Page | 42 |
| End Page | 45 |
| ISSN | 09133771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308998 |
| JaLCDOI | 10.18926/19710 |
|---|---|
| Title Alternative | Study on anti-allergic action of Terfenadine |
| FullText URL | 058_005_011.pdf |
| Author | Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Kitani, Hikaru| |
| Abstract | 選択的H(1)受容体拮抗薬であるTerfenadineの抗アレルギー作用，特にIgE系反応によるヒスタミン，およびCa ionophore A23187による好中球からのleukotrienes遊離に対する抑制作用を，ヒト末梢血白血球を用いて検討した。１．Terfenadineは，抗ヒトIgE刺激による健康人好塩基球および特異抗原刺激による気管支喘息患者好塩基球からのヒスタミン遊離に対して，全血法でのin vitro添加実験では有意の抑制作用を示さなかった。 2．洗浄白血球法によるin vitro添加実験では，Terfenadineは特異抗原および抗ヒトIgE刺激時の気管支喘息患者好塩基球からのヒスタミン，Ca ionophore A23187刺激時のleukotriene B(4)遊離に対して有意の抑制効果を示した。3．Terfenadineの内服によるin vivoの抑制実験では，IgE系反応による健康人および気管支喘息患者好塩基球からのヒスタミン遊離に対して有意の抑制効果は見られなかったが，特異抗原による皮膚反応に対しては明らかな抑制作用が観察された。以上より，Terfenadineは，組織肥満細胞および組織へと遊走してきた好塩基球に対してはある程度の抑制作用を有しているものと考えられた。 |
| Keywords | 夕一フェナンジン (Terfenadine) lgE系反応 (IgE-mediated reaction) ヒスタミン (histamine) 好塩基球 (basophils) |
| Publication Title | 環境病態研報告 |
| Published Date | 1987-08 |
| Volume | volume58 |
| Start Page | 5 |
| End Page | 11 |
| ISSN | 09133771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002309197 |
| JaLCDOI | 10.18926/11648 |
|---|---|
| Title Alternative | 種々の長さのスペーサーをもつハプテン化ボスファチジルエタノールアミンの新しい合成法 |
| FullText URL | 062_032_037.pdf |
| Author | Ishimori, Yoshio| Yasuda, Tatuji| |
| Abstract | The antigenicity of liposomes sensitized with haptenated phosphatidylethanolamine (PE) and the reactivity of the liposomes with complement depended on the length of the spacer between hapten and PE. To establish the optimal conditions for the assay, haptenated PE's with various length of spacers are required. In the previous method, hapten-spacer molecule was first synthesized to which PE was conjugated. Therefore, even different hapten molecules and different length of spacer molecules were used, every combination of hapten and spacer has to be synthesized. A new procedure for preparing hapten-spacer-PE was described here. We first prepared conjugates between PE and various length of spacer molecule, the terminal of which is an amino residue. These molecules react well with activated hapten molecules, giving a good yield of hapten-spacer-PE. |
| Keywords | Haptenated phosphatidylethanolamine (ハプテン化ホスファチジルエタノールアミン) Spacer (スペーサー) Liposomes (リポソーム) |
| Publication Title | 環境病態研報告 |
| Published Date | 1991-08 |
| Volume | volume62 |
| Start Page | 32 |
| End Page | 37 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002313629 |
| JaLCDOI | 10.18926/15065 |
|---|---|
| Title Alternative | The biochemical and biological activities of JUN. |
| FullText URL | 062_071_075.pdf |
| Author | Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Asaumi, Noboru| Tanizaki, Yoshiro| |
| Abstract | c-junはニワトリの癌ウイルスから分離された癌遺伝子（v-jun）のproto－oncogeneであり，その遺伝子産物は細胞内転写促進因子AP－1の主成分である。v－jun，c-junのトランスフォーム能を検討するために，我々はv-jun，ニワトリc-jun遺伝子さらにJUN遺伝子の種々の組換え体を複製能を持つレトロウイルスベクター（RCAS）に挿入し，CEF細胞（ニワトリ胎児線維芽細胞）にトランスフェクションした。その結果4か所存在する両者の構造的相違のうち，アミノ末端近くの27アミノ酸の欠損と3' untranslated regionの欠損が十分なトランスフォーム能と転写促進能発現に必須であることが明らかとなった。これらの部分がどのように機能発現に関与しているかは，これからの研究を待たねばならない。 |
| Keywords | 癌遺伝子 (Oncogene) JUN遺伝子 (JUN gene) レトロウイルスベクター (Retrovirus Vector) トランスフェクション (Transfection) トランスフォーム (Transform) |
| Publication Title | 環境病態研報告 |
| Published Date | 1991-08 |
| Volume | volume62 |
| Start Page | 71 |
| End Page | 75 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307874 |
| JaLCDOI | 10.18926/19758 |
|---|---|
| Title Alternative | Separation of paripheral leukocytes by counterflow centrifugation elutriation |
| FullText URL | 059_037_041.pdf |
| Author | Sudo, Michiyasu| Matsubara, Fumie| Araki, Hiroyuki| Kitani, Hikaru| Tanizaki, Yoshiro| |
| Abstract | JE－6B rotor（Beckman）を用いてcounterflow centrifugation elutriationによる末梢血白血球の分離を試み，若干の検討を加えた。1．flow rateが低い場合はリンパ球が大部分を占めたが，flow rateの増加とともに頻度は減少した。2． flow rateの増加とともに，好塩基球の頻度が増加し，9－10ml／minでは頻度のみでなく細胞数の増加も認められた。各fractionにおけるヒスタミン含有量も同様の傾向が認められた。3．好中球のpeakはflow rate 13ml／minであり以後減少を示した。4．最終段階で好酸球が増加傾向を示しChamber内で最も高値を示した。以上の結果よりcounterflow centrifugation elutriationによる末梢血白血球細胞分離は，in vitroにおける実験に有用な手段である可能性が示唆された。 |
| Keywords | 逆流負荷遠心法 (Counterflow centrifugation elutriation) JE－6Bローター (JE-6B rotor) 細胞分離 (Cell separation) 好塩基球 (Basophils) |
| Publication Title | 環境病態研報告 |
| Published Date | 1988-08 |
| Volume | volume59 |
| Start Page | 37 |
| End Page | 41 |
| ISSN | 09133771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002309189 |
| JaLCDOI | 10.18926/19842 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性喘息に対する温泉療法の遠隔効果 |
| FullText URL | 061_001_006.pdf |
| Author | Tanazaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Okuda, Hiroyuki| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | The immediate effects (IEs) and distant effects (DEs) of spa therapy were observed in 67 patients with steroid- dependent intractable asthma (SDIA). (1) The IEs of spa therapy evaluated one week after spa therapy were considerably high, and the efficacy rate was 61.5% in type Ⅰa, 82.7% in type Ⅰb, and 83.4% in type Ⅱ asthmatics. (2) The DEs of spa therapy on SDIA were also observed. The efficacy rate was 50.2% in type Ⅰa, 54.3% in type Ⅰb and 63.7% in type Ⅱ asthmatics. (3) The DEs of spa therapy were different between cases with and without maintenance therapy (MT). The efficacy rate of DEs was generally high (72.8～91.7%) in cases with MT, and low (16.7～40.0%) in cases without MT. These results show that MT is very important to keep the IEs of spa therapy high for a long time. |
| Keywords | lmmediate effects (即時的効果) Distant effects (遠隔効果) Maintenance therapy (継続療法) Spa therapy (温泉療法) Steroid-dependent intractable asthma (ステロイド依存性重症難治性喘息) |
| Publication Title | 環境病態研報告 |
| Published Date | 1990-09 |
| Volume | volume61 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 09133771 |
| language | English |
| File Version | publisher |
| NAID | 120002309169 |
| JaLCDOI | 10.18926/11668 |
|---|---|
| Title Alternative | カンジダ特異的IgG(4)抗体と気管支喘息 |
| FullText URL | 062_001_004.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Takatori, Akimasa| Okuda, Hiroyuki| Harada, Hideo| |
| Abstract | Serum levels of Candida-specific IgG(4) antibodies were examined in 66 patients with bronchial asthma, relating to patient age and asthma severity. 1. The levels of Candida-specific IgG(4) antibodies were the highest in patients with 60+years of age, compared to the levels in cases with 0-39 and 40-59 years of age. 2. In cases with 40-59 years of age, the levels of Candida-specific IgG(4) were significantly higher in cases with long-term steroid therapy (severe intractable asthma) than in cases without steroid regimen. The results suggest that increased levels of Candida-specific IgG(4) were observed in relation to patient age and asthma severity. |
| Keywords | Candida (カンジダ) Sepcific IgG(4) (特異的IgG(4)) Bronchial asthma (気管支喘息) Aging (加齢) Asthma severity (喘息重症度) |
| Publication Title | 環境病態研報告 |
| Published Date | 1991-08 |
| Volume | volume62 |
| Start Page | 1 |
| End Page | 4 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002313495 |
| JaLCDOI | 10.18926/11685 |
|---|---|
| Title Alternative | 日本に於ける二酸化炭素泉療法の現況 |
| FullText URL | 061_068_072.pdf |
| Author | Komoto, Yoshiaki| Soda, Mitsuhiro| Hirai, Shunichi| Morisue, Shinhachi| Suzuka, Ichio| Yorozu, Hidenori| |
| Abstract | Natural CO(2) springs have been scarcely utilized in Japan, whereas artificial CO(2) bathing has become popular by the introduction of CO(2) tablets and other apparatus for CO(2) water supply. Artificial CO(2) bathing is indicated for degenerative connective tissue disorders such as scleroderma, common stiff and painful shoulders, chronic joint pain, lumbago, and trophic changes due to insufficient peripheral circulation by virtue of the increase of tissue pO(2) and the improvement of tissue perfusion. Artificial CO(2) bathing promotes recovery from fatigue and is beneficial in women whose health has been adversely affected by cold. |
| Keywords | CO(2) -balneotherapy Artificial CO(2) -bathing Tissue pO(2) |
| Publication Title | 環境病態研報告 |
| Published Date | 1990-09 |
| Volume | volume61 |
| Start Page | 68 |
| End Page | 72 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002313982 |
| JaLCDOI | 10.18926/11579 |
|---|---|
| Title Alternative | 気管支喘息患者末梢血好塩基球の抗ヒトIgEおよびカルシウムイオノフォァA23187に対する反応性について |
| FullText URL | 061_016_022.pdf |
| Author | Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Okuda, Hiroyuki| Komagoe, Haruki| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions. |
| Keywords | Histamine release (ヒスタミン遊離) Basophils (好塩基球) Anti-lgE (抗ヒトIgE) Calcium ionophore A 23187 (カルシウムイオノフォァA23187) Bronchial asthma (気管支喘息) |
| Publication Title | 環境病態研報告 |
| Published Date | 1990-09 |
| Volume | volume61 |
| Start Page | 16 |
| End Page | 22 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002313673 |
| JaLCDOI | 10.18926/19755 |
|---|---|
| Title Alternative | 気管支喘息および慢性気管支炎患者における抗ヒトIgEによる好塩基球からのヒスタミン遊離 |
| FullText URL | 059_031_036.pdf |
| Author | Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Araki, Hiroyuki| Tsuji, Mitsuaki| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | Histamine release from basophils induced by anti-IgE was studied in 8 patients with chronic bronchitis and 50 patients with bronchial asthma by analyzing doseresponse curves. As the result, there were no significant differences in maximum percent histamine release from basophils among three groups of healthy subjects (24.7± 14.2%), patients with chronic bronchitis (27.7±22.1%) and those with bronchial asthma (28.4±17.0%). In the patients with bronchial asthma, the maximum percent histamine release was higher in accordance with higher serum IgE levels, and low maximum percent release was observed in patients with intrinsic asthma (14.1±7.2%). Study of dose-response curves of anti-IgE-induced histamine release showed that a negative slope from E(2) to E(1) was observed in both healthy subjects and patients with chronic bronchitis. The majority of asthmatics with serum IgE levels of 501IU/ml or over showed a positive slope from E(2) to E(1). |
| Keywords | Basophil response (好塩基球の反応性) Anti-lgE (抗ヒトIgE) Histamine release (ヒスタミン遊離) chronic bronchitis (慢性気管支炎) bronchial asthma (気管支喘息) |
| Publication Title | 環境病態研報告 |
| Published Date | 1988-08 |
| Volume | volume59 |
| Start Page | 31 |
| End Page | 36 |
| ISSN | 09133771 |
| language | English |
| File Version | publisher |
| NAID | 120002309114 |
| Author | Institute for Environmental Medicine, Okayama University Medical Scool| |
|---|---|
| Published Date | 1989-07 |
| Publication Title | 環境病態研報告 |
| Volume | volume60 |
| Content Type | Others |
| Author | Institute for Environmental Medicine, Okayama University Medical Scool| |
|---|---|
| Published Date | 1988-08 |
| Publication Title | 環境病態研報告 |
| Volume | volume59 |
| Content Type | Others |
| Author | 中村 寿美江| 石湯 和子| 谷本 悦子| |
|---|---|
| Published Date | 1986-07 |
| Publication Title | 環境病態研報告 |
| Volume | volume57 |
| Content Type | Others |
